Thioacetyl Modifiers

Thioacetyl Modifiers in uniform PEG thiolation reagents are PEG-based molecules that contain a thioacetyl-protected thiol (-SCOCH₃) group, allowing for the controlled introduction of reactive thiols into biomolecules or surfaces.

The thioacetyl group remains stable during conjugation steps and can be selectively deprotected—typically using hydroxylamine—to yield a free thiol for subsequent coupling reactions.

These reagents offer precise temporal control of thiol activation, making them valuable in applications such as protein modification, nanoparticle functionalization, and drug delivery system assembly.