Classical Cross-Linkers

Classical cross-linkers are chemical reagents used to covalently join two biomolecules, typically through reactive functional groups such as amines, sulfhydryls, or carboxyls. These cross-linkers are widely used to stabilize protein-protein, protein-nucleic acid, or protein-lipid interactions in biochemical and structural studies. The spacer arm length and cleavability of classical cross-linkers can be tailored for specific experimental needs. These reagents are essential tools in applications such as antibody labeling, protein complex analysis, and targeted drug delivery.

Vector Labs offers a comprehensive selection of classical cross-linkers and related reagents, including accelerating ligands, labeling kits, dimethylformamide solvents, heterobifunctional linkers reactive to thiol/carboxyl or amine/thiol groups, specialized buffers, aldehyde-hydrazine linkers, and homobifunctional carboxyl-reactive monoprotected cross-linkers for versatile bioconjugation applications.