Thiol Reactive

Thiol-Reactive Uniform mPEG (methoxy polyethylene glycol) Modifiers are PEG derivatives equipped with electrophilic groups—such as maleimide, iodoacetamide, or vinyl sulfone—that selectively react with thiol (-SH) groups on cysteine residues in proteins or other biomolecules. These reagents form stable covalent bonds, enabling precise PEGylation for enhanced solubility, stability, and reduced immunogenicity. The uniform mPEG structure ensures consistent performance, making them ideal for therapeutic conjugates, surface modifications, and targeted delivery applications.