DOTA Radioisotope Delivery Reagents

Chelator-Based Linkers for Radiometal Conjugation

DOTA radioisotope delivery reagents are functionalized chelators designed for stable incorporation of radiometals such as ⁶⁴Cu, ⁶⁸Ga, ⁹⁰Y, and ¹⁷⁷Lu into biomolecules. These reagents enable site-specific labeling through reactive groups (e.g., NHS esters, amines, azides) and often include monodisperse PEG (dPEG®) spacers to enhance solubility and reduce non-specific binding. Ideal for PET/SPECT imaging and targeted radiotherapy, DOTA-based linkers support the development of well-defined, stable radioconjugates for diagnostic and therapeutic use.