Accelerating Ligands

Copper(I)-catalyzed Azide-Alkyne Click Chemistry (CuAAC) relies on the presence of Copper(I) ions (Cu⁺). These ions are prone to oxidation which decreases the amount of active Cu⁺ available for reactions and leads to the formation of harmful byproducts which increase cytotoxicity in living cells.

Ligands with tertiary amine and triazine groups stabilize Cu⁺ by protecting it from degradation thus boosting the efficiency of CuAAC reactions. In addition, the reduced toxicity improves compatibility with biological systems.

Vector offers a comprehensive portfolio of CuAAC accelerating ligands providing options to meet the unique needs of your azide-alkyne cycloaddition reactions: THPTA, BTTAA, BTTES, BTTP, and TBTA.