Enhance Bioconjugation with High-Efficiency CuAAC Click Chemistry Reagents
Click chemistry reactions are renowned for their outstanding selectivity, efficiency, and versatility across a wide range of applications.
Among them, the Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC) is one of the most widely used and flexible reactions. CuAAC involves a 1,3-dipolar cycloaddition that links an azide and an alkyne in the presence of a copper(I) catalyst, producing a stable 1,4-disubstituted-1,2,3-triazole. Known for its high yields and exceptional specificity, CuAAC click chemistry has become a vital tool in both biological and chemical research

The Role of Accelerating Ligands in CuAAC:
To further enhance the efficiency and biocompatibility of CuAAC reactions Accelerating Ligands act to stabilize the copper catalyst and reduce cytotoxicity. For researchers looking to optimize CuAAC for specific applications, a variety of ligands are available to optimize reaction conditions to maximum efficiency and minimize cytotoxicity: THPTA, BTTAA, BTTES, BTTP, and TBTA.
Key Features of CuAAC Reactions:

Selectivity:

Solvent Versatility:

Small, Inert Tags:

Quantitative Yields:

Versatile Options:
Key Benefits of CuAAC Reactions:
Superior Selectivity:
Higher Efficiency:
Flexible Reaction Conditions:
Broad Applicability of CuAAC Reactions:
- Biomolecule Conjugation (ex. proteins, peptides, glycans, nucleic acids, lipids, nanoparticles)
- Organic Synthesis
- Nanotechnology and Material Science
- Metabolic Labeling
- Peptide and Protein Engineering
- Tissue Engineering and Regenerative Medicine
- Chemical Biology
- Surface functionalization
- Metabolomics