BioChronicles Blog

BioDesign click chemistry crosslinkers are designed for versatility and can be utilized in an assortment of applications.

This guide explains how to select maleimide crosslinkers on linear and multi-arm dPEG® linkers, with pH best practices, thiol/amine selectivity, solubility notes, and examples for ADCs, lipids, and proteins.

In the first of our three part series on Bioconjugation, we’ll be exploring what’s involved, how it enables life science research, the challenges associated with it, and the excitement in future work.

In the previous section, we discussed the methods of bioconjugation. And the marriage of a biomolecule and a small molecule has given rise to various modalities commonly used in biomedical research. Here, we focus on the applications in the fields of therapeutics, diagnostics, protein-protein interactions, and nanotechnology.

With knowledge of the applications that bioconjugation can play into, we finish by highlighting its key advantages and critical uses. While the applications are much broader than what we summarize here, we can deduce common threads between these methods.

With applications ranging from drug targeting to genome sequencing, bioconjugation provides tools for more effective imaging and drug discovery methods. Join us as we explore the possibilities in this article.

Bioconjugation offers a way to chemically link two molecules to form a single hybrid, where at least one of the molecules in the partnership is a biomolecule. The resulting product retains the activity of each component, yet also gains novel functionality that is not possible with either molecule alone. In a recent webinar, Dr. Craig Pow, Director of Technical Services at Vector Laboratories provided an introduction to bioconjugation and its applications, as well as key factors to success.