Amino-dPEG®24-acid, product number QBD-10317, is a PEGylated amino acid. A primary amine group and a propionic acid group sit on opposite ends of a long (76 atoms), single molecular weight polyethylene glycol (PEG) spacer of discrete length (dPEG®). The highly hydrophilic, discrete PEG spacer (Ð = 1) increases the hydrodynamic volume and imparts water solubility to conjugates that incorporate it. Moreover, Amino-dPEG®24-acid benefitted numerous applications, including peptide synthesis, peptide modification, surface modification, oligonucleotide sequencing, drug delivery, and small molecule modification.
| Unit Size | 100 mg, 1000 mg |
|---|---|
| Molecular Weight | 1146.35; single compound |
| Chemical formula | C₅₁H₁₀₃NO₂₆ |
| CAS | 756526-07-4 |
| Purity | > 97% |
| Spacers | dPEG® Spacer is 76 atoms and 89.0 Å |
| Shipping | Ambient |
| Typical solubility properties (for additional information contact Customer Support) | Methylene chloride, DMAC or DMSO or water. |
| Storage and handling | -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure. |
Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.
Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.
PEG-Labeled Nucleotides and Nanopore Detection for Single Molecule DNA Sequencing by Synthesis. Shiv Kumar, Chuanjuan Tao, Minchen Chien, Brittney Hellner, Arvind Balijepalli, Joseph W. F. Robertson, Zengmin Li, James J. Russo, Joseph E. Reiner3, John J. Kasianowicz & Jingyue Ju. Scientific Reports. 2012, 2 (684), September 21, 2012. DOI: 10.1038/srep00684.
Proton-sponge activity and receptor-targeting of sequence-defined nucleic acid carriers. Ulrich Benjamin Lachelt. October 21, 2014.
ICAM-1 Targeted Catalase Encapsulated PLGA-b-PEG Nanoparticles against Vascular Oxidative Stress. Sari, E.; Tunc-Sarisozen, Y.; Mutlu, H.; Shahbazi, R.; Ucar, G.; Ulubayram, K. Journal of Microencapsulation 2015, 32 (7), 687–698. https://doi.org/10.3109/02652048.2015.1073384.
Applicable patents and legal notices are available at legal notices.
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