Polymer Secondary Antibodies, Reagents, and Kits

Simplified Workflow, Sensitive Results.

 ImmPRESS™ Polymer Detection Empowers High-Performance Immunodetection Results 

Vector’s ImmPRESS Polymer Detection Reagents provide researchers with robust, sensitive, and streamlined solutions for high-performance immunohistochemistry (IHC) applications.  

The ImmPRESS technology leverages novel conjugation chemistries to create highly sensitive, enzyme-polymer antibody reagents. Our unique micro-polymers of highly active horseradish peroxidase (HRP) or alkaline phosphatase (AP) are combined with affinity-purified and pre-adsorbed secondary antibodies to deliver crisp, sensitive staining of target antibodies with minimal non-specific binding. 

Why Choose Our ImmPRESS Polymer Detection System?

Advanced Polymer Detection

Micro-polymer conjugates deliver crisp, high-intensity staining of primary antibody targets, even for membrane, nuclear, and low-abundance antigens.

Simplified IHC Workflow

Ready-to-use, optimized reagents simplify protocols, saving time without compromising sensitivity.

Flexible Enzyme Choices

Available with HRP or AP to suit different assay requirements.

Broad Compatibility

Designed to work with commonly used primary antibody species for seamless integration into existing workflows.

Reliable Performance in Animal Models

Pre-adsorbed formulations reduce cross-reactivity, making them ideal for research on diverse animal and veterinary specimens.

Streamlined Multiplex Staining

Dual enzyme options support multi-target detection while maintaining specificity and signal separation.

Compatible with Manual & Automated Platforms

Designed for flexibility, ImmPRESS reagents perform reliably in both manual staining and automated IHC platforms.

ImmPRESS Reagents to Meet Workflow Requirements

Which kit is right for you?

ImmPRESS kits are built to maximize detection of low or unknown abundance antigens for all circumstances. Whether you are looking for the convenience of a single-step protocol, a streamlined double labeling process, increased sensitivity, or efficient mouse-on-mouse staining with minimal background noise, there is an ImmPRESS kit for every application.

One-Step Detection Kits

ImmPRESS One-Step detection kits are species-specific and provide superior signal-to-noise detection of target antigens. Each kit includes:

ImmPRESS Polymer Antibody Reagent in the species of your choice, conjugated with peroxidase
2.5% Normal Horse Serum for blocking (ready-to-use)

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Two-Step Amplified Detection Kits

ImmPRESS HRP technology is paired with an amplifier antibody to provide a significant increase in workflow sensitivity. Each kit includes:

BLOXALL^® Endogenous HRP/AP Blocking Solution
2.5% Normal serum for blocking non-specific binding
Amplifier Antibody (either goat anti-mouse IgG or goat anti-rabbit IgG)
ImmPRESS Excel Amplified HRP Polymer Reagent (anti-goat IgG)
ImmPACT^® DAB EqV Substrate

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Double Staining Kits

Easy-to-use double staining kits feature an ImmPRESS AP/ImmPRESS HRP reagent cocktail which recognizes one rabbit antigen and one mouse antigen in a single step. Each kit includes:

BLOXALL^® Blocking Solution
2.5% Normal Serum
ImmPRESS Duet Duet HRP/AP Polymer Reagent
ImmPRESS HRP Anti-Mouse IgG and ImmPRESS AP Anti-Rabbit IgG

ImmPRESS HRP Anti-Mouse IgG and ImmPRESS AP Anti-Rabbit IgG
ImmPACT^® DAB EqV Substrate (HRP, brown)
ImmPACT^® Vector^® Red Substrate (AP, magenta)

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ImmPRESS Mouse-on-Mouse Detection

The Mouse-on-Mouse (M.O.M.) ImmPRESS HRP (Peroxidase) Polymer Kit is designed for species-on-species detection by using a proprietary Mouse Ig Blocking Reagent and an HRP polymer reagent to minimize endogenous mouse Ig staining, providing clear and specific antigen detection in mouse tissues, all with a simple, pre-optimized protocol. Use these kits to select for:

Transgene and knock-out mice models
Genetically modified mice
Mouse xenograft tissue
Normal mouse tissue

ImmPRESS Kit Selection Guide

Choose the optimal ImmPRESS Kit for your application by comparing the type of kit with the target species. For the best results, select the kit with the same species of antibody as the tissue in which it will be used.

Target Species		ImmPRESS HRP	ImmPRESS AP	ImmPRESS HRP Veterinary Reagent	ImmPRESS Excel Amplified Detection	ImmPRESS HRP PLUS Kits
Rabbit	made in horse	MP-7401	MP-5401	MP-6401-15	MP-7601	MP-7801-15
Rabbit	made in goat	MP-7451
Mouse	made in horse	MP-7402	MP-5402	MP-6402-15	MP-7602	MP-7802-15
Mouse	made in goat	MP-7452
Mouse (rat adsorbed)	made in horse	MP-7422-15
Mouse & Rabbit	made in horse	MP-7500				MP-7800-15
Rat	made in goat	MP-7404-50	MP-5404-15
Rat (mouse adsorbed)	made in goat	MP-7444-15	MP-5444-15
Goat	made in horse	MP-7405	MP-5405

Polymer Secondary Antibody and Reagent Technical and Educational Resources

For more information on ImmPRESS polymer technology in immunohistochemistry applications, including automated IHC protocols, explore the following resources.

ImmPRESS Polymer Detection Brochure

Learn more about how ImmPRESS system streamlines workflows while providing sensitivity and excellent signal strength.

Automated IHC Protocols using ImmPRESS Polymer Reagents

Review methodology for implementing ImmPRESS polymer reagents in a variety of automated staining platforms.