Thiol Group – VectorLabs https://staging.vectorlabs.com From linker design and synthesis, bioconjugated design and manufacturing, biomolecule labeling and functionalization, and detection system and solutions, our team is here to help you move forward, with impact. Wed, 22 Oct 2025 16:26:50 +0000 en-US hourly 1 https://wordpress.org/?v=6.9 https://staging.vectorlabs.com/wp-content/uploads/2024/11/V-favicon-02-100x100.png Thiol Group – VectorLabs https://staging.vectorlabs.com 32 32 Biotin (Long Arm) Maleimide https://staging.vectorlabs.com/products/biotin-long-arm-maleimide/ Sat, 29 Apr 2023 17:46:04 +0000 https://staging.vectorlabs.com/?post_type=product&p=13315 Description

Biotin (Long Arm) Maleimide is designed for biotinylating proteins, nucleic acids or other molecules containing one or more thiol groups. The presence of the 6-aminohexanoate spacer arm between the maleimide group and biotin reduces the possibility of steric hinderance. Molecules to be labeled with Biotin (Long Arm) Maleimide require free thiol groups. In the case of proteins, Biotin (Long Arm) Maleimide will react with exposed cysteine residues. Alternatively, free thiols may be generated by reducing disulfide bonds or by modifying other reactive groups such as primary amines with compounds like Traut’s reagent (2-iminothiolane).

Specifications

 
Unit Size 12 mg
Target for Labeling DNA, Oligonucleotides, PNA, Protein, RNA
Recommended Storage Storage in solution not recommended. – 20°C to – 80 °C.
Molecular Weight 479.6
Required Reactive Group Thiol Group
Tag/Group Incorporated Biotin
Safety Title WARNING: NA – www.P65Warnings.ca.gov

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Description

Biotin (Long Arm) Maleimide is designed for biotinylating proteins, nucleic acids or other molecules containing one or more thiol groups. The presence of the 6-aminohexanoate spacer arm between the maleimide group and biotin reduces the possibility of steric hinderance. Molecules to be labeled with Biotin (Long Arm) Maleimide require free thiol groups. In the case of proteins, Biotin (Long Arm) Maleimide will react with exposed cysteine residues. Alternatively, free thiols may be generated by reducing disulfide bonds or by modifying other reactive groups such as primary amines with compounds like Traut’s reagent (2-iminothiolane).

Specifications

 
Unit Size12 mg
Target for LabelingDNA, Oligonucleotides, PNA, Protein, RNA
Recommended StorageStorage in solution not recommended. – 20°C to – 80 °C.
Molecular Weight479.6
Required Reactive GroupThiol Group
Tag/Group IncorporatedBiotin
Safety TitleWARNING: NA – www.P65Warnings.ca.gov

Documents

Citations

Technical Information

Biotin (Long Arm) Maleimide reacts readily under mild acid or neutral pH conditions in aqueous solution with free sulfhydryl groups such as cysteine residues or thiol groups introduced chemically into proteins, nucleic acids, or other macromolecules.

For labeling nucleic acids, thiols can be introduced into DNA, RNA, or oligonucleotides using the 5′ EndTag™ or 3′ EndTag™ nucleic acid labeling systems.

Because of the extraordinary affinity of avidin and streptavidin to biotin and the many biotin-avidin/streptavidin systems available, the biotin label is ideal for a variety of applications including in situ hybridization, blotting, and affinity binding.

The spacer arm in this derivative insures that the biotin is fully accessible to avidin or streptavidin detection systems.

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