Neurobiology – VectorLabs https://staging.vectorlabs.com From linker design and synthesis, bioconjugated design and manufacturing, biomolecule labeling and functionalization, and detection system and solutions, our team is here to help you move forward, with impact. Wed, 22 Oct 2025 17:15:31 +0000 en-US hourly 1 https://wordpress.org/?v=6.9 https://staging.vectorlabs.com/wp-content/uploads/2024/11/V-favicon-02-100x100.png Neurobiology – VectorLabs https://staging.vectorlabs.com 32 32 NEUROBIOTIN® Tracer https://staging.vectorlabs.com/products/neurobiotin-tracer/ Tue, 02 May 2023 15:56:09 +0000 https://staging.vectorlabs.com/?post_type=product&p=14294 Description

NEUROBIOTIN Tracer (SP-1120) is an amino derivative of biotin that can be used as an intracellular label for cells, particularly neurons. It is used for visualizing neural architecture and for the identification of gap junction coupling.

Features:

  • Can be used in many types of preparations including in vivo, whole mounts, slice preparations, or cultured cells
  • Can be delivered by many routes such as intracellular electrodes, microinjection, cut-loading, or scrape-loading
  • Can be detected using avidin or streptavidin systems with either chromogenic or fluorescence visualization methods

Advantages over biocytin and other neuronal labels:

  • Better solubility
  • More efficiently iontophoresed
  • Remains in cell longer
  • Non-toxic
  • Can be fixed with formalin or glutaraldehyde

Specifications

Unit Size 20 mg, 50 mg
Chemical Formula C12H23ClN4O2S
Recommended Storage 2-8 °C (desiccated). Once in solution, store frozen.
Molecular Weight 322.8
Neuronal Tracer – Direction of Transport Anterograde/Retrograde
Detection Method Avidin(Streptavidin)/Biotin Method, Chromogenic, Fluorescence

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Description

NEUROBIOTIN Tracer (SP-1120) is an amino derivative of biotin that can be used as an intracellular label for cells, particularly neurons. It is used for visualizing neural architecture and for the identification of gap junction coupling.

Features:

  • Can be used in many types of preparations including in vivo, whole mounts, slice preparations, or cultured cells
  • Can be delivered by many routes such as intracellular electrodes, microinjection, cut-loading, or scrape-loading
  • Can be detected using avidin or streptavidin systems with either chromogenic or fluorescence visualization methods

 

Advantages over biocytin and other neuronal labels:

  • Better solubility
  • More efficiently iontophoresed
  • Remains in cell longer
  • Non-toxic
  • Can be fixed with formalin or glutaraldehyde

Specifications

Unit Size20 mg, 50 mg
Chemical FormulaC12H23ClN4O2S
Recommended Storage2-8 °C (desiccated). Once in solution, store frozen.
Molecular Weight322.8
Neuronal Tracer – Direction of TransportAnterograde/Retrograde
Detection MethodAvidin(Streptavidin)/Biotin Method, Chromogenic, Fluorescence

Documents

Citations

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]]> BLOXALL® Endogenous Blocking Solution, Peroxidase and Alkaline Phosphatase https://staging.vectorlabs.com/products/bloxall-endogenous-peroxidase-and-ap/ Tue, 02 May 2023 01:36:21 +0000 https://staging.vectorlabs.com/?post_type=product&p=13869 Description

BLOXALL Endogenous Peroxidase and Alkaline Phosphatase Blocking Solution is a dual enzyme blocking reagent that inactivates endogenous peroxidase, pseudoperoxidase, and alkaline phosphatase in formalin-fixed, paraffin-embedded tissue sections, frozen tissue sections, and cell preparations. This reagent is provided as a ready-to-use reagent in a convenient dropper bottle.

Features:

  • More effective than conventional blocking methods
  • Single 10 minute incubation step
  • 100 ml solution

Specifications

 
Unit Size 100 ml
Applications Immunohistochemistry / Immunocytochemistry, Immunofluorescence, In situ hybridization, Neurobiology
Recommended Storage 2-8 °C
Recommended Usage BLOXALL Endogenous Peroxidase and Alkaline Phosphatase Blocking Solution is a dual enzyme blocking reagent that inactivates endogenous peroxidase, pseudoperoxidase, and alkaline phosphatase in formalin-fixed, paraffin-embedded tissue sections, frozen tissue sections, and cell preparations.
Blocking Action Endogenous Peroxidase, Endogenous Alkaline Phosphatase

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Description

BLOXALL Endogenous Peroxidase and Alkaline Phosphatase Blocking Solution is a dual enzyme blocking reagent that inactivates endogenous peroxidase, pseudoperoxidase, and alkaline phosphatase in formalin-fixed, paraffin-embedded tissue sections, frozen tissue sections, and cell preparations. This reagent is provided as a ready-to-use reagent in a convenient dropper bottle.

Features: 

  • More effective than conventional blocking methods
  • Single 10 minute incubation step
  • 100 ml solution

Specifications

 
Unit Size100 ml
ApplicationsImmunohistochemistry / Immunocytochemistry, Immunofluorescence, In situ hybridization, Neurobiology
Recommended Storage2-8 °C
Recommended UsageBLOXALL Endogenous Peroxidase and Alkaline Phosphatase Blocking Solution is a dual enzyme blocking reagent that inactivates endogenous peroxidase, pseudoperoxidase, and alkaline phosphatase in formalin-fixed, paraffin-embedded tissue sections, frozen tissue sections, and cell preparations.
Blocking ActionEndogenous Peroxidase, Endogenous Alkaline Phosphatase

Documents

Citations

Technical Information

Tissues can contain endogenous peroxidase, pseudoperoxidase, and/or alkaline phosphatase activity that will produce background staining if an alkaline phosphatase and/or peroxidase detection system and corresponding substrates are used. 

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]]> Wheat Germ Agglutinin (WGA), Peroxidase https://staging.vectorlabs.com/products/peroxidase-conjugated-wheat-germ-agglutinin/ Fri, 28 Apr 2023 19:51:54 +0000 https://staging.vectorlabs.com/?post_type=product&p=12841 Description

Peroxidase conjugated Wheat Germ Agglutinin is specially prepared for neuronal transport studies. This product is supplied as 40 mg/ml of protein in a 2 mg package ready for injection. After tissue preparation, detection can be readily achieved with a peroxidase substrate.

Specifications

Unit Size 2 mg
Applications Immunohistochemistry / Immunocytochemistry, Neurobiology, Blotting Applications, ELISAs, Glycobiology
Conjugate Peroxidase
Sugar Specificity N-Acetylglucosamine
Safety Title WARNING: Cancer – www.P65Warnings.ca.gov

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Description

Peroxidase conjugated Wheat Germ Agglutinin is specially prepared for neuronal transport studies. This product is supplied as 40 mg/ml of protein in a 2 mg package ready for injection. After tissue preparation, detection can be readily achieved with a peroxidase substrate.

Specifications

Unit Size2 mg
ApplicationsImmunohistochemistry / Immunocytochemistry, Neurobiology, Blotting Applications, ELISAs, Glycobiology
ConjugatePeroxidase
Sugar SpecificityN-Acetylglucosamine
Safety TitleWARNING: Cancer – www.P65Warnings.ca.gov

Documents

Citations

Technical Information

Wheat germ agglutinin (WGA) contains a group of closely related isolectins, with an isoelectric point about pH 9. The receptor sugar for WGA is N-acetylglucosamine, with preferential binding to dimers and trimers of this sugar. WGA can bind oligosaccharides containing terminal N-acetylglucosamine or chitobiose, structures which are common to many serum and membrane glycoproteins. Bacterial cell wall peptidoglycans, chitin, cartilage glycosaminoglycans, and glycolipids can also bind WGA. Native WGA has also been reported to interact with some glycoproteins via sialic acid residues (see succinylated WGA). This lectin is used for the purification of insulin receptors and for neuronal tracing.

WGA-HRP can be used for both anterograde and retrograde tracing. Our peroxidase-wheat germ agglutinin is specially prepared for neuronal transport studies. WGA-peroxidase features a high concentration of protein and is supplied in a 2 mg package at 40 mg/ml ready for injection. Unconjugated wheat germ agglutinin, also used in neuronal studies is available as 10 mg and 25 mg of salt-free, lyophilized lectin.

Inhibiting/Eluting Sugar: Chitin Hydrolysate or 500 mM N-acetylglucosamine with salt and/or acid elution generally required

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