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		<title>m-dPEG®₂-NHS ester</title>
		<link>https://staging.vectorlabs.com/products/m-dpeg2-nhs-ester/</link>
		
		<dc:creator><![CDATA[Vector Laboratories R&D]]></dc:creator>
		<pubDate>Sat, 24 Feb 2024 02:10:07 +0000</pubDate>
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					<description><![CDATA[<p>m-dPEG®2-NHS ester, product number QBD-10327, is a short (8 atoms, 8.5 Å), methyl-terminated, discrete-length polyethylene glycol (dPEG®) spacer, functionalized as the N-hydroxysuccinimidyl (NHS) ester and designed for modification of surfaces containing accessible free amines. NHS reacts optimally with free amines at pH 7.0 – 7.5. The active ester’s rate of hydrolysis to the carboxylic acid accelerates with increasing pH. Please note that modification of surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.</p>
<p>One potential application for this product include charge modification of a biomolecule by modifying positively charged free amines with the uncharged m-dPEG®2-NHS ester. Another potential application is to use m-dPEG®2-NHS ester in a mixed surface modification (for example, an amine-coated glass or silica surface) where the shorter dPEG® product passivates the surface while longer dPEG® products contain reactive groups for additional functionalization of the surface. Other potential or published applications for this product include the following:<br />
surface modification of silica-shelled quantum dots;<br />
coating of carbon nanotubes and other hydrophobic surfaces;<br />
N-terminal peptide modification; and<br />
various imaging applications.</p>
<h3>Specifications</h3>
<table id="product-attribute-specs-table" class="data table additional-attributes" width="585">
<tbody>
<tr>
<th class="col label" scope="row">Unit Size</th>
<td class="col data" data-th="Unit Size">100 mg, 1000 mg</td>
</tr>
<tr>
<th class="col label" scope="row">Molecular Weight</th>
<td class="col data" data-th="Applications">245.23; single compound</td>
</tr>
<tr>
<th class="col label" scope="row">Chemical formula</th>
<td class="col data chemicalStructure">C₁₀H₁₅NO₆</td>
</tr>
<tr>
<th class="col label" scope="row">CAS</th>
<td class="col data" data-th="Target Species">1127247-34-0</td>
</tr>
<tr>
<th class="col label" scope="row">Purity</th>
<td class="col data" data-th="Target Species">&#62; 98%</td>
</tr>
<tr>
<th class="col label" scope="row">Spacers</th>
<td class="col data" data-th="Target Species">dPEG® Spacer is 8 atoms and 8.5 Å</td>
</tr>
<tr>
<th class="col label" scope="row">Shipping</th>
<td class="col data" data-th="Target Species">Ambient</td>
</tr>
<tr>
<th class="col label" scope="row">Typical solubility properties (for additional information contact Customer Support)</th>
<td class="col data">Methylene chloride, Acetonitrile, DMAC or DMSO.</td>
</tr>
<tr>
<th class="col label" scope="row">Storage and handling</th>
<td class="col data">-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.</td>
</tr>
</tbody>
</table>
<p>The post <a rel="nofollow" href="https://staging.vectorlabs.com/products/m-dpeg2-nhs-ester/">m-dPEG®₂-NHS ester</a> appeared first on <a rel="nofollow" href="https://staging.vectorlabs.com">VectorLabs</a>.</p>
]]></description>
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                                                            <h2 class="eael-tab-title title-after-icon" >Description</h2>                                                    </li>
                                            <li id="specifications" class="inactive eael-tab-item-trigger eael-tab-nav-item" aria-selected="false" data-tab="2" role="tab" tabindex="-1" aria-controls="specifications-tab" aria-expanded="false">
                            
                            
                            
                                                            <h2 class="eael-tab-title title-after-icon" >Specifications</h2>                                                    </li>
                                            <li id="documents" class="inactive eael-tab-item-trigger eael-tab-nav-item" aria-selected="false" data-tab="3" role="tab" tabindex="-1" aria-controls="documents-tab" aria-expanded="false">
                            
                            
                            
                                                            <h2 class="eael-tab-title title-after-icon" >Documents</h2>                                                    </li>
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                                                            <h2 class="eael-tab-title title-after-icon" >References</h2>                                                    </li>
                                    </ul>
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            <div class="eael-tabs-content">
		        
                    <div id="description-tab" class="clearfix eael-tab-content-item inactive" data-title-link="description-tab">
				        <h3>Description</h3><p>m-dPEG®2-NHS ester, product number QBD-10327, is a short (8 atoms, 8.5 Å), methyl-terminated, discrete-length polyethylene glycol (dPEG®) spacer, functionalized as the N-hydroxysuccinimidyl (NHS) ester and designed for modification of surfaces containing accessible free amines. NHS reacts optimally with free amines at pH 7.0 – 7.5. The active ester’s rate of hydrolysis to the carboxylic acid accelerates with increasing pH. Please note that modification of surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.</p><p>One potential application for this product include charge modification of a biomolecule by modifying positively charged free amines with the uncharged m-dPEG®2-NHS ester. Another potential application is to use m-dPEG®2-NHS ester in a mixed surface modification (for example, an amine-coated glass or silica surface) where the shorter dPEG® product passivates the surface while longer dPEG® products contain reactive groups for additional functionalization of the surface. Other potential or published applications for this product include the following:<br />surface modification of silica-shelled quantum dots;<br />coating of carbon nanotubes and other hydrophobic surfaces;<br />N-terminal peptide modification; and<br />various imaging applications.</p>                    </div>
		        
                    <div id="specifications-tab" class="clearfix eael-tab-content-item inactive" data-title-link="specifications-tab">
				        <h3>Specifications</h3><table id="product-attribute-specs-table" class="data table additional-attributes" width="585"><tbody><tr><th class="col label" scope="row">Unit Size</th><td class="col data" data-th="Unit Size">100 mg, 1000 mg</td></tr><tr><th class="col label" scope="row">Molecular Weight</th><td class="col data" data-th="Applications">245.23; single compound</td></tr><tr><th class="col label" scope="row">Chemical formula</th><td class="col data chemicalStructure">C₁₀H₁₅NO₆</td></tr><tr><th class="col label" scope="row">CAS</th><td class="col data" data-th="Target Species">1127247-34-0</td></tr><tr><th class="col label" scope="row">Purity</th><td class="col data" data-th="Target Species">&gt; 98%</td></tr><tr><th class="col label" scope="row">Spacers</th><td class="col data" data-th="Target Species">dPEG® Spacer is 8 atoms and 8.5 Å</td></tr><tr><th class="col label" scope="row">Shipping</th><td class="col data" data-th="Target Species">Ambient</td></tr><tr><th class="col label" scope="row">Typical solubility properties (for additional information contact Customer Support)</th><td class="col data">Methylene chloride, Acetonitrile, DMAC or DMSO.</td></tr><tr><th class="col label" scope="row">Storage and handling</th><td class="col data">-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.</td></tr></tbody></table><h3><br /><br /></h3>                    </div>
		        
                    <div id="documents-tab" class="clearfix eael-tab-content-item inactive" data-title-link="documents-tab">
				        <h3>Documents</h3><div class="explorer_section applications container documentSection catalog-product-document"><ul class="document_list"><li class="documentContainer documentItem"><a href="https://staging.vectorlabs.com/productattachments/sds/VL_QBD-10327_sds.pdf" target="_blank" rel="noopener">Safety Data Sheet</a></li><li><a class="woocommerce-print-products-pdf-link" href="https://staging.vectorlabs.com/products/m-dpeg2-nhs-ester/?print-products=pdf" target="_blank">Datasheet</a></li></ul></div>                    </div>
		        
                    <div id="references-tab" class="clearfix eael-tab-content-item inactive" data-title-link="references-tab">
				        <h3>References</h3><p>Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.<br /><br />Short polyethylene glycol chains densely bound to soft nanotube channels for inhibition of protein aggregation. N. Kameta, T. Matsuzawa, K. Yaoi, and M. Masuda. RSC Advances. 2016, 6 (43) pp 36744-36750. April 7, 2016. DOI: 10.1039/C6RA06793J.<br /><br />Hairpin Structure of a Biarsenical- Tetracysteine Motif Determined by NMR Spectroscopy, Fatemeh Madani, Jesper Lind, Peter Damberg, Stephen R. Adams, Roger Y. Tsien, and Astrid O. Graslund. JACS (J. Am. Chem. Soc.). 2009, 131 (13), pp 4613–4615. March 12, 2009. DOI: 10.1021/ja809315x.<br /><br />Silica-Shelled Single Quantum Dot Micelles as Imaging Probes with Dual or Multimodality. Rumiana Bakalova, Zhivko Zhelev, Ichio Aoki, Hideki Ohba, Yusuke Imai, and Iwao Kanno. Anal. Chem. 2006, 78 (16) pp 5925–5932. July 14, 2006. DOI: 10.1021/ac060412b.</p>                    </div>
		                    </div>
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		<p>The post <a rel="nofollow" href="https://staging.vectorlabs.com/products/m-dpeg2-nhs-ester/">m-dPEG®₂-NHS ester</a> appeared first on <a rel="nofollow" href="https://staging.vectorlabs.com">VectorLabs</a>.</p>
]]></content:encoded>
					
		
		
			</item>
		<item>
		<title>m-dPEG®₂-acid</title>
		<link>https://staging.vectorlabs.com/products/m-dpeg2-acid/</link>
		
		<dc:creator><![CDATA[Vector Laboratories R&D]]></dc:creator>
		<pubDate>Sat, 24 Feb 2024 02:10:06 +0000</pubDate>
				<guid isPermaLink="false">https://staging.vectorlabs.com/?post_type=product&#038;p=36010</guid>

					<description><![CDATA[<p>m-dPEG®2-acid, product number QBD-10326, is a very short, methyl-capped, discrete chain length polyethylene glycol (dPEG®) spacer. The reactive end of the molecule terminates as a propionic acid group. This group can be directly coupled to free amines on biomolecules and surfaces using EDC or another carbodiimide. Alternately, the reactive end can be functionalized with N-hydroxysuccinimide (NHS); 2,3,5,6-tetrafluorophenol (TFP); 2,3,4,5,6-pentafluorophenol (PFP); or some other activating agent for reaction with amines.</p>
<p>m-dPEG®2-acid can modify amine-functionalized surfaces (carbon nanotubes, other nanoparticles, quantum dots, etc.) or free amines on biomolecules (e.g., peptides and proteins). Coating surfaces or biomolecules with m-dPEG®2-acid can reduce or eliminate non-specific binding and increase hydrophilicity. Please note that modification of surface amines on biomolecules with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.</p>
<h3>Specifications</h3>
<table id="product-attribute-specs-table" class="data table additional-attributes" width="585">
<tbody>
<tr>
<th class="col label" scope="row">Unit Size</th>
<td class="col data" data-th="Unit Size">100 mg, 1000 mg</td>
</tr>
<tr>
<th class="col label" scope="row">Molecular Weight</th>
<td class="col data" data-th="Applications">148.16; single compound</td>
</tr>
<tr>
<th class="col label" scope="row">Chemical formula</th>
<td class="col data chemicalStructure">C₆H₁₂O₄</td>
</tr>
<tr>
<th class="col label" scope="row">CAS</th>
<td class="col data" data-th="Target Species">149577-05-9</td>
</tr>
<tr>
<th class="col label" scope="row">Purity</th>
<td class="col data" data-th="Target Species">&#62; 98%</td>
</tr>
<tr>
<th class="col label" scope="row">Spacers</th>
<td class="col data" data-th="Target Species">dPEG® Spacer is 8 atoms and 8.5 Å</td>
</tr>
<tr>
<th class="col label" scope="row">Shipping</th>
<td class="col data" data-th="Target Species">Ambient</td>
</tr>
<tr>
<th class="col label" scope="row">Typical solubility properties (for additional information contact Customer Support)</th>
<td class="col data">Methylene chloride, Acetonitrile, DMAC or DMSO.</td>
</tr>
<tr>
<th class="col label" scope="row">Storage and handling</th>
<td class="col data">-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.</td>
</tr>
</tbody>
</table>
<p>The post <a rel="nofollow" href="https://staging.vectorlabs.com/products/m-dpeg2-acid/">m-dPEG®₂-acid</a> appeared first on <a rel="nofollow" href="https://staging.vectorlabs.com">VectorLabs</a>.</p>
]]></description>
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                                                            <h2 class="eael-tab-title title-after-icon" >Description</h2>                                                    </li>
                                            <li id="specifications" class="inactive eael-tab-item-trigger eael-tab-nav-item" aria-selected="false" data-tab="2" role="tab" tabindex="-1" aria-controls="specifications-tab" aria-expanded="false">
                            
                            
                            
                                                            <h2 class="eael-tab-title title-after-icon" >Specifications</h2>                                                    </li>
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                                                            <h2 class="eael-tab-title title-after-icon" >Documents</h2>                                                    </li>
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                                                            <h2 class="eael-tab-title title-after-icon" >References</h2>                                                    </li>
                                    </ul>
            </div>
            
            <div class="eael-tabs-content">
		        
                    <div id="description-tab" class="clearfix eael-tab-content-item inactive" data-title-link="description-tab">
				        <h3>Description</h3><p>m-dPEG®2-acid, product number QBD-10326, is a very short, methyl-capped, discrete chain length polyethylene glycol (dPEG®) spacer. The reactive end of the molecule terminates as a propionic acid group. This group can be directly coupled to free amines on biomolecules and surfaces using EDC or another carbodiimide. Alternately, the reactive end can be functionalized with N-hydroxysuccinimide (NHS); 2,3,5,6-tetrafluorophenol (TFP); 2,3,4,5,6-pentafluorophenol (PFP); or some other activating agent for reaction with amines.</p><p>m-dPEG®2-acid can modify amine-functionalized surfaces (carbon nanotubes, other nanoparticles, quantum dots, etc.) or free amines on biomolecules (e.g., peptides and proteins). Coating surfaces or biomolecules with m-dPEG®2-acid can reduce or eliminate non-specific binding and increase hydrophilicity. Please note that modification of surface amines on biomolecules with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.</p>                    </div>
		        
                    <div id="specifications-tab" class="clearfix eael-tab-content-item inactive" data-title-link="specifications-tab">
				        <h3>Specifications</h3><table id="product-attribute-specs-table" class="data table additional-attributes" width="585"><tbody><tr><th class="col label" scope="row">Unit Size</th><td class="col data" data-th="Unit Size">100 mg, 1000 mg</td></tr><tr><th class="col label" scope="row">Molecular Weight</th><td class="col data" data-th="Applications">148.16; single compound</td></tr><tr><th class="col label" scope="row">Chemical formula</th><td class="col data chemicalStructure">C₆H₁₂O₄</td></tr><tr><th class="col label" scope="row">CAS</th><td class="col data" data-th="Target Species">149577-05-9</td></tr><tr><th class="col label" scope="row">Purity</th><td class="col data" data-th="Target Species">&gt; 98%</td></tr><tr><th class="col label" scope="row">Spacers</th><td class="col data" data-th="Target Species">dPEG® Spacer is 8 atoms and 8.5 Å</td></tr><tr><th class="col label" scope="row">Shipping</th><td class="col data" data-th="Target Species">Ambient</td></tr><tr><th class="col label" scope="row">Typical solubility properties (for additional information contact Customer Support)</th><td class="col data">Methylene chloride, Acetonitrile, DMAC or DMSO.</td></tr><tr><th class="col label" scope="row">Storage and handling</th><td class="col data">-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.</td></tr></tbody></table><h3><br /><br /></h3>                    </div>
		        
                    <div id="documents-tab" class="clearfix eael-tab-content-item inactive" data-title-link="documents-tab">
				        <h3>Documents</h3><div class="explorer_section applications container documentSection catalog-product-document"><ul class="document_list"><li class="documentContainer documentItem"><a href="https://staging.vectorlabs.com/productattachments/sds/VL_QBD-10326_sds.pdf" target="_blank" rel="noopener">Safety Data Sheet</a></li><li><a class="woocommerce-print-products-pdf-link" href="https://staging.vectorlabs.com/products/m-dpeg2-acid/?print-products=pdf" target="_blank">Datasheet</a></li></ul></div>                    </div>
		        
                    <div id="references-tab" class="clearfix eael-tab-content-item inactive" data-title-link="references-tab">
				        <h3>References</h3><p>Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.</p>                    </div>
		                    </div>
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		<p>The post <a rel="nofollow" href="https://staging.vectorlabs.com/products/m-dpeg2-acid/">m-dPEG®₂-acid</a> appeared first on <a rel="nofollow" href="https://staging.vectorlabs.com">VectorLabs</a>.</p>
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		<title>MAL-dPEG®₂-acid</title>
		<link>https://staging.vectorlabs.com/products/mal-dpeg2-acid/</link>
		
		<dc:creator><![CDATA[Vector Laboratories R&D]]></dc:creator>
		<pubDate>Sat, 24 Feb 2024 02:07:46 +0000</pubDate>
				<guid isPermaLink="false">https://staging.vectorlabs.com/?post_type=product&#038;p=35660</guid>

					<description><![CDATA[<p>MAL-dPEG®2-acid, product number QBD-10265, is a crosslinker that joins sulfhydryl groups to free amines through a single molecular weight polyethylene glycol (PEG) chain of discrete length (dPEG®). The maleimidopropyl moiety reacts with sulfhydryl groups via a Michael addition reaction. The propionic acid terminus of the molecule reacts directly with free amines using EDC or another carbodiimide to form amide bonds. Alternatively, activation of the propionic acid group with N-hydroxysuccinimide (NHS), 2,3,5,6-tetrafluorophenol (TFP), or some other acylating agent permits amide bond formation under mild, controlled conditions.</p>
<h3>Specifications</h3>
<table id="product-attribute-specs-table" class="data table additional-attributes" width="585">
<tbody>
<tr>
<th class="col label" scope="row">Unit Size</th>
<td class="col data" data-th="Unit Size">100 mg, 1000 mg</td>
</tr>
<tr>
<th class="col label" scope="row">Molecular Weight</th>
<td class="col data" data-th="Applications">328.32; single compound</td>
</tr>
<tr>
<th class="col label" scope="row">Chemical formula</th>
<td class="col data chemicalStructure">C₁₄H₂₀N₂O₇</td>
</tr>
<tr>
<th class="col label" scope="row">CAS</th>
<td class="col data" data-th="Target Species">756525-98-1</td>
</tr>
<tr>
<th class="col label" scope="row">Purity</th>
<td class="col data" data-th="Target Species">&#62; 98%</td>
</tr>
<tr>
<th class="col label" scope="row">Spacers</th>
<td class="col data" data-th="Target Species">dPEG® Spacer is 16 atoms and 17.5 Å</td>
</tr>
<tr>
<th class="col label" scope="row">Shipping</th>
<td class="col data" data-th="Target Species">Ambient</td>
</tr>
<tr>
<th class="col label" scope="row">Typical solubility properties (for additional information contact Customer Support)</th>
<td class="col data">Methylene chloride, Acetonitrile, DMAC or DMSO.</td>
</tr>
<tr>
<th class="col label" scope="row">Storage and handling</th>
<td class="col data">-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.</td>
</tr>
</tbody>
</table>
<p>The post <a rel="nofollow" href="https://staging.vectorlabs.com/products/mal-dpeg2-acid/">MAL-dPEG®₂-acid</a> appeared first on <a rel="nofollow" href="https://staging.vectorlabs.com">VectorLabs</a>.</p>
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										<content:encoded><![CDATA[		<div data-elementor-type="product-post" data-elementor-id="35660" class="elementor elementor-35660" data-elementor-post-type="product">
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                                                            <h2 class="eael-tab-title title-after-icon" >Description</h2>                                                    </li>
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                                                            <h2 class="eael-tab-title title-after-icon" >Specifications</h2>                                                    </li>
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                                                            <h2 class="eael-tab-title title-after-icon" >Documents</h2>                                                    </li>
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                                                            <h2 class="eael-tab-title title-after-icon" >References</h2>                                                    </li>
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                    <div id="description-tab" class="clearfix eael-tab-content-item inactive" data-title-link="description-tab">
				        <h3>Description</h3><p>MAL-dPEG®2-acid, product number QBD-10265, is a crosslinker that joins sulfhydryl groups to free amines through a single molecular weight polyethylene glycol (PEG) chain of discrete length (dPEG®). The maleimidopropyl moiety reacts with sulfhydryl groups via a Michael addition reaction. The propionic acid terminus of the molecule reacts directly with free amines using EDC or another carbodiimide to form amide bonds. Alternatively, activation of the propionic acid group with N-hydroxysuccinimide (NHS), 2,3,5,6-tetrafluorophenol (TFP), or some other acylating agent permits amide bond formation under mild, controlled conditions.</p>                    </div>
		        
                    <div id="specifications-tab" class="clearfix eael-tab-content-item inactive" data-title-link="specifications-tab">
				        <h3>Specifications</h3><table id="product-attribute-specs-table" class="data table additional-attributes" style="height: 186px;" width="585"><tbody><tr><th class="col label" scope="row">Unit Size</th><td class="col data" data-th="Unit Size">100 mg, 1000 mg</td></tr><tr><th class="col label" scope="row">Molecular Weight</th><td class="col data" data-th="Applications">328.32; single compound</td></tr><tr><th class="col label" scope="row">Chemical formula</th><td class="col data chemicalStructure">C₁₄H₂₀N₂O₇</td></tr><tr><th class="col label" scope="row">CAS</th><td class="col data" data-th="Target Species">756525-98-1</td></tr><tr><th class="col label" scope="row">Purity</th><td class="col data" data-th="Target Species">&gt; 98%</td></tr><tr><th class="col label" scope="row">Spacers</th><td class="col data" data-th="Target Species">dPEG® Spacer is 16 atoms and 17.5 Å</td></tr><tr><th class="col label" scope="row">Shipping</th><td class="col data" data-th="Target Species">Ambient</td></tr><tr><th class="col label" scope="row">Typical solubility properties (for additional information contact Customer Support)</th><td class="col data">Methylene chloride, Acetonitrile, DMAC or DMSO.</td></tr><tr><th class="col label" scope="row">Storage and handling</th><td class="col data">-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.</td></tr></tbody></table>                    </div>
		        
                    <div id="documents-tab" class="clearfix eael-tab-content-item inactive" data-title-link="documents-tab">
				        <h3>Documents</h3><div class="explorer_section applications container documentSection catalog-product-document"><ul class="document_list"><li class="documentContainer documentItem"><a href="https://staging.vectorlabs.com/productattachments/sds/VL_QBD-10265_sds.pdf" target="_blank" rel="noopener">Safety Data Sheet</a></li><li><a class="woocommerce-print-products-pdf-link" href="https://staging.vectorlabs.com/products/mal-dpeg2-acid/?print-products=pdf" target="_blank">Datasheet</a></li></ul></div>                    </div>
		        
                    <div id="references-tab" class="clearfix eael-tab-content-item inactive" data-title-link="references-tab">
				        <h3>References</h3><p>Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0); See pp. 276-335 for general description and use of heterobifunctional crosslinkers, and the specific sample protocol for SMCC or sulfo-SMCC on pp. 283-286.<br /><br />Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.<br /><br />Synthesis and anti-HIV activity of trivalent CD4-mimetic miniproteins. Hengguang Li, Yongjun Guan, Agnieszka Szczepanska, Antonio J. Moreno-Vargas, Ana T. Carmona, Inmaculada Robina, George K. Lewis and Lai-Xi Wang. Bioorganic &amp; Medicinal Chemistry. 2007, 15 (12) pp 4220–4228. June 15, 2007. doi.org/10.1016/j.bmc.2007.03.064.</p>                    </div>
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		<p>The post <a rel="nofollow" href="https://staging.vectorlabs.com/products/mal-dpeg2-acid/">MAL-dPEG®₂-acid</a> appeared first on <a rel="nofollow" href="https://staging.vectorlabs.com">VectorLabs</a>.</p>
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		<title>Fmoc-N-amido-dPEG®₂-acid</title>
		<link>https://staging.vectorlabs.com/products/fmoc-n-amido-dpeg2-acid/</link>
		
		<dc:creator><![CDATA[Vector Laboratories R&D]]></dc:creator>
		<pubDate>Sat, 24 Feb 2024 02:07:32 +0000</pubDate>
				<guid isPermaLink="false">https://staging.vectorlabs.com/?post_type=product&#038;p=35559</guid>

					<description><![CDATA[<p>Fmoc-N-amido-dPEG®2-acid, product number QBD-10243, is one of a broad line of products designed for use in peptide synthesis. The short (16 atoms), discrete PEG (dPEG®) spacer is functionalized with a propionic acid group on one end and Fmoc-protected amine on the other. The product can be added to the N-terminus of a growing peptide chain or to a primary-amine-functionalized side chain of an amino acid such as lysine. The dPEG®2 spacer imparts water solubility to the peptide to which it is conjugated.</p>
<h3>Description</h3>
<p>Fmoc-N-amido-dPEG®2-acid, product number QBD-10243, is a peptide synthesis product used to introduce a short (10 atoms), hydrophilic spacer into a peptide chain using standard peptide chemistry. The Fmoc protecting group can be removed using standard peptide chemistry.</p>
<p>Fmoc-N-amido-dPEG®2-acid, QBD-10243, works well in solid-phase and solution-phase synthetic processes. The dPEG® can be joined to the N-terminal end of a peptide chain. After removal of the Fmoc protecting group, further synthesis can be carried out to create a peptide with a flexible hinge. The peptide sequences on either side of the dPEG® spacer can be identical or different.</p>
<p>In addition, the short dPEG® linker can provide spacing between two units in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® means that the construct will gain water solubility while remaining soluble in an organic solvent. The Fmoc protecting group removes easily with a solution of piperidine in N,N-dimethylformamide (DMF).</p>
<h3>Specifications</h3>
<table id="product-attribute-specs-table" class="data table additional-attributes" width="585">
<tbody>
<tr>
<th class="col label" scope="row">Unit Size</th>
<td class="col data" data-th="Unit Size">1000 mg</td>
</tr>
<tr>
<th class="col label" scope="row">Molecular Weight</th>
<td class="col data" data-th="Applications">399.44; single compound</td>
</tr>
<tr>
<th class="col label" scope="row">Chemical formula</th>
<td class="col data chemicalStructure">C₂₂H₂₅NO₆</td>
</tr>
<tr>
<th class="col label" scope="row">CAS</th>
<td class="col data" data-th="Target Species">872679-70-4</td>
</tr>
<tr>
<th class="col label" scope="row">Purity</th>
<td class="col data" data-th="Target Species">&#62; 98%</td>
</tr>
<tr>
<th class="col label" scope="row">Spacers</th>
<td class="col data" data-th="Target Species">dPEG® Spacer is 10 atoms and 10.9 Å</td>
</tr>
<tr>
<th class="col label" scope="row">Shipping</th>
<td class="col data" data-th="Target Species">Ambient</td>
</tr>
<tr>
<th class="col label" scope="row">Typical solubility properties (for additional information contact Customer Support)</th>
<td class="col data">Methylene chloride, Acetontrile, DMAC or DMSO.</td>
</tr>
<tr>
<th class="col label" scope="row">Storage and handling</th>
<td class="col data">-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.</td>
</tr>
</tbody>
</table>
<p>The post <a rel="nofollow" href="https://staging.vectorlabs.com/products/fmoc-n-amido-dpeg2-acid/">Fmoc-N-amido-dPEG®₂-acid</a> appeared first on <a rel="nofollow" href="https://staging.vectorlabs.com">VectorLabs</a>.</p>
]]></description>
										<content:encoded><![CDATA[		<div data-elementor-type="product-post" data-elementor-id="35559" class="elementor elementor-35559" data-elementor-post-type="product">
						<section data-particle_enable="false" data-particle-mobile-disabled="false" class="elementor-section elementor-top-section elementor-element elementor-element-33729e6b elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="33729e6b" data-element_type="section">
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									<p>Fmoc-N-amido-dPEG®2-acid, product number QBD-10243, is one of a broad line of products designed for use in peptide synthesis. The short (16 atoms), discrete PEG (dPEG®) spacer is functionalized with a propionic acid group on one end and Fmoc-protected amine on the other. The product can be added to the N-terminus of a growing peptide chain or to a primary-amine-functionalized side chain of an amino acid such as lysine. The dPEG®2 spacer imparts water solubility to the peptide to which it is conjugated.</p>								</div>
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                                                            <h2 class="eael-tab-title title-after-icon" >Description</h2>                                                    </li>
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                                                            <h2 class="eael-tab-title title-after-icon" >Specifications</h2>                                                    </li>
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                                                            <h2 class="eael-tab-title title-after-icon" >Documents</h2>                                                    </li>
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				        <h3>Description</h3><p>Fmoc-N-amido-dPEG®2-acid, product number QBD-10243, is a peptide synthesis product used to introduce a short (10 atoms), hydrophilic spacer into a peptide chain using standard peptide chemistry. The Fmoc protecting group can be removed using standard peptide chemistry.</p><p>Fmoc-N-amido-dPEG®2-acid, QBD-10243, works well in solid-phase and solution-phase synthetic processes. The dPEG® can be joined to the N-terminal end of a peptide chain. After removal of the Fmoc protecting group, further synthesis can be carried out to create a peptide with a flexible hinge. The peptide sequences on either side of the dPEG® spacer can be identical or different.</p><p>In addition, the short dPEG® linker can provide spacing between two units in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® means that the construct will gain water solubility while remaining soluble in an organic solvent. The Fmoc protecting group removes easily with a solution of piperidine in N,N-dimethylformamide (DMF).</p>                    </div>
		        
                    <div id="specifications-tab" class="clearfix eael-tab-content-item inactive" data-title-link="specifications-tab">
				        <h3>Specifications</h3><table id="product-attribute-specs-table" class="data table additional-attributes" style="height: 186px;" width="585"><tbody><tr><th class="col label" scope="row">Unit Size</th><td class="col data" data-th="Unit Size">1000 mg</td></tr><tr><th class="col label" scope="row">Molecular Weight</th><td class="col data" data-th="Applications">399.44; single compound</td></tr><tr><th class="col label" scope="row">Chemical formula</th><td class="col data chemicalStructure">C₂₂H₂₅NO₆</td></tr><tr><th class="col label" scope="row">CAS</th><td class="col data" data-th="Target Species">872679-70-4</td></tr><tr><th class="col label" scope="row">Purity</th><td class="col data" data-th="Target Species">&gt; 98%</td></tr><tr><th class="col label" scope="row">Spacers</th><td class="col data" data-th="Target Species">dPEG® Spacer is 10 atoms and 10.9 Å</td></tr><tr><th class="col label" scope="row">Shipping</th><td class="col data" data-th="Target Species">Ambient</td></tr><tr><th class="col label" scope="row">Typical solubility properties (for additional information contact Customer Support)</th><td class="col data">Methylene chloride, Acetontrile, DMAC or DMSO.</td></tr><tr><th class="col label" scope="row">Storage and handling</th><td class="col data">-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.</td></tr></tbody></table>                    </div>
		        
                    <div id="documents-tab" class="clearfix eael-tab-content-item inactive" data-title-link="documents-tab">
				        <h3>Documents</h3><div class="explorer_section applications container documentSection catalog-product-document"><ul class="document_list"><li class="documentContainer documentItem"><a href="https://staging.vectorlabs.com/productattachments/sds/VL_QBD-10243_sds.pdf" target="_blank" rel="noopener">Safety Data Sheet</a></li><li><a class="woocommerce-print-products-pdf-link" href="https://staging.vectorlabs.com/products/fmoc-n-amido-dpeg2-acid/?print-products=pdf" target="_blank">Datasheet</a></li></ul></div>                    </div>
		        
                    <div id="references-tab" class="clearfix eael-tab-content-item inactive" data-title-link="references-tab">
				        <h3>References</h3><p>Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.<br /><br />Functional PEG-Modified Thin Films for Biological Detection. Aaron S. Anderson, Andrew M. Dattelbaum, Gabriel A. Montano, Dominique N. Price, Jurgen G. Schmidt, Jennifer S. Martinez, W. Kevin Grace, Karen M. Grace, and Basil I. Swanson. Langmuir. 2008, 24 (5), pp 2240–2247. January 30, 2008. DOI: 10.1021/la7033438.<br /><br />Polyproline-Rod Approach to Isolating Protein Targets of Bioactive Small Molecules: Isolation of a New Target of Indomethacin. Shin-ichi Sato, Youngjoo Kwon, Shinji Kamisuki, Neeta Srivastava, Quian Mao, Yoshinori Kawazoe, and Motonari Uesugi. J. Am. Chem. Soc. 2007, 129 (4), pp 873–880. January 4, 2007. DOI: 10.1021/ja0655643.<br /><br />Oriented Surface Immobilization of Antibodies at the Conserved Nucleotide Binding Site for Enhanced Antigen Detection. Nathan J Alves, Tanyel Kiziltepe, and Basar Bilgicer. Langmuir. 2012, 28 (25) pp 9640-9648. May 21, 2012. DOI: 10.1021/la301887s.<br /><br />Enhanced Cellular Uptake of Peptide-Targeted Nanoparticles through Increased Peptide Hydrophilicity and Optimized Ethylene Glycol Peptide-Linker Length. Jared F. Stefanick, Jonathan D. Ashley, and Basar Bilgicer. ACS Nano. 2013, 7 (9) pp 8115–8127. August 29, 2013. DOI: 10.1021/nn4033954.<br /><br />Selective photocrosslinking of functional ligands to antibodies via the conserved nucleotide binding site. Nathan J. Alves, Matthew M. Champion, Jared F. Stefanick, Michael W. Handlogten, Demetri T. Moustakas, Yunhua Shi, Bryan F. Shawd, Rudolph M. Navari, Tanyel Kiziltepe, Basar Bilgicer. Biomaterials. 2013, 34 (22) pp 5700–5710. April 16, 2013. DOI:.org/10.1016/j.biomaterials.2013.03.082.<br /><br />Design, Synthesis and Evaluation of a Neurokinin 1 Receptor-Targeted Near IR Dye for Fluorescence Guided Surgery of Neuroendocrine Cancers. Ananda Kumar Kanduluru, Madduri Srinivasarao, and Philip S. Low. Bioconjugate Chemistry. 2016, pp 1-20. August 16, 2016. DOI: 10.1021/acs.bioconjchem.6b00374.<br /><br />One-Pot Isolation of a Desired Human Genome Fragment by Using a Biotinylated pcPNA/S1 Nuclease Combination. Arivazhagan Rajendran , Narumi Shigi, Jun Sumaoka, and Makoto Komiyama. Biochemistry. 2018, 57, pp 2908-2912. May 3, 2018. DOI: 10.1021/acs.biochem.8b00202.<br /><br />Stapled, Long-Acting Glucagon-like Peptide 2 Analog with Efficacy in Dextran Sodium Sulfate Induced Mouse Colitis Models. Peng-Yu Yang , Huafei Zou, Candy Lee, Avinash Muppidi, Elizabeth Chao, Qiangwei Fu, Xiaozhou Luo, Danling Wang, Peter G. Schultz, and Weijun Shen. Journal of Medicinial Chemistry. 2018, 61, pp 3218-3223. March 12, 2018. DOI: 10.1021/acs.jmedchem.7b00768.<br /><br />Evaluation of the Pharmacokinetic Effects of Various Linking Group Using the 111In-DOTA-X-BBN(7−14)NH2 Structural Paradigm in a Prostate Cancer Model. Jered C. Garrison, Tammy L. Rold, Gary L. Sieckman, Farah Naz, Samantha V. Sublett, Said Daibes Figueroa, Wynn A. Volkert and Timothy J. Hoffman. Bioconjugate Chem. 2008, 19 (9) pp 1803–1812. August 20, 2008. DOI: 10.1021/bc8001375.<br /><br />PEG-Peptide Conjugates. Ian W Hamley. Biomacromolecules. 2014. April 1, 2014. DOI: 10.1021/bm500246w.<br /><br />Dual-receptor targeted strategy in nanoparticle design achieves tumor cell selectivity through cooperativity. Jared Francis Stefanick, David Thomas Omstead, Tanyel Kiziltepeabc and Basar Bilgicer. Nanoscale. 2019. Fenruary 17, 2019. DOI: 10.1039/C8NR09431D<br /><br />Designer covalent heterobivalent inhibitors prevent IgE-dependent responses to peanut allergen. Peter E. 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