TFP Ester – VectorLabs https://staging.vectorlabs.com From linker design and synthesis, bioconjugated design and manufacturing, biomolecule labeling and functionalization, and detection system and solutions, our team is here to help you move forward, with impact. Wed, 22 Oct 2025 17:21:12 +0000 en-US hourly 1 https://wordpress.org/?v=6.9 https://staging.vectorlabs.com/wp-content/uploads/2024/11/V-favicon-02-100x100.png TFP Ester – VectorLabs https://staging.vectorlabs.com 32 32 Hydroxy-dPEG®₂₄-TFP ester https://staging.vectorlabs.com/products/hydroxy-dpeg24-tfp-ester/ Sat, 24 Feb 2024 02:16:42 +0000 https://staging.vectorlabs.com/?post_type=product&p=39432 Hydroxy-dPEG®24-TFP ester, product number QBD-11349, is a long (76 atoms, 88.8 Å), hydroxy-terminated, single molecular weight, discrete polyethylene glycol (dPEG®) compound functionalized with a 2,3,5,6-tetrafluorophenyl (TFP) ester for conjugation to primary and secondary amines. This product can be used for modification of amine-functionalized surfaces (e.g., silica, glass), modification of proteins and peptides at accessible amine sites on the molecules, the construction of discrete PEG dendrimers, and many other applications. The free hydroxy end of the dPEG® spacer can be functionalized for further reactions or left unmodified to increase hydrophilicity or modify the charge of conjugate molecules and surfaces.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 1295.40; single compound
Chemical formula C₅₇H₁₀₂F₄O₂₇
CAS N/A
Purity > 97%
Spacers dPEG® Spacer is 76 atoms and 88.8 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) DCM, Methanol, Ethanol, Acetonitrile, Water, Ethyle Acetate, or Acetone.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Hydroxy-dPEG®₂₄-TFP ester appeared first on VectorLabs.

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Description

Hydroxy-dPEG®24-TFP ester, product number QBD-11349, is a long (76 atoms, 88.8 Å), hydroxy-terminated, single molecular weight, discrete polyethylene glycol (dPEG®) compound functionalized with a 2,3,5,6-tetrafluorophenyl (TFP) ester for conjugation to primary and secondary amines. This product can be used for modification of amine-functionalized surfaces (e.g., silica, glass), modification of proteins and peptides at accessible amine sites on the molecules, the construction of discrete PEG dendrimers, and many other applications. The free hydroxy end of the dPEG® spacer can be functionalized for further reactions or left unmodified to increase hydrophilicity or modify the charge of conjugate molecules and surfaces.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight1295.40; single compound
Chemical formulaC₅₇H₁₀₂F₄O₂₇
CASN/A
Purity> 97%
SpacersdPEG® Spacer is 76 atoms and 88.8 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)DCM, Methanol, Ethanol, Acetonitrile, Water, Ethyle Acetate, or Acetone.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

The post Hydroxy-dPEG®₂₄-TFP ester appeared first on VectorLabs.

]]> Hydroxy-dPEG®₁₂-TFP ester https://staging.vectorlabs.com/products/hydroxy-dpeg12-tfp-ester/ Sat, 24 Feb 2024 02:16:41 +0000 https://staging.vectorlabs.com/?post_type=product&p=39424 Hydroxy-dPEG®12-TFP ester, product number QBD-11345, is a medium-length (40 atoms, 46.2 Å), hydroxy-terminated, single molecular weight, discrete polyethylene glycol (dPEG®) compound functionalized with a 2,3,5,6-tetrafluorophenyl (TFP) ester for conjugation to primary and secondary amines. This product can be used for modification of amine-functionalized surfaces (e.g., silica, glass), modification of proteins and peptides at accessible amine sites on the molecules, the construction of discrete PEG dendrimers, and many other applications. The free hydroxy end of the dPEG® spacer can be functionalized for further reactions or left unmodified to increase hydrophilicity or modify the charge of conjugate molecules and surfaces.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 766.77; single compound
Chemical formula C₃₃H₅₄F₄O₁₅
CAS N/A
Purity > 97%
Spacers dPEG® Spacer is 40 atoms and 46.2 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) DCM, Methanol, Ethanol, Acetonitrile, Water, Ethyle Acetate, or Acetone.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Hydroxy-dPEG®₁₂-TFP ester appeared first on VectorLabs.

]]>

Description

Hydroxy-dPEG®12-TFP ester, product number QBD-11345, is a medium-length (40 atoms, 46.2 Å), hydroxy-terminated, single molecular weight, discrete polyethylene glycol (dPEG®) compound functionalized with a 2,3,5,6-tetrafluorophenyl (TFP) ester for conjugation to primary and secondary amines. This product can be used for modification of amine-functionalized surfaces (e.g., silica, glass), modification of proteins and peptides at accessible amine sites on the molecules, the construction of discrete PEG dendrimers, and many other applications. The free hydroxy end of the dPEG® spacer can be functionalized for further reactions or left unmodified to increase hydrophilicity or modify the charge of conjugate molecules and surfaces.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight766.77; single compound
Chemical formulaC₃₃H₅₄F₄O₁₅
CASN/A
Purity> 97%
SpacersdPEG® Spacer is 40 atoms and 46.2 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)DCM, Methanol, Ethanol, Acetonitrile, Water, Ethyle Acetate, or Acetone.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

The post Hydroxy-dPEG®₁₂-TFP ester appeared first on VectorLabs.

]]> Hydroxy-dPEG®₄-TFP ester https://staging.vectorlabs.com/products/hydroxy-dpeg4-tfp-ester/ Sat, 24 Feb 2024 02:16:40 +0000 https://staging.vectorlabs.com/?post_type=product&p=39416 Hydroxy-dPEG®4-TFP ester, product number QBD-11341, is a short (16 atoms, 17.9 Å), hydroxy-terminated, single molecular weight, discrete polyethylene glycol (dPEG®) compound functionalized with a 2,3,5,6-tetrafluorophenyl (TFP) ester for conjugation to primary and secondary amines. This product can be used for modification of amine-functionalized surfaces (e.g., silica, glass), modification of proteins and peptides at accessible amine sites on the molecules, the construction of discrete PEG dendrimers, and many other applications. The free hydroxy end of the dPEG® spacer can be functionalized for further reactions or left unmodified to increase hydrophilicity or modify the charge of conjugate molecules and surfaces.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 414.35; single compound
Chemical formula C₁₇H₂₂F₄O₇
CAS N/A
Purity > 97%
Spacers dPEG® Spacer is 16 atoms and 17.9 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) DCM, Methanol, Ethanol, Acetonitrile, Water, Ethyle Acetate, or Acetone.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Hydroxy-dPEG®₄-TFP ester appeared first on VectorLabs.

]]>

Description

Hydroxy-dPEG®4-TFP ester, product number QBD-11341, is a short (16 atoms, 17.9 Å), hydroxy-terminated, single molecular weight, discrete polyethylene glycol (dPEG®) compound functionalized with a 2,3,5,6-tetrafluorophenyl (TFP) ester for conjugation to primary and secondary amines. This product can be used for modification of amine-functionalized surfaces (e.g., silica, glass), modification of proteins and peptides at accessible amine sites on the molecules, the construction of discrete PEG dendrimers, and many other applications. The free hydroxy end of the dPEG® spacer can be functionalized for further reactions or left unmodified to increase hydrophilicity or modify the charge of conjugate molecules and surfaces.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight414.35; single compound
Chemical formulaC₁₇H₂₂F₄O₇
CASN/A
Purity> 97%
SpacersdPEG® Spacer is 16 atoms and 17.9 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)DCM, Methanol, Ethanol, Acetonitrile, Water, Ethyle Acetate, or Acetone.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

The post Hydroxy-dPEG®₄-TFP ester appeared first on VectorLabs.

]]> m-dPEG®₂₅-TFP ester https://staging.vectorlabs.com/products/m-dpeg25-tfp-ester/ Sat, 24 Feb 2024 02:16:33 +0000 https://staging.vectorlabs.com/?post_type=product&p=39351 m-dPEG®25-TFP ester, product number QBD-11290, is a long (77 atoms, 89.9 Å), methyl-terminated, discrete-chain-length polyethylene glycol (dPEG®) spacer functionalized with a 2,3,5,6-tetrafluorophenyl (TFP) ester for reaction with free amines. m-dPEG®25-TFP ester is just one member of an comprehensive line of methyl-terminated PEGylation reagents that includes dPEG® spacers containing 2 to 49 ethylene glycol units.

TFP esters react optimally with free amines at pH 7.5 – 8.0 and are generally more hydrolytically stable in water and aqueous buffers than NHS esters. In aqueous media, the hydrolytic rate of the ester to the carboxylic acid increases with increasing pH. Reacting surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

Many applications could employ m-dPEG®25-TFP ester, including the following:
dendrimer construction;
PK and immunogenicity improvements for dendrimers, peptides, and proteins;
cell surface engineering;
peptide synthesis and modification to improve water solubility or decrease immunogenicity;
coating of nanoparticles, quantum dots, and carbon nanotubes; and
prevention of protein aggregation.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 1309.42; single compound
Chemical formula C₅₈H₁₀₄F₄O₂₇
CAS N/A
Purity > 98%
Spacers dPEG® Spacer is 77 atoms and 89.9 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) DCM, Methanol, Ethanol, Acetonitrile, Water, Ethyle Acetate, or Acetone.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post m-dPEG®₂₅-TFP ester appeared first on VectorLabs.

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Description

m-dPEG®25-TFP ester, product number QBD-11290, is a long (77 atoms, 89.9 Å), methyl-terminated, discrete-chain-length polyethylene glycol (dPEG®) spacer functionalized with a 2,3,5,6-tetrafluorophenyl (TFP) ester for reaction with free amines. m-dPEG®25-TFP ester is just one member of an comprehensive line of methyl-terminated PEGylation reagents that includes dPEG® spacers containing 2 to 49 ethylene glycol units.

TFP esters react optimally with free amines at pH 7.5 – 8.0 and are generally more hydrolytically stable in water and aqueous buffers than NHS esters. In aqueous media, the hydrolytic rate of the ester to the carboxylic acid increases with increasing pH. Reacting surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

Many applications could employ m-dPEG®25-TFP ester, including the following:
dendrimer construction;
PK and immunogenicity improvements for dendrimers, peptides, and proteins;
cell surface engineering;
peptide synthesis and modification to improve water solubility or decrease immunogenicity;
coating of nanoparticles, quantum dots, and carbon nanotubes; and
prevention of protein aggregation.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight1309.42; single compound
Chemical formulaC₅₈H₁₀₄F₄O₂₇
CASN/A
Purity> 98%
SpacersdPEG® Spacer is 77 atoms and 89.9 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)DCM, Methanol, Ethanol, Acetonitrile, Water, Ethyle Acetate, or Acetone.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

The post m-dPEG®₂₅-TFP ester appeared first on VectorLabs.

]]> m-dPEG®₂₅-amido-dPEG®₂₄-TFP ester https://staging.vectorlabs.com/products/m-dpeg25-amido-dpeg24-tfp-ester/ Sat, 24 Feb 2024 02:14:56 +0000 https://staging.vectorlabs.com/?post_type=product&p=37455 m-dPEG®25-amido-dPEG®24-TFP ester, product number QBD-11096, is a long (153 atoms, 178.9 Å), methyl-terminated, discrete-chain-length polyethylene glycol (dPEG®) spacer functionalized with a 2,3,5,6-tetrafluorophenyl (TFP) ester for reaction with free amines. It is effectively a single molecular weight mPEG49 linker with an amide linkage in the middle of the discrete PEG chain. m-dPEG®25-amido-dPEG®24-TFP ester is just one member of an comprehensive line of methyl-terminated PEGylation reagents that includes dPEG® spacers containing 2 to 49 ethylene glycol units.

TFP esters react optimally with free amines at pH 7.5 – 8.0 and are generally more hydrolytically stable in water and aqueous buffers than NHS esters. In aqueous media, the hydrolytic rate of the ester to the carboxylic acid increases with increasing pH. Reacting surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

Many applications could employ m-dPEG®25-amido-dPEG®24-TFP ester, including the following:
dendrimer construction;
PK and immunogenicity improvements for dendrimers, peptides, and proteins;
cell surface engineering;
peptide synthesis and modification to improve water solubility or decrease immunogenicity;
coating of nanoparticles, quantum dots, and carbon nanotubes; and
prevention of protein aggregation.

Specifications

Unit Size 100mg, 1000mg
Molecular Weight 2437.76; single compound
Chemical formula C₁₀₉H₂₀₅F₄NO₅₂
CAS N/A
Purity > 98%
Spacers dPEG® Spacer is 153 atoms and 178.9 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Water, Dimethylacetamide, Acetonitrile, or Methylene Chloride
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post m-dPEG®₂₅-amido-dPEG®₂₄-TFP ester appeared first on VectorLabs.

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Description

m-dPEG®25-amido-dPEG®24-TFP ester, product number QBD-11096, is a long (153 atoms, 178.9 Å), methyl-terminated, discrete-chain-length polyethylene glycol (dPEG®) spacer functionalized with a 2,3,5,6-tetrafluorophenyl (TFP) ester for reaction with free amines. It is effectively a single molecular weight mPEG49 linker with an amide linkage in the middle of the discrete PEG chain. m-dPEG®25-amido-dPEG®24-TFP ester is just one member of an comprehensive line of methyl-terminated PEGylation reagents that includes dPEG® spacers containing 2 to 49 ethylene glycol units.

TFP esters react optimally with free amines at pH 7.5 – 8.0 and are generally more hydrolytically stable in water and aqueous buffers than NHS esters. In aqueous media, the hydrolytic rate of the ester to the carboxylic acid increases with increasing pH. Reacting surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

Many applications could employ m-dPEG®25-amido-dPEG®24-TFP ester, including the following:
dendrimer construction;
PK and immunogenicity improvements for dendrimers, peptides, and proteins;
cell surface engineering;
peptide synthesis and modification to improve water solubility or decrease immunogenicity;
coating of nanoparticles, quantum dots, and carbon nanotubes; and
prevention of protein aggregation.

Specifications

Unit Size100mg, 1000mg
Molecular Weight2437.76; single compound
Chemical formulaC₁₀₉H₂₀₅F₄NO₅₂
CASN/A
Purity> 98%
SpacersdPEG® Spacer is 153 atoms and 178.9 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Water, Dimethylacetamide, Acetonitrile, or Methylene Chloride
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

The post m-dPEG®₂₅-amido-dPEG®₂₄-TFP ester appeared first on VectorLabs.

]]> m-dPEG®₁₃-TFP ester https://staging.vectorlabs.com/products/m-dpeg13-tfp-ester/ Sat, 24 Feb 2024 02:14:51 +0000 https://staging.vectorlabs.com/?post_type=product&p=37417 m-dPEG®13-TFP ester, product number QBD-11087, is a medium-length (41 atoms, 47.3 Å), methyl-terminated, discrete-chain-length polyethylene glycol (dPEG®) spacer functionalized with a 2,3,5,6-tetrafluorophenyl (TFP) ester for reaction with free amines. m-dPEG®13-TFP ester is just one member of an comprehensive line of methyl-terminated dPEG® products that includes dPEG® spacers containing 2 to 49 ethylene glycol units.

TFP esters react optimally with free amines at pH 7.5 – 8.0 and are generally more hydrolytically stable in water and aqueous buffers than NHS esters. In aqueous media, the hydrolytic rate of the ester to the carboxylic acid increases with increasing pH. Reacting surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

Many applications could employ m-dPEG®13-TFP ester, including the following:
vaccine development (modifying the immunogenicity of biomolecules);
dendrimer construction;
PK and immunogenicity improvements for dendrimers, peptides, and proteins;
cell surface engineering;
peptide synthesis and modification to improve water solubility or decrease immunogenicity;
coating of nanoparticles, quantum dots, and carbon nanotubes; and
prevention of protein aggregation.

Specifications

Unit Size 100mg, 1000mg
Molecular Weight 780.793; single compound
Chemical formula C₃₄H₅₆F₄O₁₅
CAS N/A
Purity > 98%
Spacers dPEG® Spacer is 41 atoms and 47.3 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene Chloride, Acetone, Methanol, Acetonitrile, Ethyl Acetate, DMSO, DMAC, or DMF.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post m-dPEG®₁₃-TFP ester appeared first on VectorLabs.

]]>

Description

m-dPEG®13-TFP ester, product number QBD-11087, is a medium-length (41 atoms, 47.3 Å), methyl-terminated, discrete-chain-length polyethylene glycol (dPEG®) spacer functionalized with a 2,3,5,6-tetrafluorophenyl (TFP) ester for reaction with free amines. m-dPEG®13-TFP ester is just one member of an comprehensive line of methyl-terminated dPEG® products that includes dPEG® spacers containing 2 to 49 ethylene glycol units.

TFP esters react optimally with free amines at pH 7.5 – 8.0 and are generally more hydrolytically stable in water and aqueous buffers than NHS esters. In aqueous media, the hydrolytic rate of the ester to the carboxylic acid increases with increasing pH. Reacting surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

Many applications could employ m-dPEG®13-TFP ester, including the following:
vaccine development (modifying the immunogenicity of biomolecules);
dendrimer construction;
PK and immunogenicity improvements for dendrimers, peptides, and proteins;
cell surface engineering;
peptide synthesis and modification to improve water solubility or decrease immunogenicity;
coating of nanoparticles, quantum dots, and carbon nanotubes; and
prevention of protein aggregation.

Specifications

Unit Size100mg, 1000mg
Molecular Weight780.793; single compound
Chemical formulaC₃₄H₅₆F₄O₁₅
CASN/A
Purity> 98%
SpacersdPEG® Spacer is 41 atoms and 47.3 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene Chloride, Acetone, Methanol, Acetonitrile, Ethyl Acetate, DMSO, DMAC, or DMF.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

The post m-dPEG®₁₃-TFP ester appeared first on VectorLabs.

]]> m-dPEG®₁₂-TFP ester https://staging.vectorlabs.com/products/m-dpeg12-tfp-ester/ Sat, 24 Feb 2024 02:09:51 +0000 https://staging.vectorlabs.com/?post_type=product&p=35872 m-dPEG®12-TFP ester, product number QBD-10306, is a medium-length (38 atoms, 44.0 Å), methyl-terminated, discrete-length polyethylene glycol (dPEG®) spacer. With a reactive end of 2,3,5,6-tetrafluorophenyl (TFP) ester, m-dPEG®12-TFP ester is designed to modify surfaces having accessible free amines.

Free amines react optimally with TFP esters in aqueous media at pH 7.5 – 8.0. TFP esters are more hydrolytically stable in water and aqueous buffers than NHS esters. Nevertheless, in aqueous media, the rate at which the ester hydrolyzes to the carboxylic acid increases as the pH increases. Moreover, it should be noted that reacting surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

There are numerous applications that could successfully employ m-dPEG®12-TFP ester, including the following:
vaccine development;
cell surface engineering;
imaging applications to reduce background and non-specific interactions;
construction of dendrimers;
coating of nanoparticles, quantum dots, and carbon nanotubes;
improving PK and BD of biomolecules; and,
preventing enzyme aggregation.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 736.75; single compound
Chemical formula C₃₂H₅₂F₄O₁₄
CAS N/A
Purity > 98%
Spacers dPEG® Spacer is 38 atoms and 44.0 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetonitrile, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

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Description

m-dPEG®12-TFP ester, product number QBD-10306, is a medium-length (38 atoms, 44.0 Å), methyl-terminated, discrete-length polyethylene glycol (dPEG®) spacer. With a reactive end of 2,3,5,6-tetrafluorophenyl (TFP) ester, m-dPEG®12-TFP ester is designed to modify surfaces having accessible free amines.

Free amines react optimally with TFP esters in aqueous media at pH 7.5 – 8.0. TFP esters are more hydrolytically stable in water and aqueous buffers than NHS esters. Nevertheless, in aqueous media, the rate at which the ester hydrolyzes to the carboxylic acid increases as the pH increases. Moreover, it should be noted that reacting surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

There are numerous applications that could successfully employ m-dPEG®12-TFP ester, including the following:
vaccine development;
cell surface engineering;
imaging applications to reduce background and non-specific interactions;
construction of dendrimers;
coating of nanoparticles, quantum dots, and carbon nanotubes;
improving PK and BD of biomolecules; and,
preventing enzyme aggregation.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight736.75; single compound
Chemical formulaC₃₂H₅₂F₄O₁₄
CASN/A
Purity> 98%
SpacersdPEG® Spacer is 38 atoms and 44.0 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

The post m-dPEG®₁₂-TFP ester appeared first on VectorLabs.

]]> m-dPEG®₂₄-TFP ester https://staging.vectorlabs.com/products/m-dpeg24-tfp-ester/ Sat, 24 Feb 2024 02:09:49 +0000 https://staging.vectorlabs.com/?post_type=product&p=35864 m-dPEG®24-TFP ester, product number QBD-10303, is a long (74 atoms, 86.2 Å), methyl-terminated, discrete-length polyethylene glycol (dPEG®) spacer. With a reactive end of 2,3,5,6-tetrafluorophenyl (TFP) ester, m-dPEG®24-TFP ester is designed to modify surfaces having accessible free amines.

Free amines react optimally with TFP esters in aqueous media at pH 7.5 – 8.0. TFP esters are more hydrolytically stable in water and aqueous buffers than NHS esters. Nevertheless, in aqueous media, the rate at which the ester hydrolyzes to the carboxylic acid increases as the pH increases. Moreover, it should be noted that reacting surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

Many applications could potentially use m-dPEG®24-TFP ester successfully. Among those applications are:
cell surface engineering;
PK, BD, and immunogenicity profile improvements for biomolecules;
imaging applications by reducing background and non-specific binding;
dendrimer construction;
nanoparticle, quantum dot, and carbon nanotube surface coating; and,
prevention of protein aggregation.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 1265.38; single compound
Chemical formula C₅₆H₁₀₀F₄O₂₆
CAS N/A
Purity > 97%
Spacers dPEG® Spacer is 74 atoms and 86.2 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetonitrile, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post m-dPEG®₂₄-TFP ester appeared first on VectorLabs.

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Description

m-dPEG®24-TFP ester, product number QBD-10303, is a long (74 atoms, 86.2 Å), methyl-terminated, discrete-length polyethylene glycol (dPEG®) spacer. With a reactive end of 2,3,5,6-tetrafluorophenyl (TFP) ester, m-dPEG®24-TFP ester is designed to modify surfaces having accessible free amines.

Free amines react optimally with TFP esters in aqueous media at pH 7.5 – 8.0. TFP esters are more hydrolytically stable in water and aqueous buffers than NHS esters. Nevertheless, in aqueous media, the rate at which the ester hydrolyzes to the carboxylic acid increases as the pH increases. Moreover, it should be noted that reacting surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

Many applications could potentially use m-dPEG®24-TFP ester successfully. Among those applications are:
cell surface engineering;
PK, BD, and immunogenicity profile improvements for biomolecules;
imaging applications by reducing background and non-specific binding;
dendrimer construction;
nanoparticle, quantum dot, and carbon nanotube surface coating; and,
prevention of protein aggregation.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight1265.38; single compound
Chemical formulaC₅₆H₁₀₀F₄O₂₆
CASN/A
Purity> 97%
SpacersdPEG® Spacer is 74 atoms and 86.2 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

The post m-dPEG®₂₄-TFP ester appeared first on VectorLabs.

]]> m-dPEG®₁₂-amido-dPEG®₁₂-TFP ester https://staging.vectorlabs.com/products/m-dpeg12-amido-dpeg12-tfp-ester/ Sat, 24 Feb 2024 02:05:01 +0000 https://staging.vectorlabs.com/?post_type=product&p=35129 "m-dPEG®12-amido-dPEG®12-TFP ester, product number QBD-10149, is a long (77 atoms, 91.3 Å), methyl-terminated, discrete-length polyethylene glycol (dPEG®) spacer. The reactive end of the molecule is a 2,3,5,6-tetrafluorophenyl (TFP) ester. An amide bond joining two discrete PEG subunits is in the molecule's center. m-dPEG®12-amido-dPEG®12-TFP ester is designed to modify surfaces containing accessible free amines. Applications for m-dPEG®12-amido-dPEG®12-TFP ester include cell surface engineering, improving PK/BD, reducing bioconjugate immunogenicity, preventing protein aggregation, constructing dendrimers, and many more.

m-dPEG®12-amido-dPEG®12-TFP ester reacts with amine-functionalized surfaces (carbon nanotubes, nanoparticles made of silica or various metals, quantum dots, and similar types of products) or free amines on biomolecules. When used to coat surfaces or modify biomolecules, m-dPEG®12-amido-dPEG®12-TFP ester reduces or eliminates non-specific binding and increases water solubility. Crucially, the elimination of non-specific binding may increase the signal-to-noise ratio in imaging applications and assays where this is a consideration. Please note that modifying the surface amines of biomolecules with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates. When reacting TFP esters with free amines, the optimal pH range is 7.5 - 8.5."

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 1336.45; single compound
Chemical formula C₅₉H₁₀₅F₄NO₂₇
CAS N/A
Purity > 96%
Spacers dPEG® Spacer is 77 atoms and 91.3 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene Chloride, Acetonitrile, DMSO, DMAC or DMF.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post m-dPEG®₁₂-amido-dPEG®₁₂-TFP ester appeared first on VectorLabs.

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Description

m-dPEG®12-amido-dPEG®12-TFP ester, product number QBD-10149, is a long (77 atoms, 91.3 Å), methyl-terminated, discrete-length polyethylene glycol (dPEG®) spacer. The reactive end of the molecule is a 2,3,5,6-tetrafluorophenyl (TFP) ester. An amide bond joining two discrete PEG subunits is in the molecule’s center. m-dPEG®12-amido-dPEG®12-TFP ester is designed to modify surfaces containing accessible free amines. Applications for m-dPEG®12-amido-dPEG®12-TFP ester include cell surface engineering, improving PK/BD, reducing bioconjugate immunogenicity, preventing protein aggregation, constructing dendrimers, and many more.

m-dPEG®12-amido-dPEG®12-TFP ester reacts with amine-functionalized surfaces (carbon nanotubes, nanoparticles made of silica or various metals, quantum dots, and similar types of products) or free amines on biomolecules. When used to coat surfaces or modify biomolecules, m-dPEG®12-amido-dPEG®12-TFP ester reduces or eliminates non-specific binding and increases water solubility. Crucially, the elimination of non-specific binding may increase the signal-to-noise ratio in imaging applications and assays where this is a consideration. Please note that modifying the surface amines of biomolecules with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates. When reacting TFP esters with free amines, the optimal pH range is 7.5 – 8.5.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 1336.45; single compound
Chemical formula C₅₉H₁₀₅F₄NO₂₇
CAS N/A
Purity > 96%
Spacers dPEG® Spacer is 77 atoms and 91.3 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene Chloride, Acetonitrile, DMSO, DMAC or DMF.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

  1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

The post m-dPEG®₁₂-amido-dPEG®₁₂-TFP ester appeared first on VectorLabs.

]]> m-dPEG®₄₈-NH-CO(CH₂)₃CO-TFP ester https://staging.vectorlabs.com/products/m-dpeg48-nh-coch23co-tfp-ester/ Sat, 24 Feb 2024 02:04:58 +0000 https://staging.vectorlabs.com/?post_type=product&p=35105 m-dPEG®48-NH-CO(CH2)3CO-TFP ester, product number QBD-10143, is a long (151 atoms, 178.5 Å), methyl-terminated, discrete-length polyethylene glycol (dPEG®) spacer. With a reactive end of 2,3,5,6-tetrafluorophenyl (TFP) ester, m-dPEG®48-NH-CO(CH2)3CO-TFP ester is designed to modify surfaces containing available free amines.

In aqueous media, free amines react optimally with TFP esters at pH 7.5 – 8.5. Compared to N-hydroxysuccinimidyl (NHS) esters, TFP esters are more hydrolytically stable in water and aqueous buffer. Nevertheless, in aqueous media, the rate at which the ester hydrolyzes to the carboxylic acid increases as the pH rises. Moreover, please note that reacting free amines on biomolecules with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

Many applications potentially could use m-dPEG®48-NH-CO(CH2)3CO-TFP ester successfully. Among those applications are: cell surface engineering; PK, BD, and immunogenicity profile improvements for biomolecules; imaging applications, by reducing background and non-specific binding and consequently increasing the signal-to-noise ratio; dendrimer construction; nanoparticle, quantum dot, and carbon nanotube surface coating; and, prevention of protein aggregation."

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 2407.76; single compound
Chemical formula C₁₀₈H₂₀₃F₄NO₅₁
CAS N/A
Purity > 97%
Spacers dPEG® Spacer is 151 atoms and 178.5 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene Chloride, DMAC, DMSO, DMF or Acetonitrile.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post m-dPEG®₄₈-NH-CO(CH₂)₃CO-TFP ester appeared first on VectorLabs.

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Description

m-dPEG®48-NH-CO(CH2)3CO-TFP ester, product number QBD-10143, is a long (151 atoms, 178.5 Å), methyl-terminated, discrete-length polyethylene glycol (dPEG®) spacer. With a reactive end of 2,3,5,6-tetrafluorophenyl (TFP) ester, m-m-dPEG®48-NH-CO(CH2)3CO-TFP ester is designed to modify surfaces containing available free amines.

In aqueous media, free amines react optimally with TFP esters at pH 7.5 – 8.5. Compared to N-hydroxysuccinimidyl (NHS) esters, TFP esters are more hydrolytically stable in water and aqueous buffer. Nevertheless, in aqueous media, the rate at which the ester hydrolyzes to the carboxylic acid increases as the pH rises. Moreover, please note that reacting free amines on biomolecules with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

Many applications potentially could use m-dPEG®48-NH-CO(CH2)3CO-TFP ester successfully. Among those applications are: cell surface engineering; PK, BD, and immunogenicity profile improvements for biomolecules; imaging applications, by reducing background and non-specific binding and consequently increasing the signal-to-noise ratio; dendrimer construction; nanoparticle, quantum dot, and carbon nanotube surface coating; and, prevention of protein aggregation.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 2407.76; single compound
Chemical formula C₁₀₈H₂₀₃F₄NO₅₁
CAS N/A
Purity > 97%
Spacers dPEG® Spacer is 151 atoms and 178.5 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene Chloride, DMAC, DMSO, DMF or Acetonitrile.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

  1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

The post m-dPEG®₄₈-NH-CO(CH₂)₃CO-TFP ester appeared first on VectorLabs.

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