NHS Ester – VectorLabs https://staging.vectorlabs.com From linker design and synthesis, bioconjugated design and manufacturing, biomolecule labeling and functionalization, and detection system and solutions, our team is here to help you move forward, with impact. Wed, 22 Oct 2025 17:21:08 +0000 en-US hourly 1 https://wordpress.org/?v=6.9 https://staging.vectorlabs.com/wp-content/uploads/2024/11/V-favicon-02-100x100.png NHS Ester – VectorLabs https://staging.vectorlabs.com 32 32 m-dPEG®₂₅-NHS ester https://staging.vectorlabs.com/products/m-dpeg25-nhs-ester/ Sat, 24 Feb 2024 02:16:35 +0000 https://staging.vectorlabs.com/?post_type=product&p=39359 m-dPEG®25-NHS ester, product number QBD-11291, is a long (77 atoms, 89.9 Å), methyl-terminated, discrete-chain-length polyethylene glycol (dPEG®) spacer functionalized with an N-hydroxysuccinimidyl (NHS) ester for reaction with free amines. m-dPEG®25-NHS ester is just one member of an comprehensive line of methyl-terminated PEGylation reagents that includes dPEG® spacers containing 2 to 49 ethylene glycol units.

NHS esters react optimally with free amines at pH 7.0 – 7.5. In aqueous media, the hydrolytic rate of the ester to the carboxylic acid increases with increasing pH. Reacting surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

Many applications could employ m-dPEG®25-NHS ester, including the following:
dendrimer construction;
PK and immunogenicity improvements for dendrimers, peptides, and proteins;
cell surface engineering;
peptide synthesis and modification to improve water solubility or decrease immunogenicity;
coating of nanoparticles, quantum dots, and carbon nanotubes; and
prevention of protein aggregation.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 1258.44; single compound
Chemical formula C₅₆H₁₀₇NO₂₉
CAS N/A
Purity > 98%
Spacers dPEG® Spacer is 77 atoms and 89.9 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) DCM, Methanol, Ethanol, Acetonitrile, Water, Ethyle Acetate, or Acetone.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

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Description

m-dPEG®25-NHS ester, product number QBD-11291, is a long (77 atoms, 89.9 Å), methyl-terminated, discrete-chain-length polyethylene glycol (dPEG®) spacer functionalized with an N-hydroxysuccinimidyl (NHS) ester for reaction with free amines. m-dPEG®25-NHS ester is just one member of an comprehensive line of methyl-terminated PEGylation reagents that includes dPEG® spacers containing 2 to 49 ethylene glycol units.

NHS esters react optimally with free amines at pH 7.0 – 7.5. In aqueous media, the hydrolytic rate of the ester to the carboxylic acid increases with increasing pH. Reacting surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

Many applications could employ m-dPEG®25-NHS ester, including the following:
dendrimer construction;
PK and immunogenicity improvements for dendrimers, peptides, and proteins;
cell surface engineering;
peptide synthesis and modification to improve water solubility or decrease immunogenicity;
coating of nanoparticles, quantum dots, and carbon nanotubes; and
prevention of protein aggregation.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight1258.44; single compound
Chemical formulaC₅₆H₁₀₇NO₂₉
CASN/A
Purity> 98%
SpacersdPEG® Spacer is 77 atoms and 89.9 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)DCM, Methanol, Ethanol, Acetonitrile, Water, Ethyle Acetate, or Acetone.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

The post m-dPEG®₂₅-NHS ester appeared first on VectorLabs.

]]> m-dPEG®₁₃-NHS ester https://staging.vectorlabs.com/products/m-dpeg13-nhs-ester/ Sat, 24 Feb 2024 02:14:50 +0000 https://staging.vectorlabs.com/?post_type=product&p=37409 m-dPEG®13-NHS ester, product number QBD-11086, is a medium-length (41 atoms, 47.3 Å), methyl-terminated, discrete-chain-length polyethylene glycol (dPEG®) spacer functionalized with an N-hydroxysuccinimidyl (NHS) ester for reaction with free amines. m-dPEG®13-NHS ester is just one member of a comprehensive line of methyl-terminated dPEG® products that includes dPEG® spacers containing 2 to 49 ethylene glycol units.

NHS esters react optimally with free amines at pH 7.0 – 7.5. In aqueous media, the hydrolytic rate of the ester to the carboxylic acid increases with increasing pH. Reacting surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.
Many applications could employ m-dPEG®13-NHS ester, including the following:
vaccine development (modifying the immunogenicity of biomolecules);
dendrimer construction;
PK and immunogenicity improvements for dendrimers, peptides, and proteins;
cell surface engineering;
peptide synthesis and modification to improve water solubility or decrease immunogenicity;
coating of nanoparticles, quantum dots, and carbon nanotubes; and
prevention of protein aggregation.

Specifications

Unit Size 100mg, 1000mg
Molecular Weight 729.807; single compound
Chemical formula C₃₂H₅₉NO₁₇
CAS N/A
Purity > 98%
Spacers dPEG® Spacer is 41 atoms and 47.3 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene Chloride, DMSO, Acetonitrile, Acetone, Methanol, Ethyl Acetate, DMAC, or DMF.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post m-dPEG®₁₃-NHS ester appeared first on VectorLabs.

]]>

Description

m-dPEG®13-NHS ester, product number QBD-11086, is a medium-length (41 atoms, 47.3 Å), methyl-terminated, discrete-chain-length polyethylene glycol (dPEG®) spacer functionalized with an N-hydroxysuccinimidyl (NHS) ester for reaction with free amines. m-dPEG®13-NHS ester is just one member of a comprehensive line of methyl-terminated dPEG® products that includes dPEG® spacers containing 2 to 49 ethylene glycol units.

NHS esters react optimally with free amines at pH 7.0 – 7.5. In aqueous media, the hydrolytic rate of the ester to the carboxylic acid increases with increasing pH. Reacting surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.
Many applications could employ m-dPEG®13-NHS ester, including the following:
vaccine development (modifying the immunogenicity of biomolecules);
dendrimer construction;
PK and immunogenicity improvements for dendrimers, peptides, and proteins;
cell surface engineering;
peptide synthesis and modification to improve water solubility or decrease immunogenicity;
coating of nanoparticles, quantum dots, and carbon nanotubes; and
prevention of protein aggregation.

Specifications

Unit Size100mg, 1000mg
Molecular Weight729.807; single compound
Chemical formulaC₃₂H₅₉NO₁₇
CASN/A
Purity> 98%
SpacersdPEG® Spacer is 41 atoms and 47.3 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene Chloride, DMSO, Acetonitrile, Acetone, Methanol, Ethyl Acetate, DMAC, or DMF.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

The post m-dPEG®₁₃-NHS ester appeared first on VectorLabs.

]]> m-dPEG®₃₇-NHS ester https://staging.vectorlabs.com/products/m-dpeg37-nhs-ester/ Sat, 24 Feb 2024 02:13:47 +0000 https://staging.vectorlabs.com/?post_type=product&p=37162 m-dPEG®37-NHS ester, product number QBD-10910, is a long (112 atoms, 133.9 Å), methyl-terminated, discrete-length polyethylene glycol (dPEG®) spacer functionalized with an N-hydroxysuccinimidyl (NHS) ester to modify surfaces having accessible free amines.

Free amines react optimally with NHS esters in aqueous media at pH 7.0 – 7.5. In aqueous media, the rate at which the ester hydrolyzes to the carboxylic acid increases with increasing pH. Moreover, it should be noted that reacting surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

m-dPEG®37-NHS ester, product number QBD-10910, has been used successfully to modify silica shelled quantum dots used in imaging applications to make them water-soluble. Also, it has been employed to improve the pharmacokinetic (PK) and biodistribution (BD) properties of an antibody that targets an epitope that is found exclusively in adenocarcinomas. Carbon nanotubes and inorganic nanoparticles with amine-functionalized surfaces could also be modified to passivate the surface and make it hydrophilic. Moreover, proteins and other biomolecules conjugated to this product will have higher water solubility, reduced or eliminated antigenicity, reduced propensity to aggregate, and improved PK and BD properties.

Specifications

Unit Size 100mg, 1000mg
Molecular Weight 1787.07; single compound
Chemical formula C₈₀H₁₅₅NO₄₁
CAS 756525-94-7
Purity > 97%
Spacers dPEG® Spacer is 112 atoms and 133.9 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetonitrile, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post m-dPEG®₃₇-NHS ester appeared first on VectorLabs.

]]>

Description

m-dPEG®37-NHS ester, product number QBD-10910, is a long (112 atoms, 133.9 Å), methyl-terminated, discrete-length polyethylene glycol (dPEG®) spacer functionalized with an N-hydroxysuccinimidyl (NHS) ester to modify surfaces having accessible free amines.

Free amines react optimally with NHS esters in aqueous media at pH 7.0 – 7.5. In aqueous media, the rate at which the ester hydrolyzes to the carboxylic acid increases with increasing pH. Moreover, it should be noted that reacting surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

m-dPEG®37-NHS ester, product number QBD-10910, has been used successfully to modify silica shelled quantum dots used in imaging applications to make them water-soluble. Also, it has been employed to improve the pharmacokinetic (PK) and biodistribution (BD) properties of an antibody that targets an epitope that is found exclusively in adenocarcinomas. Carbon nanotubes and inorganic nanoparticles with amine-functionalized surfaces could also be modified to passivate the surface and make it hydrophilic. Moreover, proteins and other biomolecules conjugated to this product will have higher water solubility, reduced or eliminated antigenicity, reduced propensity to aggregate, and improved PK and BD properties.

Specifications

Unit Size100mg, 1000mg
Molecular Weight1787.07; single compound
Chemical formulaC₈₀H₁₅₅NO₄₁
CAS756525-94-7
Purity> 97%
SpacersdPEG® Spacer is 112 atoms and 133.9 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Silica-Shelled Single Quantum Dot Micelles as Imaging Probes with Dual or Multimodality. Rumiana Bakalova, Zhivko Zhelev, Ichio Aoki, Hideki Ohba, Yusuke Imai, and Iwao Kanno. Anal. Chem. 2006, 78 (16) pp 5925–5932. July 14, 2006. DOI: 10.1021/ac060412b.

Engineering PEGylated Antibody Fragments for Enhanced Properties and Cancer Detection. Shubham Mangla. Knowledge Bank. 2016, May 2016.

Tuning surface functionalities of Sub-10 nm-sized nanocarriers to target outer retina in designing drug delivery agents for intravitreal administration. Suyeon You, Hyoungtai Kim, Hye-youn Junga, Boram Kim, Eun Jung Lee, Jin Woo Kim, Yoonkyung Kim. Biomaterials. 2020. DOI: 10.1016/j.biomaterials.2020.120188

The post m-dPEG®₃₇-NHS ester appeared first on VectorLabs.

]]> m-dPEG®₂-NHS ester https://staging.vectorlabs.com/products/m-dpeg2-nhs-ester/ Sat, 24 Feb 2024 02:10:07 +0000 https://staging.vectorlabs.com/?post_type=product&p=36018 m-dPEG®2-NHS ester, product number QBD-10327, is a short (8 atoms, 8.5 Å), methyl-terminated, discrete-length polyethylene glycol (dPEG®) spacer, functionalized as the N-hydroxysuccinimidyl (NHS) ester and designed for modification of surfaces containing accessible free amines. NHS reacts optimally with free amines at pH 7.0 – 7.5. The active ester’s rate of hydrolysis to the carboxylic acid accelerates with increasing pH. Please note that modification of surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

One potential application for this product include charge modification of a biomolecule by modifying positively charged free amines with the uncharged m-dPEG®2-NHS ester. Another potential application is to use m-dPEG®2-NHS ester in a mixed surface modification (for example, an amine-coated glass or silica surface) where the shorter dPEG® product passivates the surface while longer dPEG® products contain reactive groups for additional functionalization of the surface. Other potential or published applications for this product include the following:
surface modification of silica-shelled quantum dots;
coating of carbon nanotubes and other hydrophobic surfaces;
N-terminal peptide modification; and
various imaging applications.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 245.23; single compound
Chemical formula C₁₀H₁₅NO₆
CAS 1127247-34-0
Purity > 98%
Spacers dPEG® Spacer is 8 atoms and 8.5 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetonitrile, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post m-dPEG®₂-NHS ester appeared first on VectorLabs.

]]>

Description

m-dPEG®2-NHS ester, product number QBD-10327, is a short (8 atoms, 8.5 Å), methyl-terminated, discrete-length polyethylene glycol (dPEG®) spacer, functionalized as the N-hydroxysuccinimidyl (NHS) ester and designed for modification of surfaces containing accessible free amines. NHS reacts optimally with free amines at pH 7.0 – 7.5. The active ester’s rate of hydrolysis to the carboxylic acid accelerates with increasing pH. Please note that modification of surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

One potential application for this product include charge modification of a biomolecule by modifying positively charged free amines with the uncharged m-dPEG®2-NHS ester. Another potential application is to use m-dPEG®2-NHS ester in a mixed surface modification (for example, an amine-coated glass or silica surface) where the shorter dPEG® product passivates the surface while longer dPEG® products contain reactive groups for additional functionalization of the surface. Other potential or published applications for this product include the following:
surface modification of silica-shelled quantum dots;
coating of carbon nanotubes and other hydrophobic surfaces;
N-terminal peptide modification; and
various imaging applications.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight245.23; single compound
Chemical formulaC₁₀H₁₅NO₆
CAS1127247-34-0
Purity> 98%
SpacersdPEG® Spacer is 8 atoms and 8.5 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Short polyethylene glycol chains densely bound to soft nanotube channels for inhibition of protein aggregation. N. Kameta, T. Matsuzawa, K. Yaoi, and M. Masuda. RSC Advances. 2016, 6 (43) pp 36744-36750. April 7, 2016. DOI: 10.1039/C6RA06793J.

Hairpin Structure of a Biarsenical- Tetracysteine Motif Determined by NMR Spectroscopy, Fatemeh Madani, Jesper Lind, Peter Damberg, Stephen R. Adams, Roger Y. Tsien, and Astrid O. Graslund. JACS (J. Am. Chem. Soc.). 2009, 131 (13), pp 4613–4615. March 12, 2009. DOI: 10.1021/ja809315x.

Silica-Shelled Single Quantum Dot Micelles as Imaging Probes with Dual or Multimodality. Rumiana Bakalova, Zhivko Zhelev, Ichio Aoki, Hideki Ohba, Yusuke Imai, and Iwao Kanno. Anal. Chem. 2006, 78 (16) pp 5925–5932. July 14, 2006. DOI: 10.1021/ac060412b.

The post m-dPEG®₂-NHS ester appeared first on VectorLabs.

]]> m-dPEG®₁₂-NHS ester https://staging.vectorlabs.com/products/m-dpeg12-nhs-ester/ Sat, 24 Feb 2024 02:07:43 +0000 https://staging.vectorlabs.com/?post_type=product&p=35644 m-dPEG®12-NHS ester, product number QBD-10262, is a medium-length (38 atoms, 44.7 Å), methyl-terminated, discrete-chain-length polyethylene glycol (dPEG®) spacer functionalized with an N-hydroxysuccinimidyl (NHS) ester for reaction with amines.

NHS esters react optimally with free amines at pH 7.0 – 7.5. In aqueous media, the hydrolytic rate of the ester to the carboxylic acid increases with increasing pH. Reacting surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

Many applications employ this m-dPEG®12-NHS ester. Published papers using this product include uses in:
vaccine development;
cell surface engineering;
multimodal imaging;
stable antimicrobial, cytotoxic dendrimers;
nanoparticles for siRNA delivery;
coating of nanoparticles, quantum dots, and carbon nanotubes;
PK and immunogenicity improvements for organophosphorus hydrolase;
PK and immunogenicity improvements for poly-L-lysine dendrimers used as drug delivery vehicles to tumors; and,
preventing enzyme aggregation.
m-dPEG®12-NHS ester, product number QBD-10262, is just one member of a comprehensive line of methyl-terminated dPEG® products, including dPEG® spacers containing 2 to 49 ethylene glycol units.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 685.75; single compound
Chemical formula C₃₀H₅₅NO₁₆
CAS 756525-94-7
Purity > 98%
Spacers dPEG® Spacer is 38 atoms and 44.7 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetonitrile, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post m-dPEG®₁₂-NHS ester appeared first on VectorLabs.

]]>

Description

m-dPEG®12-NHS ester, product number QBD-10262, is a medium-length (38 atoms, 44.7 Å), methyl-terminated, discrete-chain-length polyethylene glycol (dPEG®) spacer functionalized with an N-hydroxysuccinimidyl (NHS) ester for reaction with amines.

NHS esters react optimally with free amines at pH 7.0 – 7.5. In aqueous media, the hydrolytic rate of the ester to the carboxylic acid increases with increasing pH. Reacting surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

Many applications employ this m-dPEG®12-NHS ester. Published papers using this product include uses in:
vaccine development;
cell surface engineering;
multimodal imaging;
stable antimicrobial, cytotoxic dendrimers;
nanoparticles for siRNA delivery;
coating of nanoparticles, quantum dots, and carbon nanotubes;
PK and immunogenicity improvements for organophosphorus hydrolase;
PK and immunogenicity improvements for poly-L-lysine dendrimers used as drug delivery vehicles to tumors; and,
preventing enzyme aggregation.
m-dPEG®12-NHS ester, product number QBD-10262, is just one member of a comprehensive line of methyl-terminated dPEG® products, including dPEG® spacers containing 2 to 49 ethylene glycol units.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight685.75; single compound
Chemical formulaC₃₀H₅₅NO₁₆
CAS756525-94-7
Purity> 98%
SpacersdPEG® Spacer is 38 atoms and 44.7 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

The impact of molecular Weight and PEG Chain Length on the Systemic Pharmacokinetics of PEGylated Poly L-Lysine Dendrimers. Lisa M. Kaminskas, Ben J. Boyd, Peter Karellas, Guy Y. Krippner, Romina Lessene, Brian Kelly, and Christopher J. H. Porter. Molecular Pharmaceutics. 2008, 5 (3), pp 449–463. April 5, 2008. DOI: 10.1021/mp7001208.

Pharmacokinetics and Tumor Disposition of PEGylated Methotrexate Conjugated Poly-L-lysine Dendrimers. Lisa M. Kaminskas, Brian D. Kelly, Victoria M. McLeod, Ben J. Boyd, Guy Y. Krippner, Elizabeth D. Williams, and Christopher J. H. Porter, Molecular Pharmaceutics, Vol. 6, No. 4, 2009, 6 (4), pp 1190-1204, May 19, 2009. DOI: 10.1021/mp900049a.

Hairpin Structure of a Biarsenical- Tetracysteine Motif Determined by NMR Spectroscopy. Fatemeh Madani, Jesper Lind, Peter Damberg, Stephen R. Adams, Roger Y. Tsien, and Astrid O. Graslund. Journal of the American Chemical Society. 2009, 131 (13), pp 4613–4615. March 12, 2009. DOI: 10.1021/ja809315x.

Improved pharmacokinetics and immunogenicity profile of organophosphorus hydrolase by chemical modification with polyethylene glycol. Boris N. Novikov, Janet K. Grimsley, Rory J. Kern, James R. Wild, Melinda E. Wales. Journal of Controlled Release. 2010, 146 (3) pp 318-325. September 15, 2010. DOI: 10.1016/j.jconrel.2010.06.003.

Antibacterial activity and cytotoxicity of PEGylated poly(amidoamine) dendrimers. Analette I. Lopez, Rose Y. Reins, Alison M. McDermott, Barbara W. Trautner and Chengzhi Cai. Molecular BioSystems. 2009, 10 (5) pp 1148–1156. May 26, 2009. DOI: 10.1039/b904746h.

Stability, Antimicrobial Activity, and Cytotoxicity of Poly(amidoamine) Dendrimers on Titanium Substrates. Lin Wang, Uriel J. Erasquin, Meirong Zhao, Li Ren, Martin Yi Zhang, Gary J. Cheng, Yingjun Wang, and Chengzhi Cai. ACS Applied Materials & Interfaces. 2011, 3 (8), pp 2885-2894. July 20, 2011. DOI: 10.1021/am2004398.

Prevention of benzyl alcohol-induced aggregation of chymotrypsinogen by PEGylation. José A. Rodríguez-Martínez, Izarys Rivera-Rivera and Kai Griebenow. Journal of Pharmacy and Pharmacology. 2011, 63 (6), pp 800–805. January 6, 2011. DOI: 10.1111/j.2042-7158.2011.01288.

Development and Application of a Multimodal Contrast Agent for SPECT/CT Hybrid Imaging. Jason M. Criscione, Lawrence W. Dobrucki, Zhen W. Zhuang, Xenophon Papademetris, Michael Simons, Albert J. Sinusas and Tarek M. Fahmy. Bioconjugate Chemistry. 2011, 22 (9), pp 1784–1792. August 18, 2011. DOI: 10.1021/bc200162r.

Antibacterial Activities of Poly (amidoamine) Dendrimers Terminated with Amino and Poly(ethylene glycol) Groups. Michelle K. Calabretta, Amit Kumar, Alison M. McDermott, and Chengzhi Cai. Biomacromolecules. 2007, 8 (6) pp 1807-1811. May 19, 2007. DOI: 10.1021/bm0701088.

Enhancement of the CD8+ T cell response to a subdominant epitope of respiratory syncytial virus by deletion of an immunodominant epitope. Hoyin Mok, Sujin Lee, David W. Wright, and James E. Crowe Jr. Vaccine. 2008, 26 (37) pp 4775-4782. September 2, 2008. DOI: 10.1016/j.vaccine.2008.07.012.

Silica-Shelled Single Quantum Dot Micelles as Imaging Probes with Dual or Multimodality. Rumiana Bakalova, Zhivko Zhelev, Ichio Aoki, Hideki Ohba, Yusuke Imai, and Iwao Kanno. Analytical Chemistry. 2006, 78 (16) pp 5925–5932. July 14, 2006. DOI: 10.1021/ac060412b.

Multifunctional Separation Mechanism on Poly(oxyethylene) Stationary Phases in Capillary Liquid Chromatography. Toyohide Takeuchi and Lee Wah Lim. Analytical Sciences. 2010, 26 (9) pp 937-941. September 10, 2010. DOI: 10.2116/analsci.26.937.

N-Alkylated aminopyrazines for use as hydrophilic optical agents. Amruta R. Poreddy, Bethel Asmelash, Karen P. Galen, Richard M. Fitch, Jeng-Jong Shieh, James M. Wilcox, Tasha M. Schoenstein, Jolette K. Wojdyla, Kimberly R. Gaston, John N. Freskos, William L. Neumann, Raghavan Rajagopalan, Hyo-Yang Ahn, James G. Kostelc, Martin P. Debreczeny, Kevin D. Belfield, and Richard B. Dorshow. SPIE. Digital Library, Optical Molecular Probes and Industry. 2009. 7190. January 24, 2009. DOI: 10.1117/12.809287.

Reconstitution of the M13 Major Coat Protein and Its Transmembrane Peptide Segment on a DNA Template. Weijun Li, Itai Suez and Francis C. Szoka, Jr. ACS Biochemistry. 2007, 46 (29) pp 8579–8591. June 27, 2007. DOI: 10.1021/bi700165m.

Acid-degradable cationic methacrylamide polymerized in the presence of plasmid DNA as tunable non-viral gene carrier. In Kap Ko, Assem Ziady, Shiwei Lu, Young Jik Kwon. Biomaterials. 2008, 29 (28) pp 3872–3881. June 27, 2008. DOI: 10.1016/j.biomaterials.2008.06.003.

Electrostatic readout of DNA microarrays with charged microspheres. Nathan G Clack, Khalid Salaita, and Jay T Groves. Nature Biotechnology. 2008, 26 (7) pp 825-830. June 29, 2008. DOI: 10.1038/nbt1416.

Poly(ethylene oxide)-bonded stationary phase for capillary ion chromatography. Toyohide Takeuchi, Budhi Oktavia, Lee Wah Lim. Anal Bioanal Chem. 2009, 393(4) pp 1267-1272. November 30, 2008. DOI: 10.1007/s00216-008-2533-7.

An adsorption chromatography assay to probe bulk particle transport through hydrogels. I. Vladescu, O. Lieleg, S. Jang, and Katharina Ribbeck. Journal of Pharmaceutical Sciences. 2012, 101 (1) pp 436-442. September 8, 2011. DOI: 10.1002/jps.2273.

Biomolecular strategies for cell surface engineering. John Tanner Wilson. Smartech. 2008, December 5, 2008.

Investigations into Improving the Separation of PEGylated Proteins. Vita Knudson, Tividar Farkas, and Michael McGinley. Phenomenex, (TN-1034).

Stabilization of α-chymotrypsin upon PEGylation correlates with reduced structural dynamics. Jose A. Rodriguez-Martinez, Ricardo J. Sola, Betzaida Castillo, Hector R. Cintron-Colon, Izarys Rivera-Rivera, Gabriel Barletta, Kai Griebenow. Biotechnology and Bioengineering. 2008, 101 (6) pp 1142-1149. December 15, 2008. DOI: 10.1002/bit.22014.

Development of a widefield SERS imaging endoscope. Patrick Z. McVeigh, Rupananda J. Mallia, Israel Veilleux, Brian C. Wilson. SPIE Proceedings. 2012, 8217 (1) pp 1-6. February 13, 2012. DOI: 10.1117/12.907304.

Characterization of Particle Translocation through Mucin Hydrogels. Oliver Lieleg, Ioana Vladescu, and Katharina Ribbeck. Biophysical Journal. 2010, 98 (9) pp 1782–1789. May 5, 2010. DOI: 10.1016/j.bpj.2010.01.012.

Short polyethylene glycol chains densely bound to soft nanotube channels for inhibition of protein aggregation. N. Kameta, T. Matsuzawa, K. Yaoi, and M. Masuda. RSC Advances. 2016, 6 (43) pp 36744-36750. April 7, 2016. DOI: 10.1039/C6RA06793J.

Site directed Pegylation: Role of pH and temperature, to increase the productivity of insulin oligomer conjugate. Ashutosh Sudhir Naik, Koduru srivatsa, Krishnappa Mane, Phanichand Kodali, Laxmi Adhikary. Journal of Pharmaceutical and Biological Sciences. 2017, 5(4) pp 155-160. 2017. https://innovativepublication.com/admin/uploaded_files/JPBS_5(4)_155-160.pdf

Protease-triggered siRNA delivery vehicles. David B. Rozema, Andrei V. Blokhin, Darren H. Wakefield, Jonathan D. Benson, Jeffrey C. Carlson, Jason J. Klein, Lauren J. Almeida, Anthony L. Nicholas, Holly L. Hamilton, Qili Chu, Julia O. Hegge, So C. Wong, Vladimir S. Trubetskoy, Collin M. Hagen, Eric Kitas, Jon A. Wolff, and David L. Lewis. Journal of Controlled Release. 2017, 209 pp 57-66. 7/10/2015. DOI: 10.1016/j.jconrel.2015.04.012.

Multivalent Benzamidine Molecules for Plasmin Inhibition: Effect of Valency and Linker Length. Tanmaye Nallan Chakravarthula, Dr. Ziqian Zeng, Prof. Nathan J. Alves. ChemMedChem, Volume 17, Issue 22, (2022), 09/16/2022, https://doi.org/10.1002/cmdc.202200364.

The post m-dPEG®₁₂-NHS ester appeared first on VectorLabs.

]]> m-dPEG®₈-NHS ester https://staging.vectorlabs.com/products/m-dpeg8-nhs-ester/ Sat, 24 Feb 2024 02:07:40 +0000 https://staging.vectorlabs.com/?post_type=product&p=35627 m-dPEG®8-NHS ester, product number QBD-10260, is a medium-length (26 atoms, 29.8 Å), methyl-terminated, discrete-length polyethylene glycol (dPEG®) spacer functionalized with an N-hydroxysuccinimidyl (NHS) ester for reactions with free amines. NHS reacts optimally with free amines at pH 7.0 – 7.5. The hydrolytic rate of the ester to the carboxylic acid increases with increasing pH. Please note that modification of surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

Many applications employ this m-dPEG®8-NHS ester. Published papers using this product include:
imaging applications;
design of a delivery mechanism for an anti-HIV therapeutic peptide;
coating of carbon nanotubes, gold nanoshells, and silica shelled quantum dots;
PK improvement of organophosphorus hydrolase in a therapeutic application;
peptide synthesis; and,
development of antibacterial, cytotoxic dendrimers.
m-dPEG®8-NHS ester, product number QBD-10260, is just one member of an comprehensive line of methyl-terminated dPEG® products. This line includes dPEG® spacers containing 2 to 49 ethylene glycol units.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 509.54; single compound
Chemical formula C₂₂H₃₉NO₁₂
CAS 756525-90-3
Purity > 97%
Spacers dPEG® Spacer is 26 atoms and 29.8 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetonitrile, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post m-dPEG®₈-NHS ester appeared first on VectorLabs.

]]>

Description

m-dPEG®8-NHS ester, product number QBD-10260, is a medium-length (26 atoms, 29.8 Å), methyl-terminated, discrete-length polyethylene glycol (dPEG®) spacer functionalized with an N-hydroxysuccinimidyl (NHS) ester for reactions with free amines. NHS reacts optimally with free amines at pH 7.0 – 7.5. The hydrolytic rate of the ester to the carboxylic acid increases with increasing pH. Please note that modification of surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

Many applications employ this m-dPEG®8-NHS ester. Published papers using this product include:
imaging applications;
design of a delivery mechanism for an anti-HIV therapeutic peptide;
coating of carbon nanotubes, gold nanoshells, and silica shelled quantum dots;
PK improvement of organophosphorus hydrolase in a therapeutic application;
peptide synthesis; and,
development of antibacterial, cytotoxic dendrimers.
m-dPEG®8-NHS ester, product number QBD-10260, is just one member of an comprehensive line of methyl-terminated dPEG® products. This line includes dPEG® spacers containing 2 to 49 ethylene glycol units.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight509.54; single compound
Chemical formulaC₂₂H₃₉NO₁₂
CAS756525-90-3
Purity> 97%
SpacersdPEG® Spacer is 26 atoms and 29.8 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Short polyethylene glycol chains densely bound to soft nanotube channels for inhibition of protein aggregation. N. Kameta, T. Matsuzawa, K. Yaoi, and M. Masuda. RSC Advances. 2016, 6 (43) pp 36744-36750. April 7, 2016. DOI: 10.1039/C6RA06793J.

Laser-Activated Gene Silencing via Gold Nanoshell-siRNA Conjugates,Gary B Braun, Alessia Pallaoro, Guohui Wi, Dimitris Missirlis, Joseph A. Zasadzinski, Matthew Tirrell, and Norbert O. Reich. ACS Nano. 2009, 3 (7), pp 2007–2015. June 15, 2009. DOI:10.1021/nn900469q.

Hairpin Structure of a Biarsenical- Tetracysteine Motif Determined by NMR Spectroscopy, Fatemeh Madani, Jesper Lind, Peter Damberg, Stephen R. Adams, Roger Y. Tsien, and Astrid O. Graslund. JACS. 2009, 131 (13), pp 4613–4615. March 12, 2009. DOI: 10.1021/ja809315x.

Potent D-peptide inhibitors of HIV-1 entry, Brett D. Welch, Andrew P. VanDemark, Annie Heroux, Christopher P. Hill, and Michael S. Kay. PNAS. 2007, 43 (104), pp 16828-16833. October 23, 2007. DOI: 10.1073/pnas.0708109104.

Improved pharmacokinetics and immunogenicity profile of organophosphorus hydrolase by chemical modification with polyethylene glycol. Boris N. Novikov, Janet K. Grimsley, Rory J. Kern, James R. Wild, Melinda E. Wales. Elsevier. 2010, 3 (146) pp 318-325. September 15, 2010. DOI: 10.1016/j.jconrel.2010.06.003.

Antibacterial activity and cytotoxicity of PEGylated poly(amidoamine) dendrimersw. Analette I. Lopez, Rose Y. Reins, Alison M. McDermott, Barbara W. Trautner and Chengzhi Cai. Molecular BioSystems. 2009, 10 (5), pp 1148-1156. May 28, 2009. DOI: 10.1039/b904746h.

Silica-Shelled Single Quantum Dot Micelles as Imaging Probes with Dual or Multimodality. Rumiana Bakalova, Zhivko Zhelev, Ichio Aoki, Hideki Ohba, Yusuke Imai, and Iwao Kanno. Anal. Chem. 2006, 78 (16) pp 5925–5932. July 14, 2006. DOI: 10.1021/ac060412b.

Development of Polyethylene Glycol-Conjugated Alendronate, a Novel Nitrogen-Containing Bisphosphonate Derivative: Evaluation of Absorption, Safety, and Effects After Intrapulmonary Administration in Rats. HIDEMASA KATSUMI, MIKI TAKASHIMA, JUN-ICHI SANO, KAZUSHI NISHIYAMA, NORIKO KITAMURA, TOSHIYASU SAKANE, TORU HIBI, AKIRA YAMAMOTO. Journal of Pharmaceutical Sciences. 2011, 100 (9) pp 3783-3792. May 12, 2011. DOI: 10.1002/jps.22620.

Novel Comb-Shaped PEGModification Enhances the Osteoclastic Inhibitory Effect and Bone Delivery of Osteoprotegerin After Intravenous Administration in Ovariectomized Rats. Yoshihiro Miyaji, Yuji Kasuya, Yoshitake Furuta, Atsushi Kurihara, Masayuki Takahashi, Ken-ichi Ogawara, Takashi Izumi & Osamu Okazaki & Kazutaka Higaki. Pharmaceutical Research. 2012, 29 (11) pp 3143-3155. June 23, 2012. DOI 10.1007/s11095-012-0807-4.

Laser-Activated Gene Silencing via Gold Nanoshell-siRNA Conjugates,Gary B Braun, Alessia Pallaoro, Guohui Wi, Dimitris Missirlis, Joseph A. Zasadzinski, Matthew Tirrell, and Norbert O. Reich. ACS Nano. 2009, 3 (7), pp 2007–2015. June 15, 2009. DOI:10.1021/nn900469q.

Hairpin Structure of a Biarsenical- Tetracysteine Motif Determined by NMR Spectroscopy, Fatemeh Madani, Jesper Lind, Peter Damberg, Stephen R. Adams, Roger Y. Tsien, and Astrid O. Graslund. JACS. 2009, 131 (13), pp 4613–4615. March 12, 2009. DOI: 10.1021/ja809315x.

Potent D-peptide inhibitors of HIV-1 entry, Brett D. Welch, Andrew P. VanDemark, Annie Heroux, Christopher P. Hill, and Michael S. Kay. PNAS. 2007, 43 (104), pp 16828-16833. October 23, 2007. DOI: 10.1073/pnas.0708109104.

Improved pharmacokinetics and immunogenicity profile of organophosphorus hydrolase by chemical modification with polyethylene glycol. Boris N. Novikov, Janet K. Grimsley, Rory J. Kern, James R. Wild, Melinda E. Wales. Elsevier. 2010, 3 (146) pp 318-325. September 15, 2010. DOI: 10.1016/j.jconrel.2010.06.003.

Antibacterial activity and cytotoxicity of PEGylated poly(amidoamine) dendrimersw. Analette I. Lopez, Rose Y. Reins, Alison M. McDermott, Barbara W. Trautner and Chengzhi Cai. Molecular BioSystems. 2009, 10 (5), pp 1148-1156. May 28, 2009. DOI: 10.1039/b904746h.

Silica-Shelled Single Quantum Dot Micelles as Imaging Probes with Dual or Multimodality. Rumiana Bakalova, Zhivko Zhelev, Ichio Aoki, Hideki Ohba, Yusuke Imai, and Iwao Kanno. Anal. Chem. 2006, 78 (16) pp 5925–5932. July 14, 2006. DOI: 10.1021/ac060412b.

Development of Polyethylene Glycol-Conjugated Alendronate, a Novel Nitrogen-Containing Bisphosphonate Derivative: Evaluation of Absorption, Safety, and Effects After Intrapulmonary Administration in Rats. HIDEMASA KATSUMI, MIKI TAKASHIMA, JUN-ICHI SANO, KAZUSHI NISHIYAMA, NORIKO KITAMURA, TOSHIYASU SAKANE, TORU HIBI, AKIRA YAMAMOTO. Journal of Pharmaceutical Sciences. 2011, 100 (9) pp 3783-3792. May 12, 2011. DOI: 10.1002/jps.22620.

Novel Comb-Shaped PEGModification Enhances the Osteoclastic Inhibitory Effect and Bone Delivery of Osteoprotegerin After Intravenous Administration in Ovariectomized Rats. Yoshihiro Miyaji, Yuji Kasuya, Yoshitake Furuta, Atsushi Kurihara, Masayuki Takahashi, Ken-ichi Ogawara, Takashi Izumi & Osamu Okazaki & Kazutaka Higaki. Pharmaceutical Research. 2012, 29 (11) pp 3143-3155. June 23, 2012. DOI 10.1007/s11095-012-0807-4.

The post m-dPEG®₈-NHS ester appeared first on VectorLabs.

]]> Bis-dPEG®₅, half benzyl half NHS ester https://staging.vectorlabs.com/products/bis-dpeg5-half-benzyl-half-nhs-ester/ Sat, 24 Feb 2024 02:07:30 +0000 https://staging.vectorlabs.com/?post_type=product&p=35542 Bis-dPEG®5, half benzyl half NHS ester, product number QBD-10237, is a short, discrete PEG (dPEG®) modification reagent designed for stepwise reactions with amines. Both ends of the single molecular weight PEG linker terminate with propionic acid groups. One end is functionalized as the N-hydroxysuccinimidyl (NHS) ester, while the other acid end is protected as the benzyl ester. The benzyl ester can be removed using hydrogen with a palladium catalyst.

The dPEG®5 linker increases conjugates' hydrodynamic volume and hydrophilicity. QBD-10237 is useful for crosslinking amines under controlled conditions, modifying peptides at N-termini or amine-functionalized side chains, and building supramolecular constructs that require flexible, hydrophilic spacers.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 525.55; single compound
Chemical formula C₂₅H₃₅NO₁₁
CAS 1263044-84-3
Purity > 97%
Spacers dPEG® Spacer is 19 atoms and 21.7 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, DMAC, or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Bis-dPEG®₅, half benzyl half NHS ester appeared first on VectorLabs.

]]>

Description

Bis-dPEG®5, half benzyl half NHS ester, product number QBD-10237, is a short, discrete PEG (dPEG®) modification reagent designed for stepwise reactions with amines. Both ends of the single molecular weight PEG linker terminate with propionic acid groups. One end is functionalized as the N-hydroxysuccinimidyl (NHS) ester, while the other acid end is protected as the benzyl ester. The benzyl ester can be removed using hydrogen with a palladium catalyst.

The dPEG®5 linker increases conjugates’ hydrodynamic volume and hydrophilicity. QBD-10237 is useful for crosslinking amines under controlled conditions, modifying peptides at N-termini or amine-functionalized side chains, and building supramolecular constructs that require flexible, hydrophilic spacers.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight525.55; single compound
Chemical formulaC₂₅H₃₅NO₁₁
CAS1263044-84-3
Purity> 97%
SpacersdPEG® Spacer is 19 atoms and 21.7 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, DMAC, or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

  1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

The post Bis-dPEG®₅, half benzyl half NHS ester appeared first on VectorLabs.

]]> m-dPEG®₄-NHS ester https://staging.vectorlabs.com/products/m-dpeg4-nhs-ester/ Sat, 24 Feb 2024 02:07:09 +0000 https://staging.vectorlabs.com/?post_type=product&p=35375 "m-dPEG®4-NHS ester, product number QBD-10211, is a short (14 atoms, 15.6 Å), methyl-terminated, discrete length polyethylene glycol (dPEG®) spacer designed for the modification of surfaces containing accessible free amines. The carboxyl terminus of the dPEG® spacer is activated with N-hydroxysuccinimide (NHS) and reacts optimally with free amines at pH 7.0 – 7.5. The rate of hydrolysis of the active ester to the carboxylic acid accelerates with increasing pH. Please note that modification of surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

Numerous applications employ this product. The applications in which this product has been successfully employed include:
cell surface engineering;
surface modification of biomolecules;
coating of carbon nanotubes, quantum dots, and other hydrophobic surfaces;
acoustic sensor development;
diagnostic films for pathogen detection, and,
various imaging applications.
m-dPEG®4-NHS ester, product number 10211, is just one member of an extensive line of methyl-terminated dPEG® products that includes dPEG® spacers containing 2 to 49 ethylene glycol units."

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 333.33; single compound
Chemical formula C₁₄H₂₃NO₈
CAS 622405-78-1
Purity > 98%
Spacers dPEG® Spacer is 14 atoms and 15.600 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetonitrile, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post m-dPEG®₄-NHS ester appeared first on VectorLabs.

]]>

Description

m-dPEG®4-NHS ester, product number QBD-10211, is a short (14 atoms, 15.6 Å), methyl-terminated, discrete length polyethylene glycol (dPEG®) spacer designed for the modification of surfaces containing accessible free amines. The carboxyl terminus of the dPEG® spacer is activated with N-hydroxysuccinimide (NHS) and reacts optimally with free amines at pH 7.0 – 7.5. The rate of hydrolysis of the active ester to the carboxylic acid accelerates with increasing pH. Please note that modification of surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

Numerous applications employ this product. The applications in which this product has been successfully employed include:
cell surface engineering;
surface modification of biomolecules;
coating of carbon nanotubes, quantum dots, and other hydrophobic surfaces;
acoustic sensor development;
diagnostic films for pathogen detection, and,
various imaging applications.
m-dPEG®4-NHS ester, product number 10211, is just one member of an extensive line of methyl-terminated dPEG® products that includes dPEG® spacers containing 2 to 49 ethylene glycol units.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight333.33; single compound
Chemical formulaC₁₄H₂₃NO₈
CAS622405-78-1
Purity> 98%
SpacersdPEG® Spacer is 14 atoms and 15.600 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Molecular Dendritic Transporter Nanoparticle Vectors Provide Efficient Intracellular Delivery of Peptides. Sharon K. Hamilton and Eva Harth. ACS Nano. 2009, 3 (2), pp 402–410. February 5, 2009. DOI: 10.1021/nn800679z.

Synthesis and Characterization of a New class of Cationic Protein Polymers for Multivalent Display and Biomaterial Applications. Nicolynn E. Davis, Lindsay S. Karfield-Sulzer, Sheng Ding, and Annelise E. Barron. Biomacromolecules. 2009, 10 (5), pp 1125–1134. April 10, 2009. DOI: 10.1021/bm801348g.

Noncovalent Cell Surface Engineering with Cationic Graft Copolymers. John T. Wilson, Venkata R. Krishnamurthy, Wanxing Cui, Zheng Qu, and Elliot L. Chaikof. J. Am. Chem. Soc. 2009, 131 (51), pp 18228–18229. December 4, 2009. DOI: 10.1021/ja908887v.

The impact of molecular Weight and PEG Chain Length on the Systemic Pharmacokinetics of PEGylated Poly L-Lysine Dendrimers. Lisa M. Kaminskas, Ben J. Boyd, Peter Karellas, Guy Y. Krippner, Romina Lessene, Brian Kelly, and Christopher J. H. Porter. Mol. Pharmaceutics. 2008, 5 (3), pp 449–463. April 5, 2008. DOI: 10.1021/mp7001208.

Hairpin Structure of a Biarsenical- Tetracysteine Motif Determined by NMR Spectroscopy. Fatemeh Madani, Jesper Lind, Peter Damberg, Stephen R. Adams, Roger Y. Tsien, and Astrid O. Graslund. Journal of the American Chemical Society. 2009, 131 (13), pp 4613–4615. March 12, 2009. DOI: 10.1021/ja809315x.

Improved pharmacokinetics and immunogenicity profile of organophosphorus hydrolase by chemical modification with polyethylene glycol. Boris N. Novikov, Janet K. Grimsley, Rory J. Kern, James R. Wild, Melinda E. Wales. Journal of Controlled Release. 2010, 146 (3) pp 318-325. September 15, 2010. DOI: 10.1016/j.jconrel.2010.06.003.

Bioconjugation of Ln3+-Doped LaF3 Nanoparticles to Avidin. Peter R. Diamente, Robert D. Burke, and Frank C. J. M. van Veggel. Langmuir. 2006, 22 (4) pp 1782–1788. December 30, 2005. DOI: 10.1021/la052589r.

Silica-Shelled Single Quantum Dot Micelles as Imaging Probes with Dual or Multimodality. Rumiana Bakalova, Zhivko Zhelev, Ichio Aoki, Hideki Ohba, Yusuke Imai, and Iwao Kanno. Anal. Chem. 2006, 78 (16) pp 5925–5932. July 14, 2006. DOI: 10.1021/ac060412b.

Multifunctional Separation Mechanism on Poly(oxyethylene) Stationary Phases in Capillary Liquid Chromatography. Toyohide Takeuchi and Lee Wah Lim. Analytical Sciences. 2010, 26 (9) pp 937-941. September 10, 2010. DOI: 10.2116/analsci.26.937

Self-Assembly of Solid-Supported Membranes Using a Triggered Fusion of Phospholipid-Enriched Proteoliposomes Prepared from the Inner Mitochondrial Membrane. Celine Elie-Caille, Ophe´lie Fliniaux, Jacques Pantigny,Jean-Claude Mazie`re, and Christian Bourdillon. Langmuir. 2005, 21 (10) pp 4661–4668. April 7, 2005. DOI: 10.1021/la046973k.

Robust Sensing Films for Pathogen Detection and Medical Diagnostics. Aaron S. Anderson ; Andrew M. Dattelbaum ; Harshini Mukundan ;Dominique N. Price ; W. Kevin Grace ; Basil I. Swanson. Frontiers in Pathogen Detection: From Nanosensors to Systems., 2009, Proc. Of SPIE 7167. 71670q-1 February 18, 2009. 10.1117/12.809383.

Biomolecular Strategies for Cell Surface Engineering. John Tanner Wilson. Doctoral Dissertation, Georgia Institute of Technology: Atlanta, Georgia USA, 2009.

A study of polyethylene glycol backfilling for enhancing target recognition using QCM-D and DPI. Yanqiu Du, Jing Jin, and Wei Jiang. Journal of Materials Chemistry B. 2018, 6, pp 6217-6224. September 21, 2018. DOI: 10.1039/c8tb01526k.

Biological and Structural Basis for Aha1 Regulation of Hsp90 ATPase Activity in Maintaining Proteostasis in the Human Disease Cystic Fibrosis. Atanas V. Koulov, Paul LaPointe, Bingwen Lu, Abbas Razvi, Judith Coppinger,_ Meng-Qiu Dong, Jeanne Matteson, Rob Laister, Cheryl Arrowsmith, John R. Yates III, and William E. Balch. Molecular Biology of the Cell. 2010, 21 pp 871–884. March 15, 2010. DOI: 10.1091/mbc.E09–12–1017.

Bacteriophage T4 Nanoparticles as Materials in Sensor Applications: Variables That Influence Their Organization and Assembly on Surfaces. Marie J. Archer and Jinny L. Liu. Sensors. 2009, 9 (8) pp 6298-6311. August 12, 2009. DOI: 10.3390/s90806298

Surface Modification on Acoustic Wave Biosensors for Enhanced Specificity. Onursal Onen, Asad A. Ahmad, Rasim Guldiken and Nathan D. Gallant. Sensors. 2012, 12 pp 12317-12328. September 10, 2012. DOI: 10.3390/s120912317.

Surface Functionalization and Analysis Thereof for an Ovarian Cancer Diagnostic Biosensor. Asad Ali Ahmad. USF Scholor Commons. 2011, 1 (1) pp 297-416. June 21, 2011. DOI: scholarcommons.usf.edu/etd/2977.

Production of microporous aluminum oxide electrodes as supports for tethered lipid bilayers of large surface area. Ophélie Fliniaux, Céline Elie-Caille, Jacques Pantigny, Christian Bourdillon. Electrochemistry Communications. 2005, 7(7) pp 697-702. April 19, 2005. DOI: 10.1016/j.elecom.2005.04.023

Modified Epidermal Growth Factor Receptor (EGFR)-Bearing Liposomes (MRBLs) Are Sensitive to EGF in Solution. Albert Wong. PloS One.2009, 4 (10) e7391. September 14, 2009. DOI: 10.1371/journal.pone.0007391.

Short polyethylene glycol chains densely bound to soft nanotube channels for inhibition of protein aggregation. N. Kameta, T. Matsuzawa, K. Yaoi, and M. Masuda. RSC Advances. 2016, 6 (43) pp 36744-36750. April 7, 2016. DOI: 10.1039/C6RA06793J.

Transport of biomolecules to binding partners displayed on the surface of microbeads arrayed in traps in a microfluidic cell. Xiaoxiao Chen, Thomas F Leary, and Charles Maldarelli. Biomicrofluidics. 2017, 11 (1) pp 014101. January 4, 2017. DOI: 10.1063/1.4973247.

A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages. Mafalda M.A. Pereira, Ines Mahu, Elsa Seixas, Noelia Martinez-Sanchez, Nadiya Kubasova, Roksana M. Pirzgalska, Paul Cohen, Marcelo O. Dietrich, Miguel Lopez, Goncalo J.L. Bernardes, and Ana I. Domingos. Nature Communications. 2017, 8 (14967) pp 1-10. April 3, 2017. DOI: 10.1038/ncomms14967.

The structural arrangement at intersubunit interfaces in homomeric kainate receptors. Douglas B. Litwin, Elisa Carrillo, Sana A. Shaikh, Vladimir Berka & Vasanthi Jayaraman. Scientific Reporter. 2019. May 6, 2019. DOI: 10.1038/s41598-019-43360-x

An in vitro single-molecule assay for eukaryotic cap-dependent translation initiation kinetics. Hongyun Wang, Lexi Sun, Anthony Gaba, Xiaohui Qu. Nucleic Acids Research, 2019, gkz1066. November 13, 2019. DOI: 10.1093/nar/gkz1066

Phase controlled SERS enhancement, Yuanhui Zheng, Lorenzo Rosa, Thibaut Thai, Soon Hock Ng, Saulius Juodkazis & Udo Bach. Scientific Reports (Nature Publisher Group); London Vol. 9, Iss. 1, (Jan 2019). January 24, 2019. DOI:10.1038/s41598-018-36491-0

Tuning surface functionalities of Sub-10 nm-sized nanocarriers to target outer retina in designing drug delivery agents for intravitreal administration. Suyeon You, Hyoungtai Kim, Hye-youn Junga, Boram Kim, Eun Jung Lee, Jin Woo Kim, Yoonkyung Kim. Biomaterials. 2020. DOI: 10.1016/j.biomaterials.2020.120188

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Soluble amyloid beta-containing aggregates are present throughout the brain at early stages of Alzheimer’s disease. Dimitrios I Sideris, John S H Danial, Derya Emin, Francesco S Ruggeri, Zengjie Xia, Yu P Zhang, Evgeniia Lobanova, Helen Dakin, Suman De, Alyssa Miller, Jason C Sang, Tuomas P J Knowles, Michele Vendruscolo, Graham Fraser, Damian Crowther, David Klenerman. Brain Communications. 2021, Volume 3, Issue 3. 07/02/2021. DOI: 10.1093/braincomms/fcab147

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The post m-dPEG®₄-NHS ester appeared first on VectorLabs.

]]> Acid-dPEG®₂₅-NHS ester https://staging.vectorlabs.com/products/acid-dpeg25-nhs-ester/ Sat, 24 Feb 2024 02:04:55 +0000 https://staging.vectorlabs.com/?post_type=product&p=35086 Acid-dPEG®25-NHS ester, product number QBD-10140, is an amine-reactive crosslinker that is designed to facilitate intermolecular crosslinking with free amines at each end of the crosslinker through a single molecular weight, discrete polyethylene glycol (dPEG®) backbone. Because one end of the chain terminates in a propionic acid group while the other end terminates as the N-hydroxysuccinimidyl (NHS) ester of propionic acid, this product can effectively overcome the problems typically afflicting homobifunctional crosslinkers. Moreover, the carboxylic acid end can remain unmodified, allowing the carboxylic acid to be used as a charge modifier in supramolecular and bioconjugate construction. Furthermore, the non-immunogenic amphiphilic dPEG® backbone imparts water solubility to conjugate molecules, which can improve the performance of conjugates.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 1316.47; single compound
Chemical formula C₅₈H₁₀₉NO₃₁
CAS N/A
Purity > 97%
Spacers dPEG® Spacer is 79 atoms and 92.5 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene Chloride, Acetonitrile, DMF, DMSO or DMAC.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Acid-dPEG®₂₅-NHS ester appeared first on VectorLabs.

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Description

Acid-dPEG®25-NHS ester, product number QBD-10140, is an amine-reactive crosslinker that is designed to facilitate intermolecular crosslinking with free amines at each end of the crosslinker through a single molecular weight, discrete polyethylene glycol (dPEG®) backbone. Because one end of the chain terminates in a propionic acid group while the other end terminates as the N-hydroxysuccinimidyl (NHS) ester of propionic acid, this product can effectively overcome the problems typically afflicting homobifunctional crosslinkers. Moreover, the carboxylic acid end can remain unmodified, allowing the carboxylic acid to be used as a charge modifier in supramolecular and bioconjugate construction. Furthermore, the non-immunogenic amphiphilic dPEG® backbone imparts water solubility to conjugate molecules, which can improve the performance of conjugates.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 1316.47; single compound
Chemical formula C₅₈H₁₀₉NO₃₁
CAS N/A
Purity > 97%
Spacers dPEG® Spacer is 79 atoms and 92.5 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene Chloride, Acetonitrile, DMF, DMSO or DMAC.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

  1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

  2. Small Molecule–Protein Hybrid for Voltage Imaging via Quenching of Bioluminescence. Brittany R. Benlian, Pavel E. Z. Klier, Kayli N. Martinez, Marie K. Schwinn, Thomas A. Kirkland, and Evan W. Miller. ACS Sensors. 2021. 03/16/2021. DOI: 10.1021/acssensors.1c00058

The post Acid-dPEG®₂₅-NHS ester appeared first on VectorLabs.

]]> Acid-dPEG®₁₃-NHS ester https://staging.vectorlabs.com/products/acid-dpeg13-nhs-ester/ Sat, 24 Feb 2024 02:04:54 +0000 https://staging.vectorlabs.com/?post_type=product&p=35078 Acid-dPEG®13-NHS ester, product number QBD-10127, is an amine-reactive crosslinker that is designed to facilitate intermolecular crosslinking with free amines at each end of the crosslinker through a single molecular weight, discrete polyethylene glycol (dPEG®) backbone. Because one end of the chain terminates in a propionic acid group while the other end terminates as the N-hydroxysuccinimidyl (NHS) ester of propionic acid, this product can effectively overcome the problems typically afflicting homobifunctional crosslinkers. Moreover, the carboxylic acid end can remain unmodified, allowing the carboxylic acid to be used as a charge modifier in supramolecular and bioconjugate construction. Furthermore, the non-immunogenic amphiphilic dPEG® backbone imparts water solubility to conjugate molecules, which can improve the performance of conjugates.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 787.38; single compound
Chemical formula C₃₄H₆₁NO₁₉
CAS N/A
Purity > 97%
Spacers dPEG® Spacer is 43 atoms and 50.0 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Acid-dPEG®₁₃-NHS ester appeared first on VectorLabs.

]]>

Description

Acid-dPEG®13-NHS ester, product number QBD-10127, is an amine-reactive crosslinker that is designed to facilitate intermolecular crosslinking with free amines at each end of the crosslinker through a single molecular weight, discrete polyethylene glycol (dPEG®) backbone. Because one end of the chain terminates in a propionic acid group while the other end terminates as the N-hydroxysuccinimidyl (NHS) ester of propionic acid, this product can effectively overcome the problems typically afflicting homobifunctional crosslinkers. Moreover, the carboxylic acid end can remain unmodified, allowing the carboxylic acid to be used as a charge modifier in supramolecular and bioconjugate construction. Furthermore, the non-immunogenic amphiphilic dPEG® backbone imparts water solubility to conjugate molecules, which can improve the performance of conjugates.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 787.38; single compound
Chemical formula C₃₄H₆₁NO₁₉
CAS N/A
Purity > 97%
Spacers dPEG® Spacer is 43 atoms and 50.0 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

  1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

The post Acid-dPEG®₁₃-NHS ester appeared first on VectorLabs.

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