MTr-Thiol – VectorLabs https://staging.vectorlabs.com From linker design and synthesis, bioconjugated design and manufacturing, biomolecule labeling and functionalization, and detection system and solutions, our team is here to help you move forward, with impact. Wed, 22 Oct 2025 17:19:31 +0000 en-US hourly 1 https://wordpress.org/?v=6.9 https://staging.vectorlabs.com/wp-content/uploads/2024/11/V-favicon-02-100x100.png MTr-Thiol – VectorLabs https://staging.vectorlabs.com 32 32 Methoxytrityl-S-dPEG®₁₂-acid https://staging.vectorlabs.com/products/methoxytrityl-s-dpeg12-acid/ Sat, 24 Feb 2024 02:13:29 +0000 https://staging.vectorlabs.com/?post_type=product&p=37035 Methoxytrityl-S-dPEG®12-acid, product number QBD-10846, permits the introduction of a protected thiol-dPEG® spacer/linker onto a molecule by reaction with a free amine. The dPEG®12 linker is functionalized with a methoxytrityl (Mmt)-protected thiol group one end and an amine-reactive propionic acid moiety on the other. The Mmt protecting group is easily removed under relatively mild conditions using dilute trifluoroacetic acid (TFA) with a scavenger.

QBD-10846 permits our customers to insert a medium-length (39 atoms, 46.8 Å) dPEG® into a peptide chain using familiar solid phase or solution phase chemistry. The dPEG® can be inserted at the N-terminus of a peptide chain or on any amino acid side chain with an exposed free amine. In addition, the dPEG® spacer can be used simply to provide additional distance in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® means that the construct will gain some degree of water solubility while remaining soluble in organic solvent. The Mmt protecting group removes relatively easily with a dilute solution of TFA that also contains a scavenger such as triethylsilane (TES) or triisopropylsilane (TIPS). Once the thiol group is deprotected, it can be reacted with another thiol to form a disulfide bond or with any thiol-reactive group such as maleimide, bromoacetamide, alkene (thiol-ene reaction) or alkyne (thiol-yne reaction).

Upon activation, Methoxytrityl-S-dPEG®12-acid reacts with any free amine, whether on a peptide, surface, or other molecule. This allows for a broad range of applications where this product can be employed to convert an amine to a thiol.

Specifications

Unit Size 100mg, 1000mg
Molecular Weight 907.11; single compound
Chemical formula C₄₇H₇₀O₁₅S
CAS 1334169-94-6
Purity > 97%
Spacers dPEG® Spacer is 39 atoms and 46.8 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetonitrile, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Methoxytrityl-S-dPEG®₁₂-acid appeared first on VectorLabs.

]]>

Description

Methoxytrityl-S-dPEG®12-acid, product number QBD-10846, permits the introduction of a protected thiol-dPEG® spacer/linker onto a molecule by reaction with a free amine. The dPEG®12 linker is functionalized with a methoxytrityl (Mmt)-protected thiol group one end and an amine-reactive propionic acid moiety on the other. The Mmt protecting group is easily removed under relatively mild conditions using dilute trifluoroacetic acid (TFA) with a scavenger.

QBD-10846 permits our customers to insert a medium-length (39 atoms, 46.8 Å) dPEG® into a peptide chain using familiar solid phase or solution phase chemistry. The dPEG® can be inserted at the N-terminus of a peptide chain or on any amino acid side chain with an exposed free amine. In addition, the dPEG® spacer can be used simply to provide additional distance in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® means that the construct will gain some degree of water solubility while remaining soluble in organic solvent. The Mmt protecting group removes relatively easily with a dilute solution of TFA that also contains a scavenger such as triethylsilane (TES) or triisopropylsilane (TIPS). Once the thiol group is deprotected, it can be reacted with another thiol to form a disulfide bond or with any thiol-reactive group such as maleimide, bromoacetamide, alkene (thiol-ene reaction) or alkyne (thiol-yne reaction).

Upon activation, Methoxytrityl-S-dPEG®12-acid reacts with any free amine, whether on a peptide, surface, or other molecule. This allows for a broad range of applications where this product can be employed to convert an amine to a thiol.

Specifications

Unit Size100mg, 1000mg
Molecular Weight907.11; single compound
Chemical formulaC₄₇H₇₀O₁₅S
CAS1334169-94-6
Purity> 97%
SpacersdPEG® Spacer is 39 atoms and 46.8 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Gold Nanoparticles Functionalized with Peptides for Specific Affinity Aggregation Assays of Estrogen Receptors and Their Agonists. Yoshiyuki Takatsuji, Shinya Ikeno and Tetsuya Haruyama. Sensors. 2012, 12 (4), pp 4952-4961. April 18, 2012. DOI: 10.3390/s120404952.

The post Methoxytrityl-S-dPEG®₁₂-acid appeared first on VectorLabs.

]]> Methoxytrityl-S-dPEG®₄-acid https://staging.vectorlabs.com/products/methoxytrityl-s-dpeg4-acid/ Sat, 24 Feb 2024 02:09:48 +0000 https://staging.vectorlabs.com/?post_type=product&p=35850 Methoxytrityl-S-dPEG®4-acid, product number QBD-10301, permits the introduction of a protected thiol-dPEG® spacer/linker onto a molecule by reaction with a free amine. The linker length is 16 atoms (18.3 Å). The methoxytrityl (Mmt) protected thiol deprotects under mild conditions using dilute trifluoroacetic acid (TFA) with a scavenger. This compound is useful in peptide synthesis and peptide modification, where a free thiol needs to be introduced into the parent molecule.

Description

Methoxytrityl-S-dPEG®4-acid, product number QBD-10301, permits the introduction of a protected thiol-dPEG® spacer/linker onto a molecule by reaction with a free amine. The methoxytrityl (Mmt) protected thiol deprotects under mild conditions using dilute trifluoroacetic acid (TFA) with a scavenger. This compound is useful in peptide synthesis and modification, where a free thiol must be introduced into the parent molecule.

Product number QBD-10301 permits our customers to insert a short (16 atom, 18.3Å) dPEG® into a peptide chain using familiar solid phase or solution phase chemistry. Upon activation, Methoxytrityl-S-dPEG®4-acid reacts with any free amine. This allows for a broad range of situations where this product can be employed to convert an amine to a thiol. The dPEG® can be inserted at the N-terminus of a peptide chain or on any amino acid side chain with an exposed free amine. In addition, the short dPEG® spacer can be used simply to provide additional distance in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® means that the construct will gain some degree of water solubility while remaining soluble in organic solvent. The Mmt protecting group removes relatively easily with a dilute solution of TFA that also contains a scavenger such as triethylsilane (TES) or triisopropylsilane (TIPS). Once the thiol group is deprotected, it can be reacted with another thiol to form a disulfide bond or with any thiol-reactive group such as maleimide, bromoacetamide, alkene (thiol-ene reaction) or alkyne (thiol-yne reaction).

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 554.70; single compound
Chemical formula C₃₁H₃₈O₇S
CAS 1263047-31-9
Purity > 98%
Spacers dPEG® Spacer is 16 atoms and 18.3 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetonitrile, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Methoxytrityl-S-dPEG®₄-acid appeared first on VectorLabs.

]]>

Methoxytrityl-S-dPEG®4-acid, product number QBD-10301, permits the introduction of a protected thiol-dPEG® spacer/linker onto a molecule by reaction with a free amine. The linker length is 16 atoms (18.3 Å). The methoxytrityl (Mmt) protected thiol deprotects under mild conditions using dilute trifluoroacetic acid (TFA) with a scavenger. This compound is useful in peptide synthesis and peptide modification, where a free thiol needs to be introduced into the parent molecule.

Description

Methoxytrityl-S-dPEG®4-acid, product number QBD-10301, permits the introduction of a protected thiol-dPEG® spacer/linker onto a molecule by reaction with a free amine. The methoxytrityl (Mmt) protected thiol deprotects under mild conditions using dilute trifluoroacetic acid (TFA) with a scavenger. This compound is useful in peptide synthesis and modification, where a free thiol must be introduced into the parent molecule.

Product number QBD-10301 permits our customers to insert a short (16 atom, 18.3Å) dPEG® into a peptide chain using familiar solid phase or solution phase chemistry. Upon activation, Methoxytrityl-S-dPEG®4-acid reacts with any free amine. This allows for a broad range of situations where this product can be employed to convert an amine to a thiol. The dPEG® can be inserted at the N-terminus of a peptide chain or on any amino acid side chain with an exposed free amine. In addition, the short dPEG® spacer can be used simply to provide additional distance in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® means that the construct will gain some degree of water solubility while remaining soluble in organic solvent. The Mmt protecting group removes relatively easily with a dilute solution of TFA that also contains a scavenger such as triethylsilane (TES) or triisopropylsilane (TIPS). Once the thiol group is deprotected, it can be reacted with another thiol to form a disulfide bond or with any thiol-reactive group such as maleimide, bromoacetamide, alkene (thiol-ene reaction) or alkyne (thiol-yne reaction).

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight554.70; single compound
Chemical formulaC₃₁H₃₈O₇S
CAS1263047-31-9
Purity> 98%
SpacersdPEG® Spacer is 16 atoms and 18.3 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Gold Nanoparticles Functionalized with Peptides for Specific Affinity Aggregation Assays of Estrogen Receptors and Their Agonists. Yoshiyuki Takatsuji, Shinya Ikeno and Tetsuya Haruyama. Sensors. 2012, 12 (4), pp 4952-4961. April 18, 2012. DOI: 10.3390/s120404952.

The post Methoxytrityl-S-dPEG®₄-acid appeared first on VectorLabs.

]]> Methoxytrityl-S-dPEG®₈-acid https://staging.vectorlabs.com/products/methoxytrityl-s-dpeg8-acid/ Sat, 24 Feb 2024 02:05:04 +0000 https://staging.vectorlabs.com/?post_type=product&p=35158 Methoxytrityl-S-dPEG®8-acid is a discrete PEG (dPEG®) modification reagent that terminates in a propionic acid group on one end and a methoxytrityl-protected thiol on the other. The linker length is 28 atoms (32.5 Å). This product is useful for the thiolation of peptides and small molecules.

Description

"Methoxytrityl-S-dPEG®8-acid, product number QBD-10166, permits the introduction of a protected thiol-dPEG® spacer/linker onto a molecule by reaction with a free amine. The methoxytrityl (Mmt) protected thiol deprotects under relatively mild conditions using dilute trifluoroacetic acid (TFA) with a scavenger.

QBD-10166 permits our customers to insert a short (28 atoms, 32.5Å) dPEG® into a peptide chain using familiar solid phase or solution phase chemistry. The dPEG® can be inserted at the N-terminus of a peptide chain or on any amino acid side chain with an exposed free amine. In addition, the short dPEG® spacer can be used simply to provide additional distance in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® means that the construct will gain some degree of water solubility while remaining soluble in organic solvent. The Mmt protecting group removes relatively easily with a dilute solution of TFA that also contains a scavenger such as triethylsilane (TES) or triisopropylsilane (TIPS). Once the thiol group is deprotected, it can be reacted with another thiol to form a disulfide bond or with any thiol-reactive group such as maleimide, bromoacetamide, alkene (thiol-ene reaction) or alkyne (thiol-yne reaction).

Upon activation, Methoxytrityl-S-dPEG®8-acid reacts with any free amine, whether on a peptide, surface, or other molecule. This allows for a broad range of applications where this product can be employed to convert an amine to a thiol."

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 730.91; single compound
Chemical formula C₃₉H₅₄O₁₁S
CAS 1334177-82-0
Purity > 97%
Spacers dPEG® Spacer is 28 atoms and 32.5 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetonitrile, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Methoxytrityl-S-dPEG®₈-acid appeared first on VectorLabs.

]]>

Methoxytrityl-S-dPEG®8-acid is a discrete PEG (dPEG®) modification reagent that terminates in a propionic acid group on one end and a methoxytrityl-protected thiol on the other. The linker length is 28 atoms (32.5 Å). This product is useful for the thiolation of peptides and small molecules.

Description

Methoxytrityl-S-dPEG®8-acid, product number QBD-10166, permits the introduction of a protected thiol-dPEG® spacer/linker onto a molecule by reaction with a free amine. The methoxytrityl (Mmt) protected thiol deprotects under relatively mild conditions using dilute trifluoroacetic acid (TFA) with a scavenger.

QBD-10166 permits our customers to insert a short (28 atoms, 32.5Å) dPEG® into a peptide chain using familiar solid phase or solution phase chemistry. The dPEG® can be inserted at the N-terminus of a peptide chain or on any amino acid side chain with an exposed free amine. In addition, the short dPEG® spacer can be used simply to provide additional distance in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® means that the construct will gain some degree of water solubility while remaining soluble in organic solvent. The Mmt protecting group removes relatively easily with a dilute solution of TFA that also contains a scavenger such as triethylsilane (TES) or triisopropylsilane (TIPS). Once the thiol group is deprotected, it can be reacted with another thiol to form a disulfide bond or with any thiol-reactive group such as maleimide, bromoacetamide, alkene (thiol-ene reaction) or alkyne (thiol-yne reaction).

Upon activation, Methoxytrityl-S-dPEG®8-acid reacts with any free amine, whether on a peptide, surface, or other molecule. This allows for a broad range of applications where this product can be employed to convert an amine to a thiol.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight730.91; single compound
Chemical formulaC₃₉H₅₄O₁₁S
CAS1334177-82-0
Purity> 97%
SpacersdPEG® Spacer is 28 atoms and 32.5 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

  1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

  2. Gold Nanoparticles Functionalized with Peptides for Specific Affinity Aggregation Assays of Estrogen Receptors and Their Agonists. Yoshiyuki Takatsuji, Shinya Ikeno and Tetsuya Haruyama. Sensors. 2012, 12 (4), pp 4952-4961. April 18, 2012. DOI: 10.3390/s120404952.

The post Methoxytrityl-S-dPEG®₈-acid appeared first on VectorLabs.

]]>