Fmoc-Amine – VectorLabs https://staging.vectorlabs.com From linker design and synthesis, bioconjugated design and manufacturing, biomolecule labeling and functionalization, and detection system and solutions, our team is here to help you move forward, with impact. Wed, 22 Oct 2025 17:21:09 +0000 en-US hourly 1 https://wordpress.org/?v=6.9 https://staging.vectorlabs.com/wp-content/uploads/2024/11/V-favicon-02-100x100.png Fmoc-Amine – VectorLabs https://staging.vectorlabs.com 32 32 Fmoc-N-amido-dPEG®₂₄-amido-dPEG®₂₄-acid https://staging.vectorlabs.com/products/fmoc-n-amido-dpeg24-amido-dpeg24-acid/ Sat, 24 Feb 2024 02:16:35 +0000 https://staging.vectorlabs.com/?post_type=product&p=39367 Fmoc-N-amido-dPEG®24-amido-dPEG®24-acid, product number QBD-11301, is one of a broad line of products designed for use in peptide synthesis. The long (152 atoms), flexible, discrete PEG (dPEG®) spacer is functionalized with a propionic acid group on one end and Fmoc-protected amine on the other. The spacer length is effectively forty-eight ethylene oxide units (i.e., PEG48). The compound can be added to the N-terminus of a growing peptide chain or to a primary-amine-functionalized side chain of an amino acid such as lysine. The non-immunogenic dPEG®24-amido-dPEG®24 spacer increases the hydrodynamic volume and imparts water solubility to the conjugate molecule.

QBD-11301 permits our customers to insert a dPEG® spacer into a peptide chain using familiar Fmoc chemistry using solid phase or solution phase chemistry. However, due to the spacer's length, it likely will work better in solution-phase syntheses. The dPEG® compound can be inserted at either end of the peptide chain or in the middle of two amino acid sequences to provide a flexible linker between distinct functional peptides. Additionally, the dPEG® spacer can be used to provide spacing in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® products means that the construct gains hydrodynamic volume and water solubility while remaining soluble in organic solvent. The Fmoc protecting group is removed easily with a solution of piperidine in N,N-dimethylformamide (DMF).

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 2496.96; single compound
Chemical formula C₁₁₇H₂₁₄N₂O₅₃
CAS N/A
Purity > 98%
Spacers dPEG® Spacer is 152 atoms and 178.7 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene Chloride, DMAC or Acetonitrile.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Fmoc-N-amido-dPEG®₂₄-amido-dPEG®₂₄-acid appeared first on VectorLabs.

]]>

Description

Fmoc-N-amido-dPEG®24-amido-dPEG®24-acid, product number QBD-11301, is one of a broad line of products designed for use in peptide synthesis. The long (152 atoms), flexible, discrete PEG (dPEG®) spacer is functionalized with a propionic acid group on one end and Fmoc-protected amine on the other. The spacer length is effectively forty-eight ethylene oxide units (i.e., PEG48). The compound can be added to the N-terminus of a growing peptide chain or to a primary-amine-functionalized side chain of an amino acid such as lysine. The non-immunogenic dPEG®24-amido-dPEG®24 spacer increases the hydrodynamic volume and imparts water solubility to the conjugate molecule.

QBD-11301 permits our customers to insert a dPEG® spacer into a peptide chain using familiar Fmoc chemistry using solid phase or solution phase chemistry. However, due to the spacer’s length, it likely will work better in solution-phase syntheses. The dPEG® compound can be inserted at either end of the peptide chain or in the middle of two amino acid sequences to provide a flexible linker between distinct functional peptides. Additionally, the dPEG® spacer can be used to provide spacing in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® products means that the construct gains hydrodynamic volume and water solubility while remaining soluble in organic solvent. The Fmoc protecting group is removed easily with a solution of piperidine in N,N-dimethylformamide (DMF).

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight2496.96; single compound
Chemical formulaC₁₁₇H₂₁₄N₂O₅₃
CASN/A
Purity> 98%
SpacersdPEG® Spacer is 152 atoms and 178.7 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene Chloride, DMAC or Acetonitrile.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

The post Fmoc-N-amido-dPEG®₂₄-amido-dPEG®₂₄-acid appeared first on VectorLabs.

]]> Fmoc-N-amido-dPEG®₃₆-acid https://staging.vectorlabs.com/products/fmoc-n-amido-dpeg36-acid/ Sat, 24 Feb 2024 02:13:40 +0000 https://staging.vectorlabs.com/?post_type=product&p=37112 Fmoc-N-amido-dPEG®36-acid, product number QBD-10903, is one of a broad line of products designed for use in peptide synthesis. The long (112 atoms), flexible, discrete PEG (dPEG®) spacer is functionalized with a propionic acid group on one end and Fmoc-protected amine on the other. The compound can be added to the N-terminus of a growing peptide chain or to a primary-amine-functionalized side chain of an amino acid such as lysine. The non-immunogenic dPEG®36 spacer increases the hydrodynamic volume and imparts water solubility to the conjugate molecule.

QBD-10903 permits our customers to insert a dPEG® spacer into a peptide chain using familiar Fmoc chemistry using solid phase or solution phase chemistry. However, due to the spacer's length, it may work better in solution-phase syntheses. The dPEG® compound can be inserted at either end of the peptide chain or in the middle of two amino acid sequences to provide a flexible linker between distinct functional peptides. Additionally, the dPEG® spacer can be used to provide spacing in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® products means that the construct gains hydrodynamic volume and water solubility while remaining soluble in organic solvent. The Fmoc protecting group is removed easily with a solution of piperidine in N,N-dimethylformamide (DMF).

Specifications

Unit Size 100mg, 1000mg
Molecular Weight 1897.22; single compound
Chemical formula C₉₀H₁₆₁NO₄₀
CAS 756526-01-9
Purity > 98%
Spacers dPEG® Spacer is 112 atoms and 131.4 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetontrile, DMAC, DMSO or water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Fmoc-N-amido-dPEG®₃₆-acid appeared first on VectorLabs.

]]>

Description

“Fmoc-N-amido-dPEG®36-acid, product number QBD-10903, is one of a broad line of products designed for use in peptide synthesis. The long (112 atoms), flexible, discrete PEG (dPEG®) spacer is functionalized with a propionic acid group on one end and Fmoc-protected amine on the other. The compound can be added to the N-terminus of a growing peptide chain or to a primary-amine-functionalized side chain of an amino acid such as lysine. The non-immunogenic dPEG®36 spacer increases the hydrodynamic volume and imparts water solubility to the conjugate molecule.

QBD-10903 permits our customers to insert a dPEG® spacer into a peptide chain using familiar Fmoc chemistry using solid phase or solution phase chemistry. However, due to the spacer’s length, it may work better in solution-phase syntheses. The dPEG® compound can be inserted at either end of the peptide chain or in the middle of two amino acid sequences to provide a flexible linker between distinct functional peptides. Additionally, the dPEG® spacer can be used to provide spacing in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® products means that the construct gains hydrodynamic volume and water solubility while remaining soluble in organic solvent. The Fmoc protecting group is removed easily with a solution of piperidine in N,N-dimethylformamide (DMF).”

Specifications

Unit Size100mg, 1000mg
Molecular Weight1897.22; single compound
Chemical formulaC₉₀H₁₆₁NO₄₀
CAS756526-01-9
Purity> 98%
SpacersdPEG® Spacer is 112 atoms and 131.4 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetontrile, DMAC, DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Lipo-Oligomer Nanoformulations for Targeted Intracellular Protein Delivery. Peng Zhang, Benjamin Steinborn, Ulrich Lachelt, Stefan Zahler, and Ernst Wagner. Biomacromolecules. 2017, June 26, 2017. DOI: 10.1021/acs.biomac.7b00666.

Flexible antibodies with nonprotein hinges. Daniel J. Capon, Naoki Kaneko, Takayuki Yoshimori, Takashi Shimada, Florian M. Wurm, Peter K. Hwang, Xiaohe Tong, Staci A. Adams, Graham Simmons, Taka-Aki Sato and Koichi Tanaka. The Japan Academy, Series B. 2011, 87 (9) pp 603-616. November 11, 2011. DOI: 10.2183/pjab.87.603.

A Systematic Analysis of Peptide Linker Length and Liposomal Polyethylene Glycol Coating on Cellular Uptake of Peptide-Targeted Liposomes. Jared F. Stefanick, Jonathan D. Ashley, Tanyel Kiziltepe, and Basar Bilgicer. ACS Nano. 2013, 7 (4) pp 2935–2947. February 19, 2013. DOI: 10.1021/nn305663e.

Enhanced Cellular Uptake of Peptide-Targeted Nanoparticles through Increased Peptide Hydrophilicity and Optimized Ethylene Glycol Peptide-Linker Length. Jared F. Stefanick, Jonathan D. Ashley, and Basar Bilgicer. ACS Nano. 2013, 7 (9) pp 8115–8127. August 29, 2013. DOI: 10.1021/nn4033954.

PEG-Peptide Conjugates. Ian W Hamley. Biomacromolecules. 2014, 15 (5) pp 1543-1559. April 1, 2014. DOI: 10.1021/bm500246w.

Evaluation of Nonpeptidic Ligand Conjugates for SPECT Imaging of Hypoxic and Carbonic Anhydrase IX-Expressing Cancers. Peng-Cheng Lv, Karson S. Putt, and Philip S. Low. Bioconjugate Chemistry. 2016, 27, pp 1762-1769. June 30, 2016. DOI: 10.1021/acs.bioconjchem.6b00271.

Bioresponsive nanocarries for targeted intracellular delivery of proteins and peptides. Ruth Elisabeth and Johanna Roder. Dissertation zur Erlangung des Doktorgrades der Fakultat fur Chemie und Pharmazie der Ludwig-Maximilians-Universitat Munchen. 2016, pp 1-128.

Efficient capture of circulating tumor cells with low molecular weight folate receptor-specific ligands. Yingwen Hu, Danyang Chen, John V Napoleon, Madduri Srinivasarao, Sunil Singhal, Cagri A Savran, Philip S Low. Scientific Reports. 2022. May 20, 2022. https://doi.org/10.1038/s41598-022-12118-3

The post Fmoc-N-amido-dPEG®₃₆-acid appeared first on VectorLabs.

]]> Fmoc-N-amido-dPEG®₂₄-acid https://staging.vectorlabs.com/products/fmoc-n-amido-dpeg24-acid/ Sat, 24 Feb 2024 02:09:55 +0000 https://staging.vectorlabs.com/?post_type=product&p=35897 Fmoc-N-amido-dPEG®24-acid, product number QBD-10313, is one of a broad line of products designed for use in peptide synthesis. The long (76 atoms), discrete PEG (dPEG®) spacer is functionalized with a propionic acid group on one end and Fmoc-protected amine on the other. The compound can be added to the N-terminus of a growing peptide chain or to a primary-amine-functionalized side chain of an amino acid such as lysine. The dPEG®24 spacer imparts water solubility to the peptide to which it is conjugated.

QBD-10313 permits our customers to insert a dPEG® spacer into a peptide chain using familiar Fmoc chemistry using solid phase or solution phase chemistry. The dPEG® compound can be inserted at either end of the peptide chain or in the middle of two amino acid sequences to provide a flexible linker between distinct functional peptides. Additionally, the dPEG® spacer can be used to provide spacing in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® products means that the construct gains hydrodynamic volume and water solubility while remaining soluble in organic solvent. The Fmoc protecting group removes easily with a solution of piperidine in N,N-dimethylformamide (DMF).

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 1368.59; single compound
Chemical formula C₆₆H₁₁₃NO₂₈
CAS 756526-01-9
Purity > 98%
Spacers dPEG® Spacer is 76 atoms and 89.0 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetontrile, DMAC, DMSO or water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Fmoc-N-amido-dPEG®₂₄-acid appeared first on VectorLabs.

]]>

Description

Fmoc-N-amido-dPEG®24-acid, product number QBD-10313, is one of a broad line of products designed for use in peptide synthesis. The long (76 atoms), discrete PEG (dPEG®) spacer is functionalized with a propionic acid group on one end and Fmoc-protected amine on the other. The compound can be added to the N-terminus of a growing peptide chain or to a primary-amine-functionalized side chain of an amino acid such as lysine. The dPEG®24 spacer imparts water solubility to the peptide to which it is conjugated.

QBD-10313 permits our customers to insert a dPEG® spacer into a peptide chain using familiar Fmoc chemistry using solid phase or solution phase chemistry. The dPEG® compound can be inserted at either end of the peptide chain or in the middle of two amino acid sequences to provide a flexible linker between distinct functional peptides. Additionally, the dPEG® spacer can be used to provide spacing in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® products means that the construct gains hydrodynamic volume and water solubility while remaining soluble in organic solvent. The Fmoc protecting group removes easily with a solution of piperidine in N,N-dimethylformamide (DMF).

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight1368.59; single compound
Chemical formulaC₆₆H₁₁₃NO₂₈
CAS756526-01-9
Purity> 98%
SpacersdPEG® Spacer is 76 atoms and 89.0 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetontrile, DMAC, DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Effect of PEGylation of N-WASP181-200 on the Inhibitory Potency for Renal Aminoglycoside Accumulation. Kenju Fujii, Junya Nagai, Takeshi Sawada, Ryko Yumoto, and Mikihisa Takano, Bioconjugate Chemistry. 2009, 20 (8), pp 1553–1558 July 2, 2009. DOI: 10.1021/bc900094g.

Site-Specific Conjugation of Monodispersed DOTA-PEGn to a Thiolated Diabody Reveals the Effect of Increasing PEG Size on Kidney Clearance and Tumor Uptake with Improved 64-Copper PET Imaging. Lin Li,Desiree Crow, Fabio Turatti, James R. Bading, Anne-Line Anderson, Erasmus Poku, Paul J. Yazaki, Jenny Carmichael, David Leong, Michael P. Wheatcroft,Andrew A. Raubitschek, Peter J. Hudson,David Colcher, and John E. Shively.Bioconjugate Chemistry. 2011, 22 (4), pp 709–716 March 12, 2011. DOI: 10.1021/bc100464e.

Flexible antibodies with nonprotein hinges. Daniel J. Capon, Naoki Kaneko, Takayuki Yoshimori, Takashi Shimada, Florian M. Wurm, Peter K. Hwang, Xiaohe Tong, Staci A. Adams, Graham Simmons, Taka-Aki Sato and Koichi Tanaka. The Japan Academy. 2011, 87 (9) pp 603-616. November 11, 2011. DOI: 10.2183/pjab.87.603.

Defined Folate-PEG-siRNA Conjugates for Receptor-specific Gene Silencing. Christian Dohmen, Thomas Fröhlich, Ulrich Lächelt, Ingo Röhl, Hans-Peter Vornlocher, Philipp Hadwiger and Ernst Wagner. Molecular Therapy Nucleic Acids. 2012, 1 (e7) January 31, 2012. DOI: 10.1038/mtna.2011.10.

Precise and multifunctional conjugates for targeted siRNA delivery. Prof. Dr. Ernst Wagner Prof. Dr. Wolfgang Friess. Dissertation zur Erlangung des Doktorgrades der Fakultät für Chemie und Pharmazie der Ludwig-Maximilians-Universität München. April 27, 2012.

Enhanced Cellular Uptake of Peptide-Targeted Nanoparticles through Increased Peptide Hydrophilicity and Optimized Ethylene Glycol Peptide-Linker Length. Jared F. Stefanick, Jonathan D. Ashley, and Basar Bilgicer. ACS Nano. 2013, 7 (9) pp 8115-8127. August 29, 2013. DOI: 10.1021/nn4033954.

A Systematic Analysis of Peptide Linker Length and Liposomal Polyethylene Glycol Coating on Cellular Uptake of Peptide-Targeted Liposomes. Jared F. Stefanick, Jonathan D. Ashley, Tanyel Kiziltepe, and Basar Bilgicer. ACS Nano. 2013, 7 (4) pp 2935–2947. February 19, 2013. DOI: 10.1021/nn305663e.


Enhanced Cellular Uptake of Peptide-Targeted Nanoparticles through Increased Peptide Hydrophilicity and Optimized Ethylene Glycol Peptide-Linker Length. Jared F. Stefanick, Jonathan D. Ashley, and Basar Bilgicer. ACS Nano. 2013, 7 (9) pp 8115–8127. August 29, 2013. DOI: 10.1021/nn4033954.


Solid-phase-assisted synthesis of targeting peptide–PEG–oligo(ethane amino) amides for receptor-mediated gene delivery. Irene Martin, Christian Dohmen, Carlos Mas-Moruno, Christina Troiber, Petra Kos, David Schaffert, Ulrich Lächelt, Meritxell Teixidó, Michael Günther, Horst Kessler, Ernest Giralt and Ernst Wagner. Organic & Biomolecular Chemistry. 2012, 10 pp 3258-3268. February 23, 2012. DOI: 10.1039/C2OB06907E.

Design of a Heterobivalent Ligand to Inhibit IgE Clustering on Mast Cells. Michael W. Handlogten, Tanyel Kiziltepe, Demetri T. Moustakas, and Basxar Bilgicer. Chemistry & Biology. 2011, 18 (9) pp 1179–1188. September 23, 2011. DOI: 10.1016/j.chembiol.2011.06.012.

Design of a Heterobivalent Inhibitor of Allergy and More Physiologically Relevant Allergy Models. Michael William Handlogten. University of Notre Dame. 2013, March 28, 2013.

PEG-Peptide Conjugates. Ian W Hamley. Biomacromolecules. 2014, 15 (5) pp 1543-1559. April 1, 2014. DOI: 10.1021/bm500246w.

Synthetic Polyglutamylation of Dual-Functional MTX Ligands for Enhanced Combined Cytotoxicity of Poly(I:C) Nanoplexes. Ulrich Lächelt Valentin Wittmann, Katharina Müller, Daniel Edinger, Petra Kos, Miriam Höhn, and Ernst Wagner. Molecular Pharmaceutics. 2014, 11 (8) pp 2631-2639. April 22, 2014. DOI: 10.1021/MP500017u.

Histidine-rich stabilized polyplexes for cMet-directed tumor-targeted gene transfer. Petra Kos, Ulrich Lachelt, Annika Herrmann, Fruke Martina Mickler, Markus Doblinger, Dongsheng He, Ana Krhac Levacic, Stephan Morys, Christoph Brauchle, and Ernst Wagner. Nanoscale. 2015, 7 (12), pp 5350-5362 February 15, 2015. DOI: 10.1039/c4nr06556e.

Nanosized Multifunctional Polyplexes for Receptor-Mediated SiRNA Delivery. Christian Dohmen, Daniel Edinger, Thomas Frohlich, Laura Schreiner, Ulrich Lachelt, Christina Troiber, Joachim Radler, Philipp Hadwiger, Hans-Peter Vornlocher, and Ernst Wagner. ACS Nano. 2012, 6 (6), pp 5198-5208. May 30, 2012. DOI: 10.1021/nn300960m.

Combinatorial optimization of sequence-defined oligo(ethanamino)amides for folate receptor-targeted pDNA and siRNA delivery. Dongsheng He, Katharina Muller, Ana Krhac, Petra Kos, Ulrich Lachelt, and Ernst Wagner. Bioconjugate Chemistry. 2016, January 3, 2016. DOI: 10.1021/acs.bioconjchem.5b00649.

Combinal optimization of nucleic acid carriers for folate-targeted delivery. Dongsheng He. 2016.

Orthogonal Cysteine Protection Enables Homogeneous Multi-Drug Antibody-Drug Conjugates. Matthew R Levengood, Xinqun Zhang, Joshua H Hunter, Kim K Emmerton, Jamie B Miyamoto, Timothy S Lewis, and Peter D Senter. Angewandte Chemie. 2016, 55 pp 1-6. December 14, 2016. DOI: 10.1002/anie.201608292.

Oligaminoamide-Based siRNA Formulations for Folate Receptor-Directed Tumor Targeting and Gene Silencing. Dian-Jang Lee. The Faculty of Chemistry and Pharmacy. 2016, pp 1-107. March 11, 2016.

Influence of Defined Hydrophilic Blocks within Oligoaminoamide Copolymers: Compaction versus Sheilding of pDNA Nanoparticles. Stephan Morys, Ana Krhac Levacic, Sarah Urnauer, Susanne Kempter, Sarah Kern, Joachim O Radler, Christine Spitzweg, Ulrich Lachelt, and Ernst Wagner. Polymers. 2017, 9 (4) pp 1-20. April 19, 2017. DOI: 10.3390/polym9040142.

Systemic Delivery of Folate-PEG siRNA Lipopolyplexes with Enhanced Intracellular Intracellular Stability for In Vivo Gene Silencing in Leukemia. Dian-Jang Lee, Eva Kessel, Taavi Lehto, Xueying Liu, Naoto Yoshinaga, Kart Padari, Ying-Chen Chen, Susanne Kempter, Satoshi Uchida, Joachim O. Radler, Margus Pooga, Ming-Thau Sheu, Kazunori Kataoka, and Ernst Wagner. Bioconjugate Chemistry. 2017, August 3, 2017. DOI: 10.1021/acs.bioconjchem.7b00383.

Protein Transduction by Lipo-Oligoaminoamide Nanoformulations. Peng Zhang. Dissertation zur Erlangung des Doktorgrades der Fakultat fur Chemie and Pharmazie der Ludwig-Maximilians-Universitat Munchen. 2017, pp 1-102. July 25, 2017. https://edoc.ub.uni-muenchen.de/21022/1/Zhang_Peng.pdf

Peptide Inhibitor of Complement C1 Inhibits the Peroxidase Activity of Hemoglobin and Myoglobin. Pamela S. Hair, Kenji M. Cunnion, and Neel K. Krishna. Hindawi International Journal of Peptides. 2017, 2017(9454583) pp 1-10. September 10, 2017. http://doi.org/10.1155/2017/9454583.

Tumoral gene silencing by receptor-targeted combinatorial siRNA polyplexes. Dian-Jang Lee, Dongsheng He, Eva Kessel, Kärt Padari, Susanne Kempter, Ulrich Lächelt, Joachim O. Rädler, Margus Pooga, Ernst Wagner. Journal of Controlled Release. 2016, 244 (B) pp 280-291. 12/28/2016. DOI: 10.1016/j.jconrel.2016.06.011.

Dual-Targeted Polyplexes Based on Sequence-Defined Peptide–PEG–Oligoamino Amides. Petra Kos,
Ulrich Lächelt, Dongsheng He, Yu Nie, Zhongwei Gu, and Ernst Wa. Journal of Pharmaceutical Sciences. 2014, 104 (2) pp 464-475. 9/29/2014. DOI: 10.1002/jps.24194.

Telomere-specific chromatin capture using a pyrrole–imidazole polyamide probe for the identification of proteins and non-coding RNAs. Satoru Ide, Asuka Sasaki, Yusuke Kawamoto, Toshikazu Bando, Hiroshi Sugiyama & Kazuhiro Maeshima. Epigenetics & Chromatin. 2021. October 9, 2021. https://doi.org/10.1186/s13072-021-00421-8

Selective sodium iodide symporter (NIS) gene therapy of glioblastoma mediated by EGFR-targeted lipopolyplexes. Rebekka Spellerberg, Teoman Benli-Hoppe, Carolin Kitzberger, Simone Berger, Kathrin A Schmohl, Nathalie Schwenk, Hsi-Yu Yen, Christian Zach, Franz Schilling, Wolfgang A Weber, Roland E Kälin, Rainer Glass, Peter J Nelson, Ernst Wagner, Christine Spitzweg. Molecular Therapy Oncolytics. 2021. Volume 23, p432-446. October 29, 2021. https://doi.org/10.1016/j.omto.2021.10.011

Transferrin Receptor Targeted Polyplexes Completely Comprised of Sequence-Defined Components. Teoman Benli-Hoppe, Şurhan Göl Öztürk, Özgür Öztürk, Simone Berger, Ernst Wagner, Mina Yazdi. Macromolecular Rapid Communications. 2021. Volume 43, Issue 12. October 29, 2021. https://doi.org/10.1002/marc.202100602

The post Fmoc-N-amido-dPEG®₂₄-acid appeared first on VectorLabs.

]]> Fmoc-N-amido-dPEG®₁₂-acid https://staging.vectorlabs.com/products/fmoc-n-amido-dpeg12-acid/ Sat, 24 Feb 2024 02:08:03 +0000 https://staging.vectorlabs.com/?post_type=product&p=35761 Fmoc-N-amido-dPEG®12-acid, product number QBD-10283, is one of a broad line of products designed for use in peptide synthesis. The medium-length (40 atoms), discrete PEG (dPEG®) spacer is functionalized with a propionic acid group on one end and Fmoc-protected amine on the other. The compound can be added to the N-terminus of a growing peptide chain or to a primary-amine-functionalized side chain of an amino acid such as lysine. The dPEG®12 spacer imparts water solubility to the peptide to which it is conjugated.

QBD-10283 permits our customers to insert a medium-length (40 atoms) dPEG® into a peptide chain using familiar Fmoc chemistry. The product works equally well in solid phase and solution phase synthetic processes. The dPEG® can be inserted at either end of the peptide chain or in the middle of two amino acid sequences to provide a flexible spacer between distinct functional peptides. Additionally, the dPEG® spacer can be used to provide spacing in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® means that the construct will gain water solubility while remaining soluble in organic solvent. The Fmoc protecting group removes easily with a solution of piperidine in N,N-dimethylformamide (DMF).

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 839.96; single compound
Chemical formula C₄₂H₆₅NO₁₆
CAS 756526-01-9
Purity > 98%
Spacers dPEG® Spacer is 40 atoms and 46.5 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetontrile, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Fmoc-N-amido-dPEG®₁₂-acid appeared first on VectorLabs.

]]>

Description

Fmoc-N-amido-dPEG®12-acid, product number QBD-10283, is one of a broad line of products designed for use in peptide synthesis. The medium-length (40 atoms), discrete PEG (dPEG®) spacer is functionalized with a propionic acid group on one end and Fmoc-protected amine on the other. The compound can be added to the N-terminus of a growing peptide chain or to a primary-amine-functionalized side chain of an amino acid such as lysine. The dPEG®12 spacer imparts water solubility to the peptide to which it is conjugated.

QBD-10283 permits our customers to insert a medium-length (40 atoms) dPEG® into a peptide chain using familiar Fmoc chemistry. The product works equally well in solid phase and solution phase synthetic processes. The dPEG® can be inserted at either end of the peptide chain or in the middle of two amino acid sequences to provide a flexible spacer between distinct functional peptides. Additionally, the dPEG® spacer can be used to provide spacing in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® means that the construct will gain water solubility while remaining soluble in organic solvent. The Fmoc protecting group removes easily with a solution of piperidine in N,N-dimethylformamide (DMF).

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight839.96; single compound
Chemical formulaC₄₂H₆₅NO₁₆
CAS756526-01-9
Purity> 98%
SpacersdPEG® Spacer is 40 atoms and 46.5 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetontrile, DMAC or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Optimization of Xenon Biosensors for Detection of Protein Interactions. Thomas J. Lowery, Sandra Garcia, Lana Chavez, E. Janette Ruiz, Tom Wu, Thierry Brotin, Jean-Pierre Dutasta, David S. King, Peter G. Schultz, Alex Pines, and David E. Wemmer. ChemBioChem. 2006, 7 (1), pp 65-73. January 9, 2006. DOI: 10.1002/cbic.200500327.

Monodispersed DOTA-PEG-Conjugated Anti-TAG-72 Diabody Has Low Kidney Uptake and High Tumor-to-Blood Ratios FResulting in Improved Cu PET. Lin Li, Fabio Turatti, Desiree Crow, James R. Bading, Anne-Line Anderson, Erasmus Poku, Paul J. Yazaki, Lawrence E. Williams, Debra Tamvakis, Paul Sanders, David Leong, Andrew Raubitschek, peter J. Hudson, David Colcher, and John E. Shively. Journal of Nuclear Medicine. 2010, 51 (7), pp 1139-1146. June 16, 2010. DOI: 10.2967/jnumed.109.074153.

Photocleavable Peptide-Conjugated Magnetic Beads for Protein Kinase Assays by MALDI-TOF. MS. Guangchang Zhou, Xiaoliang Yan, Ding Wu, and Stephen J. Kron. Bioconjugate Chemistry. 2010, 21 (10), pp 1917–1924. September 22, 2010. DOI: 10.1021/bc1003058.

Neutrophil Targeting Heterobivalent SPECT Imaging Probe: cFLFLF-PEG-TKPPR-99mTc. Yi Zhang, Li Xiao, Mahendra D. Chordia, Landon W. Locke, Mark B. Williams, Stuart S. Berr, and Dongfeng Pan. Bioconjugate Chemistry. 2010, 21 (10), pp 1788–1793 September 15, 2010. DOI: 10.1021/bc100063a.

Calcium Condensed LABL-TAT Complexes Effectively Target Gene Delivery to ICAM-1 Expressing Cells. Supang Khondee, Abdulgader Baoum, Teruna J. Siahaan, and Cory Berkland. Molecular Pharmaceutics. 2011, 8 (3), pp 788–798. April 7, 2011. DOI: 10.1021/mp100393j.

Site-Specific Conjugation of Monodispersed DOTA-PEGn to a Thiolated Diabody Reveals the Effect of Increasing PEG Size on Kidney Clearance and Tumor Uptake with Improved 64-Copper PET Imaging. Lin Li,Desiree Crow, Fabio Turatti, James R. Bading, Anne-Line Anderson, Erasmus Poku, Paul J. Yazaki, Jenny Carmichael, David Leong, Michael P. Wheatcroft,Andrew A. Raubitschek, Peter J. Hudson,David Colcher, and John E. Shively. Bioconjugate Chemistry. 2011, 22 (4), pp 709–716. March 12, 2011. DOI: 10.1021/bc100464e.

Flexible antibodies with nonprotein hinges. Daniel J. Capon, Naoki Kaneko, Takayuki Yoshimori, Takashi Shimada, Florian M. Wurm, Peter K. Hwang, Xiaohe Tong, Staci A. Adams, Graham Simmons, Taka-Aki Sato and Koichi Tanaka. The Japan Academy Series B Physical and Biological Sciences. 2011, 87 (9), pp 603-616. November 11, 2011. DOI: 10.2183/pjab.87.603.

Enhanced Cellular Uptake of Peptide-Targeted Nanoparticles through Increased Peptide Hydrophilicity and Optimized Ethylene Glycol Peptide-Linker Length. Jared F. Stefanick, Jonathan D. Ashley, and Basar Bilgicer. ACS Nano. 2013, 7 (9) pp 8115-8127. August 29, 2013. DOI: 10.1021/nn4033954.

A Systematic Analysis of Peptide Linker Length and Liposomal Polyethylene Glycol Coating on Cellular Uptake of Peptide-Targeted Liposomes. Jared F. Stefanick, Jonathan D. Ashley, Tanyel Kiziltepe, and Basar Bilgicer. ACS Nano. 2013, 7 (4) pp 2935–2947. February 19, 2013. DOI: 10.1021/nn305663e.

Enhanced Cellular Uptake of Peptide-Targeted Nanoparticles through Increased Peptide Hydrophilicity and Optimized Ethylene Glycol Peptide-Linker Length. Jared F. Stefanick, Jonathan D. Ashley, and Basar Bilgicer. ACS Nano. 2013, 7 (9) pp 8115–8127. August 29, 2013. DOI: 10.1021/nn4033954.

Oriented Surface Immobilization of Antibodies at the Conserved Nucleotide Binding Site for Enhanced Antigen Detection. Nathan J Alves, Tanyel Kiziltepe, and Basar Bilgicer. Langmuir. 2012, 28 (25) pp 9640–9648. May 21, 2012. DOI: 10.1021/la301887s.

Hepatocyte Targeting of Nucleic Acid Complexes and Liposomes by a T7 Phage p17 Peptide. So C. Wong, Darren Wakefield, Jason Klein, Sean D. Monahan, David B. Rozema, David L. Lewis, Lori Higgs, James Ludtke, Alex V. Sokoloff, and Jon A. Wolff. Molecular Pharmaceutics. 2006, 3 (4) pp 386-397. March 28, 2006. DOI: 10.1021/mp050108r.

Evaluation of Nonpeptidic Ligand Conjugates for SPECT Imaging of Hypoxic and Carbonic Anhydrase IX-Expressing Cancers. Peng-Cheng Lv, Karson S. Putt, and Philip S. Low. Bioconjugate Chemistry. 2016, 27, pp 1762-1769. June 30, 2016. DOI: 10.1021/acs.bioconjchem.6b00271.

Synthesis of the Cyanine 7 labeled neutrophil-specific agents for noninvasive near infrared fluorescence imaging. Xiao L, Zhang Y, Liu Z, Yang M, Pu L, Pan D. Bioorganic & Medicinal Chemistry Letters. 2010, 20 (12) pp 3515-3517. June 15, 2010. DOI: 10.1016/j.bmcl.2010.04.136.

PEG-Peptide Conjugates. Ian W Hamley. Biomacromolecules. 2014, 15 (5) pp 1543-1559. April 1, 2014. DOI: 10.1021/bm500246w.

Controlled liposome fusion mediated by SNARE protein mimics. Hana Robson Marsden, Alexander V. Korobko,Tingting Zheng, Jens Voskuhla and Alexander Kros. Biomaterials Science. 2013, 1 (10) pp 1046-1054. June 4, 2013. DOI: 10.1039/C3BM60040H.

SNARE protein analog-mediated membrane fusion. Pawan Kumar, Samit Guha and Ulf Diederichsen. Journal of Peptide Science. 2015, April 7, 2015. DOI: 10.1002/psc.2773.

In Situ Modification of Plain Liposomes with Lipidated Coiled Coil Forming Peptides Induces Membrane Fusion. Frank Versluis , Jens Voskuhl , Bartjan van Kolck , Harshal Zope , Marien Bremmer , Tjerk Albregtse and Alexander Kros. Journal of the American Chemical Society. 2013, 135 (21), pp 8057–8062. May 9, 2013. DOI: 10.1021/ja4031227.

A Reduced SNARE Model for Membrane Fusion. Hana Robson Marsden, Nina A. Elbers, Paul H., H. Bomans, Nico A.J.M.Sommerdijk and Alexander Kros. Communications. 2009, 48 pp 2330-2333. February 16, 2009. DOI: 10.1002/anie.200804493.

Insights into the role of sulfated glycans in cancer cell adhesion and migration through use of branched peptide probe. Jlenia Brunetti, Lorenzo Depau, Chiara Falciani, Mariangela Gentile, Elisabetta Mandarini, Giulia Riolo, Pietro Lupetti, Alessandro Pini, and Luisa Bracci. Scientific Reports. 2016, 6 (27174). June 3, 2016. DOI: 10.1038/srep27174.

Bioresponsive nanocarries for targeted intracellular delivery of proteins and peptides. Ruth Elisabeth and Johanna Roder. Dissertation zur Erlangung des Doktorgrades der Fakultat fur Chemie und Pharmazie der Ludwig-Maximilians-Universitat Munchen. 2016, pp 1-128.

Bioresponsive nanocarries for targeted intracellular delivery of proteins and peptides. Ruth Elisabeth and Johanna Roder. Dissertation zur Erlangung des Doktorgrades der Fakultat fur Chemie und Pharmazie der Ludwig-Maximilians-Universitat Munchen. 2016, pp 1-128.

Influence of Defined Hydrophilic Blocks within Oligoaminoamide Copolymers: Compaction versus Sheilding of pDNA Nanoparticles. Stephan Morys, Ana Krhac Levacic, Sarah Urnauer, Susanne Kempter, Sarah Kern, Joachim O Radler, Christine Spitzweg, Ulrich Lachelt, and Ernst Wagner. Polymers. 2017, 9 (4) pp 1-20. April 19, 2017. DOI: 10.3390/polym9040142.

Control of strand registry by attachment of PEG chains to amyloid peptides influences nanostructure. Valeria Castelletto, Ge Cheng, Steve Furzeland, Derek Atkinsb and Ian W. Hamley. Soft matter. 2012, 8, pp 5434-5438. April 16, 2012. DOI:10.1039/C2SM25546D.

Morphological Transformation of Peptide Nanoassemblies through Conformational Transition of Core-forming Peptides. Tomonori Waku, Naoyuki Hirata, Masamichi Nozaki, Kanta Nogami, Shigeru Kunugi and Naoki Tanaka. Polymers. 2018, 11 (1), 39. December 28, 2018. https://doi.org/10.3390/polym11010039

Membrane-Fusogen Distance Is Critical for Efficient Coiled-Coil-Peptide-Mediated Liposome Fusion. Geert A. Daudey, Harshal R. Zope, Jens Voskuhl, Alexander Kros , and Aimee L. Boyle. Langmuir. 2017, 33 (43) pp 12443-12452. 10/5/2017. DOI: 10.1021/acs.langmuir.7b02931.

Use of a leukocyte-targeted peptide probe as a potential tracer for imaging the tuberculosis granuloma. Landon W. Locke, Shankaran Kothandaraman, Michael Tweedle, Sarah Chaney, Daniel J. Wozniak, and Larry S. Schlesinger. Tuberculosis. 2018, 108 pp 201-210. January 8, 2018. DOI: 10.1016/j.tube.2018.01.001.

Coiled-coil formation of the membrane-fusion K/E peptides viewed by electron paramagnetic resonance. Pravin Kumar, Martin van Son, Tingting Zheng, Dayenne Valdink, Jan Raap, Alexander Kros, and Martina Huber. PLOS ONE. 2018, 13 (1) pp 1-13. January 19, 2018. DOI: 10.1371/journal.pone.0191197.

Near-infrared quantum dots labelled with a tumor selective tetrabranched peptide for in vivo imaging. Jlenia Brunetti, Giulia Riolo, Mariangela Gentile, Andrea Bernini, Eugenio Paccagnini, Chiara Falciani, Luisa Lozzi, Silvia Scali, Lorenzo Depau, Alessandro Pini, Pietro Lupetti, and Luisa Bracci. Journal of Nanobiotechnology. 2018, 16 (21) pp. 1-10. March 3, 2018. DOI: 10.1186/s12951-018-0346-1.

Targeted Polymer-Based Probes for Fluorescence Guided Visualization and Potential Surgery of EGFR-Positive Head-and-Neck Tumors. Robert Pola ,Eliška Böhmová ,Marcela Filipová,Michal Pechar,Jan Pankrác, David Větvička, Tomáš Olejár, Martina Kabešová, Pavla Poučková, Luděk Šefc, Michal Zábrodský, Olga Janoušková, Jan Bouček, and Tomáš Etrych. Pharmaceutics 2020, 12(1), 31; January 1, 2020. https://doi.org/10.3390/pharmaceutics12010031

Polymer Cancerostatics Containing Cell-Penetrating Peptides: Internalization Efficacy Depends on Peptide Type and Spacer Length. Eliška Böhmová ,Robert Pola, Michal Pechar, Jozef Parnica, Daniela Machová, Olga Janoušková and Tomáš Etrych. Pharmaceutics 2020, 12(1), 59; January 10, 2020. https://doi.org/10.3390/pharmaceutics12010059

A Novel Bivalent Mannosylated Targeting Ligand Displayed on Nanoparticles Selectively Targets Anti-Inflammatory M2 Macrophages. Peiming Chen, Xiaoping Zhang, Alessandro Venosa, In Heon Lee, Daniel Myers, Jennifer A. Holloway, Robert K. Prud’homme, Dayuan Gao, Zoltan Szekely, Jeffery D. Laskin, Debra L. Laskin, and Patrick J. Sinko. Pharmaceutics 2020, 12(3), 243. March 8, 2020. DOI: 10.3390/pharmaceutics12030243

A New NT4 Peptide-Based Drug Delivery System for Cancer Treatment. Jlenia Brunetti, Sara Piantini, Marco Fragai, Silvia Scali, Giulia Cipriani, Lorenzo Depau, Alessandro Pini, Chiara Falciani, Stefano Menichetti and Luisa Bracci. Molecules 2020, 25(5), 1088; February 28, 2020. DOI: 10.3390/molecules25051088

Efficient capture of circulating tumor cells with low molecular weight folate receptor-specific ligands. Yingwen Hu, Danyang Chen, John V Napoleon, Madduri Srinivasarao, Sunil Singhal, Cagri A Savran, Philip S Low. Scientific Reports. 2022. May 20, 2022. https://doi.org/10.1038/s41598-022-12118-3

The post Fmoc-N-amido-dPEG®₁₂-acid appeared first on VectorLabs.

]]> Fmoc-N-amido-dPEG®₈-acid https://staging.vectorlabs.com/products/fmoc-n-amido-dpeg8-acid/ Sat, 24 Feb 2024 02:07:53 +0000 https://staging.vectorlabs.com/?post_type=product&p=35705 Fmoc-N-amido-dPEG®8-acid, product number QBD-10273, is one of a broad line of products designed for use in peptide synthesis. The short (28 atoms), discrete PEG (dPEG®) spacer is functionalized with a propionic acid group on one end and Fmoc-protected amine on the other. The compound can be added to the N-terminus of a growing peptide chain or to a primary-amine-functionalized side chain of an amino acid such as lysine. The dPEG®8 spacer imparts water solubility to the peptide to which it is conjugated.

QBD-10273 permits our customers to insert a short (28 atoms) dPEG® into a peptide chain using familiar Fmoc chemistry. The product works equally well in solid phase and solution phase synthetic processes. The dPEG® can be inserted at either end of the peptide chain or in the middle of two amino acid sequences to provide a flexible spacer between distinct functional peptides. Additionally, the short dPEG® spacer can be used to provide extra distance in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® means that the construct will gain some degree of water solubility while remaining soluble in organic solvent. The Fmoc protecting group removes easily with a solution of piperidine in N,N-dimethylformamide (DMF).

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 663.75; single compound
Chemical formula C₃₄H₄₉NO₁₂
CAS 756526-02-0
Purity > 98%
Spacers dPEG® Spacer is 28 atoms and 32.2 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetontrile, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Fmoc-N-amido-dPEG®₈-acid appeared first on VectorLabs.

]]>

Description

Fmoc-N-amido-dPEG®8-acid, product number QBD-10273, is one of a broad line of products designed for use in peptide synthesis. The short (28 atoms), discrete PEG (dPEG®) spacer is functionalized with a propionic acid group on one end and Fmoc-protected amine on the other. The compound can be added to the N-terminus of a growing peptide chain or to a primary-amine-functionalized side chain of an amino acid such as lysine. The dPEG®8 spacer imparts water solubility to the peptide to which it is conjugated.

QBD-10273 permits our customers to insert a short (28 atoms) dPEG® into a peptide chain using familiar Fmoc chemistry. The product works equally well in solid phase and solution phase synthetic processes. The dPEG® can be inserted at either end of the peptide chain or in the middle of two amino acid sequences to provide a flexible spacer between distinct functional peptides. Additionally, the short dPEG® spacer can be used to provide extra distance in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® means that the construct will gain some degree of water solubility while remaining soluble in organic solvent. The Fmoc protecting group removes easily with a solution of piperidine in N,N-dimethylformamide (DMF).

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight663.75; single compound
Chemical formulaC₃₄H₄₉NO₁₂
CAS756526-02-0
Purity> 98%
SpacersdPEG® Spacer is 28 atoms and 32.2 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetontrile, DMAC or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Polyproline-Rod Approach to Isolating Protein Targets of Bioactive Small Molecules: Isolation of a New Target of Indomethacin. Shin-ichi Sato, Youngjoo Kwon, Shinji Kamisuki, Neeta Srivastava, Quian Mao, Yoshinori Kawazoe, and Motonari Uesugi. Journal of the American Chemical Society. 2007, 129 (4), pp 873–880. January 4, 2007. DOI: 10.1021/ja0655643.

New Enzyme-Activated Solubility-Switchable Contrast Agent for Magnetic Resonance Imaging: From Synthesis to in Vivo Imaging. Beata Jastrzabska, Rejean Lebel, Helene Therriault, J. Oliver McIntyre, Emanuel Escher, Briggitte Guerin, Benoit Paquette, Witold A. Neugebauer, and Martin Lepage. Journal of Medicinal Chemistry. 2009, 52 (6) pp 1576–1581. February 19, 2009. DOI: 10.1021/jm801411h.

A Non-Chromatographic Method for the Purification of a Bivalently Active Monoclonal IgG Antibody from Biological Fluids. Basar Bilgicer, Samuel W. Thomas III, Bryan F. Shaw, George K. Kaufman, Vijay M. Krishnamurthy, Lara A. Estroff, Jerry Yang, and George M. Whitesides. Journal of the American Chemical Society. 2009, 131 (26) pp 9361–9367. June 17, 2009. DOI: 10.1021/ja9023836.

Photocleavable peptide-oligonucleotide conjugates for protein kinase assays by MALDI-TOF MS. Guangchang Zhou, Faraz Khan, Qing Dai, Juliesta E Sylvester and Stephen J Kron. Molecular BioSystems. 2012, 8 (9), pp 2395-2404. June 13, 2012. DOI: 10.1039/C2MB25163A.

A Synthetic Trivalent Hapten that Aggregates anti-2,4-DNP IgG into Bicyclic Trimers. Başar Bilgiçer, Demetri T. Moustakas, and George M. Whitesides. Journal of the American Chemical Society. 2007, 129 (12) pp 3722-3728. February 28, 2007. DOI: 10.1021/ja067159h.

Determination of bacterial viability by selective capture using surface-bound siderophores. Mark L. Wolfenden, Rama M. Sakamuri, Aaron S. Anderson, Lakshman Prasad, Jurgen G. Schmidt, Harshini Mukundan. Advances in Biological Chemistry. 2012, 2 (4) pp 396-402 September 30, 2012. DOI: 10.4236/abc.2012.24049.

Synthetic Allergen Design Reveals the Significance of Moderate Affinity Epitopes in Mast Cell Degranulation. Michael W. Handlogten, Tanyel Kiziltepe, Nathan J. Alves, and Basar Bilgicer. ACS Chemical Biology. 2012, 7 (11) pp 1796–1801. August 10, 2012. DOI: 10.1021/cb300193f.

Enhanced Cellular Uptake of Peptide-Targeted Nanoparticles through Increased Peptide Hydrophilicity and Optimized Ethylene Glycol Peptide-Linker Length. Jared F. Stefanick, Jonathan D. Ashley, and Basar Bilgicer. ACS Nano. 2013, 7 (9) pp 8115–8127. August 29, 2013. DOI: 10.1021/nn4033954.

Novel solubility-switchable MRI agent allows the noninvasive detection of matrix metalloproteinase-2 activity In vivo in a mouse model. Rejean Lebel, Beata Jastrzebska, Helene Therriault, Marie-Michele Cournoyer, J. Oliver McIntyre, Emanuel Escher, Witold Neugebauer, Benoit Paquette, and Martin Lepage. Magnetic Resonance in Medicine. 2008, 60 (5) pp 1056–1065. October 27, 2008. DOI: 10.1002/mrm.21741.

Design of a Heterotetravalent Synthetic Allergen That Reflects Epitope Heterogeneity and IgE Antibody Variability to Study Mast Cell Degranulation. Michael W. Handlogten, Tanyel Kiziltepe and Basar Bilgicer. Biochem. J. 2013, 449 (1) pp 91–99. January 1, 2013. DOI: 10.1042/BJ20121088.

Design of a Heterobivalent Ligand to Inhibit IgE Clustering on Mast Cells. Michael W. Handlogten, Tanyel Kiziltepe, Demetri T. Moustakas, and Basxar Bilgicer. Chemistry & Biology. 2011, 18 (9) pp 1179–1188. September 23, 2011. DOI: 10.1016/j.chembiol.2011.06.012.

Design of a Heterobivalent Inhibitor of Allergy and More Physiologically Relevant Allergy Models. Michael William Handlogten. University of Notre Dame. 2013, March 28, 2013.

PEG-Peptide Conjugates. Ian W Hamley. Biomacromolecules. 2014, 15 (5) pp 1543-1559. April 1, 2014. DOI: 10.1021/bm500246w.

Positron Emission Tomographic Imaging of Copper 64– and Gallium 68–Labeled Chelator Conjugates of
the Somatostatin Agonist Tyr3-Octreotate. Jessie R. Nedrow, Alexander G. White, Jalpa Modi, Kim Nguyen, Albert J. Chang and Carolyn J. Anderson. Molecular Imaging. 2014, 13 pp 1-13. Decebmer 14, 2014. DOI: 10.2310/7290.2014.00020.

Peripheral administration of a long-acting peptide OT receptor agonist inhibits fear induced freezing. Meera E. Modi, Mark J. Majchrzak, Kari R. Fonseca, Angela Doran, Sarah Osgood, Michelle Vanase-Frawley, Eric Feyfant, Heather McInnes, Ramin Darvari, Derek L. Buhl, and Natasha M. Kablaoui. JPET. 2016, 357 (3). May 23, 2016. DOI: 10.1124/jpet.116.232702.

Designer covalent heterobivalent inhibitors prevent IgE-dependent responses to peanut allergen. Peter E. Deak, Baksun Kim, Amina Abdul Qayum, Jaeho Shin, Girish Vitalpur, Kirsten M. Kloepfer, Matthew J. Turner, Neal Smith, Wayne G. Shreffler, Tanyel Kiziltepe, Mark H. Kaplan, and Basar Bilgicer. 2019. April 8, 2019. DOI: 10.1073/pnas.1820417116

Membrane-Fusogen Distance Is Critical for Efficient Coiled-Coil-Peptide-Mediated Liposome Fusion. Geert A. Daudey, Harshal R. Zope, Jens Voskuhl, Alexander Kros , and Aimee L. Boyle. Langmuir. 2017, 33 (43) pp 12443-12452. 10/5/2017. DOI: 10.1021/acs.langmuir.7b02931.

The post Fmoc-N-amido-dPEG®₈-acid appeared first on VectorLabs.

]]> Fmoc-N-amido-dPEG®₂-acid https://staging.vectorlabs.com/products/fmoc-n-amido-dpeg2-acid/ Sat, 24 Feb 2024 02:07:32 +0000 https://staging.vectorlabs.com/?post_type=product&p=35559 Fmoc-N-amido-dPEG®2-acid, product number QBD-10243, is one of a broad line of products designed for use in peptide synthesis. The short (16 atoms), discrete PEG (dPEG®) spacer is functionalized with a propionic acid group on one end and Fmoc-protected amine on the other. The product can be added to the N-terminus of a growing peptide chain or to a primary-amine-functionalized side chain of an amino acid such as lysine. The dPEG®2 spacer imparts water solubility to the peptide to which it is conjugated.

Description

Fmoc-N-amido-dPEG®2-acid, product number QBD-10243, is a peptide synthesis product used to introduce a short (10 atoms), hydrophilic spacer into a peptide chain using standard peptide chemistry. The Fmoc protecting group can be removed using standard peptide chemistry.

Fmoc-N-amido-dPEG®2-acid, QBD-10243, works well in solid-phase and solution-phase synthetic processes. The dPEG® can be joined to the N-terminal end of a peptide chain. After removal of the Fmoc protecting group, further synthesis can be carried out to create a peptide with a flexible hinge. The peptide sequences on either side of the dPEG® spacer can be identical or different.

In addition, the short dPEG® linker can provide spacing between two units in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® means that the construct will gain water solubility while remaining soluble in an organic solvent. The Fmoc protecting group removes easily with a solution of piperidine in N,N-dimethylformamide (DMF).

Specifications

Unit Size 1000 mg
Molecular Weight 399.44; single compound
Chemical formula C₂₂H₂₅NO₆
CAS 872679-70-4
Purity > 98%
Spacers dPEG® Spacer is 10 atoms and 10.9 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetontrile, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Fmoc-N-amido-dPEG®₂-acid appeared first on VectorLabs.

]]>

Fmoc-N-amido-dPEG®2-acid, product number QBD-10243, is one of a broad line of products designed for use in peptide synthesis. The short (16 atoms), discrete PEG (dPEG®) spacer is functionalized with a propionic acid group on one end and Fmoc-protected amine on the other. The product can be added to the N-terminus of a growing peptide chain or to a primary-amine-functionalized side chain of an amino acid such as lysine. The dPEG®2 spacer imparts water solubility to the peptide to which it is conjugated.

Description

Fmoc-N-amido-dPEG®2-acid, product number QBD-10243, is a peptide synthesis product used to introduce a short (10 atoms), hydrophilic spacer into a peptide chain using standard peptide chemistry. The Fmoc protecting group can be removed using standard peptide chemistry.

Fmoc-N-amido-dPEG®2-acid, QBD-10243, works well in solid-phase and solution-phase synthetic processes. The dPEG® can be joined to the N-terminal end of a peptide chain. After removal of the Fmoc protecting group, further synthesis can be carried out to create a peptide with a flexible hinge. The peptide sequences on either side of the dPEG® spacer can be identical or different.

In addition, the short dPEG® linker can provide spacing between two units in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® means that the construct will gain water solubility while remaining soluble in an organic solvent. The Fmoc protecting group removes easily with a solution of piperidine in N,N-dimethylformamide (DMF).

Specifications

Unit Size1000 mg
Molecular Weight399.44; single compound
Chemical formulaC₂₂H₂₅NO₆
CAS872679-70-4
Purity> 98%
SpacersdPEG® Spacer is 10 atoms and 10.9 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetontrile, DMAC or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Functional PEG-Modified Thin Films for Biological Detection. Aaron S. Anderson, Andrew M. Dattelbaum, Gabriel A. Montano, Dominique N. Price, Jurgen G. Schmidt, Jennifer S. Martinez, W. Kevin Grace, Karen M. Grace, and Basil I. Swanson. Langmuir. 2008, 24 (5), pp 2240–2247. January 30, 2008. DOI: 10.1021/la7033438.

Polyproline-Rod Approach to Isolating Protein Targets of Bioactive Small Molecules: Isolation of a New Target of Indomethacin. Shin-ichi Sato, Youngjoo Kwon, Shinji Kamisuki, Neeta Srivastava, Quian Mao, Yoshinori Kawazoe, and Motonari Uesugi. J. Am. Chem. Soc. 2007, 129 (4), pp 873–880. January 4, 2007. DOI: 10.1021/ja0655643.

Oriented Surface Immobilization of Antibodies at the Conserved Nucleotide Binding Site for Enhanced Antigen Detection. Nathan J Alves, Tanyel Kiziltepe, and Basar Bilgicer. Langmuir. 2012, 28 (25) pp 9640-9648. May 21, 2012. DOI: 10.1021/la301887s.

Enhanced Cellular Uptake of Peptide-Targeted Nanoparticles through Increased Peptide Hydrophilicity and Optimized Ethylene Glycol Peptide-Linker Length. Jared F. Stefanick, Jonathan D. Ashley, and Basar Bilgicer. ACS Nano. 2013, 7 (9) pp 8115–8127. August 29, 2013. DOI: 10.1021/nn4033954.

Selective photocrosslinking of functional ligands to antibodies via the conserved nucleotide binding site. Nathan J. Alves, Matthew M. Champion, Jared F. Stefanick, Michael W. Handlogten, Demetri T. Moustakas, Yunhua Shi, Bryan F. Shawd, Rudolph M. Navari, Tanyel Kiziltepe, Basar Bilgicer. Biomaterials. 2013, 34 (22) pp 5700–5710. April 16, 2013. DOI:.org/10.1016/j.biomaterials.2013.03.082.

Design, Synthesis and Evaluation of a Neurokinin 1 Receptor-Targeted Near IR Dye for Fluorescence Guided Surgery of Neuroendocrine Cancers. Ananda Kumar Kanduluru, Madduri Srinivasarao, and Philip S. Low. Bioconjugate Chemistry. 2016, pp 1-20. August 16, 2016. DOI: 10.1021/acs.bioconjchem.6b00374.

One-Pot Isolation of a Desired Human Genome Fragment by Using a Biotinylated pcPNA/S1 Nuclease Combination. Arivazhagan Rajendran , Narumi Shigi, Jun Sumaoka, and Makoto Komiyama. Biochemistry. 2018, 57, pp 2908-2912. May 3, 2018. DOI: 10.1021/acs.biochem.8b00202.

Stapled, Long-Acting Glucagon-like Peptide 2 Analog with Efficacy in Dextran Sodium Sulfate Induced Mouse Colitis Models. Peng-Yu Yang , Huafei Zou, Candy Lee, Avinash Muppidi, Elizabeth Chao, Qiangwei Fu, Xiaozhou Luo, Danling Wang, Peter G. Schultz, and Weijun Shen. Journal of Medicinial Chemistry. 2018, 61, pp 3218-3223. March 12, 2018. DOI: 10.1021/acs.jmedchem.7b00768.

Evaluation of the Pharmacokinetic Effects of Various Linking Group Using the 111In-DOTA-X-BBN(7−14)NH2 Structural Paradigm in a Prostate Cancer Model. Jered C. Garrison, Tammy L. Rold, Gary L. Sieckman, Farah Naz, Samantha V. Sublett, Said Daibes Figueroa, Wynn A. Volkert and Timothy J. Hoffman. Bioconjugate Chem. 2008, 19 (9) pp 1803–1812. August 20, 2008. DOI: 10.1021/bc8001375.

PEG-Peptide Conjugates. Ian W Hamley. Biomacromolecules. 2014. April 1, 2014. DOI: 10.1021/bm500246w.

Dual-receptor targeted strategy in nanoparticle design achieves tumor cell selectivity through cooperativity. Jared Francis Stefanick, David Thomas Omstead, Tanyel Kiziltepeabc and Basar Bilgicer. Nanoscale. 2019. Fenruary 17, 2019. DOI: 10.1039/C8NR09431D

Designer covalent heterobivalent inhibitors prevent IgE-dependent responses to peanut allergen. Peter E. Deak, Baksun Kim, Amina Abdul Qayum, Jaeho Shin, Girish Vitalpur, Kirsten M. Kloepfer, Matthew J. Turner, Neal Smith, Wayne G. Shreffler, Tanyel Kiziltepe, Mark H. Kaplan, and Basar Bilgicer. 2019. April 8, 2019. DOI: 10.1073/pnas.1820417116

Membrane-Fusogen Distance Is Critical for Efficient Coiled-Coil-Peptide-Mediated Liposome Fusion. Geert A. Daudey, Harshal R. Zope, Jens Voskuhl, Alexander Kros , and Aimee L. Boyle. Langmuir. 2017, 33 (43) pp 12443-12452. 10/5/2017. DOI: 10.1021/acs.langmuir.7b02931.

Design and Evaluation of Novel Polymyxin Fluorescent Probes. Bo Yun , Kade D. Roberts, Philip E. Thompson, Roger L. Nation, Tony Velkov, and Jian Li. Sensors. 2017, 17 (11) pp 2598. 11/11/2017. DOI: 10.3390/s17112598.

Engineering peptide-targeted liposomal nanoparticles optimized for improved selectivity for HER2-positive breast cancer cells to achieve enhanced in vivo efficacy. Baksun Kim, Jaeho Shin, Junmin Wu, David T. Omstead, Tanyel Kiziltepe, Laurie E. Littlepage, Basar Bilgicer. Journal of Controlled Release. 2020. Volume 322, 10 June 2020, Pages 530-541. April 8, 2020. DOI: 10.1016/j.jconrel.2020.04.010

In vivo evaluation of CD38 and CD138 as targets for nanoparticle-based drug delivery in multiple myeloma. David T. Omstead, Franklin Mejia, Jenna Sjoerdsma, Baksun Kim, Jaeho Shin, Sabrina Khan, Junmin Wu, Tanyel Kiziltepe, Laurie E. Littlepage & Basar Bilgicer. Journal of Hematology & Oncology. 2020. 13, Article number: 145 (2020). 11/02/20. DOI: 10.1186/s13045-020-00965-4

The post Fmoc-N-amido-dPEG®₂-acid appeared first on VectorLabs.

]]> Fmoc-N-amido-dPEG®₄-acid https://staging.vectorlabs.com/products/fmoc-n-amido-dpeg4-acid/ Sat, 24 Feb 2024 02:07:11 +0000 https://staging.vectorlabs.com/?post_type=product&p=35383 Fmoc-N-amido-dPEG®4-acid, product number QBD-10213, is one of a broad line of products designed for use in peptide synthesis. The short (16 atoms), discrete PEG (dPEG®) spacer is functionalized with a propionic acid group on one end and an Fmoc-protected amine on the other. The compound can be added to the N-terminus of a growing peptide chain or to a primary-amine-functionalized side chain of an amino acid such as lysine. The dPEG®4 spacer imparts water solubility to the peptide to which it is conjugated.

QBD-10213 permits our customers to insert a short (16 atoms) dPEG® into a peptide chain using familiar Fmoc chemistry. The product works equally well in solid phase and solution phase synthetic processes. The dPEG® can be inserted at either end of the peptide chain or in the middle of two amino acid sequences to provide a flexible spacer between distinct functional peptides. Additionally, the short dPEG® spacer can be used to provide extra distance in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® means that the construct will gain some degree of water solubility while remaining soluble in organic solvent. The Fmoc protecting group removes easily with a solution of piperidine in N,N-dimethylformamide (DMF).

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 487.54; single compound
Chemical formula C₂₆H₃₃NO₈
CAS 557756-85-1
Purity > 98%
Spacers dPEG® Spacer is 16 atoms and 18.0Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetontrile, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Fmoc-N-amido-dPEG®₄-acid appeared first on VectorLabs.

]]>

Description

Fmoc-N-amido-dPEG®4-acid, product number QBD-10213, is one of a broad line of products designed for use in peptide synthesis. The short (16 atoms), discrete PEG (dPEG®) spacer is functionalized with a propionic acid group on one end and an Fmoc-protected amine on the other. The compound can be added to the N-terminus of a growing peptide chain or to a primary-amine-functionalized side chain of an amino acid such as lysine. The dPEG®4 spacer imparts water solubility to the peptide to which it is conjugated.

QBD-10213 permits our customers to insert a short (16 atoms) dPEG® into a peptide chain using familiar Fmoc chemistry. The product works equally well in solid phase and solution phase synthetic processes. The dPEG® can be inserted at either end of the peptide chain or in the middle of two amino acid sequences to provide a flexible spacer between distinct functional peptides. Additionally, the short dPEG® spacer can be used to provide extra distance in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® means that the construct will gain some degree of water solubility while remaining soluble in organic solvent. The Fmoc protecting group removes easily with a solution of piperidine in N,N-dimethylformamide (DMF).

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight487.54; single compound
Chemical formulaC₂₆H₃₃NO₈
CAS557756-85-1
Purity> 98%
SpacersdPEG® Spacer is 16 atoms and 18.0Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetontrile, DMAC or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Novel Synthetic Route to Peptide-Capped Gold Nanoparticles. Takeshi Serizawa, Yu Hirai, and Mamoru Aizawa. Langmuir. 2009, 25 (20), pp 12229–12234. September 21, 2009. DOI: 10.1021/la9021799.

Controlling HBV Replication in Vivo by Intravenous Administration of Triggered PEGylated siRNA-Nanoparticles. Sergio Carmona, Michael R. Jorgensen, Soumia Kolli, Carol Crowther, Felix H. Salazar, Patricia L. Marion, Masato Fujino, Yukikazu Natori, Maya Thanou, Patrick Arbuthnot, and Andrew D. Miller. Mol. Pharmaceutic., 2009, 6 (3), pp 706–717. January 21,2009. DOI: 10.1021/mp800157x.

Species Differences of Bombesin Analog Interactions with GRP-R Define the Choice of Animal Models in the Development of GRP-R-Targeting Drugs. Theodosia Maina, PhD; Berthold A. Nock, PhD; Hanwen Zhang, Anastasia Nikolopoulou, Msci, Beatrice Waser, PhD; Jean Claude Reubi, MD; and Helmut R. Maecke, PhD. Journal of Nuclear Medicine. 2005, 46 (5) pp. 823-830. January 23, 2005.

Polyproline-Rod Approach to Isolating Protein Targets of Bioactive Small Molecules: Isolation of a New Target of Indomethacin. Shin-ichi Sato, Youngjoo Kwon, Shinji Kamisuki, Neeta Srivastava, Quian Mao, Yoshinori Kawazoe, and Motonari Uesugi. J. Am. Chem. Soc. 2007, 129 (4), pp 873–880. January 4, 2007. DOI: 10.1021/ja0655643.

Photocleavable Peptide-Conjugated Magnetic Beads for Protein Kinase Assays by MALDI-TOF. MS. Guangchang Zhou, Xiaoliang Yan, Ding Wu, and Stephen J. Kron. Bioconjugate Chem. 2010, 21 (10), pp 1917–1924. September 22, 2010. DOI: 10.1021/bc1003058.

Neutrophil Targeting Heterobivalent SPECT Imaging Probe: cFLFLF-PEG-TKPPR-99mTc. Yi Zhang, Li Xiao, Mahendra D. Chordia, Landon W. Locke, Mark B. Williams, Stuart S. Berr, and Dongfeng Pan. Bioconjugate Chem. 2010, 21 (10), pp 1788–1793. September 15, 2010. DOI: 10.1021/bc100063a.

Evaluation of 99mTc-Labeled Cyclic RGD Peptide with a PEG4 Linker for Thrombosis Imaging: Comparison with DMP444. Wei Fang, Jia He, Young-Seung Kim, Yang Zhou, and Shuang Liu. Bioconjugate Chem. 2011, 22 (8), pp 1715–1722. July 24, 2011. DOI: 10.1021/bc2003742.

Expanding the Scope of Biocatalysis: Oxidative Biotransformations on Solid-Supported Substrates. Sarah J. Brooks, Lydie Coulombel, Disha Ahuja, Douglas S. Clark, and Jonathan S. Dordick. Advanced Synthesis & Catalysis. 2008, 350 (10), pp 1517–1525. July 7, 2008. DOI:10.1002/adsc.200800188.

Development of Peptide Nucleic Acid Probes for Detection of the HER2 Oncogene.
Belhu Metaferia., Jun S. Wei., Young K. Song, Jennifer Evangelista, Konrad Aschenbach, Peter Johansson, Xinyu Wen, Qingrong Chen, Albert Lee, Heidi Hempel, Jinesh S. Gheeya, Stephanie Getty, Romel Gomez, Javed Khan. PLoS ONE. 2012, 8 (4) e58870. April 10, 2013. DOI: 10.1371/journal.pone.0058870.

Enhanced Cellular Uptake of Peptide-Targeted Nanoparticles through Increased Peptide Hydrophilicity and Optimized Ethylene Glycol Peptide-Linker Length. Jared F. Stefanick, Jonathan D. Ashley, and Basar Bilgicer. ACS Nano. 2013, 7 (9) pp 8115–8127. August 29, 2013. DOI: 10.1021/nn4033954.

PulmoBind, an Adrenomedullin-Based Molecular Lung Imaging Tool. Myriam Létourneau, Quang Trinh Nguyen, Francois Harel, Alain Fournier, and Jocelyn Dupuis. J Nucl Med. 2013, 54 (10) pp 1789-1796. October 1, 2013. DOI:10.2967/jnumed.112.118984.

Liposomes containing monophosphoryl lipid A: A potent adjuvant system for inducing antibodies to heroin hapten analogs. Gary R. Matyas, Alexander V. Mayorova, Kenner C. Rice, Arthur E. Jacobson, Kejun Cheng, Malliga R. Iyer, Fuying Li, Zoltan Becka, Kim D. Janda, Carl R. Alvinga. Vaccine. 2013, 31 (26) pp 2804-2810. June 10, 2013. DOI:.org/10.1016/j.vaccine.2013.04.027.

Design of a heterotetravalent synthetic allergen that reflects epitope heterogeneity and IgE antibody variability to study mast cell degranulation. Michael W. Handlogten, Tanyel Kiziltepe and Basar Bilgicer. Biochem. J. 2013, 449 pp 91–99. October 11, 2011. DOI:10.1042/BJ20121088.

Design of a Heterobivalent Ligand to Inhibit IgE Clustering on Mast Cells. Michael W. Handlogten, Tanyel Kiziltepe, Demetri T. Moustakas, and Basxar Bilgicer. Chemistry & Biology. 2011, 18 (9) pp 1179–1188. September 23, 2011. DOI 10.1016/j.chembiol.2011.06.012.

Robust Sensing Films for Pathogen Detection and Medical Diagnostics. Aaron S. Anderson ; Andrew M. Dattelbaum ; Harshini Mukundan ;Dominique N. Price ; W. Kevin Grace ; Basil I. Swanson. Frontiers in Pathogen Detection: From Nanosensors to Systems., 2009, Proc. Of SPIE 7167. 71670q-1 February 18, 2009. 10.1117/12.809383.

Optical Imaging of Integrin αv β3 Expression with Near-Infrared Fluorescent RGD Dimer with Tetra(ethylene glycol) Linkers. Zhaofei Liu, Shuanglong Liu, Gang Niu, Fan Wang, Shuang Liu, Xiaoyuan Chen. Mol Imaging. 2010, 9 (1) pp 21-29. February 1, 2010. DOI: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629979/.

Spring-Loaded Model Revisited: Paramyxovirus Fusion Requires Engagement of a Receptor Binding Protein beyond Initial Triggering of the Fusion Protein. Matteo Porotto, Ilaria DeVito, Samantha G. Palmer, Eric M. Jurgens, Jia L. Yee, Christine C. Yokoyama, Antonello Pessi and Anne Moscona. J. Virol. 2011, 85 (24) pp 12867-12880. DOI: 10.1128/JVI.05873-11.

Tumor Uptake of the RGD Dimeric Probe 99mTc-G3-2P4-RGD2 is Correlated with Integrin rv_3 Expressed on both Tumor Cells and Neovasculature. Zhaofei Liu, Bing Jia, Jiyun Shi, Xiaona Jin, Huiyun Zhao, Fang Li, Shuang Liu, and Fan Wang. Bioconjugate Chem. 2010, 21 (3) pp 548-555. February 25, 2010. DOI: 10.1021/bc900547d.

Quantifying Cellular Internalization with a Fluorescent Click Sensor. Laura I. Selby, Luigi Aurelio, Daniel Yuen, Bim Graham, and Angus P. R. Johnston. ACS Sensors. 2018, 3, pp 1182-1189. April 20, 2018. DOI: 10.1021/acssensors.8b00219.

Radionuclides in Targeted Therapy of Cancer. Adina Elena STANCIU. Rev. Roum. Chim. 2012, 57 (1) pp 5-13. May 27, 2011. DOI: http://web.icf.ro/rrch/.

Improving Tumor-Targeting Capability and Pharmacokinetics of 99mTc-Labeled Cyclic RGD Dimers with PEG4 Linkers. Lijun Wang, Jiyun Shi, Young-Seung Kim, Shizhen Zhai, Bing Jia, Huiyun Zhao, Zhaofei Liu, Fan Wang, Xiaoyuan Chen and Shuang Liu. Molecular Pharmaceutics. 2009, 6 (1) pp 231–245. December 9, 2008. DOI: 10.1021/mp800150r.

Improving Tumor Uptake and Pharmacokinetics of 64Cu-Labeled Cyclic RGD Peptide Dimers with Gly3 and PEG4 Linkers. Jiyun Shi, Young-Seung Kim, Shizhen Zhai, Zhaofei Liu, Xiaoyuan Chen and Shuang Liu. Bioconjugate Chemistry. 2009, 20 (4) pp 750–759. March 25, 2009. DOI: 10.1021/bc800455p.

Evaluation of the Pharmacokinetic Effects of Various Linking Group Using the 111In-DOTA-X-BBN(7−14)NH2 Structural Paradigm in a Prostate Cancer Model. Jered C. Garrison, Tammy L. Rold, Gary L. Sieckman, Farah Naz, Samantha V. Sublett, Said Daibes Figueroa, Wynn A. Volkert and Timothy J. Hoffman. Bioconjugate Chem. 2008, 19 (9) pp 1803–1812. August 20, 2008. DOI: 10.1021/bc8001375.

Two 90Y-Labeled Multimeric RGD Peptides RGD4 and 3PRGD2 for Integrin Targeted Radionuclide Therapy. Zhaofei Liu, Jiyun Shi, Bing Jia, Zilin Yu, Yan Liu, Huiyun Zhao, Fang Li, Jie Tian, Xiaoyuan Chen, Shuang Liu, and Fan Wang.Two 90Y-Labeled Multimeric RGD Peptides RGD4 and 3PRGD2 for Integrin Targeted Radionuclide Therapy. Zhaofei Liu, Jiyun Shi, Bing Jia, Zilin Yu, Yan Liu, Huiyun Zhao, Fang Li, Jie Tian, Xiaoyuan Chen, Shuang Liu, and Fan Wang. Mol. Pharmaceutics. 2011, 8 (2) pp 591–599. January 19, 2011. DOI: 10.1021/mp100403y.

Impact of PKM Linkers on Biodistribution Characteristics of the 99mTc-Labeled Cyclic RGDfK Dimer. Shuang Liu, Zhengjie He, Wen-Yuan Hsieh, Young-Seung Kim, and Young Jiang. Bioconjugate Chem. 2006, 17 (6) pp 1499–1507. November 1, 2006. DOI: 10.1021/bc060235l.

99mTc-Galacto-RGD2: A Novel 99mTc-Labeled Cyclic RGD Peptide Dimer Useful for Tumor Imaging. Shundong Ji, Andrzej Czerwinski, Yang Zhou, Guoqiang Shao, Francisco Valenzuela, Paweł Sowiński, Satendra Chauhan, Michael Pennington, and Shuang Liu. Mol. Pharmaceutics. 2013, 10 (9) pp 3304–3314. July 22, 2013. DOI: 10.1021/mp400085d.

2-Mercaptoacetylglycylglycyl (MAG2) as a Bifunctional Chelator for 99mTc-Labeling of Cyclic RGD Dimers: Effect of Technetium Chelate on Tumor Uptake and Pharmacokinetics. Jiyun Shi, Young-Seung Kim, Sudipta Chakraborty, Bing Jia, Fan Wang and Shuang Liu. Bioconjugate Chemistry. 2009, 20(8) pp 1559–1568. July 15, 2009. DOI: 10.1021/bc9001739.

Robust Sensing Films for Pathogen Detection and Medical Diagnostics. Aaron S. Anderson ; Andrew M. Dattelbaum ; Harshini Mukundan ;Dominique N. Price ; W. Kevin Grace ; Basil I. Swanson. Frontiers in Pathogen Detection: From Nanosensors to Systems., 2009, Proc. Of SPIE 7167. 71670q-1 February 18, 2009. 10.1117/12.809383.

PEG-Peptide Conjugates. Ian W Hamley. Biomacromolecules. 2014. April 1, 2014. DOI: 10.1021/bm500246w.

Molecular Imaging of the Human Pulmonary Vascular Endothelium Using an Adrenomedullin Receptor Ligand. Francois Harel, Xavier Levac, Quang T. Nguyen, Myriam Le´tourneau, Sophie Marcil, Vincent Finnerty, Marie`ve Cossette, Alain Fournier, and Jocelyn Dupuis. Molecular Imaging. 2015, pp 1-9. March 1, 2015. DOI: 10.2310/7290.2015.00003.

Toward the Optimization of Bombesin-Based Radiotracers for Tumor Targeting. Ibai E. Valverde, Sandra Vomstein, and Thomas L. Mindt. Journal of Medicinal Chemistry. 2016, April 7, 2016. DOI: 10.1021/acs.jmedchem.6b00025.

In vitro and in vivo efficacy, toxicity, bio-distribution and resistance selection of a novel antibacterial drug candidate. Jlenia Brunetti, Chiara Falciani, Giulia Roscia, Simona Pollini, Stefano Bindi, Silvia Scali, Unai Cossio Arrieta, Vanessa Gomez-Vallejo, Leila Quercini, Elisa Lbba, Marco Prato, Gian Maria Rossolini, Jordi Llop, Luisa Bracci, and Alessandro Pini. Scientific Reports. 2016, 6 (26077). May 12, 2016. DOI: 10.1038/srep26077.

Activity-based protein profiling reveals active serine proteases that drive malignancy of human ovarian clear cell carcinoma. Christine Mehner, Alexandra Hockla, Mathew Coban, Benjamin Madden, Rosendo Estrada, Derek C Radisky, Evette S Radisky. Journal Of Biological Chemistry. 2022. Volume 298, Issue 8. June 16, 2022. https://doi.org/10.1016/j.jbc.2022.102146

The post Fmoc-N-amido-dPEG®₄-acid appeared first on VectorLabs.

]]> Fmoc-N-amido-dPEG®₆-acid https://staging.vectorlabs.com/products/fmoc-n-amido-dpeg6-acid/ Sat, 24 Feb 2024 02:04:40 +0000 https://staging.vectorlabs.com/?post_type=product&p=34895 "Fmoc-N-amido-dPEG®6-acid, product number QBD-10063, is one of a broad line of products designed for use in peptide synthesis. The short (22 atoms), discrete PEG (dPEG®) spacer is functionalized with a propionic acid group on one end and Fmoc-protected amine on the other. The product can be added to the N-terminus of a growing peptide chain or to a primary-amine-functionalized side chain of an amino acid such as lysine. The dPEG®6 spacer imparts water solubility to the peptide to which it is conjugated.

QBD-10063 permits our customers to insert a dPEG® spacer into a peptide chain using familiar Fmoc chemistry using solid phase or solution phase chemistry. The dPEG® compound can be inserted at either end of the peptide chain or in the middle of two amino acid sequences to provide a flexible linker between distinct functional peptides. Additionally, the dPEG® spacer can be used to provide spacing in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® products means that the construct gains hydrodynamic volume and water solubility while remaining soluble in organic solvent. The Fmoc protecting group removes easily with a solution of piperidine in N,N-dimethylformamide (DMF)."

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 575.65; single compound
Chemical formula C₃₀H₄₁NO₁₀
CAS
882847-34-9
Purity > 98%
Spacers
dPEG® Spacer is 22 atoms and 25.1 Å
Shipping
Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetontrile, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Fmoc-N-amido-dPEG®₆-acid appeared first on VectorLabs.

]]>

Description

Fmoc-N-amido-dPEG®6-acid, product number QBD-10063, is one of a broad line of products designed for use in peptide synthesis. The short (22 atoms), discrete PEG (dPEG®) spacer is functionalized with a propionic acid group on one end and Fmoc-protected amine on the other. The product can be added to the N-terminus of a growing peptide chain or to a primary-amine-functionalized side chain of an amino acid such as lysine. The dPEG®6 spacer imparts water solubility to the peptide to which it is conjugated.

QBD-10063 permits our customers to insert a dPEG® spacer into a peptide chain using familiar Fmoc chemistry using solid phase or solution phase chemistry. The dPEG® compound can be inserted at either end of the peptide chain or in the middle of two amino acid sequences to provide a flexible linker between distinct functional peptides. Additionally, the dPEG® spacer can be used to provide spacing in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® products means that the construct gains hydrodynamic volume and water solubility while remaining soluble in organic solvent. The Fmoc protecting group removes easily with a solution of piperidine in N,N-dimethylformamide (DMF).

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 575.65; single compound
Chemical formula C₃₀H₄₁NO₁₀
CAS
882847-34-9
Purity > 98%
Spacers
dPEG® Spacer is 22 atoms and 25.1 Å
Shipping
Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetontrile, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

  1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.
  2. Polyproline-Rod Approach to Isolating Protein Targets of Bioactive Small Molecules: Isolation of a New Target of Indomethacin. Shin-ichi Sato, Youngjoo Kwon, Shinji Kamisuki, Neeta Srivastava, Quian Mao, Yoshinori Kawazoe, and Motonari Uesugi. J. Am. Chem. Soc. 2007, 129 (4), pp 873–880. January 4, 2007. DOI: 10.1021/ja0655643.
  3. Design and Synthesis of Multifunctional Gold Nanoparticles Bearing Tumor-Associated Glycopeptide Antigens as Potential Cancer Vaccines. Raymond P. Brinãs, Andreas Sundgren, Padmini Sahoo, Susan Morey, Kate Rittenhouse-Olson, Greg E. Wilding, Wei Deng, and Joseph J. Barchi, Jr. Bioconjugate Chem. 2012, 23 (8), pp 1513-1523. July 19, 2012. DOI: 10.1021/bc200606s.
  4. Mechanistic Studies of a Peptidic GRP78 Ligand for Cancer Cell-Specific Drug Delivery. Ying Liu, Sebastian C.J. Steiniger, YoungSoo Kim, Gunnar F. Kaufmann, Brunhilde Felding-Habermann, and Kim D. Janda. Molecular Pharmaceutics 2007 4(3) p 435-447. January 2007. DOI:10.1021/mp060122j.
  5. Multifunctional nanoparticles as simulants for a gravimetric Immunoassay. Scott A. Miller, Leslie A. Hiatt, Robert G. Keil, David W. Wright, and David E. Cliffel. Analytical and Bioanalytical Chemistry. 2011, 399 (3) pp 1021-1029 January 1, 2011. DOI:10.1007/s00216-010-4419-8.
  6. Evaluation of Phage Display Discovered Peptides as Ligands for Prostate-Specific Membrane Antigen (PSMA). Duanwen Shen, Fei Xie, W. Barry Edwards. PLoS ONE. 2013, 8 (7), pp e68339. July 25, 2013. DOI: 10.1371/journal.pone.0068339.
  7. A Systematic Analysis of Peptide Linker Length and Liposomal Polyethylene Glycol Coating on Cellular Uptake of Peptide-Targeted Liposomes. Jared F. Stefanick, Jonathan D. Ashley, Tanyel Kiziltepe, and Basar Bilgicer. ACS Nano. 2013, 7 (4) pp 2935–2947. February 19, 2013. DOI: 10.1021/nn305663e.
  8. Enhanced Cellular Uptake of Peptide-Targeted Nanoparticles through Increased Peptide Hydrophilicity and Optimized Ethylene Glycol Peptide-Linker Length. Jared F. Stefanick, Jonathan D. Ashley, and Basar Bilgicer. ACS Nano. 2013, 7 (9) pp 8115–8127. August 29, 2013. DOI: 10.1021/nn4033954.
  9. Novel Monodisperse PEGtide Dendrons: Design, Fabrication, and Evaluation of Mannose Receptor-Mediated Macrophage Targeting. Jieming Gao, Peiming Chen, Yashveer Singh, Xiaoping Zhang, Zoltan Szekely, Stanley Stein, and Patrick J. Sinko. Bioconjugate Chem. 2013, 24 (8) pp 1332–1344. June 29, 2013. DOI: 10.1021/bc400011v.
  10. B-Peptide Conjugates: Syntheses and CD and NMR Investigations of B/a-Chimeric Peptides, of a DPA-B-Decapeptide, and of a PEGylated b-Heptapeptide. James Gardiner, Raveendra I. Mathad, Berhard Jaun, Jurg V. Schreiber, Oliver Flogel, and Dieter Seebach. Helvetica Chimica Acta. 2009, 92 (12) pp 2698-2721. December 17, 2009. DOI: 10.1002/hlca.200900325.
  11. Immunomodulation of the NLRP3 Inflammasome through Structure-Based Activator Design and Functional Regulation via Lysosomal Rupture. Saikat Manna, William J. Howitz, Nathan J. Oldenhuis, Alexander C. Eldredge, Jingjing Shen, Fnu Naorem Nihesh, Melissa B. Lodoen, Zhibin Guan, and Aaron P. Esser-Kahn. ACS Central Science. 2018, 4, pp 982-995. July 2, 2018. DOI: 10.1021/acscentsci.8b00218.
  12. PEG-Peptide Conjugates. Ian W Hamley. Biomacromolecules. 2014. April 1, 2014. DOI: 10.1021/bm500246w.
  13. Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in Rodent Plasma and Its Effect on ADC Efficacy. Magdalena Dorywalska, Pavel Strop, Jody A. Melton-Witt, Adela Hasa-Moreno, Santiago E. Farias, Meritxell Galindo Casas, Kathy Delaria, Victor Lui, Kris Poulsen, Janette Sutton, Gary Bolton, Dahui Zhou, Ludivine Moine, Russell Dushin, Thomas-Jaume Pons, Arvind Rajpal. Plos One. 2015, 10 (7) e0132282. July 10, 2015. DOI: 10.1371/journal.pone.0132282.
  14. A Synthetic Virus-Like Particle Streptococcal Vaccine Candidate Using B-Cell Epitopes from the Proline-Rich Region of Pneumococcal Surface Protein A. Marco Tamborrini, Nina Geib, Aniebrys Marrero-Nodarse, Maja Jud, Julia Hauser, Celestine Aho, Araceli Lamelas, Armando Zuniga, Gerd Pluschke, Arin Ghasparian and John A. Robinson. Vaccines. 2015, 3 (4), pp 850-874, October 16, 2015. DOI: 10.3390/vaccines3040850.
  15. Nanoallergens: A multivalent platform for studying and evaluating potency of allergen epitopes in cellular degranulation. Peter E Deak, Maura R Vrabel, Vincenzo J Pizzuti, Tanyel Kiziltepe, and Basar Bilgicer. Experimental Biology and Medicine. 2016, 0 pp 1-11. April 13, 2016. DOI: 10.1177/1535370216644533.
  16. Control of strand registry by attachment of PEG chains to amyloid peptides influences nanostructure. Valeria Castelletto, Ge Cheng, Steve Furzeland, Derek Atkinsb and Ian W. Hamley. Soft matter. 2012, 8, pp 5434-5438. April 16, 2012. DOI:10.1039/C2SM25546D.
  17. Optimizing design parameters of a peptide targeted liposomal nanoparticle in an in vivo multiple myeloma disease model after initial evaluation in vitro. Jared F. Stefanick, David T. Omstead, Jonathan D. Ashley, Peter E. Deak, Nur Mustafaoglu, Tanyel Kiziltepe, Basar Bilgicer. Journal of Controlled Releases. 2019, 311-312 pp 190-200. August 29, 2019. https://doi.org/10.1016/j.jconrel.2019.08.033.
  18. Engineering peptide-targeted liposomal nanoparticles optimized for improved selectivity for HER2-positive breast cancer cells to achieve enhanced in vivo efficacy. Baksun Kim, Jaeho Shin, Junmin Wu, David T. Omstead, Tanyel Kiziltepe, Laurie E. Littlepage, Basar Bilgicer. Journal of Controlled Release. 2020. Volume 322, 10 June 2020, Pages 530-541. April 8, 2020. DOI: 10.1016/j.jconrel.2020.04.010
  19. High Density Display of an Anti-Angiogenic Peptide on Micelle Surfaces Enhances Their Inhibition of αvβ3 Integrin-Mediated Neovascularization In Vitro. Rajini Nagaraj, Trevor Stack, Sijia Yi, Benjamin Mathew, Kenneth R Shull, Evan A Scott, Mathew T Mathew and Divya Rani Bijukumar.Nanomaterials 2020, 10(3), 581;March 22, 2020. DOI: 10.3390/nano10030581
  20. Efficient capture of circulating tumor cells with low molecular weight folate receptor-specific ligands. Yingwen Hu, Danyang Chen, John V Napoleon, Madduri Srinivasarao, Sunil Singhal, Cagri A Savran, Philip S Low. Scientific Reports. 2022. May 20, 2022. https://doi.org/10.1038/s41598-022-12118-3

The post Fmoc-N-amido-dPEG®₆-acid appeared first on VectorLabs.

]]> Fmoc-N-amido-dPEG®₅-acid https://staging.vectorlabs.com/products/fmoc-n-amido-dpeg5-acid/ Sat, 24 Feb 2024 02:04:37 +0000 https://staging.vectorlabs.com/?post_type=product&p=34879 "Fmoc-N-amido-dPEG®5-acid, product number QBD-10053, is one of a broad line of products designed for use in peptide synthesis. The short (19 atoms), discrete PEG (dPEG®) spacer is functionalized with a propionic acid group on one end and Fmoc-protected amine on the other. The product can be added to the N-terminus of a growing peptide chain or to a primary-amine-functionalized side chain of an amino acid such as lysine. The dPEG®5 spacer imparts water solubility to the peptide to which it is conjugated.

QBD-10053 permits our customers to insert a dPEG® spacer into a peptide chain using familiar Fmoc chemistry using solid phase or solution phase chemistry. The dPEG® compound can be inserted at either end of the peptide chain or in the middle of two amino acid sequences to provide a flexible linker between distinct functional peptides. Additionally, the dPEG® spacer can be used to provide spacing in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® products means that the construct gains hydrodynamic volume and water solubility while remaining soluble in organic solvent. The Fmoc protecting group removes easily with a solution of piperidine in N,N-dimethylformamide (DMF)."

Specifications

Unit Size 1000 mg
Molecular Weight 531.59; single compound
Chemical formula C₂₈H₃₇NO₉
CAS
882847-32-7
Purity > 98%
Spacers
dPEG® Spacer is 19 atoms and 21.6 Å
Shipping
Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetontrile, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Fmoc-N-amido-dPEG®₅-acid appeared first on VectorLabs.

]]>

Description

Fmoc-N-amido-dPEG®5-acid, product number QBD-10053, is one of a broad line of products designed for use in peptide synthesis. The short (19 atoms), discrete PEG (dPEG®) spacer is functionalized with a propionic acid group on one end and Fmoc-protected amine on the other. The product can be added to the N-terminus of a growing peptide chain or to a primary-amine-functionalized side chain of an amino acid such as lysine. The dPEG®5 spacer imparts water solubility to the peptide to which it is conjugated.

QBD-10053 permits our customers to insert a dPEG® spacer into a peptide chain using familiar Fmoc chemistry using solid phase or solution phase chemistry. The dPEG® compound can be inserted at either end of the peptide chain or in the middle of two amino acid sequences to provide a flexible linker between distinct functional peptides. Additionally, the dPEG® spacer can be used to provide spacing in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® products means that the construct gains hydrodynamic volume and water solubility while remaining soluble in organic solvent. The Fmoc protecting group removes easily with a solution of piperidine in N,N-dimethylformamide (DMF).

Specifications

Unit Size 1000 mg
Molecular Weight 531.59; single compound
Chemical formula C₂₈H₃₇NO₉
CAS
882847-32-7
Purity > 98%
Spacers
dPEG® Spacer is 19 atoms and 21.6 Å
Shipping
Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetontrile, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

  1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

  2. Design of a modular tetrameric scaffold for the synthesis of membrane-localized D-peptide inhibitors of HIV-1 entry. J. Nicholas Francis, Joseph S Redman, Debra M Eckert, and Michael S. Kay. Bioconjugate Chemistry. 2012, 23 (6), pp 1252-1258. May 1, 2012. DOI: 10.1021/bc300076f.

  3. Enhanced Cellular Uptake of Peptide-Targeted Nanoparticles through Increased Peptide Hydrophilicity and Optimized Ethylene Glycol Peptide-Linker Length. Jared F. Stefanick, Jonathan D. Ashley, and Basar Bilgicer. ACS Nano. 2013, 7 (9) pp 8115–8127. August 29, 2013. DOI: 10.1021/nn4033954.

The post Fmoc-N-amido-dPEG®₅-acid appeared first on VectorLabs.

]]> Fmoc-N-amido-dPEG®₃-acid https://staging.vectorlabs.com/products/fmoc-n-amido-dpeg3-acid/ Sat, 24 Feb 2024 02:04:33 +0000 https://staging.vectorlabs.com/?post_type=product&p=34839 Description

Fmoc-N-amido-dPEG®3-acid, product number QBD-10033, is one of a broad line of products designed for use in peptide synthesis. The short (13 atoms), discrete PEG (dPEG®) spacer is functionalized with a propionic acid group on one end and Fmoc-protected amine on the other. The product can be added to the N-terminus of a growing peptide chain or to a primary-amine-functionalized side chain of an amino acid such as lysine. The dPEG®3 spacer imparts water solubility to the peptide to which it is conjugated.

QBD-10033 permits our customers to insert a dPEG® spacer into a peptide chain using familiar Fmoc chemistry using solid phase or solution phase chemistry. The dPEG® compound can be inserted at either end of the peptide chain or in the middle of two amino acid sequences to provide a flexible linker between distinct functional peptides. Additionally, the dPEG® spacer can be used to provide spacing in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® products means that the construct gains hydrodynamic volume and water solubility while remaining soluble in organic solvent. The Fmoc protecting group removes easily with a solution of piperidine in N,N-dimethylformamide (DMF).

Specifications

Unit Size 1000 mg
Molecular Weight 443.49; single compound
Chemical formula C₂₄H₂₉NO₇
CAS
867062-95-1
Purity > 98%
Spacers
dPEG® Spacer is 13 atoms and 14.4 Å
Shipping
Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetontrile, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Fmoc-N-amido-dPEG®₃-acid appeared first on VectorLabs.

]]>

Description

Fmoc-N-amido-dPEG®3-acid, product number QBD-10033, is one of a broad line of products designed for use in peptide synthesis. The short (13 atoms), discrete PEG (dPEG®) spacer is functionalized with a propionic acid group on one end and Fmoc-protected amine on the other. The product can be added to the N-terminus of a growing peptide chain or to a primary-amine-functionalized side chain of an amino acid such as lysine. The dPEG®3 spacer imparts water solubility to the peptide to which it is conjugated.

QBD-10033 permits our customers to insert a dPEG® spacer into a peptide chain using familiar Fmoc chemistry using solid phase or solution phase chemistry. The dPEG® compound can be inserted at either end of the peptide chain or in the middle of two amino acid sequences to provide a flexible linker between distinct functional peptides. Additionally, the dPEG® spacer can be used to provide spacing in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® products means that the construct gains hydrodynamic volume and water solubility while remaining soluble in organic solvent. The Fmoc protecting group removes easily with a solution of piperidine in N,N-dimethylformamide (DMF).

Specifications

Unit Size 1000 mg
Molecular Weight 443.49; single compound
Chemical formula C₂₄H₂₉NO₇
CAS
867062-95-1
Purity > 98%
Spacers
dPEG® Spacer is 13 atoms and 14.4 Å
Shipping
Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetontrile, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

  1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

  2. Trivalent PEGylated Platform for the Conjugation of Bioactive Compounds. Angela Torres, Carlos Mas-Moruno, Enrique Perez-Paya, Fernando Albericio, and Miriam Royo. Bioconjugate Chem. 2011, 22 (10), pp 2172–2178. August 25, 2011. DOI: 10.1021/bc100393g.

  3. Development of Peptide Nucleic Acid Probes for Detection of the HER2 Oncogene. Belhu Metaferia., Jun S. Wei., Young K. Song, Jennifer Evangelista, Konrad Aschenbach, Peter Johansson, Xinyu Wen, Qingrong Chen, Albert Lee, Heidi Hempel, Jinesh S. Gheeya, Stephanie Getty, Romel Gomez, Javed Khan. PLoS ONE. 2012, 8 (4) e58870. April 10, 2013. DOI: 10.1371/journal.pone.0058870.

  4. Enhanced Cellular Uptake of Peptide-Targeted Nanoparticles through Increased Peptide Hydrophilicity and Optimized Ethylene Glycol Peptide-Linker Length. Jared F. Stefanick, Jonathan D. Ashley, and Basar Bilgicer. ACS Nano. 2013, 7 (9) pp 8115–8127. August 29, 2013. DOI: 10.1021/nn4033954.

  5. Quantifying Cellular Internalization with a Fluorescent Click Sensor. Laura I. Selby, Luigi Aurelio, Daniel Yuen, Bim Graham, and Angus P. R. Johnston. ACS Sensors. 2018, 3, pp 1182-1189. April 20, 2018. DOI: 10.1021/acssensors.8b00219.

  6. Fc-Binding Antibody-Recruiting Molecules Targeting Prostate-Specific Membrane Antigen: Defucosylation of Antibody for Efficacy Improvement. Sasaki K, Harada M, Yoshikawa T, Tagawa H, Harada Y, Yonemitsu Y, Ryujin T, Kishimura A, Mori T, Katayama Y. Preprint from ChemRxiv, 14 Jul 2020
    DOI: 10.26434/chemrxiv.12654602.v1 PPR: PPR187646

  7. Peptide Amphiphilic-Based Supramolecular Structures with Anti-HIV-1 Activity. Gómara Elena, María José, Pons Pons, Ramon; Herrera, Carolina, Ziprin, Paul, Haro Villar, Isabel Haro. Bioconjugate Chemistry. 2021. Volume 32, Issue 9. 07/13/2021. DOI: 10.1021/acs.bioconjchem.1c00292

The post Fmoc-N-amido-dPEG®₃-acid appeared first on VectorLabs.

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