3 EO – VectorLabs https://staging.vectorlabs.com From linker design and synthesis, bioconjugated design and manufacturing, biomolecule labeling and functionalization, and detection system and solutions, our team is here to help you move forward, with impact. Wed, 22 Oct 2025 17:20:50 +0000 en-US hourly 1 https://wordpress.org/?v=6.9 https://staging.vectorlabs.com/wp-content/uploads/2024/11/V-favicon-02-100x100.png 3 EO – VectorLabs https://staging.vectorlabs.com 32 32 Bromoacetamido-dPEG®₃-azide https://staging.vectorlabs.com/products/bromoacetamido-dpeg3-azide/ Sat, 24 Feb 2024 02:15:21 +0000 https://staging.vectorlabs.com/?post_type=product&p=39306 Bromoacetamido-dPEG®3-azide, product number QBD-11217, is discrete PEG (dPEG®) crosslinker that facilitates the crosslinking of free thiols with click chemistry alkyne partners across a short (16 atoms, 17.5 Å) single molecular weight PEG bridge.

The short, amphiphilic dPEG® linker adds hydrodynamic volume to conjugate molecules and increases their water solubility. The flexible, non-immunogenic spacer can reduce or eliminate renal clearance and help shield conjugates from opsonization through the increased hydrodynamic volume the dPEG® linker imparts.

The bromoacetate moiety reacts chemoselectively with free thiols at pH >8.0. It is an alternative to the maleimide group and is used in situations where the target molecule needs to be at a high pH. The azide group reacts with a suitable alkyne partner via metal-catalyzed (Cu, Ru) or strain-promoted (copper-free) click chemistry. Moreover, Bromoacetamido-dPEG®3-azide is stable, unlike MAL-PEG-azide constructs, which are somewhat unstable.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 339.19; single compound
Chemical formula C₁₀H₁₉BrN₄O₄
CAS N/A
Purity > 98%
Spacers dPEG® Spacer is 16 atoms and 17.5 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene Chloride, Methanol, Acetone, Acetonitrile, DMF, or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

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Description

Bromoacetamido-dPEG®3-azide, product number QBD-11217, is discrete PEG (dPEG®) crosslinker that facilitates the crosslinking of free thiols with click chemistry alkyne partners across a short (16 atoms, 17.5 Å) single molecular weight PEG bridge.

The short, amphiphilic dPEG® linker adds hydrodynamic volume to conjugate molecules and increases their water solubility. The flexible, non-immunogenic spacer can reduce or eliminate renal clearance and help shield conjugates from opsonization through the increased hydrodynamic volume the dPEG® linker imparts.

The bromoacetate moiety reacts chemoselectively with free thiols at pH >8.0. It is an alternative to the maleimide group and is used in situations where the target molecule needs to be at a high pH. The azide group reacts with a suitable alkyne partner via metal-catalyzed (Cu, Ru) or strain-promoted (copper-free) click chemistry. Moreover, Bromoacetamido-dPEG®3-azide is stable, unlike MAL-PEG-azide constructs, which are somewhat unstable.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight339.19; single compound
Chemical formulaC₁₀H₁₉BrN₄O₄
CASN/A
Purity> 98%
SpacersdPEG® Spacer is 16 atoms and 17.5 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene Chloride, Methanol, Acetone, Acetonitrile, DMF, or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

The post Bromoacetamido-dPEG®₃-azide appeared first on VectorLabs.

]]> MAL-dPEG®₃-Lipoamide https://staging.vectorlabs.com/products/mal-dpeg3-lipoamide/ Sat, 24 Feb 2024 02:13:20 +0000 https://staging.vectorlabs.com/?post_type=product&p=36949 MAL-dPEG®3-Lipoamide, product number 10817, is a heterobifunctional crosslinker functionalized with a maleimidopropyl group and a lipoic acid moiety on opposite ends of a short (27 atoms, 31.1 Å), single molecular weight, discrete PEG (dPEG®) crosslinker. The lipoic acid moiety forms dative bonds with gold, silver, and other metals and can be used to coat or passivate metal surfaces. The maleimide group forms stable thioether bonds with free thiols and can be used to immobilize a sulfhydryl-containing biomolecule such as a peptide or antibody fragment to a metal surface through the dPEG®-lipoamide linkage. The flexible, non-immunogenic, hydrophilic dPEG® linker adds water solubility and increases the conjugate's hydrodynamic volume.

Specifications

Unit Size 100mg, 1000mg
Molecular Weight 559.74; single compound
Chemical formula C₂₅H₄₁N₃O₇S₂
CAS 1334172-72-3
Purity > 98%
Spacers dPEG® Spacer is 27 atoms and 31.1 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, DMA or DMSO. Limited solubility in acetonitrile.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post MAL-dPEG®₃-Lipoamide appeared first on VectorLabs.

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Description

MAL-dPEG®3-Lipoamide, product number 10817, is a heterobifunctional crosslinker functionalized with a maleimidopropyl group and a lipoic acid moiety on opposite ends of a short (27 atoms, 31.1 Å), single molecular weight, discrete PEG (dPEG®) crosslinker. The lipoic acid moiety forms dative bonds with gold, silver, and other metals and can be used to coat or passivate metal surfaces. The maleimide group forms stable thioether bonds with free thiols and can be used to immobilize a sulfhydryl-containing biomolecule such as a peptide or antibody fragment to a metal surface through the dPEG®-lipoamide linkage. The flexible, non-immunogenic, hydrophilic dPEG® linker adds water solubility and increases the conjugate’s hydrodynamic volume.

Specifications

Unit Size100mg, 1000mg
Molecular Weight559.74; single compound
Chemical formulaC₂₅H₄₁N₃O₇S₂
CAS1334172-72-3
Purity> 98%
SpacersdPEG® Spacer is 27 atoms and 31.1 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, DMA or DMSO. Limited solubility in acetonitrile.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0), pp. 188-190, 458-497, 924-935.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Focal adhesion regulation through microcontact printing of protein nanoparticles on self-assembled monolayers for cell guidance. Albert Martinez Moreno. DUGiDocs. 2016, June 1, 2016. DOI: http://hdl.handle.net/10256/12960.

The post MAL-dPEG®₃-Lipoamide appeared first on VectorLabs.

]]> Bis-dPEG®₃-NHS ester https://staging.vectorlabs.com/products/bis-dpeg3-nhs-ester/ Sat, 24 Feb 2024 02:12:06 +0000 https://staging.vectorlabs.com/?post_type=product&p=36720 Bis-dPEG®3-NHS ester, product number QBD-10726, is a homobifunctional, amine-reactive, crosslinking reagent. Each end of the short (13 atoms, 14.6 Å), single molecular weight, discrete PEG (dPEG®) linker is functionalized as the N-hydroxysuccinimidyl (NHS) ester of a propionic acid group. The optimal pH range for reacting the end groups is 7.0 - 7.5. The product is soluble in water and many organic solvents; however, in water, it hydrolyzes rapidly. Therefore, we advise against storing aqueous stock solutions of this product. Rather, unused material in aqueous media should be discarded promptly.

Specifications

Unit Size 100mg, 1000mg
Molecular Weight 444.39; single compound
Chemical formula C₁₈H₂₄N₂O₁₁
CAS 1314378-16-9
Purity > 98%
Spacers dPEG® Spacer is 13 atoms and 14.6 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetonitrile, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Bis-dPEG®₃-NHS ester appeared first on VectorLabs.

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Description

Bis-dPEG®3-NHS ester, product number QBD-10726, is a homobifunctional, amine-reactive, crosslinking reagent. Each end of the short (13 atoms, 14.6 Å), single molecular weight, discrete PEG (dPEG®) linker is functionalized as the N-hydroxysuccinimidyl (NHS) ester of a propionic acid group. The optimal pH range for reacting the end groups is 7.0 – 7.5. The product is soluble in water and many organic solvents; however, in water, it hydrolyzes rapidly. Therefore, we advise against storing aqueous stock solutions of this product. Rather, unused material in aqueous media should be discarded promptly.

Specifications

Unit Size100mg, 1000mg
Molecular Weight444.39; single compound
Chemical formulaC₁₈H₂₄N₂O₁₁
CAS1314378-16-9
Purity> 98%
SpacersdPEG® Spacer is 13 atoms and 14.6 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

The post Bis-dPEG®₃-NHS ester appeared first on VectorLabs.

]]> Azido-dPEG®₃-amine https://staging.vectorlabs.com/products/azido-dpeg3-amine/ Sat, 24 Feb 2024 02:11:17 +0000 https://staging.vectorlabs.com/?post_type=product&p=36297 Azido-dPEG®3-amine, product number QBD-10522, is a carbonyl-reactive, biocompatible crosslinking reagent that can participate in multiple types of reactions. The product consists of an azide group and an amine group on opposite ends of a single molecular weight, discrete polyethylene glycol (dPEG®) chain. Alkynes react with the azido group in metal-catalyzed or strain-promoted click chemistry to yield triazole derivatives. Moreover, the azide group functions as a masked amine that reduces to a primary amine via a suitable reducing agent. Furthermore, Azido-dPEG®3-amine can participate in a Staudinger ligation with appropriate phosphine derivatives to create a water-soluble product.

Several patents and scientific publications specifically cite the use of Azido-dPEG®3-amine. The amphiphilic dPEG® product adds hydrodynamic volume and imparts water solubility to any compound to which it is conjugated. Also, because the terminal azide group functions in multiple different types of reactions, Azido-dPEG®3-amine can act as either a heterobifunctional, click chemistry crosslinker or a monoprotected homobifunctional crosslinking reagent.

The published uses of Azido-dPEG®3-amine include the following:
Detection of SK2 Channels on Hippocampal Neurons
Preparation of probes uses to study sickle cell disease;
Construction of tunable supramolecular assemblies;
Development of a long-acting drug-delivery system of the peptidic somatostatin agonist octreotide; and,
Design and application of a biotinylated probe of calenduloside E.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 218.25; single compound
Chemical formula C₈H₁₈N₄O₃
CAS 134179-38-7
Purity > 98%
Spacers dPEG® Spacer is 14 atoms and 15.4 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetonitrile, DMAC, or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Azido-dPEG®₃-amine appeared first on VectorLabs.

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Description

Azido-dPEG®3-amine, product number QBD-10522, is a carbonyl-reactive, biocompatible crosslinking reagent that can participate in multiple types of reactions. The product consists of an azide group and an amine group on opposite ends of a single molecular weight, discrete polyethylene glycol (dPEG®) chain. Alkynes react with the azido group in metal-catalyzed or strain-promoted click chemistry to yield triazole derivatives. Moreover, the azide group functions as a masked amine that reduces to a primary amine via a suitable reducing agent. Furthermore, Azido-dPEG®3-amine can participate in a Staudinger ligation with appropriate phosphine derivatives to create a water-soluble product.

Several patents and scientific publications specifically cite the use of Azido-dPEG®3-amine. The amphiphilic dPEG® product adds hydrodynamic volume and imparts water solubility to any compound to which it is conjugated. Also, because the terminal azide group functions in multiple different types of reactions, Azido-dPEG®3-amine can act as either a heterobifunctional, click chemistry crosslinker or a monoprotected homobifunctional crosslinking reagent.

The published uses of Azido-dPEG®3-amine include the following:
Detection of SK2 Channels on Hippocampal Neurons
Preparation of probes uses to study sickle cell disease;
Construction of tunable supramolecular assemblies;
Development of a long-acting drug-delivery system of the peptidic somatostatin agonist octreotide; and,
Design and application of a biotinylated probe of calenduloside E.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight218.25; single compound
Chemical formulaC₈H₁₈N₄O₃
CAS134179-38-7
Purity> 98%
SpacersdPEG® Spacer is 14 atoms and 15.4 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC, or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Detection of SK2 Channels on Hippocampal Neurons. Jamie L. Maciaszek University of Connecticut (2012) DigitalCommons@Uconn Master’s Theses Paper 237 April 20, 2012. http://digitalcommons.uconn.edu/gs_theses/237.

Epinephrine Modulates BCAM/Lu and ICAM-4 Expression on the Sickle Cell Trait Red Blood Cell Membrane. Jamie L. Maciaszek, Biree Andemariam, Greg Huber, and George Lykotrafitis. Biophysical Journal. 2012, 102 pp 1137–1143. January 27, 2012. DOI: 10.1016/j.bpj.2012.01.050.

Subcutaneously Administered Self-Cleaving Hydrogel-Octreotide Conjugates Provide Very Long-Acting Octreotide. Eric L. Schneider, Jeff Henise, Ralph Reid, Gary W. Ashley, and Daniel V. Santi. Bioconjugate Chemistry. 2016, June 2, 2016. DOI: 10.1021/acs.bioconjchem.6b00188.

The proteomic profiling of calenduloside E targets in HUVEC: design, synthesis and application of biotinylated probe BCEA. Yu Tian, Shan Wang, Hai Shang, Min Wang, Guibo Sun, Xudong Xu, and Xiaobo Sun. Royal Society of Chemistry. 2017, 7, pp 6259-6265. January 18, 2017. DOI: 10.1039/c6ra25572h.

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]]> CBZ-N-amido-dPEG®₃-amine https://staging.vectorlabs.com/products/cbz-n-amido-dpeg3-amine/ Sat, 24 Feb 2024 02:07:51 +0000 https://staging.vectorlabs.com/?post_type=product&p=35684 CBZ-N-amido-dPEG®₃-amine, product number QBD-10269 is a monoprotected, homobifunctional, carbonyl-reactive crosslinker. It is useful for joining two aldehydes, carboxylic acids, or active esters across a short, discrete PEG linker. The CBZ protecting group can be removed easily using hydrogen and palladium. Care should be taken to prevent or minimize exposure to air because the free amine oxidizes readily.

Specifications

Unit Size 1000 mg
Molecular Weight 354.44; single compound
Chemical formula C₁₈H₃₀N₂O₅
CAS 220156-99-0
Purity > 98%
Spacers dPEG® Spacer is 15 atoms and 16.9 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, DMAC, DMSO or water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

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Description

CBZ-N-amido-dPEG®₃-amine, product number QBD-10269 is a monoprotected, homobifunctional, carbonyl-reactive crosslinker. It is useful for joining two aldehydes, carboxylic acids, or active esters across a short, discrete PEG linker. The CBZ protecting group can be removed easily using hydrogen and palladium. Care should be taken to prevent or minimize exposure to air because the free amine oxidizes readily.

Specifications

Unit Size1000 mg
Molecular Weight354.44; single compound
Chemical formulaC₁₈H₃₀N₂O₅
CAS220156-99-0
Purity> 98%
SpacersdPEG® Spacer is 15 atoms and 16.9 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, DMAC, DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

The post CBZ-N-amido-dPEG®₃-amine appeared first on VectorLabs.

]]> t-boc-N-amido-dPEG®₃-amine https://staging.vectorlabs.com/products/t-boc-n-amido-dpeg3-amine/ Sat, 24 Feb 2024 02:07:23 +0000 https://staging.vectorlabs.com/?post_type=product&p=35497 t-boc-N-amido-dPEG®3-amine, product number QBD-10225, is a monoprotected, diamine-functionalized, homobifunctional crosslinking PEGylation reagent containing a short, single molecular weight PEG linker. One of the two primary carboxylate-reactive groups is protected as a tert-butyl carbamate. Both ends of the molecule react with carboxylic acids, aldehydes, and ketones. Carboxylic acids react with this product to form amide bonds, while reactions with aldehydes and ketones form Schiff bases that are reducible to secondary amines. The mono-protected end of the molecule gives the user tighter control over crosslinking.

Specifications

Unit Size 1000 mg
Molecular Weight 320.42; single compound
Chemical formula C₁₅H₃₂N₂O₅
CAS 194920-62-2
Purity > 98%
Spacers dPEG® Spacer is 15 atoms and 16.9 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetonitrile, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

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Description

t-boc-N-amido-dPEG®3-amine, product number QBD-10225, is a monoprotected, diamine-functionalized, homobifunctional crosslinking PEGylation reagent containing a short, single molecular weight PEG linker. One of the two primary carboxylate-reactive groups is protected as a tert-butyl carbamate. Both ends of the molecule react with carboxylic acids, aldehydes, and ketones. Carboxylic acids react with this product to form amide bonds, while reactions with aldehydes and ketones form Schiff bases that are reducible to secondary amines. The mono-protected end of the molecule gives the user tighter control over crosslinking.

Specifications

Unit Size1000 mg
Molecular Weight320.42; single compound
Chemical formulaC₁₅H₃₂N₂O₅
CAS194920-62-2
Purity> 98%
SpacersdPEG® Spacer is 15 atoms and 16.9 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Design and Synthesis of Bis-Biotin-Containing Reagents for Applications Utilizing Monoclonal Antibody-Based Pretargeting system with Streptavidin Mutants, D. Scott Wibur, Steven I. Park, Ming-Kuan Chyan, Feng Wan, Donald K. Hamlin, Jaideep Shenoi, Yukang Lin, Shani M. Wilbur, Franz Buchegger, Anastasia Pantelias, John M. Pagel, and Oliver W. Press. Bioconjugate Chem. 2010, 21 (7), pp 1225–1238. July 2, 2010. DOI: 10.1021/bc100030q.

Novel Nanoassemblies Composed of Squfalenoyl—Paclitaxel Derivatives: Synthesis, Characterization, and Biological Evaluation, Franco Dosio, L. Harivardhan Reddy, Annalisa Ferrero, Barbara Stella, Luigi Cattel, and Patrick Couvreur. Bioconjugate Chem. 2010, 21 (7), pp 1349–1361. July 2, 2010. DOI: 10.1021/bc100154g.

A continuous fluorescence displacement assay for BioA: An enzyme involved in biotin biosynthesis. Daniel J. Wilson, Ce Shi, Benjamin P. Duckworth, Joseph M. Muretta, Ujjini Manjunatha, Yuk Y. Sham, David D. Thomas, and Courtney C. Aldrich. Analytical Biochemistry. 2011, 416 (1) pp 27-38. September 2011. DOI:10.1016/j.ab.2011.05.003.

Thiol-Mediated Anchoring of Ligands to Self-Assembled Monolayers for Studies of Biospecific Interactions. Kunal V. Gujraty, Randolph Ashton, Sridhar R. Bethi, Sandesh Kate, Christopher J. Faulkner, G. Kane Jennings, and Ravi S. Kane. Langmuir. 2006, 22 (24) pp 10157–10162. October 19, 2006.DOI: 10.1021/la0621463.

Design, Synthesis, and Validation of a Branched Flexible Linker for Bioactive Peptides. Martina E. Bowen, Yasunari Monguchi, Rajesh Sankaranarayanan, Josef Vagner, Lucinda J. Begay, Liping Xu, Bhumasamudram Jagadish, Victor J. Hruby, Robert J. Gillies, and Eugene A. Mash. J. Org. Chem. 2007, 72 (5) pp 1675–1680. February 6, 2007. DOI: 10.1021/jo062276g.

Time-resolved fluorescence resonance energy transfer and surface plasmon resonance-based assays for retinoid and transthyretin binding to retinol-binding protein 4. Orzala Sharif, Huiyong Hu, Heath Klock, Eric N. Hampton, Edward Nigoghossian, Mark W. Knuth, Jason Matzen, Paul Anderson, Richard Trager, Tetsuo Uno, Richard J. Glynne, Sassan M. Azarian, Jeremy S. Caldwell , Achim Brinker. Analytical Biochemistry. 2009, 392, (2) PP 162–168. September 15 , 2009. doi.org/10.1016/j.ab.2009.05.038.

Compact Biocompatible Quantum Dots via RAFT-Mediated Synthesis of Imidazole-Based Random Copolymer Ligand. Wenhao Liu, Andrew B. Greytak, Jungmin Lee, Cliff R. Wong, Jongnam Park, Lisa F. Marshall, Wen Jiang, Peter N. Curtin, Alice Y. Ting, Daniel G. Nocera, Dai Fukumura, Rakesh K. Jain and Moungi G. Bawendi. J. Am. Chem. Soc. 2010, 132 (2) pp 472–483. December 21, 2009. DOI: 10.1021/ja908137d.

The post t-boc-N-amido-dPEG®₃-amine appeared first on VectorLabs.

]]> Bis-MAL-dPEG®₃ https://staging.vectorlabs.com/products/bis-mal-dpeg3/ Sat, 24 Feb 2024 02:07:14 +0000 https://staging.vectorlabs.com/?post_type=product&p=35441 "Bis-MAL-dPEG®3, product number QBD-10215, is a short, homobifunctional, crosslinking reagent that links two molecules (e.g., peptides, proteins) together via the thiol-maleimide reaction (also known as the thiol-Michael addition). Maleimidopropionate groups functionalize each end of the molecule. A single molecular weight, discrete polyethylene glycol (dPEG®) spacer separates the two end groups.

The thiol-maleimide reaction, a type of click chemistry reaction, is a popular way to conjugate molecules. The maleimide functional group rapidly reacts with sulfhydryl groups, and the reaction is chemoselective for sulfhydryls in the pH range of 6.5 – 7.5. The discrete chain length polyethylene glycol (dPEG®) spacer between the two maleimide groups is a single molecular weight compound. Applications for this product include mapping which proteins in a complex are close together; determining ligand-receptor binding relationships; and construction of antibody-drug conjugates (ADCs), among many others."

Specifications

Unit Size 50 mg, 1000 mg
Molecular Weight 522.55; single compound
Chemical formula C₂₄H₃₄N₄O₉
CAS 756525-99-2
Purity > 98%
Spacers dPEG® Spacer is 28 atoms and 30 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

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Description

Bis-MAL-dPEG®3, product number QBD-10215, is a short, homobifunctional, crosslinking reagent that links two molecules (e.g., peptides, proteins) together via the thiol-maleimide reaction (also known as the thiol-Michael addition). Maleimidopropionate groups functionalize each end of the molecule. A single molecular weight, discrete polyethylene glycol (dPEG®) spacer separates the two end groups.

The thiol-maleimide reaction, a type of click chemistry reaction, is a popular way to conjugate molecules. The maleimide functional group rapidly reacts with sulfhydryl groups, and the reaction is chemoselective for sulfhydryls in the pH range of 6.5 – 7.5. The discrete chain length polyethylene glycol (dPEG®) spacer between the two maleimide groups is a single molecular weight compound. Applications for this product include mapping which proteins in a complex are close together; determining ligand-receptor binding relationships; and construction of antibody-drug conjugates (ADCs), among many others.

Specifications

Unit Size50 mg, 1000 mg
Molecular Weight522.55; single compound
Chemical formulaC₂₄H₃₄N₄O₉
CAS756525-99-2
Purity> 98%
SpacersdPEG® Spacer is 28 atoms and 30 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, DMAC or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Backbone Degradable Multiblock N-(2-Hydroxypropyl)methacrylamide Copolymer Conjugates via Reversible Addition Fragmentation Chain Transfer Polymerization and Thiol-ene Coupling Reaction. Huaizhong Pan, Jiyuan Yang, Pavla Kopečková, and Jindřich Kopeček. Biomacromolecules. 2011, 12 (1) pp 247–252. January 10, 2011. DOI:10.1021/bm101254e.

Quantitative evaluation of the lengths of homobifunctional protein cross-linking reagents used as molecular rulers. NORA S. GREEN, EMIL REISLER, K.N. HOUK. Protein Science. 2001, 10 (7) pp 1293-1304. March 23, 2010. DOI: 10.1101/ps.51201.

Effects of modification at the fifth residue of l-conotoxin GIIIA with bulky tags on the electrically
stimulated contraction of the rat diaphragm. M. Nakamura, Y. Oba, H. Nakamura, Y. Ishida, T. Kohno, K. Sato. Journal Peptide Res. 2004, 64 (3) pp 110-117. May 30, 2004. DOI: 10.1111/j.1399-3011.2004.00175.x.

A Divalent Immunotoxin Formed by the Disulfide Bond between Hinge Regions of Fab Domain. SeongHyeok Choi, JiEun Kim, YongChan Lee, Young-Ju Jang, Ira Pastan, MuHyeon Choe. Bull Korean Chem.Soc. 2001, 22 (12) pp 1361-1365. September 3, 2001. DOI: www.pdf.lookchem.com/pdf/32/77fb36ea-eea2-4741-a825-b3234cd24299.pdf.

Mapping Protein-Protein Interactions between MutL and MutH by crosslinking. Luis Giron-Monzon, Laura Manelyte, Robert Ahrends, Dieter Kirsch, Bernhard Spengler, and Peter Friedhoff. J. Biol. Chem. 2004, 279 ( 47) pp 49338-49345. September 14, 2004. DOI: 10.1074/jbc.M409307200.

SWI/SNF- and RSC-Catalyzed Nucleosome Mobilization Requires Internal DNA Loop Translocation within Nucleosomes. Ning Liu, Craig L. Peterson and Jeffrey J. Hayes. Molecular and Cellular Biology. 2011, 31 (20), pp 4165-4177. August 22, 2011. DOI: 10.1128/MCB.05605-11.

Mitotic Spindle Assembly around RCC1-Coated Beads in Xenopus Egg Extracts. David Halpin, Petr Kalab, Jay Wang, Karsten Weis, Rebecca Heald. PLoS Bio. 2011, 9 (12) pp e1001225. December 27, 2011. DOI: 10.1371/journal.pbio.1001225.

Chemical Trapping of the Dynamic MutS-MutL Complex Formed in DNA Mismatch Repair in Escherichia coli. Ines Winkler, Andreas D. Marx, Damien Lariviere, Roger J. Heinze, Michele Cristovao, Annet Reumer, Ute Curth, Titia K. Sixma, and Peter Friedhoff. JBC. 2011, 286 (19) pp 17326–17337. May 13, 2011. DOI:10.1074/jbc.M110.187641.

Functional Characterization of Rhodopsin Monomers and Dimers in Detergents. Beata Jastrzebska, Tadao Maeda, Li Zhu, Dimitrios Fotiadis, Slawomir Filipek, Andreas Engel, Ronald E. Stenkamp, and Krzysztof Palczewskia. JBC. 2004, 279 (52) pp 54663-54675. December 24, 2004. DOI: 10.1074/jbc.M408691200.

Enhanced Fluorescence resonance energy transfer immunoassay with improved sensitivity based on the Fab’-based immunoconjugates. Yoshiyuki Ohiro, Hiroshi Ueda, Norio Shibata, Teruyuki Nagamune. Analytical Biochemistry. 2007, 360 (2) pp 266-272. January 15, 2007. DOI:10.1016/j.ab.2006.10.025.

Purification, characterization and cloning of a ricin B-like lectin from mushroom Clitocybe nebularis with antiproliferative activity against human leukemic T cells. Jure Pohleven, Nataša Obermajer, Jerica Sabotič, Sabina Anžlovar, Kristina Sepčić, Janko Kos , Bogdan Kralj, Borut Štrukelj, Jože Brzin. Biochimica et Biophysica Acta (BBA) – General Subjects. 2009, 1790 (3) pp 173-181. December 8, 2008. DOI: 10.1016/j.bbagen.2008.11.006.

Development of a homogeneous competitive immunoassay for phosphorylated protein antigen based on the enhanced fluorescence resonance energy transfer technology. Yoshiyuki Ohiro,1,⁎ Hiroshi Ueda,2,3 Norio Shibata,1 and Teruyuki Nagamune. Journal of Bioscience and Bioengineering. 2010, 109 (1), pp 15–19. July 29, 2009. DOI: 10.1016/j.jbiosc.2009.07.004.

Analysis of the Quaternary Structure of the MutL C-terminal Domain. Jan Kosinski, Ina Steindorf, Janusz M. Bujnicki, Luis Giron-Monzon and Peter Friedhoff. Journal of Molecular Biology. 2005, 351 (4) pp 895-909. August 26, 2005. DOI: 10.1016/j.jmb.2005.06.044.

X-ray Photoelectron Spectroscopy and Differential Capacitance Study of Thiol-Functional Polysiloxane Films on Gold Supports. Patrick A. Johnson and Rastislav Levicky. Langmuir. 2004, 20 (22) pp 9621-9627. September 28, 2004. DOI: 10.1021/la048458s.

Polymercaptosiloxane Anchor Films for Robust Immobilization of Biomolecules to Gold Supports. Patrick A. Johnson and Rastislav Levicky. Langmuir . 2003, 19 (24) pp10288-10294. October 30, 2003. DOI: 10.1021/la035102s.

X-ray photoelectron spectroscopy and infrared spectroscopy study of maleimide-activated supports for immobilization of oligodeoxyribonucleotides. Gang Shen, Maria Francis G. Anand and Rastislav Levicky. Nucleic Acids Research. 2004, 32 (20) pp 5973-5980. November 10, 2004. DOI: 10.1093/nar/gkh932.

Disulfide Sensitivity in the Env Protein Underlies Lytic Inactivation of HIV-1 by Peptide Triazole Thiols. Lauren D. Bailey, Ramalingam Venkat Kalyana Sundaram, Huiyuan Li, Caitlin Duffy, Rachna Aneja, Arangassery Rosemary Bastian, Andrew P. Holmes, Kantharaju Kamanna, Adel A. Rashad and Irwin Chaiken. ACS Chemical Biology. 2015, October 12, 2015. DOI: 10.1021/acschembio.5b00381.

In vivo mapping of a dynamic ribonucleoprotein granule interactome in early Drosophila embryos. Jimiao Zheng, Ming Gao, Nhan Huynh, Samuel J. Tindell, Hieu D. L. Vo, W. Hayes McDonald, and Alexey L. Arkov. Febs Open Bio. 2016, pp 1-9. October 3, 2016. DOI: 10.1002/2211-5463.12144.

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]]> Fmoc-N-amido-dPEG®₃-acid https://staging.vectorlabs.com/products/fmoc-n-amido-dpeg3-acid/ Sat, 24 Feb 2024 02:04:33 +0000 https://staging.vectorlabs.com/?post_type=product&p=34839 Description

Fmoc-N-amido-dPEG®3-acid, product number QBD-10033, is one of a broad line of products designed for use in peptide synthesis. The short (13 atoms), discrete PEG (dPEG®) spacer is functionalized with a propionic acid group on one end and Fmoc-protected amine on the other. The product can be added to the N-terminus of a growing peptide chain or to a primary-amine-functionalized side chain of an amino acid such as lysine. The dPEG®3 spacer imparts water solubility to the peptide to which it is conjugated.

QBD-10033 permits our customers to insert a dPEG® spacer into a peptide chain using familiar Fmoc chemistry using solid phase or solution phase chemistry. The dPEG® compound can be inserted at either end of the peptide chain or in the middle of two amino acid sequences to provide a flexible linker between distinct functional peptides. Additionally, the dPEG® spacer can be used to provide spacing in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® products means that the construct gains hydrodynamic volume and water solubility while remaining soluble in organic solvent. The Fmoc protecting group removes easily with a solution of piperidine in N,N-dimethylformamide (DMF).

Specifications

Unit Size 1000 mg
Molecular Weight 443.49; single compound
Chemical formula C₂₄H₂₉NO₇
CAS
867062-95-1
Purity > 98%
Spacers
dPEG® Spacer is 13 atoms and 14.4 Å
Shipping
Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetontrile, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Fmoc-N-amido-dPEG®₃-acid appeared first on VectorLabs.

]]>

Description

Fmoc-N-amido-dPEG®3-acid, product number QBD-10033, is one of a broad line of products designed for use in peptide synthesis. The short (13 atoms), discrete PEG (dPEG®) spacer is functionalized with a propionic acid group on one end and Fmoc-protected amine on the other. The product can be added to the N-terminus of a growing peptide chain or to a primary-amine-functionalized side chain of an amino acid such as lysine. The dPEG®3 spacer imparts water solubility to the peptide to which it is conjugated.

QBD-10033 permits our customers to insert a dPEG® spacer into a peptide chain using familiar Fmoc chemistry using solid phase or solution phase chemistry. The dPEG® compound can be inserted at either end of the peptide chain or in the middle of two amino acid sequences to provide a flexible linker between distinct functional peptides. Additionally, the dPEG® spacer can be used to provide spacing in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® products means that the construct gains hydrodynamic volume and water solubility while remaining soluble in organic solvent. The Fmoc protecting group removes easily with a solution of piperidine in N,N-dimethylformamide (DMF).

Specifications

Unit Size 1000 mg
Molecular Weight 443.49; single compound
Chemical formula C₂₄H₂₉NO₇
CAS
867062-95-1
Purity > 98%
Spacers
dPEG® Spacer is 13 atoms and 14.4 Å
Shipping
Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetontrile, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

  1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

  2. Trivalent PEGylated Platform for the Conjugation of Bioactive Compounds. Angela Torres, Carlos Mas-Moruno, Enrique Perez-Paya, Fernando Albericio, and Miriam Royo. Bioconjugate Chem. 2011, 22 (10), pp 2172–2178. August 25, 2011. DOI: 10.1021/bc100393g.

  3. Development of Peptide Nucleic Acid Probes for Detection of the HER2 Oncogene. Belhu Metaferia., Jun S. Wei., Young K. Song, Jennifer Evangelista, Konrad Aschenbach, Peter Johansson, Xinyu Wen, Qingrong Chen, Albert Lee, Heidi Hempel, Jinesh S. Gheeya, Stephanie Getty, Romel Gomez, Javed Khan. PLoS ONE. 2012, 8 (4) e58870. April 10, 2013. DOI: 10.1371/journal.pone.0058870.

  4. Enhanced Cellular Uptake of Peptide-Targeted Nanoparticles through Increased Peptide Hydrophilicity and Optimized Ethylene Glycol Peptide-Linker Length. Jared F. Stefanick, Jonathan D. Ashley, and Basar Bilgicer. ACS Nano. 2013, 7 (9) pp 8115–8127. August 29, 2013. DOI: 10.1021/nn4033954.

  5. Quantifying Cellular Internalization with a Fluorescent Click Sensor. Laura I. Selby, Luigi Aurelio, Daniel Yuen, Bim Graham, and Angus P. R. Johnston. ACS Sensors. 2018, 3, pp 1182-1189. April 20, 2018. DOI: 10.1021/acssensors.8b00219.

  6. Fc-Binding Antibody-Recruiting Molecules Targeting Prostate-Specific Membrane Antigen: Defucosylation of Antibody for Efficacy Improvement. Sasaki K, Harada M, Yoshikawa T, Tagawa H, Harada Y, Yonemitsu Y, Ryujin T, Kishimura A, Mori T, Katayama Y. Preprint from ChemRxiv, 14 Jul 2020
    DOI: 10.26434/chemrxiv.12654602.v1 PPR: PPR187646

  7. Peptide Amphiphilic-Based Supramolecular Structures with Anti-HIV-1 Activity. Gómara Elena, María José, Pons Pons, Ramon; Herrera, Carolina, Ziprin, Paul, Haro Villar, Isabel Haro. Bioconjugate Chemistry. 2021. Volume 32, Issue 9. 07/13/2021. DOI: 10.1021/acs.bioconjchem.1c00292

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]]> PC Azido-NHS Ester https://staging.vectorlabs.com/products/pc-azido-nhs-ester/ Tue, 19 Sep 2023 17:42:49 +0000 https://staging.vectorlabs.com/?post_type=product&p=21212 Description

Photocleavable Azido-NHS ester reagent contains an amine reactive group linked to azido moiety through a spacer arm containing a photocleavable moiety. Molecules jointed through photocleavable linker can be efficiently photoreleased, typically >90% in 5-25 minutes using an inexpensive, near-UV, low intensity lamp (e.g. 365 nm lamp at 1-5 mW/cm2).

Specifications

Unit Size 10 mg, 25 mg, 100 mg
Molecular weight 640.59
Chemical composition C26H26N6O13
CAS N/A
Solubility DMSO, DMF, DCM, THF, Chloroform
Purity >95% (HPLC)
Appearance Yellow to slightly orange oil
Storage Conditions -20°C. Desiccate
Shipping Conditions Frozen

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Description

Photocleavable Azido-NHS ester reagent contains an amine reactive group linked to azido moiety through a spacer arm containing a photocleavable moiety. Molecules jointed through photocleavable linker can be efficiently photoreleased, typically >90% in 5-25 minutes using an inexpensive, near-UV, low intensity lamp (e.g. 365 nm lamp at 1-5 mW/cm2).

Specifications

Unit Size10 mg, 25 mg, 100 mg
Molecular weight640.59
Chemical compositionC26H26N6O13
CASN/A
SolubilityDMSO, DMF, DCM, THF, Chloroform
Purity>95% (HPLC)
AppearanceYellow to slightly orange oil
Storage Conditions-20°C. Desiccate
Shipping ConditionsFrozen

Documents

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]]> Azido-PEG3-Maleimide https://staging.vectorlabs.com/products/azido-peg3-maleimide/ Tue, 19 Sep 2023 17:42:24 +0000 https://staging.vectorlabs.com/?post_type=product&p=21207 Description

Azido-PEG3-Maleimide enables simple and efficient incorporation of azido moiety onto antibodies, cysteine-containing peptides and other thiol-containing molecules.

Azido-PEG3-Maleimide degrades quickly (hours) at room temperature. This product is provided as a two-component easy-to-use kit. The stock solution of Azido-PEG3-Maleimide is prepared with a straightforward mix-and-stir protocol in 30 min.

Specifications

Unit Size 25 mg, 100 mg, 1000 mg
Molecular weight 369.37
Chemical composition C15H23N5O6
CAS N/A
Solubility DMSO, DMF, DCM, THF, Chloroform
Appearance Colorless to slightly yellow oil
Storage Conditions -20°C. Desiccate
Shipping Conditions Ambient temperature

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Description

Azido-PEG3-Maleimide enables simple and efficient incorporation of azido moiety onto antibodies, cysteine-containing peptides and other thiol-containing molecules.

Azido-PEG3-Maleimide degrades quickly (hours) at room temperature. This product is provided as a two-component easy-to-use kit. The stock solution of Azido-PEG3-Maleimide is prepared with a straightforward mix-and-stir protocol in 30 min.

Specifications

Unit Size25 mg, 100 mg, 1000 mg
Molecular weight369.37
Chemical compositionC15H23N5O6
CASN/A
SolubilityDMSO, DMF, DCM, THF, Chloroform
AppearanceColorless to slightly yellow oil
Storage Conditions-20°C. Desiccate
Shipping ConditionsAmbient temperature

Documents

Selected References

  1. Allo, B., et al. (2018). Clickable and High-Sensitivity Metal-Containing Tags for Mass Cytometry. Bioconjugate Chem. , 29(6), 2028-38. [PubMed]

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