23 EO – VectorLabs https://staging.vectorlabs.com From linker design and synthesis, bioconjugated design and manufacturing, biomolecule labeling and functionalization, and detection system and solutions, our team is here to help you move forward, with impact. Wed, 22 Oct 2025 17:20:49 +0000 en-US hourly 1 https://wordpress.org/?v=6.9 https://staging.vectorlabs.com/wp-content/uploads/2024/11/V-favicon-02-100x100.png 23 EO – VectorLabs https://staging.vectorlabs.com 32 32 Bromoacetamido-dPEG®₂₃-azide https://staging.vectorlabs.com/products/bromoacetamido-dpeg23-azide/ Sat, 24 Feb 2024 02:15:20 +0000 https://staging.vectorlabs.com/?post_type=product&p=39298 Bromoacetamido-dPEG®23-azide, product number QBD-11205, is discrete PEG (dPEG®) crosslinker that facilitates the crosslinking of free thiols with click chemistry alkyne partners across a long (76 atoms, 88.5 Å) single molecular weight PEG bridge.

The long, amphiphilic dPEG® linker adds hydrodynamic volume to conjugate molecules and increases their water solubility. The flexible, non-immunogenic spacer reduces or eliminates renal clearance and helps shield conjugates from opsonization through the increased hydrodynamic volume the dPEG® linker imparts.

The bromoacetate moiety reacts chemoselectively with free thiols at pH >8.0. It is an alternative to the maleimide group and is used in situations where the target molecule needs to be at a high pH. The azide group reacts with a suitable alkyne partner via metal-catalyzed (Cu, Ru) or strain-promoted (copper-free) click chemistry. Moreover, Bromoacetamido-dPEG®23-azide is stable, unlike MAL-PEG-azide constructs, which are somewhat unstable.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 1220.24; single compound
Chemical formula C₅₀H₉₉BrN₄O₂₄
CAS N/A
Purity > 98%
Spacers dPEG® Spacer is 76 atoms and 88.5 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene Chloride, Methanol, Acetone, Chloroform, DMSO, DMAC, or DMF.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

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Description

Bromoacetamido-dPEG®23-azide, product number QBD-11205, is discrete PEG (dPEG®) crosslinker that facilitates the crosslinking of free thiols with click chemistry alkyne partners across a long (76 atoms, 88.5 Å) single molecular weight PEG bridge.

The long, amphiphilic dPEG® linker adds hydrodynamic volume to conjugate molecules and increases their water solubility. The flexible, non-immunogenic spacer reduces or eliminates renal clearance and helps shield conjugates from opsonization through the increased hydrodynamic volume the dPEG® linker imparts.

The bromoacetate moiety reacts chemoselectively with free thiols at pH >8.0. It is an alternative to the maleimide group and is used in situations where the target molecule needs to be at a high pH. The azide group reacts with a suitable alkyne partner via metal-catalyzed (Cu, Ru) or strain-promoted (copper-free) click chemistry. Moreover, Bromoacetamido-dPEG®23-azide is stable, unlike MAL-PEG-azide constructs, which are somewhat unstable.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight1220.24; single compound
Chemical formulaC₅₀H₉₉BrN₄O₂₄
CASN/A
Purity> 98%
SpacersdPEG® Spacer is 76 atoms and 88.5 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene Chloride, Methanol, Acetone, Chloroform, DMSO, DMAC, or DMF.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

The post Bromoacetamido-dPEG®₂₃-azide appeared first on VectorLabs.

]]> Azido-dPEG®₂₃-amine https://staging.vectorlabs.com/products/azido-dpeg23-amine/ Sat, 24 Feb 2024 02:11:20 +0000 https://staging.vectorlabs.com/?post_type=product&p=36321 Azido-dPEG®23-amine, product number QBD-10525, is a carbonyl-reactive, biocompatible crosslinking reagent that can participate in multiple types of reactions. The product consists of azide and amine groups on opposite ends of a long (72 atoms), single molecular weight, discrete polyethylene glycol (dPEG®) chain. Alkynes react with the azido group in metal-catalyzed or strain-promoted click chemistry to yield triazole derivatives. Moreover, the azide group functions as a masked amine that reduces to a primary amine via a suitable reducing agent. Furthermore, Azido-dPEG®23-amine can participate in a Staudinger ligation with appropriate phosphine derivatives to create a water-soluble product.

The amphiphilic dPEG® product adds hydrodynamic volume and imparts water solubility to any compound to which it is conjugated. Also, because the terminal azide group functions in multiple different types of reactions, Azido-dPEG®23-amine can act as either a heterobifunctional, click chemistry crosslinker or a monoprotected homobifunctional crosslinking reagent. As a heterobifunctional click chemistry reagent, the azide group reacts with alkynes to form triazoles. The amino terminus of the molecule then can react with carboxylic acids, aldehydes, or ketones to crosslink the conjugate to another molecule. As a monoprotected homobifunctional crosslinker, the amine end reacts first with carboxylic acids (or their active esters), aldehydes, or ketones, leaving the azide end of the molecule free. The reduction of the azido group with a suitable reducing agent, such as triphenylphosphine, yields a free amine that can be conjugated similarly to the conjugation of the first amine group. Reacting the amine groups with aldehydes or ketones results in labile Schiff bases that should be reduced to secondary amines for bond stability.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 1099.30; single compound
Chemical formula C₄₈H₉₈N₄O₂₃
CAS 749244-38-0
Purity > 97%
Spacers dPEG® Spacer is 72 atoms and 86.8 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetonitrile, DMAC, or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Azido-dPEG®₂₃-amine appeared first on VectorLabs.

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Description

Azido-dPEG®23-amine, product number QBD-10525, is a carbonyl-reactive, biocompatible crosslinking reagent that can participate in multiple types of reactions. The product consists of azide and amine groups on opposite ends of a long (72 atoms), single molecular weight, discrete polyethylene glycol (dPEG®) chain. Alkynes react with the azido group in metal-catalyzed or strain-promoted click chemistry to yield triazole derivatives. Moreover, the azide group functions as a masked amine that reduces to a primary amine via a suitable reducing agent. Furthermore, Azido-dPEG®23-amine can participate in a Staudinger ligation with appropriate phosphine derivatives to create a water-soluble product.

The amphiphilic dPEG® product adds hydrodynamic volume and imparts water solubility to any compound to which it is conjugated. Also, because the terminal azide group functions in multiple different types of reactions, Azido-dPEG®23-amine can act as either a heterobifunctional, click chemistry crosslinker or a monoprotected homobifunctional crosslinking reagent. As a heterobifunctional click chemistry reagent, the azide group reacts with alkynes to form triazoles. The amino terminus of the molecule then can react with carboxylic acids, aldehydes, or ketones to crosslink the conjugate to another molecule. As a monoprotected homobifunctional crosslinker, the amine end reacts first with carboxylic acids (or their active esters), aldehydes, or ketones, leaving the azide end of the molecule free. The reduction of the azido group with a suitable reducing agent, such as triphenylphosphine, yields a free amine that can be conjugated similarly to the conjugation of the first amine group. Reacting the amine groups with aldehydes or ketones results in labile Schiff bases that should be reduced to secondary amines for bond stability.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight1099.30; single compound
Chemical formulaC₄₈H₉₈N₄O₂₃
CAS749244-38-0
Purity> 97%
SpacersdPEG® Spacer is 72 atoms and 86.8 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC, or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Detection of SK2 Channels on Hippocampal Neurons. Jamie L. Maciaszek University of Connecticut (2012) DigitalCommons@Uconn Master’s Theses Paper 237 April 20, 2012. http://digitalcommons.uconn.edu/gs_theses/237.

The post Azido-dPEG®₂₃-amine appeared first on VectorLabs.

]]> t-boc-N-amido-dPEG®₂₃-amine https://staging.vectorlabs.com/products/t-boc-n-amido-dpeg23-amine/ Sat, 24 Feb 2024 02:04:51 +0000 https://staging.vectorlabs.com/?post_type=product&p=35054 t-boc-N-amido-dPEG®23-amine, product number QBD-10093, is a monoprotected, homobifunctional, discrete PEG (dPEG®) crosslinker. The amine groups react with carboxylic acids, active esters (e.g., NHS, TFP, PFP) of carboxylic acids, aldehydes, and ketones. The tert-butyl carbamate (t-boc) protecting group is removed quickly and easily under mild conditions. The dPEG® linker provides flexibility and water solubility to conjugate molecules. Examples of uses for this product include graphene quantum dot engineering, antibody and enzyme immobilization, development of biomolecular sensors, and construction of supramolecular assemblies.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 1173.42; single compund
Chemical formula C₅₃H₁₀₈N₂O₂₅
CAS N/A
Purity > 98%
Spacers dPEG® Spacer is 72 atoms and 86.8 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetonitrile, DMAC, DMSO or water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post t-boc-N-amido-dPEG®₂₃-amine appeared first on VectorLabs.

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Description

t-boc-N-amido-dPEG®23-amine, product number QBD-10093, is a monoprotected, homobifunctional, discrete PEG (dPEG®) crosslinker. The amine groups react with carboxylic acids, active esters (e.g., NHS, TFP, PFP) of carboxylic acids, aldehydes, and ketones. The tert-butyl carbamate (t-boc) protecting group is removed quickly and easily under mild conditions. The dPEG® linker provides flexibility and water solubility to conjugate molecules. Examples of uses for this product include graphene quantum dot engineering, antibody and enzyme immobilization, development of biomolecular sensors, and construction of supramolecular assemblies.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 1173.42; single compund
Chemical formula C₅₃H₁₀₈N₂O₂₅
CAS N/A
Purity > 98%
Spacers dPEG® Spacer is 72 atoms and 86.8 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetonitrile, DMAC, DMSO or water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

  1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

The post t-boc-N-amido-dPEG®₂₃-amine appeared first on VectorLabs.

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