PNP Carbonate – VectorLabs https://staging.vectorlabs.com From linker design and synthesis, bioconjugated design and manufacturing, biomolecule labeling and functionalization, and detection system and solutions, our team is here to help you move forward, with impact. Wed, 22 Oct 2025 17:05:48 +0000 en-US hourly 1 https://wordpress.org/?v=6.9 https://staging.vectorlabs.com/wp-content/uploads/2024/11/V-favicon-02-100x100.png PNP Carbonate – VectorLabs https://staging.vectorlabs.com 32 32 TCO-PNB Ester (equatorial) https://staging.vectorlabs.com/products/tco-pnb-ester-equatorial/ Tue, 19 Sep 2023 17:16:12 +0000 https://staging.vectorlabs.com/?post_type=product&p=20649 Description

TCO-PNB Ester is an amine-reactive building block used for modification of amine-containing molecule in organic media. TCO-PNB Ester is supplied as a single equatorial (major, rel-(1S-2S-5E-pR), ref 1 and 4) diastereomer. Specially formulated crystalline provides easy handling and extended shelf life.

TCO-PNB Ester is not recommended for labeling of proteins in aqueous buffers due to poor level of activation of labeled proteins (Rahim, M.K., et al., Bioconjugate Chem. 2015, 26, 352-360). TCO-PEG4-NHS Ester and TCO-PEG12-NHS Ester are well suited for protein and antibody labeling in aqueous buffers.

Specifications

Unit Size 25 mg, 100 mg, 100 mg
Molecular weight 291.30
Chemical composition C15H17NO5
CAS 1438415-89-4
Solubility DMSO, DMF, DCM, THF, Chloroform
Purity >95% (HPLC)
Appearance White to slightly grey solid
Storage Conditions -20°C. Desiccate
Shipping Conditions Ambient temperature

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Description

TCO-PNB Ester is an amine-reactive building block used for modification of amine-containing molecule in organic media. TCO-PNB Ester is supplied as a single equatorial (major, rel-(1S-2S-5E-pR), ref 1 and 4) diastereomer. Specially formulated crystalline provides easy handling and extended shelf life.

Important Product Information:
TCO-PNB Ester is not recommended for labeling of proteins in aqueous buffers due to poor level of activation of labeled proteins (Rahim, M.K., et al., Bioconjugate Chem. 2015, 26, 352-360). TCO-PEG4-NHS Ester and TCO-PEG12-NHS Ester are well suited for protein and antibody labeling in aqueous buffers.

Specifications

Unit Size25 mg, 100 mg, 100 mg
Molecular weight291.30
Chemical compositionC15H17NO5
CAS1438415-89-4
SolubilityDMSO, DMF, DCM, THF, Chloroform
Purity>95% (HPLC)
AppearanceWhite to slightly grey solid
Storage Conditions-20°C. Desiccate
Shipping ConditionsDry ice

Documents

Selected References

  1. Royzen, M., et al. (2008). A Photochemical Synthesis of Functionalized trans-Cyclooctenes Driven by Metal Complexation. J. AM. CHEM. SOC., 130: 3760-1. [PubMed]
  2. Blackman, M.L., et al. (2008). Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity. J. AM. CHEM. SOC., 130: 13518-9. [PubMed]
  3. Rahim, M.K., et al. (2015). Enhancing Reactivity for Bioorthogonal Pretargeting by Unmasking Antibody-Conjugated trans-Cyclooctenes. Bioconjugate Chem., 26: 352-60. [PubMed]
  4. Rossin, R., et al. (2013). Highly Reactive trans-Cyclooctene Tags with Improved Stability for Diels−Alder Chemistry in Living Systems. Bioconjugate Chem., 24: 1210-7. [PubMed]
 

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