Thiol PEG Acid – VectorLabs https://staging.vectorlabs.com From linker design and synthesis, bioconjugated design and manufacturing, biomolecule labeling and functionalization, and detection system and solutions, our team is here to help you move forward, with impact. Wed, 22 Oct 2025 17:19:31 +0000 en-US hourly 1 https://wordpress.org/?v=6.8.3 https://staging.vectorlabs.com/wp-content/uploads/2024/11/V-favicon-02-100x100.png Thiol PEG Acid – VectorLabs https://staging.vectorlabs.com 32 32 Thiol-dPEG®₁₂-acid https://staging.vectorlabs.com/products/thiol-dpeg12-acid/ Sat, 24 Feb 2024 02:13:30 +0000 https://staging.vectorlabs.com/?post_type=product&p=37046 Thiol-dPEG®12-acid, product number QBD-10850, is a single molecular weight, discrete-length polyethylene glycol (dPEG®) PEGylation reagent. One end of the medium-length (39 atoms, 46.8 Å) dPEG® linker terminates in a sulfhydryl (thiol) group, while a propionic acid moiety terminates the opposite end. The thiol end of the molecule forms dative bonds with gold, thioether bonds with maleimide and bromoacetate groups, and disulfide bonds with other sulfhydryl groups. The propionic acid group reacts with amines to form amide bonds. Alternatively, if it is left unreacted, the propionic acid group provides a negative charge to the conjugated molecule or modified surface.

Numerous scientific publications attest to the benefits of Thiol-dPEG®12-acid, including the following applications:
Assaying protease by using fluorescence quenching with gold nanoparticles;
Enhancing transfection efficiency;
Modulating glucose transport with gold nanoparticles;
Developing multiplexed bioassays on semiconductor gold nanocrystals;
Developing spectroscopy applications; and,
Detecting cancer through a FRET-based, NIR-activated system that uses gold nanoparticles.

Specifications

Unit Size 100mg, 1000mg
Molecular Weight 634.77; single compound
Chemical formula C₂₇H₅₄O₁₄S
CAS 1032347-93-5
Purity > 97%
Spacers dPEG® Spacer is 39 atoms and 46.8 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetonitrile, DMAC, DMSO or water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Thiol-dPEG®₁₂-acid appeared first on VectorLabs.

]]>

Description

Thiol-dPEG®12-acid, product number QBD-10850, is a single molecular weight, discrete-length polyethylene glycol (dPEG®) PEGylation reagent. One end of the medium-length (39 atoms, 46.8 Å) dPEG® linker terminates in a sulfhydryl (thiol) group, while a propionic acid moiety terminates the opposite end. The thiol end of the molecule forms dative bonds with gold, thioether bonds with maleimide and bromoacetate groups, and disulfide bonds with other sulfhydryl groups. The propionic acid group reacts with amines to form amide bonds. Alternatively, if it is left unreacted, the propionic acid group provides a negative charge to the conjugated molecule or modified surface.

Numerous scientific publications attest to the benefits of Thiol-dPEG®12-acid, including the following applications:
Assaying protease by using fluorescence quenching with gold nanoparticles;
Enhancing transfection efficiency;
Modulating glucose transport with gold nanoparticles;
Developing multiplexed bioassays on semiconductor gold nanocrystals;
Developing spectroscopy applications; and,
Detecting cancer through a FRET-based, NIR-activated system that uses gold nanoparticles.

Specifications

Unit Size100mg, 1000mg
Molecular Weight634.77; single compound
Chemical formulaC₂₇H₅₄O₁₄S
CAS1032347-93-5
Purity> 97%
SpacersdPEG® Spacer is 39 atoms and 46.8 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC, DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Gold nanoparticle-based fluorescence quenching via metal coordination for assaying protease activity. Se Yeon Park, So Min Lee, Gae Baik, Kim and Young-Pil Kim. Gold Bull. 2012, 45 pp 213–219. October 25, 2012. DOI 10.1007/s13404-012-0070-9.

Systemically probing the bottom-up synthesis of AuPAMAM conjugates for enhanced transfection efficiency. Elizabeth R. Figueroa, Stephen Yan, Nicolette K. Chamberlain-Simon, Adam Y. Lin, Aaron E. Foster, and Rebekah A. Drezek. Journal of Nanobiotechnology. 2016, 14 (24). March 31, 2016. DOI: 10.1186/s12951-016-0178-9.

Modulating the Glucose Transport by Engineering Gold Nanoparticles. Sanjib Bhattacharyya, Krishna Kattel, and Franklin Kim. Journal of Nanomedicine and Biotherapeutic Discovery. 2016, 6 (1) pp 1-5. April 30, 2016. DOI: 10.4172/2155-983X.1000141.

Use of semiconductor nanocrystals to encode microbeads for multiplexed analysis of biological samples. Mikhail A Berestovoy, Regina S Bilan, Victor Krivenkov, Igor Nabiev, and Alyona Sukhanova. IOP Science. 2017, 784 (1) pp 1742-6596. March 15, 2017. DOI: 10.1088/1742-6596/784/1/012012.

Spectroscopy Based Approaches for Detection of Ions, Alpha-L-Fucosidase, and Singlet Oxygen. Eric Waidely. University of Miami Scholarly Repository. 2017, pp 1-113. May 3, 2017. http://scholarlyrepository.miami.edu/oa_dissertations/1842.

Near-Infrared-Activated Fluorescence Resonance Energy Transfer-Based Nanocomposite to Sense MMP2-Overexpressing Oral Cancer Cells. Yung-Chieh Chan, Ming-Hsien Chan, Chieh-Wei Chen, Ru-Shi Liu, Michael Hsiao, and Din Ping Tsai. ACS Omega. 2018,3 (2) pp. 1627-1634. February 8, 2018. DOI: 10.1021/acsomega.7b01494.

Signal enhancement of optical immunosensing by gold nanoparticles. Yuan Xintong. Nanyang Technological University, School of Material Science and Engineering Thesis for the degree of Master of Engineering. 2015, pp 1-74.

Biofunctionalized Polyelectrolyte Microcapsules Encoded with Fluorescent Semiconductor Nanocrystals for Highly Specific Targeting and Imaging of Cancer Cells. Galina Nifontova, Daria Kalenichenko, Maria Baryshnikova, Fernanda Ramos Gomes, Frauke Alves, Alexander Karaulov, Igor Nabiev, and Alyona Sukhanova. Advances on Applications of Optics and Photonics – Selected Papers from the 4th International Conference on Applications of Optics and Photonics, AOP2019. November 8, 2019. DOI: 10.3390/photonics6040117

NEW FRONTIERS FOR TRIPLE NEGATIVE BREAST CANCER DETECTION AND TREATMENT: FROM MECHANICAL BIOMARKERS TO SPECIFIC NANOPARTICLE ENTRY FOR ROBOTICALLY CONTROLLED LASER-INDUCED HYPERTHERMIA. Vanessa Uzonwanne. Worchester Polytechnic Institute. 2022. May 22, 2022.

SCORe: SARS-CoV-2 Omicron Variant RBD-Binding DNA Aptamer for Multiplexed Rapid Detection and Pseudovirus Neutralization. Lucy F. Yang, Nataly Kacherovsky, Joey Liang, Stephen J. Salipante, and Suzie H. Pun. Anal. Chem. 2022, 94, 37, 12683–12690. https://doi.org/10.1021/acs.analchem.2c01993

The post Thiol-dPEG®₁₂-acid appeared first on VectorLabs.

]]> Thiol-dPEG®₄-acid https://staging.vectorlabs.com/products/thiol-dpeg4-acid/ Sat, 24 Feb 2024 02:07:36 +0000 https://staging.vectorlabs.com/?post_type=product&p=35581 Thiol-dPEG®4-acid, product number QBD-10247, contains a short, monodisperse polyethylene glycol (PEG) linker functionalized with a sulfhydryl group on one end and a propionic acid moiety on the other.The sulfhydryl forms dative bonds with gold and silver and reacts with thiol-reactive functional groups such as maleimide, bromoacetyl, SPDP, and thiol. The carboxylic acid end of the molecule couples to free amines using EDC or any suitable carbodiimide. An acylating agent such as N-hydroxysuccinimide (NHS) or 2,3,5,6-tetrafluorophenol (TFP) can enhance coupling efficiency. The carboxylate must react after the sulfhydryl conjugation.

Thiol-dPEG®4-acid forms dative bonds with gold surfaces and provides a non-immunogenic, hydrophilic spacer between the gold coat and the environment surrounding the gold. The terminal carboxylic acid can be left unmodified, or it can react with amines to crosslink other molecules to the gold.

In published scientific literature, Thiol-dPEG®4-acid in a mixed monolayer has prevented opsonization of gold nanoparticles. Other published uses for this product include coating nanoparticles, coating gold electrodes used in ion channel recording, developing aptamer-based sensors, and developing a chemical detector with nanometer-scale spatial resolution.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 282.35; single compound
Chemical formula C₁₁H₂₂O₆S
CAS 749247-06-1
Purity > 98%
Spacers dPEG® Spacer is 16 atoms and 18.3 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetonitrile, DMAC, DMSO or moderate solubility in water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Thiol-dPEG®₄-acid appeared first on VectorLabs.

]]>

Description

Thiol-dPEG®4-acid, product number QBD-10247, contains a short, monodisperse polyethylene glycol (PEG) linker functionalized with a sulfhydryl group on one end and a propionic acid moiety on the other.The sulfhydryl forms dative bonds with gold and silver and reacts with thiol-reactive functional groups such as maleimide, bromoacetyl, SPDP, and thiol. The carboxylic acid end of the molecule couples to free amines using EDC or any suitable carbodiimide. An acylating agent such as N-hydroxysuccinimide (NHS) or 2,3,5,6-tetrafluorophenol (TFP) can enhance coupling efficiency. The carboxylate must react after the sulfhydryl conjugation.

Thiol-dPEG®4-acid forms dative bonds with gold surfaces and provides a non-immunogenic, hydrophilic spacer between the gold coat and the environment surrounding the gold. The terminal carboxylic acid can be left unmodified, or it can react with amines to crosslink other molecules to the gold.

In published scientific literature, Thiol-dPEG®4-acid in a mixed monolayer has prevented opsonization of gold nanoparticles. Other published uses for this product include coating nanoparticles, coating gold electrodes used in ion channel recording, developing aptamer-based sensors, and developing a chemical detector with nanometer-scale spatial resolution.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight282.35; single compound
Chemical formulaC₁₁H₂₂O₆S
CAS749247-06-1
Purity> 98%
SpacersdPEG® Spacer is 16 atoms and 18.3 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC, DMSO or moderate solubility in water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Short-Chain PEG Mixed Monolayer Protected Gold Clusters Increase Clearance and Red Blood Cell Counts. Carrie A. Simpson, Amanda C. Agrawal, Andrzej Balinski, Kellen M. Harkness, and David E. Cliffel. ACS Nano. 2011, 5 (5), pp 3577-3584. April 7, 2011. DOI: 10.1021/nn103148x.

CdSe nano-particles coated with thiol-terminated oligo(ethylene oxide) for protein targeting reagent. Yukari Ito and Hiromori Tsutsumi. NSTI-Nanotech. 2009, 2. 2009.

A Simple Method for Ion Channel Recordings Using Fine Gold Electrode. Daichi Okuno, Minako Hirano, Hiroaki Yokota, Yukiko Onishi, Junya Ichinose, and Toru Ide. Analytical Sciences. 2016, 32 (12) pp 1353-1357. December 10, 2016. http://doi.org.10.2116/analsci.32.1353.

The combination of computational and biosensing technologies for selecting aptamer against prostate specific antigen. Pi-Chou Hsieh, Hui-Ting Lin, Wen-Yih Chen, Jeffrey J.P. Tsai, and Wen-Pin hu. 2017, pp 1-36.

Spatially Resolved Chemical Detection with a Nanoneedle-Probe-Supported Biological Nanopore. Kan Shoji, Ryuji Kawano, and Ryan J. White. ACS Nano, 2019, 13 (2), pp 2606–2614. February 6, 2019. DOI: 10.1021/acsnano.8b09667.

Milk protein-shelled gold nanoparticles with gastrointestinally active absorption for aurotherapy to brain tumor. Hyung Shik Kim, Seung JaeLee, Dong Yun Lee. Bioactive Materials. 2022, Volume 8. 02/2022. DOI: 10.1016/j.bioactmat.2021.06.026

A novel therapeutic strategy of multimodal nanoconjugates for state-of-the-art brain tumor phototherapy. Hyung Shik Kim, Minwook Seo, Tae-Eun Park, and Dong Yun Lee. SpringerLink. 2022. January 4, 2022. https://doi.org/10.1186/s12951-021-01220-9

The post Thiol-dPEG®₄-acid appeared first on VectorLabs.

]]> Thiol-dPEG®₈-acid https://staging.vectorlabs.com/products/thiol-dpeg8-acid/ Sat, 24 Feb 2024 02:05:12 +0000 https://staging.vectorlabs.com/?post_type=product&p=35219 "Thiol-dPEG®8-acid, product number QBD-10183, is a hydrophilic, flexible compound containing a single molecular weight, discrete-length polyethylene glycol (dPEG®) chain. A sulfhydryl group and a propionic acid group form the linker’s two termini. The sulfhydryl moiety reacts with other thiols, maleimido groups, the SPDP reactive group, and bromoacetamido groups, and forms dative bonds with gold and silver. Reactions of Thiol-dPEG®8-acid with sulfhydryls or SPDP form disulfide bonds. With maleimido and bromoacetamido compounds, Thiol-dPEG®8-acid reacts to form thioether linkages. Gold and silver form dative bonds with the sulfhydryl group on Thiol-dPEG®8-acid. The propionic acid moiety couples with free amines to form amide bonds.

This product can be used to modify gold and silver surfaces, crosslink amines and thiols, and thiolate biomolecules. The dPEG®8 linker imparts water solubility to the conjugate. In published scientific literature, Thiol-dPEG®8-acid has
Labeled polyester nanoparticles with 18F;
Functionalized gold nanoparticles with RGD peptides;
Demonstrated proof-of-concept detection of pathogenic biomarkers at nM limits; and,
Functionalized a localized surface plasmon resonance (LSPR) biosensor integrated with a microfluidic chip."

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 458.57; single compound
Chemical formula C₁₉H₃₈O₁₀S
CAS 866889-02-3
Purity > 98%
Spacers dPEG® Spacer is 28 atoms and 32.5 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetonitrile, DMAC, DMSO or water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Thiol-dPEG®₈-acid appeared first on VectorLabs.

]]>

Description

Thiol-dPEG®8-acid, product number QBD-10183, is a hydrophilic, flexible compound containing a single molecular weight, discrete-length polyethylene glycol (dPEG®) chain. A sulfhydryl group and a propionic acid group form the linker’s two termini. The sulfhydryl moiety reacts with other thiols, maleimido groups, the SPDP reactive group, and bromoacetamido groups, and forms dative bonds with gold and silver. Reactions of Thiol-dPEG®8-acid with sulfhydryls or SPDP form disulfide bonds. With maleimido and bromoacetamido compounds, Thiol-dPEG®8-acid reacts to form thioether linkages. Gold and silver form dative bonds with the sulfhydryl group on Thiol-dPEG®8-acid. The propionic acid moiety couples with free amines to form amide bonds.

This product can be used to modify gold and silver surfaces, crosslink amines and thiols, and thiolate biomolecules. The dPEG®8 linker imparts water solubility to the conjugate. In published scientific literature, Thiol-dPEG®8-acid has
Labeled polyester nanoparticles with 18F;
Functionalized gold nanoparticles with RGD peptides;
Demonstrated proof-of-concept detection of pathogenic biomarkers at nM limits; and,
Functionalized a localized surface plasmon resonance (LSPR) biosensor integrated with a microfluidic chip.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight458.57; single compound
Chemical formulaC₁₉H₃₈O₁₀S
CAS866889-02-3
Purity> 98%
SpacersdPEG® Spacer is 28 atoms and 32.5 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC, DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

  1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.
  2. CdSe nano-particles coated with thiol-terminated oligo(ethylene oxide) for protein targeting reagent. Yukari Ito and Hiromori Tsutsumi. NSTI-Nanotech. 2009, 2. 2009.
  3. Novel 18F labeling strategy for polyester-based
    NPs for in vivo PET-CT imaging. Primiano Pio Di Mauro, Vanessa Gómez-Vallejo, Zurine Baz, Jordi Llop, and Salvador Borros. Bioconjugate Chemistry. 2015. February 24, 2015. DOI: 10.1021/acs.bioconjchem.5b00040.
  4. Cyclic RGD Functionalized Gold Nanoparticles for Tumor Targeting. Daniela Arosio, Leonardo Manzoni, Elena M. V. Araldi, and Carlo Scolastico. Bioconjugate Chem. 2011, 22 (4), pp 664–672. March 24, 2011. DOI: 10.1021/bc100448r.
  5. Biomarker-Mediated Disruption of Coffee-Ring Formation as a Low Resource Diagnostic Indicator. Joshua R. Trantum, David W. Wright, and Frederick R. Haselton. Langmuir, 2012, 28 (4), pp 2187–2193. December 9, 2011. DOI.org/10.1021/la203903a.
  6. Enantioselective analysis of melagatran via a LSPR biosensor integrated with microfluidic chip. Longhua Guo, Yuechun Yin, Rong Huang, Bin Qiu, Zhenyu Lin, HH Yang, Jianrong Li and Guo Nan Chen. Lab on a Chip. 2012, 20 (12), pp 3901-3906. June 15, 2012. DOI: 10.1039/C2LC40388A.
  7. Magnetic Nanoparticle Tracking for One-Step Protein Seperation and Binding Kinetics Analysis. Yunlei Zhao, Guangzhong Ma, Shaopeng Wang. Journal of The Electrochemical Society. 2022. May 11, 2022. dx.doi.org/10.1149/1945-7111/ac6bc5.
  8. Charge-Sensitive Optical Detection of Binding Kinetics between Phage-Displayed Peptide Ligands and Protein Targets. Runli Liang, Yingnan Zhang, Guangzhong Ma, Shaopeng Wang. MDPI. 2022. Biosensors 2022, 12(6), 394. June 8, 2022. https://doi.org/10.3390/bios12060394

The post Thiol-dPEG®₈-acid appeared first on VectorLabs.

]]>