Amino PEG Acids – VectorLabs https://staging.vectorlabs.com From linker design and synthesis, bioconjugated design and manufacturing, biomolecule labeling and functionalization, and detection system and solutions, our team is here to help you move forward, with impact. Wed, 22 Oct 2025 17:21:10 +0000 en-US hourly 1 https://wordpress.org/?v=6.8.3 https://staging.vectorlabs.com/wp-content/uploads/2024/11/V-favicon-02-100x100.png Amino PEG Acids – VectorLabs https://staging.vectorlabs.com 32 32 Amino-dPEG®₂₄-amido-dPEG®₂₄-acid https://staging.vectorlabs.com/products/amino-dpeg24-amido-dpeg24-acid/ Sat, 24 Feb 2024 02:16:38 +0000 https://staging.vectorlabs.com/?post_type=product&p=39394 Amino-dPEG®24-amido-dPEG®24-acid, product number QBD-10907, is a PEGylated amino acid consisting of a primary amine group on one end and a propionic acid group sit on opposite ends of a long (152 atoms, 178.9 Å), single molecular weight polyethylene glycol (PEG) spacer with a discrete chain length (dPEG®). The dPEG® spacer consists of two dPEG®24 chains joined by an amide bond, giving the spacer the effective length of a dPEG48 linker. The highly hydrophilic, discrete PEG spacer (Ð = 1) increases the hydrodynamic volume and imparts water solubility to conjugates that incorporate it. Moreover, Amino-dPEG®24-amido-dPEG®24-acid may benefit numerous applications, including peptide synthesis, peptide modification, surface modification, oligonucleotide sequencing, drug delivery, and small molecule modification.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 2274.72; single compound
Chemical formula C₁₀₂H₂₀₄N₂O₅₁
CAS N/A
Purity > 97%
Spacers dPEG® Spacer is 152 atoms and 178.9 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) DMAC or DMSO or water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Amino-dPEG®₂₄-amido-dPEG®₂₄-acid appeared first on VectorLabs.

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Description

Amino-dPEG®24-amido-dPEG®24-acid, product number QBD-10907, is a PEGylated amino acid consisting of a primary amine group on one end and a propionic acid group sit on opposite ends of a long (152 atoms, 178.9 Å), single molecular weight polyethylene glycol (PEG) spacer with a discrete chain length (dPEG®). The dPEG® spacer consists of two dPEG®24 chains joined by an amide bond, giving the spacer the effective length of a dPEG48 linker. The highly hydrophilic, discrete PEG spacer (Ð = 1) increases the hydrodynamic volume and imparts water solubility to conjugates that incorporate it. Moreover, Amino-dPEG®24-amido-dPEG®24-acid may benefit numerous applications, including peptide synthesis, peptide modification, surface modification, oligonucleotide sequencing, drug delivery, and small molecule modification.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight2274.72; single compound
Chemical formulaC₁₀₂H₂₀₄N₂O₅₁
CASN/A
Purity> 97%
SpacersdPEG® Spacer is 152 atoms and 178.9 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)DMAC or DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

The post Amino-dPEG®₂₄-amido-dPEG®₂₄-acid appeared first on VectorLabs.

]]> Amino-dPEG®₃₆-acid https://staging.vectorlabs.com/products/amino-dpeg36-acid/ Sat, 24 Feb 2024 02:13:43 +0000 https://staging.vectorlabs.com/?post_type=product&p=37138 Amino-dPEG®36-acid, product number QBD-10907, is a PEGylated amino acid. A primary amine group and a propionic acid group sit on opposite ends of a long (111 atoms, 132.7 Å), single molecular weight polyethylene glycol (PEG) spacer with a discrete chain length (dPEG®). The highly hydrophilic, discrete PEG spacer (Ð = 1) increases the hydrodynamic volume and imparts water solubility to conjugates that incorporate it. Moreover, Amino-dPEG®36-acid may benefit numerous applications, including peptide synthesis, peptide modification, surface modification, oligonucleotide sequencing, drug delivery, and small molecule modification.

Specifications

Unit Size 100mg, 1000mg
Molecular Weight 1674.99; single compound
Chemical formula C₇₅H₁₅₁NO₃₈
CAS 756526-07-4
Purity > 98%
Spacers dPEG® Spacer is 111 atoms and 132.7 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, DMAC or DMSO or water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Amino-dPEG®₃₆-acid appeared first on VectorLabs.

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Description

Amino-dPEG®36-acid, product number QBD-10907, is a PEGylated amino acid. A primary amine group and a propionic acid group sit on opposite ends of a long (111 atoms, 132.7 Å), single molecular weight polyethylene glycol (PEG) spacer with a discrete chain length (dPEG®). The highly hydrophilic, discrete PEG spacer (Ð = 1) increases the hydrodynamic volume and imparts water solubility to conjugates that incorporate it. Moreover, Amino-dPEG®36-acid may benefit numerous applications, including peptide synthesis, peptide modification, surface modification, oligonucleotide sequencing, drug delivery, and small molecule modification.

Specifications

Unit Size100mg, 1000mg
Molecular Weight1674.99; single compound
Chemical formulaC₇₅H₁₅₁NO₃₈
CAS756526-07-4
Purity> 98%
SpacersdPEG® Spacer is 111 atoms and 132.7 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, DMAC or DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

PEG-Labeled Nucleotides and Nanopore Detection for Single Molecule DNA Sequencing by Synthesis. Shiv Kumar, Chuanjuan Tao, Minchen Chien, Brittney Hellner, Arvind Balijepalli, Joseph W. F. Robertson, Zengmin Li, James J. Russo, Joseph E. Reiner, John J. Kasianowicz & Jingyue Ju. Scientific Reports. 2012, 2 (684). September 21, 2012. DOI: 10.1038/srep00684.

The post Amino-dPEG®₃₆-acid appeared first on VectorLabs.

]]> Amino-dPEG®₂₄-acid https://staging.vectorlabs.com/products/amino-dpeg24-acid/ Sat, 24 Feb 2024 02:10:00 +0000 https://staging.vectorlabs.com/?post_type=product&p=35960 Amino-dPEG®24-acid, product number QBD-10317, is a PEGylated amino acid. A primary amine group and a propionic acid group sit on opposite ends of a long (76 atoms), single molecular weight polyethylene glycol (PEG) spacer of discrete length (dPEG®). The highly hydrophilic, discrete PEG spacer (Ð = 1) increases the hydrodynamic volume and imparts water solubility to conjugates that incorporate it. Moreover, Amino-dPEG®24-acid benefitted numerous applications, including peptide synthesis, peptide modification, surface modification, oligonucleotide sequencing, drug delivery, and small molecule modification.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 1146.35; single compound
Chemical formula C₅₁H₁₀₃NO₂₆
CAS 756526-07-4
Purity > 97%
Spacers dPEG® Spacer is 76 atoms and 89.0 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, DMAC or DMSO or water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Amino-dPEG®₂₄-acid appeared first on VectorLabs.

]]>

Description

Amino-dPEG®24-acid, product number QBD-10317, is a PEGylated amino acid. A primary amine group and a propionic acid group sit on opposite ends of a long (76 atoms), single molecular weight polyethylene glycol (PEG) spacer of discrete length (dPEG®). The highly hydrophilic, discrete PEG spacer (Ð = 1) increases the hydrodynamic volume and imparts water solubility to conjugates that incorporate it. Moreover, Amino-dPEG®24-acid benefitted numerous applications, including peptide synthesis, peptide modification, surface modification, oligonucleotide sequencing, drug delivery, and small molecule modification.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight1146.35; single compound
Chemical formulaC₅₁H₁₀₃NO₂₆
CAS756526-07-4
Purity> 97%
SpacersdPEG® Spacer is 76 atoms and 89.0 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, DMAC or DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

PEG-Labeled Nucleotides and Nanopore Detection for Single Molecule DNA Sequencing by Synthesis. Shiv Kumar, Chuanjuan Tao, Minchen Chien, Brittney Hellner, Arvind Balijepalli, Joseph W. F. Robertson, Zengmin Li, James J. Russo, Joseph E. Reiner3, John J. Kasianowicz & Jingyue Ju. Scientific Reports. 2012, 2 (684), September 21, 2012. DOI: 10.1038/srep00684.

Proton-sponge activity and receptor-targeting of sequence-defined nucleic acid carriers. Ulrich Benjamin Lachelt. October 21, 2014.

ICAM-1 Targeted Catalase Encapsulated PLGA-b-PEG Nanoparticles against Vascular Oxidative Stress. Sari, E.; Tunc-Sarisozen, Y.; Mutlu, H.; Shahbazi, R.; Ucar, G.; Ulubayram, K. Journal of Microencapsulation 2015, 32 (7), 687–698. https://doi.org/10.3109/02652048.2015.1073384.

The post Amino-dPEG®₂₄-acid appeared first on VectorLabs.

]]> Amino-dPEG®₁₂-acid https://staging.vectorlabs.com/products/amino-dpeg12-acid/ Sat, 24 Feb 2024 02:09:42 +0000 https://staging.vectorlabs.com/?post_type=product&p=35793 Amino-dPEG®12-acid, product number QBD-10287, is a PEGylated amino acid. A primary amine group and a propionic acid group sit on opposite ends of a polyethylene glycol spacer. The highly hydrophilic, discrete PEG spacer (Ð = 1) increases the hydrodynamic volume and imparts water solubility to conjugates that incorporate it. Moreover, Amino-dPEG®12-acid benefitted numerous applications, including peptide synthesis, surface modification, oligonucleotide sequencing, and small molecule modification.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 617.72; single compound
Chemical formula C₂₇H₅₅NO₁₄
CAS 756526-07-4
Purity > 98%
Spacers dPEG® Spacer is 40 atoms and 46.5 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Hot DMAC or DMSO or water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Amino-dPEG®₁₂-acid appeared first on VectorLabs.

]]>

Description

Amino-dPEG®12-acid, product number QBD-10287, is a PEGylated amino acid. A primary amine group and a propionic acid group sit on opposite ends of a polyethylene glycol spacer. The highly hydrophilic, discrete PEG spacer (Ð = 1) increases the hydrodynamic volume and imparts water solubility to conjugates that incorporate it. Moreover, Amino-dPEG®12-acid benefitted numerous applications, including peptide synthesis, surface modification, oligonucleotide sequencing, and small molecule modification.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight617.72; single compound
Chemical formulaC₂₇H₅₅NO₁₄
CAS756526-07-4
Purity> 98%
SpacersdPEG® Spacer is 40 atoms and 46.5 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Hot DMAC or DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Enzyme-Based Nanoscale Composites Composites for Use as Active Decontamination Surfaces. Cerasela Zoica Dinu, Guangyu Zhu, Shyam Sundhar Bale, Gaurav Anand, Philippa J. Reeder, Karl Sanford, Gregg Whited, Ravi S. Kane, and Jonathan S. Dordick. Advance Fuctional Materials. 2010, 20 (3), pp 392-398. February 8, 2010. DOI: 10.1002/adfm.200901388.

Immobilized molecular beacons: A new strategy using UV-activated poly(methyl methacrylate) surfaces to provide large fluorescence sensitivities for reporting on molecular association events. Catherine Situma, Amanda J. Moehring, Mohamed A.F. Noor, Steven A. Soper. Elsevier, Analytical Biochemistry. 2007, 363 (1), pp 35-45, April 1, 2007. DOI: 10.1016/j.ab.2006.12.029.

Antistaphylococcal Nanocomposite Films Based on Enzyme-Nanotube Conjugates. Ravindra C. Pangule, Sarah J. Brooks, Cerasela Zoica Dinu, Shyam Sundhar Bale, Sharon L. Salmon, Guangyu Zhu, Dennis W. Metzgeter, Ravi S. Kane, and Jonathan S. Dordick. ACS Nano. 2010, 4 (7), pp 3993–4000. July 6, 2010. DOI: 10.1021/nn100932t.

Development of a sensitive surface Plasmon resonance immunosensor for detection of 2, 4-dinitrotoluene with a novel oligo (ethylene glycol)-based sensor surface. Kazutaka Nagatomo, Toshikazu Kawaguchi, Norio Miura, Kiyoshi Toko, Kiyoshi Matsumoto. Elsevier, Talanta. 2009, 79 (4), pp 1142-1148. September 15, 2009. DOI: 10.1016/j.talanta.2009.02.018.

Laccase-and chloroperoxidase-nanotube paint composites with bactericidal and sporicidal activity. Navdeep Grover, Indrakant V. Borkar, Cerasela Zoica Dinu, Ravi S. Kane, Jonathan S. Dordick. Enzyme and Microbial Technology. 2012, 50 (6-7) pp 271-279. May 10, 2012. DOI: 10.1016/j.enzmictec.2012.01.006.

Perhydrolase-nanotube paint composites with sporicidal and antiviral activity. Navdeep Grover, Marc P. Douaisi, Indrakant V. Borkar, Lillian Lee, Cerasela Zoica Dinu, Ravi S. Kane, Jonathan S. Dordick. Applied Microbiology and Biotechnology. 2013, 97 (19), pp 8813-8821. October 1, 2013. DOI: 10.1007/s00253-012-4573-3.

Bionanoconjugate-based composites for decontamination of nerve agents. Indrakant V.Borkar, Cerasela Zoica Dinu, Guangyu Zhu, Ravi S. Kane, and Jonathan S. Dordick. Biotechnology Progress. 2010, 26 (6) pp 1622-1628. September 21, 2010. DOI: 10.1002/btpr.498.

Sequence-Defined Oligoamide Drug Conjugates of Pretubulysin and Methotrexate for Folate Receptor Targeted Cancer Therapy. Ines Truebenbach, Jan Gorges, Jasmin Kuhn, Sarah Kern, Emanuele Baratti, Uli Kazmaier, Ernst Wagner, and Ulrich Lachelt. Macromolecular Bioscience. 2017, pp 1-12. March 30, 2017. DOI: 10.1002/mabi.201600520.

The post Amino-dPEG®₁₂-acid appeared first on VectorLabs.

]]> Amino-dPEG®₈-acid https://staging.vectorlabs.com/products/amino-dpeg8-acid/ Sat, 24 Feb 2024 02:07:59 +0000 https://staging.vectorlabs.com/?post_type=product&p=35737 Amino-dPEG®8-acid, product number QBD-10277, is an amino PEG acid. A primary amine and propionic acid terminate the ends of the polyethylene glycol (PEG) spacer. The single molecular weight PEG spacer is discrete (Ð = 1) and highly hydrophilic. Consequently, it increases the hydrodynamic volume and imparts water solubility to conjugates that incorporate it.

Both ends of the molecule are available for conjugation. Conjugation of only one end of the dPEG® spacer may modify the overall charge of the conjugate. Many different types of coupling reactions are effective for this purpose. However, care should be taken not to use single-step EDC coupling, as this will polymerize the dPEG® product.

Scientific publications report the use of Amino-dPEG®8-acid in modifying diverse compounds including antibodies, enzymes, carbon nanotubes, and SU-8 (an epoxy-based negative photoresist) layered atop a quartz surface. In each case, amino-dPEG®8-acid was shown to improve the performance of the conjugate compared to the unmodified material. The improved conjugate performance occurred through increased signal-to-noise ratio, reduced non-specific binding, or both.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 441.51; single compound
Chemical formula C₁₉H₃₉NO₁₀
CAS 756526-04-2
Purity > 98%
Spacers dPEG® Spacer is 28 atoms and 32.2 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) DMAC or DMSO or water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Amino-dPEG®₈-acid appeared first on VectorLabs.

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Description

Amino-dPEG®8-acid, product number QBD-10277, is an amino PEG acid. A primary amine and propionic acid terminate the ends of the polyethylene glycol (PEG) spacer. The single molecular weight PEG spacer is discrete (Ð = 1) and highly hydrophilic. Consequently, it increases the hydrodynamic volume and imparts water solubility to conjugates that incorporate it.

Both ends of the molecule are available for conjugation. Conjugation of only one end of the dPEG® spacer may modify the overall charge of the conjugate. Many different types of coupling reactions are effective for this purpose. However, care should be taken not to use single-step EDC coupling, as this will polymerize the dPEG® product.

Scientific publications report the use of Amino-dPEG®8-acid in modifying diverse compounds including antibodies, enzymes, carbon nanotubes, and SU-8 (an epoxy-based negative photoresist) layered atop a quartz surface. In each case, amino-dPEG®8-acid was shown to improve the performance of the conjugate compared to the unmodified material. The improved conjugate performance occurred through increased signal-to-noise ratio, reduced non-specific binding, or both.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight441.51; single compound
Chemical formulaC₁₉H₃₉NO₁₀
CAS756526-04-2
Purity> 98%
SpacersdPEG® Spacer is 28 atoms and 32.2 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)DMAC or DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

Spacer length effects on in vitro imaging and surface accessibility of fluorescent inhibitors of prostate specific membrane antigen. Tiancheng Liu, Jessie R. Nedrow-Byers, Mark R. Hopkins, Clifford E. Berkman. Bioorganic & Medicinal Chemistry Letters. 2011, 21 (23), pp 7013–7016 October 4, 2011. DOI:10.1016/j.bmcl.2011.09.115.

Short PEG-Linkers Improve the Performance of Targeted, Activatable Monoclonal Antibody-Indocyanine Green Optical Imaging Probes. Kohei Sano, Takahito Nakajima, Kiminori Miyazaki, Yuya Ohuchi, Takashi Ikegami, Peter L. Choyke and Hisataka Kobayashi. Bioconjugate Chem. 2013, 24 (5) pp 811–816. April 22, 2013. DOI: 10.1021/bc400050k.

Novel 3D LithographicallyPrepared Solid-Phase Surfaces Made from SU-8 for Next Generation Sequencing. Hong Wang, Makgorzata Witek, Daniel Park, Jianmin Huang,Francis Barany, Steven A. Soper. Miniaturized Systems for Chem and Life Sci. 2011, pp.73-75. October 6, 2011. DOI: www.rsc.org/images/LOC/2011/PDFs/Papers/026_0829.pdf

Drug loading, dispersion stability, and therapeutic efficacy in targeted drug delivery with carbon nanotubes. Elena Heister, Vera Neves, Constanze Lamprecht, S.Ravi P. Silva, Helen M. Coley, Johnjoe McFadden. Carbon. 2011, 50 (2) pp 622-632. August 31, 2011. DOI: 10.1016/j.carbon.2011.08.074.

Enzyme Catalytic Efficiency: A Function of Bio_nano Interface Reactions. Alan S Campbell, Chenbo Dong, Fanke Meng, Jeremy Hardinger, Gabriela C Perhinschi, Nianqiang Wu, and Cerasela Zoica Dinu. ACS Applied Materials and Interfaces. 2014, 6 pp 5393-5403. March 25, 2014. DOI: dx.doi.org/10.1021/am500773g.

Redirecting extracellular proteases to molecularly guide radiosensitizing drugs to tumors. Dina V. Hingorani, Jessica L. Crisp, Matthew K. Doan, Maria F. Camargo, Maryam A. Quraishi, Joseph Aguilera, Mara Gilardi, Larry A.Gross, Tao Jiang, Wei T. Li, Weg M.Ongkeko, Ezra E. W. Cohen, j. Silvio Gutkind, Stephen R. Adams, Sunil J .Advania. Biomaterials. 2020, Volume 248, July 2020, 120032. 04/11/2020. https://doi.org/10.1016/j.biomaterials.2020.120032

The post Amino-dPEG®₈-acid appeared first on VectorLabs.

]]> Amino-dPEG®₄-acid https://staging.vectorlabs.com/products/amino-dpeg4-acid/ Sat, 24 Feb 2024 02:07:33 +0000 https://staging.vectorlabs.com/?post_type=product&p=35565 Amino-dPEG®4-acid, product number QBD-10244, is an amino PEG acid. A primary amine and propionic acid terminate the ends of the polyethylene glycol (PEG) spacer. The single molecular weight PEG spacer is discrete (Ð = 1) and highly hydrophilic. Consequently, it increases the hydrodynamic volume and imparts water solubility to conjugates that incorporate it.

Both ends of the molecule are available for conjugation. Conjugation of only one end of the dPEG® spacer may modify the overall charge of the conjugate. Many different types of coupling reactions are effective for this purpose. However, care should be taken not to use single-step EDC coupling, as this will polymerize the dPEG® product.

In the scientific literature, this product has been used to modify diverse compounds, including protein microarrays, biological molecules such as antibodies, RGD dimers, and labeled nucleotides. In each case, amino-dPEG®4-acid was shown to improve sensitivity by increasing the signal-to-noise ratio, reducing non-specific binding, or both.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 265.30; single compound
Chemical formula C₁₁H₂₃NO₆
CAS 663921-15-1
Purity > 98%
Spacers dPEG® Spacer is 16 atoms and 18.0 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) DMAC or DMSO or water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Amino-dPEG®₄-acid appeared first on VectorLabs.

]]>

Description

Amino-dPEG®4-acid, product number QBD-10244, is an amino PEG acid. A primary amine and propionic acid terminate the ends of the polyethylene glycol (PEG) spacer. The single molecular weight PEG spacer is discrete (Ð = 1) and highly hydrophilic. Consequently, it increases the hydrodynamic volume and imparts water solubility to conjugates that incorporate it.

Both ends of the molecule are available for conjugation. Conjugation of only one end of the dPEG® spacer may modify the overall charge of the conjugate. Many different types of coupling reactions are effective for this purpose. However, care should be taken not to use single-step EDC coupling, as this will polymerize the dPEG® product.

In the scientific literature, this product has been used to modify diverse compounds, including protein microarrays, biological molecules such as antibodies, RGD dimers, and labeled nucleotides. In each case, amino-dPEG®4-acid was shown to improve sensitivity by increasing the signal-to-noise ratio, reducing non-specific binding, or both.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight265.30; single compound
Chemical formulaC₁₁H₂₃NO₆
CAS663921-15-1
Purity> 98%
SpacersdPEG® Spacer is 16 atoms and 18.0 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)DMAC or DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

Carboxyl-Terminated Dendrimer-Coated Bioactive Interface for Protein Microarray: High-Sensitivity Detection of Antigen in Complex Biological Samples. Parayil Kumaran Ajikumar, Jin Kiat Ng, Yew Chung Tang, Jim Yang Lee, Gregory Stephanopoulos, and Heng-Phon Too. Langmuir. 2007, 23 (10) pp 5670–5677. March 28, 2007. DOI: 10.1021/la063717u.

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

Microwave-Mediated Synthesis of Labeled Nucleotides with Utility in the Synthesis of DNA Probes. Mark Lefever, Jerome W. Kosmeder, II, Michael Farrell, and Christopher Bieniarz. Bioconjugate Chemistry. 2010, 21 (10) pp 1773–1778. September 2, 2010. DOI: 10.1021/bc100013b.

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

Influence of Different Spacers on the Biological Profile of a DOTA-Somatostatin Analogue. Patricia Antunes, Mihaela Ginj, Martin A. Walter, Jianhua Chen, Jean-Claude Reubi, and Helmut R. Maecke. Bioconjugate Chemistry. 2007, 18 (1) pp 84–92. December 15, 2006. DOI: 10.1021/bc0601673.

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

Short PEG-Linkers Improve the Performance of Targeted, Activatable Monoclonal Antibody-Indocyanine Green Optical Imaging Probes. Kohei Sano, Takahito Nakajima, Kiminori Miyazaki, Yuya Ohuchi, Takashi Ikegami, Peter L. Choyke and Hisataka Kobayashi. Bioconjugate Chemistry. 2013, 24 (5) pp 811–816. April 22, 2013. DOI: 10.1021/bc400050k.

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

Improving Tumor-Targeting Capability and Pharmacokinetics of 99mTc-Labeled Cyclic RGD Dimers with PEG4 Linkers. Lijun Wang, Jiyun Shi, Young-Seung Kim, Shizhen Zhai, Bing Jia, Huiyun Zhao, Zhaofei Liu, Fan Wang, Xiaoyuan Chen and Shuang Liu. Molecular Pharmaceutics. 2009, 6 (1) pp 231–245. December 9, 2008. DOI: 10.1021/mp800150r.

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

Improving Tumor Uptake and Pharmacokinetics of 64Cu-Labeled Cyclic RGD Peptide Dimers with Gly3 and PEG4 Linkers. Jiyun Shi, Young-Seung Kim, Shizhen Zhai, Zhaofei Liu, Xiaoyuan Chen and Shuang Liu. Bioconjugate Chemistry. 2009, 20 (4) pp 750–759. March 25, 2009. DOI: 10.1021/bc800455p.

HT-SELEX-based identification of binding pre-miRNA hairpin-motif for small molecules. Sanjukta Mukherjee, Asako Murata, Ryoga Ishida, Ayako Sugai, Chikara Dohno, Michiaki Hamada, Sudhir Krishna, Kazuhiko Nakatani. Molecular Therapy Nucleic Acids. 2021. Volume 27, Page 165-174. November 29, 2021. https://doi.org/10.1016/j.omtn.2021.11.021

Activity-based protein profiling reveals active serine proteases that drive malignancy of human ovarian clear cell carcinoma. Christine Mehner, Alexandra Hockla, Mathew Coban, Benjamin Madden, Rosendo Estrada, Derek C Radisky, Evette S Radisky. Journal Of Biological Chemistry. 2022. Volume 298, Issue 8. June 16, 2022. https://doi.org/10.1016/j.jbc.2022.102146

TNIK Inhibition Has Dual Synergistic Effects on Tumor and Associated Immune Cells. Jaehee Kim, Juhyun Oh, Hannah M Peterson, Jonathan C T Carlson, Mikael J Pittet, Ralph Weissleder. Advanced Biology. 2022. Volume 6, Issue 8. June 8, 2022. https://doi.org/10.1002/adbi.202200030

Multiplexed single-cell analysis of FNA allows accurate diagnosis of salivary gland tumors. Juhyun Oh, Tae Yeon Yoo, Talia M Saal, Lisa Tsay , William C Faquin, Jonathan C T Carlson, Daniel G Deschler, Sara I Pai MD PhD, Ralph Weissleder MD PhD. ACS Journals. 2022. Volume 130, Issue 8, p. 581-594. June 6, 2022. https://doi.org/10.1002/cncy.22594.

In Vivo Click Chemistry Enables Multiplexed Intravital Microscopy. Jina Ko, Kilean Lucas, Rainer Kohler, Elias A Halabi, Marin Wikovitsch, Johathan C T Carlson, Ralph Weissleder. Wiley Online Library. 2022. Volume 9, Issue 24. June 24, 2022. https://doi.org/10.1002/advs.202200064

The post Amino-dPEG®₄-acid appeared first on VectorLabs.

]]> Amino-dPEG®₆-acid https://staging.vectorlabs.com/products/amino-dpeg6-acid/ Sat, 24 Feb 2024 02:04:45 +0000 https://staging.vectorlabs.com/?post_type=product&p=34946 Amino-dPEG®6-acid, product number 10067, is a PEGylated amino acid consisting of a primary amine and a propionic acid on opposite ends of a polyethylene glycol (PEG) spacer. The flexible PEG spacer is discrete (Ð = 1), having a single chain length and molecular weight. Moreover, it is highly hydrophilic, increasing the hydrodynamic volume and imparting water solubility to conjugates that incorporate it. Furthermore, Amino-dPEG®6-acid is helpful in wide-ranging applications, including peptide synthesis, surface modification, dendrimer construction, and small molecule modification.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 353.41; single compound
Chemical formula C₁₅H₃₁NO₈
CAS 905954-28-1
Purity > 98%
Spacers dPEG® Spacer is 22 atoms and 25.1 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) DMAC or DMSO or water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Amino-dPEG®₆-acid appeared first on VectorLabs.

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Description

Amino-dPEG®6-acid, product number QBD-10067, is a PEGylated amino acid consisting of a primary amine and a propionic acid on opposite ends of a polyethylene glycol (PEG) spacer. The flexible PEG spacer is discrete (Ð = 1), having a single chain length and molecular weight. Moreover, it is highly hydrophilic, increasing the hydrodynamic volume and imparting water solubility to conjugates that incorporate it. Furthermore, Amino-dPEG®6-acid is helpful in wide-ranging applications, including peptide synthesis, surface modification, dendrimer construction, and small molecule modification.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 353.41; single compound
Chemical formula C₁₅H₃₁NO₈
CAS 905954-28-1
Purity > 98%
Spacers dPEG® Spacer is 22 atoms and 25.1 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) DMAC or DMSO or water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

  1. Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

  2. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

  3. Synthesis and Preliminary Biological Evaluation of High-Drug-Load Paclitaxel-Antibody Conjugates for Tumor-Targeted Chemotherapy. Sherly Quiles, Kevin P. Raisch, Leisa L. Sanford, James A. Bonner, and Ahmad Safavy, J Med. Chem. 2010, 53 (2), pp 586-594. Dec. 3, 2009. DOI: 10.1021/jm900899g.

  4. TNIK Inhibition Has Dual Synergistic Effects on Tumor and Associated Immune Cells. Jaehee Kim, Juhyun Oh, Hannah M Peterson, Jonathan C T Carlson, Mikael J Pittet, Ralph Weissleder. Advanced Biology. 2022. Volume 6, Issue 8. June 8, 2022. https://doi.org/10.1002/adbi.202200030

The post Amino-dPEG®₆-acid appeared first on VectorLabs.

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