mPEG Thiol – VectorLabs https://staging.vectorlabs.com From linker design and synthesis, bioconjugated design and manufacturing, biomolecule labeling and functionalization, and detection system and solutions, our team is here to help you move forward, with impact. Wed, 22 Oct 2025 17:19:14 +0000 en-US hourly 1 https://wordpress.org/?v=6.8.3 https://staging.vectorlabs.com/wp-content/uploads/2024/11/V-favicon-02-100x100.png mPEG Thiol – VectorLabs https://staging.vectorlabs.com 32 32 m-dPEG®₁₂-Thiol https://staging.vectorlabs.com/products/m-dpeg12-thiol/ Sat, 24 Feb 2024 02:13:09 +0000 https://staging.vectorlabs.com/?post_type=product&p=36868 m-dPEG®12-thiol, product number QBD-10794, is a medium-length (38 atoms) monodisperse PEGylation reagent designed to modify gold and silver surfaces or biomolecules that contain free, surface-accessible thiols. One end of the spacer terminates with a methyl group, while the other end terminates with a sulfhydryl. The sulfhydryl group forms dative bonds with gold or silver, disulfides with free thiols, and thioether bonds with maleimide and bromoacetate groups.

This product is useful for the passivation of gold or silver surfaces. The hydrophilic, non-immunogenic dPEG® spacer eliminates non-specific interactions with the metal surfaces.

If reacted with free thiols on biomolecules, m-dPEG®12-thiol forms disulfide bonds. Moreover, the resulting conjugates display improved water solubility and increased hydrodynamic volume. Furthermore, conjugation of this product with biomolecules potentially reduces or eliminates non-specific interactions and immunogenicity.

Specifications

Unit Size 100mg, 1000mg
Molecular Weight 576.74; single compound
Chemical formula C₂₅H₅₂O₁₂S
CAS 134874-49-0
Purity > 98%
Spacers dPEG® Spacer is 38 atoms and 44.2 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetonitrile, DMAC, DMSO or water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post m-dPEG®₁₂-Thiol appeared first on VectorLabs.

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Description

m-dPEG®12-thiol, product number QBD-10794, is a medium-length (38 atoms) monodisperse PEGylation reagent designed to modify gold and silver surfaces or biomolecules that contain free, surface-accessible thiols. One end of the spacer terminates with a methyl group, while the other end terminates with a sulfhydryl. The sulfhydryl group forms dative bonds with gold or silver, disulfides with free thiols, and thioether bonds with maleimide and bromoacetate groups.

This product is useful for the passivation of gold or silver surfaces. The hydrophilic, non-immunogenic dPEG® spacer eliminates non-specific interactions with the metal surfaces.

If reacted with free thiols on biomolecules, m-dPEG®12-thiol forms disulfide bonds. Moreover, the resulting conjugates display improved water solubility and increased hydrodynamic volume. Furthermore, conjugation of this product with biomolecules potentially reduces or eliminates non-specific interactions and immunogenicity.

Specifications

Unit Size100mg, 1000mg
Molecular Weight576.74; single compound
Chemical formulaC₂₅H₅₂O₁₂S
CAS134874-49-0
Purity> 98%
SpacersdPEG® Spacer is 38 atoms and 44.2 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC, DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

The post m-dPEG®₁₂-Thiol appeared first on VectorLabs.

]]> m-dPEG®₈-Thiol https://staging.vectorlabs.com/products/m-dpeg8-thiol/ Sat, 24 Feb 2024 02:13:08 +0000 https://staging.vectorlabs.com/?post_type=product&p=36860 m-dPEG®8-thiol, product number QBD-10793, is a short (26 atoms) monodisperse PEGylation reagent designed to modify gold and silver surfaces or biomolecules that contain free, surface-accessible thiols. One end of the spacer terminates with a methyl group, while the other end terminates with a sulfhydryl. The sulfhydryl group forms dative bonds with gold or silver, disulfides with free thiols, and thioether bonds with maleimide and bromoacetate groups.

This product is useful for the passivation of gold or silver surfaces. The hydrophilic, non-immunogenic dPEG® spacer eliminates non-specific interactions with the metal surfaces.

If reacted with free thiols on biomolecules, m-dPEG®8-thiol forms disulfide bonds. Moreover, the resulting conjugates display improved water solubility and increased hydrodynamic volume. Furthermore, conjugation of this product with biomolecules potentially reduces or eliminates non-specific interactions and immunogenicity.

Specifications

Unit Size 100mg, 1000mg
Molecular Weight 400.53; single compound
Chemical formula C₁₇H₃₆O₈S
CAS 651042-83-0
Purity > 98%
Spacers dPEG® Spacer is 26 atoms and 30.0 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetonitrile, DMAC, DMSO or water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post m-dPEG®₈-Thiol appeared first on VectorLabs.

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Description

m-dPEG®8-thiol, product number QBD-10793, is a short (26 atoms) monodisperse PEGylation reagent designed to modify gold and silver surfaces or biomolecules that contain free, surface-accessible thiols. One end of the spacer terminates with a methyl group, while the other end terminates with a sulfhydryl. The sulfhydryl group forms dative bonds with gold or silver, disulfides with free thiols, and thioether bonds with maleimide and bromoacetate groups.

This product is useful for the passivation of gold or silver surfaces. The hydrophilic, non-immunogenic dPEG® spacer eliminates non-specific interactions with the metal surfaces.

If reacted with free thiols on biomolecules, m-dPEG®8-thiol forms disulfide bonds. Moreover, the resulting conjugates display improved water solubility and increased hydrodynamic volume. Furthermore, conjugation of this product with biomolecules potentially reduces or eliminates non-specific interactions and immunogenicity.

Specifications

Unit Size100mg, 1000mg
Molecular Weight400.53; single compound
Chemical formulaC₁₇H₃₆O₈S
CAS651042-83-0
Purity> 98%
SpacersdPEG® Spacer is 26 atoms and 30.0 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC, DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Biomarker-Mediated Disruption of Coffee-Ring Formation as a Low Resource Diagnostic Indicator. Joshua R. Trantum, David W. Wright, and Frederick R. Haselton, Langmuir, 2012, 28 (4), pp 2187–2193 December 9, 2011. DOI.org/10.1021/la203903a.

(INVITED)Quantitative detection of SARS-CoV-2 virions in aqueous mediums by IoT optical fiber sensors. Nunzio Cennamo, Girolamo D’Agostino, Laura Pasquardini, Francesco Arcadio, Chiara Perri, Nicola Coppola, Italo Francesco Angelillo, Lucia Altucci, Francesco Di Marzo, Eva Maria Parisio, Giulio Camarlinghi, Luigi Zeni. Science Direct. Volume 5. https://doi.org/10.1016/j.rio.2021.100177

The post m-dPEG®₈-Thiol appeared first on VectorLabs.

]]> m-dPEG®₄-Thiol https://staging.vectorlabs.com/products/m-dpeg4-thiol/ Sat, 24 Feb 2024 02:13:07 +0000 https://staging.vectorlabs.com/?post_type=product&p=36852 m-dPEG®4-thiol, product number QBD-10792, is a short (14 atoms) monodisperse PEGylation reagent designed to modify gold and silver surfaces or biomolecules that contain free, surface-accessible thiols. One end of the spacer terminates with a methyl group, while the other end terminates with a sulfhydryl. The sulfhydryl group forms dative bonds with gold or silver, disulfides with free thiols, and thioether bonds with maleimide and bromoacetate groups.

This product is useful for the passivation of gold surfaces. The hydrophilic, non-immunogenic dPEG® spacer eliminates non-specific interactions with the gold surface.

If reacted with free thiols on biomolecules, m-dPEG®4-thiol forms disulfide bonds. Moreover, the resulting conjugates display improved water solubility and increased hydrodynamic volume. Furthermore, conjugation of this product with biomolecules potentially reduces or eliminates non-specific interactions and immunogenicity.

Specifications

Unit Size 100mg, 1000mg
Molecular Weight 224.32; single compound
Chemical formula C₉H₂₀O₄S
CAS 52190-55-3
Purity > 98%
Spacers dPEG® Spacer is 14 atoms and 15.8 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetonitrile, DMAC, DMSO or water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post m-dPEG®₄-Thiol appeared first on VectorLabs.

]]>

Description

m-dPEG®4-thiol, product number QBD-10792, is a short (14 atoms) monodisperse PEGylation reagent designed to modify gold and silver surfaces or biomolecules that contain free, surface-accessible thiols. One end of the spacer terminates with a methyl group, while the other end terminates with a sulfhydryl. The sulfhydryl group forms dative bonds with gold or silver, disulfides with free thiols, and thioether bonds with maleimide and bromoacetate groups.

This product is useful for the passivation of gold surfaces. The hydrophilic, non-immunogenic dPEG® spacer eliminates non-specific interactions with the gold surface.

If reacted with free thiols on biomolecules, m-dPEG®4-thiol forms disulfide bonds. Moreover, the resulting conjugates display improved water solubility and increased hydrodynamic volume. Furthermore, conjugation of this product with biomolecules potentially reduces or eliminates non-specific interactions and immunogenicity.

Specifications

Unit Size100mg, 1000mg
Molecular Weight224.32; single compound
Chemical formulaC₉H₂₀O₄S
CAS52190-55-3
Purity> 98%
SpacersdPEG® Spacer is 14 atoms and 15.8 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC, DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Gold nanoparticle-based fluorescence quenching via metal coordination for assaying protease activity. Se Yeon Park, So Min Lee, Gae Baik, Kim and Young-Pil Kim. Gold Bull. 2012, 45 pp 213–219. October 25, 2012. DOI: 10.1007/s13404-012-0070-9.

Polymerase Chain Reaction-Free Variable-Number Tandem Repeat Typing Using Gold Nanoparticle–DNA Monoconjugates. Jong Young Choi , Yong Tae Kim , and Tae Seok Seo. ACS Nano 2013, 7 (3) pp 2627–2633. February 12, 2013. DOI: 10.1021/nn400004d.

Near-Infrared-Activated Fluorescence Resonance Energy Transfer-Based Nanocomposite to Sense MMP2-Overexpressing Oral Cancer Cells. Yung-Chieh Chan, Ming-Hsien Chan, Chieh-Wei Chen, Ru-Shi Liu, Michael Hsiao, and Din Ping Tsai. ACS Omega. 2018,3 (2) pp. 1627-1634. February 8, 2018. DOI: 10.1021/acsomega.7b01494.

Magnetic Nanoparticle Tracking for One-Step Protein Seperation and Binding Kinetics Analysis. Yunlei Zhao, Guangzhong Ma, Shaopeng Wang. Journal of The Electrochemical Society. 2022. May 11, 2022. dx.doi.org/10.1149/1945-7111/ac6bc5.

NEW FRONTIERS FOR TRIPLE NEGATIVE BREAST CANCER DETECTION AND TREATMENT: FROM MECHANICAL BIOMARKERS TO SPECIFIC NANOPARTICLE ENTRY FOR ROBOTICALLY CONTROLLED LASER-INDUCED HYPERTHERMIA. Vanessa Uzonwanne. Worchester Polytechnic Institute. 2022. May 22, 2022.

Charge-Sensitive Optical Detection of Binding Kinetics between Phage-Displayed Peptide Ligands and Protein Targets. Runli Liang, Yingnan Zhang, Guangzhong Ma, Shaopeng Wang. MDPI. 2022. Biosensors 2022, 12(6), 394. June 8, 2022. https://doi.org/10.3390/bios12060394

Label-Free Single-Molecule Pulldown for the Detection of Released Cellular Protein Complexes. Guangzhong Ma, Pengfei Zhang, Xinyu Zhou, Zijian Wan, and Shaopeng Wang. ACS Cent. Sci. 2022, 8, 9, 1272–1281. 2022. https://doi.org/10.1021/acscentsci.2c00602

The post m-dPEG®₄-Thiol appeared first on VectorLabs.

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