Boc Protected Aminooxy Reagents – VectorLabs https://staging.vectorlabs.com From linker design and synthesis, bioconjugated design and manufacturing, biomolecule labeling and functionalization, and detection system and solutions, our team is here to help you move forward, with impact. Wed, 22 Oct 2025 17:20:28 +0000 en-US hourly 1 https://wordpress.org/?v=6.8.3 https://staging.vectorlabs.com/wp-content/uploads/2024/11/V-favicon-02-100x100.png Boc Protected Aminooxy Reagents – VectorLabs https://staging.vectorlabs.com 32 32 Amino-dPEG®₁₁-ONH-t-boc https://staging.vectorlabs.com/products/amino-dpeg11-onh-t-boc/ Sat, 24 Feb 2024 02:15:02 +0000 https://staging.vectorlabs.com/?post_type=product&p=37501 Amino-dPEG®11-ONH-t-boc, product number QBD-11112, is a PEGylation reagent that is useful as a building block or modifier. The medium-length (38 atoms, 43.8 Å), single molecular weight discrete PEG (dPEG®) spacer is functionalized with a primary amine and a boc-protected oxyamine at opposite ends of the dPEG® chain. The amine reacts with carboxylic acids and their active esters (NHS, TFP, PFP, etc.) to form stable amide bonds. The oxyamine group reacts with aldehydes and ketones to form non-labile oxime bonds, following removal of the boc protecting group with formic acid or trifluoroacetic acid. The flexible dPEG® spacer increases conjugate molecules' hydrodynamic volume and increases their water solubiliby. Uses for this compound include building novel crosslinkers and designing water-soluble payload delivery systems.

Specifications

Unit Size 100mg, 1000mg
Molecular Weight 660.79; single compound
Chemical formula C₂₉H₆₀N₂O₁₄
CAS N/A
Purity > 97%
Spacers dPEG® Spacer is 38 atoms and 43.8 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

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Description

Amino-dPEG®11-ONH-t-boc, product number QBD-11112, is a PEGylation reagent that is useful as a building block or modifier. The medium-length (38 atoms, 43.8 Å), single molecular weight discrete PEG (dPEG®) spacer is functionalized with a primary amine and a boc-protected oxyamine at opposite ends of the dPEG® chain. The amine reacts with carboxylic acids and their active esters (NHS, TFP, PFP, etc.) to form stable amide bonds. The oxyamine group reacts with aldehydes and ketones to form non-labile oxime bonds, following removal of the boc protecting group with formic acid or trifluoroacetic acid. The flexible dPEG® spacer increases conjugate molecules’ hydrodynamic volume and increases their water solubiliby. Uses for this compound include building novel crosslinkers and designing water-soluble payload delivery systems.

Specifications

Unit Size100mg, 1000mg
Molecular Weight660.79; single compound
Chemical formulaC₂₉H₆₀N₂O₁₄
CASN/A
Purity> 97%
SpacersdPEG® Spacer is 38 atoms and 43.8 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, DMAC or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0); See pp. 276-335 for general description and use of heterobifunctional crosslinkers, and the specific sample protocol for SPDP and LC-SPDP on pp. 286-288. See Greg’s extensive index on pp. 1192-1193 for references to a number and range of applications and their respective protocols.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

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