Boc Protected Amino PEG alcohols – VectorLabs https://staging.vectorlabs.com From linker design and synthesis, bioconjugated design and manufacturing, biomolecule labeling and functionalization, and detection system and solutions, our team is here to help you move forward, with impact. Wed, 22 Oct 2025 17:16:54 +0000 en-US hourly 1 https://wordpress.org/?v=6.8.3 https://staging.vectorlabs.com/wp-content/uploads/2024/11/V-favicon-02-100x100.png Boc Protected Amino PEG alcohols – VectorLabs https://staging.vectorlabs.com 32 32 t-boc-N-amido-dPEG®₄-OH https://staging.vectorlabs.com/products/t-boc-n-amido-dpeg4-oh/ Sat, 24 Feb 2024 02:07:39 +0000 https://staging.vectorlabs.com/?post_type=product&p=35597 t-boc-N-amido-dPEG®4-OH, product number 10250, is a short, monodispersed PEGylation reagent with an alcohol on one end of the single molecular weight, discrete-length PEG (dPEG®) chain and a boc-protected amine on the other end. This product is useful for building novel constructs with dPEG® linkers. This product also permits supramolecular construction and unique side-chain modifications of amino acid residues in peptides.

The terminal alcohol of t-boc-N-amido-dPEG®4-OH can be transformed easily into a different functional group such as an aldehyde or acid. Moreover, the hydroxy group reacts with halide-functionalized compounds to form new products. For example, by reacting propargyl bromide with the terminal hydroxy group in the presence of a base, a dPEG® product with an aliphatic alkyne is formed. Thus, t-boc-N-amido-dPEG®4-OH is a building block for new constructs that incorporate a discrete-length PEGylation product.
The boc-protected amine easily deprotects with trifluoroacetic acid or another acid. The exposed amine may be reacted further or left unmodified.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 293.36; single compound
Chemical formula C₁₃H₂₇NO₆
CAS 106984-09-2
Purity > 97%
Spacers dPEG® Spacer is 13 atoms and 14.3 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetonitrile, DMAC, DMSO or moderate solubility in water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post t-boc-N-amido-dPEG®₄-OH appeared first on VectorLabs.

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Description

t-boc-N-amido-dPEG®4-OH, product number QBD-10250, is a short, monodispersed PEGylation reagent with an alcohol on one end of the single molecular weight, discrete-length PEG (dPEG®) chain and a boc-protected amine on the other end. This product is useful for building novel constructs with dPEG® linkers. This product also permits supramolecular construction and unique side-chain modifications of amino acid residues in peptides.

The terminal alcohol of t-boc-N-amido-dPEG®4-OH can be transformed easily into a different functional group such as an aldehyde or acid. Moreover, the hydroxy group reacts with halide-functionalized compounds to form new products. For example, by reacting propargyl bromide with the terminal hydroxy group in the presence of a base, a dPEG® product with an aliphatic alkyne is formed. Thus, t-boc-N-amido-dPEG®4-OH is a building block for new constructs that incorporate a discrete-length PEGylation product.
The boc-protected amine easily deprotects with trifluoroacetic acid or another acid. The exposed amine may be reacted further or left unmodified.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight293.36; single compound
Chemical formulaC₁₃H₂₇NO₆
CAS106984-09-2
Purity> 97%
SpacersdPEG® Spacer is 13 atoms and 14.3 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC, DMSO or moderate solubility in water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Effects of linker variation on the in vitro and in vivo characteristics of an In-labeled RGD peptide, Ingrid Dijkgraaf, Shuang Liu, John A.W. Kruijtzer, Annemieke C. Soede, Wim J.G. Oyen, Rob M.J. Liskamp, Frans H.M. Corstens, Otto C. Boerman. Nuclear Medicine and Biology. 2007, 1 (34), pp 29-35, January 2007. DOI: 10.1016/j.nucmedbio.2006.10.006.

The post t-boc-N-amido-dPEG®₄-OH appeared first on VectorLabs.

]]> t-boc-N-amido-dPEG®₁₂-OH https://staging.vectorlabs.com/products/t-boc-n-amido-dpeg12-oh/ Sat, 24 Feb 2024 02:05:07 +0000 https://staging.vectorlabs.com/?post_type=product&p=35176 t-boc-N-amido-dPEG®12-OH, product number QBD-10171, is a medium-length, monodispersed PEGylation reagent useful as a building block for supramolecular constructs. The terminal alcohol reacts with isothiocyanate and the active esters of carboxylic acids. The boc-protected amine is easily deprotected with TFA under mild conditions, exposing a primary amine that can be used as a charge modifier or reacted for further construction.

Description

"t-boc-N-amido-dPEG®12-OH, product number QBD-10171, is a medium-length, monodispersed PEGylation reagent. This reagent terminates with alcohol on one end of the single molecular weight, discrete-length PEG (dPEG®) chain and a boc-protected amine on the other end. QBD-10171 is useful as a building block for other constructs that contain a discrete PEG in them.

This product is useful for building unique constructs with dPEG® linkers. This product also permits supramolecular construction and unique side-chain modifications of amino acid residues in peptides. The terminal alcohol of t-boc-N-amido-dPEG®12-OH reacts readily with isothiocyanate groups and the active esters of carboxylic acids. Moreover, it can be transformed easily into different functional groups, including aldehydes, azides, amines, and aliphatic alkynes. For example, reacting propargyl bromide with the terminal hydroxy group in the presence of a base forms a dPEG® product with an aliphatic alkyne for use in click chemistry reactions. Thus, t-boc-N-amido-dPEG®12-OH is a building block for new constructs that incorporate a discrete-length PEGylation product.

The boc-protected amine easily deprotects with trifluoroacetic acid or another acid. The exposed primary amine may be left unmodified or reacted with appropriate groups for further construction."

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 645.78; single compound
Chemical formula C₂₉H₅₉NO₁₄
CAS 159156-95-3
Purity > 98%
Spacers dPEG® Spacer is 38 atoms and 42.7 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetonitrile, DMAC, DMSO or water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post t-boc-N-amido-dPEG®₁₂-OH appeared first on VectorLabs.

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t-boc-N-amido-dPEG®12-OH, product number QBD-10171, is a medium-length, monodispersed PEGylation reagent useful as a building block for supramolecular constructs. The terminal alcohol reacts with isothiocyanate and the active esters of carboxylic acids. The boc-protected amine is easily deprotected with TFA under mild conditions, exposing a primary amine that can be used as a charge modifier or reacted for further construction.

Description

t-boc-N-amido-dPEG®12-OH, product number QBD-10171, is a medium-length, monodispersed PEGylation reagent. This reagent terminates with alcohol on one end of the single molecular weight, discrete-length PEG (dPEG®) chain and a boc-protected amine on the other end. QBD-10171 is useful as a building block for other constructs that contain a discrete PEG in them.

This product is useful for building unique constructs with dPEG® linkers. This product also permits supramolecular construction and unique side-chain modifications of amino acid residues in peptides. The terminal alcohol of t-boc-N-amido-dPEG®12-OH reacts readily with isothiocyanate groups and the active esters of carboxylic acids. Moreover, it can be transformed easily into different functional groups, including aldehydes, azides, amines, and aliphatic alkynes. For example, reacting propargyl bromide with the terminal hydroxy group in the presence of a base forms a dPEG® product with an aliphatic alkyne for use in click chemistry reactions. Thus, t-boc-N-amido-dPEG®12-OH is a building block for new constructs that incorporate a discrete-length PEGylation product.

The boc-protected amine easily deprotects with trifluoroacetic acid or another acid. The exposed primary amine may be left unmodified or reacted with appropriate groups for further construction.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight645.78; single compound
Chemical formulaC₂₉H₅₉NO₁₄
CAS159156-95-3
Purity> 98%
SpacersdPEG® Spacer is 38 atoms and 42.7 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC, DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

  1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

The post t-boc-N-amido-dPEG®₁₂-OH appeared first on VectorLabs.

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