Boc-Hydrazide Reagents – VectorLabs https://staging.vectorlabs.com From linker design and synthesis, bioconjugated design and manufacturing, biomolecule labeling and functionalization, and detection system and solutions, our team is here to help you move forward, with impact. Wed, 22 Oct 2025 17:19:58 +0000 en-US hourly 1 https://wordpress.org/?v=6.8.3 https://staging.vectorlabs.com/wp-content/uploads/2024/11/V-favicon-02-100x100.png Boc-Hydrazide Reagents – VectorLabs https://staging.vectorlabs.com 32 32 Amino-dPEG®₁₂-t-boc-hydrazide https://staging.vectorlabs.com/products/amino-dpeg12-t-boc-hydrazide/ Sat, 24 Feb 2024 02:14:32 +0000 https://staging.vectorlabs.com/?post_type=product&p=37270 Amino-dPEG®12-t-boc hydrazide, product number QBD-10958, is a useful molecular modification and bioconjugation reagent consisting of a free, primary amine on one end of a medium-length (45 atoms, 50.1 Å) single molecular weight, discrete-chain-length polyethylene glycol (dPEG®) linker and a Boc-protected hydrazide group on the other end. The free amine reacts with carboxylic acids and their active esters to form a stable amide bond. Following the removal of the Boc protecting group, the hydrazide can be reacted with an aldehyde (for example, formed from periodate oxidation of carbohydrates) at pH 5 - 7 to form a hydrazone bond. Hydrazone bonds are acid labile but otherwise stable, thus allowing the conjugate or supramolecular construct to degrade under acidic conditions such as in lysosomes or the acidic extracellular microenvironments at inflammation or tumor metastasis sites. The single molecular weight, discrete PEG (dPEG®) crossbridge is water-soluble and non-immunogenic, and it adds flexibility and increases the hydrodynamic volume of conjugates and supramolecular constructs that incorporate it.

Specifications

Unit Size 100mg, 1000mg
Molecular Weight 731.87; single compound
Chemical formula C₃₂H₆₅N₃O₁₅
CAS 1334169-97-9
Purity > 98%
Spacers dPEG® Spacer is 45 atoms and 50.1 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Amino-dPEG®₁₂-t-boc-hydrazide appeared first on VectorLabs.

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Description

Amino-dPEG®12-t-boc hydrazide, product number QBD-10958, is a useful molecular modification and bioconjugation reagent consisting of a free, primary amine on one end of a medium-length (45 atoms, 50.1 Å) single molecular weight, discrete-chain-length polyethylene glycol (dPEG®) linker and a Boc-protected hydrazide group on the other end. The free amine reacts with carboxylic acids and their active esters to form a stable amide bond. Following the removal of the Boc protecting group, the hydrazide can be reacted with an aldehyde (for example, formed from periodate oxidation of carbohydrates) at pH 5 – 7 to form a hydrazone bond. Hydrazone bonds are acid labile but otherwise stable, thus allowing the conjugate or supramolecular construct to degrade under acidic conditions such as in lysosomes or the acidic extracellular microenvironments at inflammation or tumor metastasis sites. The single molecular weight, discrete PEG (dPEG®) crossbridge is water-soluble and non-immunogenic, and it adds flexibility and increases the hydrodynamic volume of conjugates and supramolecular constructs that incorporate it.

Specifications

Unit Size100mg, 1000mg
Molecular Weight731.87; single compound
Chemical formulaC₃₂H₆₅N₃O₁₅
CAS1334169-97-9
Purity> 98%
SpacersdPEG® Spacer is 45 atoms and 50.1 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, DMAC or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

The post Amino-dPEG®₁₂-t-boc-hydrazide appeared first on VectorLabs.

]]> Amino-dPEG®₈-t-boc-hydrazide https://staging.vectorlabs.com/products/amino-dpeg8-t-boc-hydrazide/ Sat, 24 Feb 2024 02:14:31 +0000 https://staging.vectorlabs.com/?post_type=product&p=37228 Amino-dPEG®8-t-boc hydrazide, product number QBD-10957, is a useful molecular modification and bioconjugation reagent consisting of a free, primary amine on one end of a medium-length (30 atoms, 35.9 Å) single molecular weight, discrete-chain-length polyethylene glycol (dPEG®) linker and a Boc-protected hydrazide group on the other end. The free amine reacts with carboxylic acids and their active esters to form a stable amide bond. Following the removal of the Boc protecting group, the hydrazide can be reacted with an aldehyde (for example, formed from periodate oxidation of carbohydrates) at pH 5 - 7 to form a hydrazone bond. Hydrazone bonds are acid labile but otherwise stable, thus allowing the conjugate or supramolecular construct to degrade under acidic conditions such as in lysosomes or the acidic extracellular microenvironments at inflammation or tumor metastasis sites. The single molecular weight, discrete PEG (dPEG®) crossbridge is water-soluble and non-immunogenic, and it adds flexibility and increases the hydrodynamic volume of conjugates and supramolecular constructs that incorporate it.

Specifications

Unit Size 100mg, 1000mg
Molecular Weight 555.66; single compound
Chemical formula C₂₄H₄₉N₃O₁₁
CAS 1334169-96-8
Purity > 98%
Spacers dPEG® Spacer is 30 atoms and 35.9 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Amino-dPEG®₈-t-boc-hydrazide appeared first on VectorLabs.

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Description

Amino-dPEG®8-t-boc hydrazide, product number QBD-10957, is a useful molecular modification and bioconjugation reagent consisting of a free, primary amine on one end of a medium-length (30 atoms, 35.9 Å) single molecular weight, discrete-chain-length polyethylene glycol (dPEG®) linker and a Boc-protected hydrazide group on the other end. The free amine reacts with carboxylic acids and their active esters to form a stable amide bond. Following the removal of the Boc protecting group, the hydrazide can be reacted with an aldehyde (for example, formed from periodate oxidation of carbohydrates) at pH 5 – 7 to form a hydrazone bond. Hydrazone bonds are acid labile but otherwise stable, thus allowing the conjugate or supramolecular construct to degrade under acidic conditions such as in lysosomes or the acidic extracellular microenvironments at inflammation or tumor metastasis sites. The single molecular weight, discrete PEG (dPEG®) crossbridge is water-soluble and non-immunogenic, and it adds flexibility and increases the hydrodynamic volume of conjugates and supramolecular constructs that incorporate it.

Specifications

Unit Size100mg, 1000mg
Molecular Weight555.66; single compound
Chemical formulaC₂₄H₄₉N₃O₁₁
CAS1334169-96-8
Purity> 98%
SpacersdPEG® Spacer is 30 atoms and 35.9 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, DMAC or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

The post Amino-dPEG®₈-t-boc-hydrazide appeared first on VectorLabs.

]]> Fmoc-N-amido-dPEG®₄-t-boc-hydrazide https://staging.vectorlabs.com/products/fmoc-n-amido-dpeg4-t-boc-hydrazide/ Sat, 24 Feb 2024 02:04:35 +0000 https://staging.vectorlabs.com/?post_type=product&p=34855 Fmoc-N-amido-dPEG®-t-boc-hydrazide, product number 10043, is a heterobifunctional PEG modifier containing a short discrete PEG chain. It is useful in syntheses where an acid-labile hydrazone functionality is required.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 601.69; single compound
Chemical formula C₃₁H₄₃N₃O₉
CAS
1263044-77-4
Purity > 98%
Spacers
dPEG® Spacer is 18 atoms and 21.1 Å
Shipping
Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetontrile, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Fmoc-N-amido-dPEG®₄-t-boc-hydrazide appeared first on VectorLabs.

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Description

Fmoc-N-amido-dPEG®-t-boc-hydrazide, product number QBD-10043, is a heterobifunctional PEG modifier containing a short discrete PEG chain. It is useful in syntheses where an acid-labile hydrazone functionality is required.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 601.69; single compound
Chemical formula C₃₁H₄₃N₃O₉
CAS
1263044-77-4
Purity > 98%
Spacers
dPEG® Spacer is 18 atoms and 21.1 Å
Shipping
Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetontrile, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

  1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

The post Fmoc-N-amido-dPEG®₄-t-boc-hydrazide appeared first on VectorLabs.

]]> Amino-dPEG®₄-t-boc-hydrazide https://staging.vectorlabs.com/products/amino-dpeg4-t-boc-hydrazide/ Sat, 24 Feb 2024 02:04:34 +0000 https://staging.vectorlabs.com/?post_type=product&p=34846 Amino-dPEG®4-t-boc hydrazide, product number QBD-10041, is a useful molecular modification and bioconjugation reagent. The product has a free, primary amine on one end of a short (18 atoms, 21.1 Å) single molecular weight, discrete-chain-length polyethylene glycol (dPEG®) linker. The other end of this linker has a boc-protected hydrazide group. The free amine reacts with carboxylic acids and their active esters to form a stable amide bond. Following the removal of the Boc protecting group, the hydrazide can be reacted with an aldehyde (for example, formed from periodate oxidation of carbohydrates) at pH 5 - 7 to form a hydrazone bond. Hydrazone bonds are acid labile but otherwise stable, thus allowing the conjugate or supramolecular construct to degrade under acidic conditions such as in lysosomes or the acidic extracellular microenvironments at inflammation or tumor metastasis sites. The single molecular weight, discrete PEG (dPEG®) crossbridge is water-soluble and non-immunogenic, and it adds flexibility and increases the hydrodynamic volume of conjugates and supramolecular constructs that incorporate it.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 379.45; single compound
Chemical formula C₁₆H₃₃N₃O₇
CAS
1263047-17-1
Purity > 98%
Spacers
dPEG® Spacer is 18 atoms and 21.1 Å
Shipping
Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Amino-dPEG®₄-t-boc-hydrazide appeared first on VectorLabs.

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Description

Amino-dPEG®4-t-boc hydrazide, product number QBD-10041, is a useful molecular modification and bioconjugation reagent. The product has a free, primary amine on one end of a short (18 atoms, 21.1 Å) single molecular weight, discrete-chain-length polyethylene glycol (dPEG®) linker. The other end of this linker has a boc-protected hydrazide group. The free amine reacts with carboxylic acids and their active esters to form a stable amide bond. Following the removal of the Boc protecting group, the hydrazide can be reacted with an aldehyde (for example, formed from periodate oxidation of carbohydrates) at pH 5 – 7 to form a hydrazone bond. Hydrazone bonds are acid labile but otherwise stable, thus allowing the conjugate or supramolecular construct to degrade under acidic conditions such as in lysosomes or the acidic extracellular microenvironments at inflammation or tumor metastasis sites. The single molecular weight, discrete PEG (dPEG®) crossbridge is water-soluble and non-immunogenic, and it adds flexibility and increases the hydrodynamic volume of conjugates and supramolecular constructs that incorporate it.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 379.45; single compound
Chemical formula C₁₆H₃₃N₃O₇
CAS
1263047-17-1
Purity > 98%
Spacers
dPEG® Spacer is 18 atoms and 21.1 Å
Shipping
Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

  1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

The post Amino-dPEG®₄-t-boc-hydrazide appeared first on VectorLabs.

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