Amino PEG alcohols – VectorLabs https://staging.vectorlabs.com From linker design and synthesis, bioconjugated design and manufacturing, biomolecule labeling and functionalization, and detection system and solutions, our team is here to help you move forward, with impact. Wed, 22 Oct 2025 17:19:37 +0000 en-US hourly 1 https://wordpress.org/?v=6.8.3 https://staging.vectorlabs.com/wp-content/uploads/2024/11/V-favicon-02-100x100.png Amino PEG alcohols – VectorLabs https://staging.vectorlabs.com 32 32 Amino-dPEG®₃₆-OH https://staging.vectorlabs.com/products/amino-dpeg36-oh/ Sat, 24 Feb 2024 02:13:35 +0000 https://staging.vectorlabs.com/?post_type=product&p=37079 Amino-dPEG®36-OH, product number QBD-10869, also known as Amino-dPEG®36-alcohol, is a long (107 atoms, 129.0 Å), monodispersed PEGylation reagent designed to modify surfaces and biomolecules. One end of the molecule terminates with a primary amine, while the other end terminates with a primary alcohol group. This extremely hydrophilic PEGylation reagent reacts with carboxylate groups via the primary amine, leaving the hydroxy terminus free for functionalization and further reactions or as a hydrophilicity or charge modifier for the conjugate molecule.

The most common uses for Amino-dPEG®36-OH include modifying biomolecules and passivating surfaces with a highly hydrophilic coating. The primary amine on one end of the dPEG® linker reacts with carboxylates to form stable amide bonds and with aldehydes and ketones to form labile Schiff bases that can be reduced to secondary amines under mild conditions for greater stability. Conjugations with this molecule most commonly use the amine-carboxylate reaction with a carbodiimide such as EDC. Alternatively, activation of carboxylate as the NHS or TFP ester followed by reaction under slightly basic conditions also permits conjugation of the carboxylate and amino moieties.

Specifications

Unit Size 100mg, 1000mg
Molecular Weight 1602.92; single compound
Chemical formula C₇₂H₁₄₇NO₃₆
CAS 933789-97-0
Purity > 97%
Spacers dPEG® Spacer is 107 atoms and 129.0 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride or water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Amino-dPEG®₃₆-OH appeared first on VectorLabs.

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Description

Amino-dPEG®36-OH, product number QBD-10869, also known as Amino-dPEG®36-alcohol, is a long (107 atoms, 129.0 Å), monodispersed PEGylation reagent designed to modify surfaces and biomolecules. One end of the molecule terminates with a primary amine, while the other end terminates with a primary alcohol group. This extremely hydrophilic PEGylation reagent reacts with carboxylate groups via the primary amine, leaving the hydroxy terminus free for functionalization and further reactions or as a hydrophilicity or charge modifier for the conjugate molecule.

The most common uses for Amino-dPEG®36-OH include modifying biomolecules and passivating surfaces with a highly hydrophilic coating. The primary amine on one end of the dPEG® linker reacts with carboxylates to form stable amide bonds and with aldehydes and ketones to form labile Schiff bases that can be reduced to secondary amines under mild conditions for greater stability. Conjugations with this molecule most commonly use the amine-carboxylate reaction with a carbodiimide such as EDC. Alternatively, activation of carboxylate as the NHS or TFP ester followed by reaction under slightly basic conditions also permits conjugation of the carboxylate and amino moieties.

Specifications

Unit Size100mg, 1000mg
Molecular Weight1602.92; single compound
Chemical formulaC₇₂H₁₄₇NO₃₆
CAS933789-97-0
Purity> 97%
SpacersdPEG® Spacer is 107 atoms and 129.0 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

The post Amino-dPEG®₃₆-OH appeared first on VectorLabs.

]]> Amino-dPEG®₂₄-OH https://staging.vectorlabs.com/products/amino-dpeg24-oh/ Sat, 24 Feb 2024 02:13:34 +0000 https://staging.vectorlabs.com/?post_type=product&p=37071 Amino-dPEG®24-OH, product number QBD-10868, also known as Amino-dPEG®24-alcohol, is a long (71 atoms, 86.0 Å), monodispersed PEGylation reagent designed to modify surfaces and biomolecules. One end of the molecule terminates with a primary amine, while the other end terminates with a primary alcohol group. This extremely hydrophilic PEGylation reagent reacts with carboxylate groups via the primary amine, leaving the hydroxy terminus free for functionalization and further reactions or as a hydrophilicity or charge modifier for the conjugate molecule.

The most common uses for Amino-dPEG®24-OH include modifying biomolecules and passivating surfaces with a highly hydrophilic coating. The primary amine on one end of the dPEG® linker reacts with carboxylates to form stable amide bonds and with aldehydes and ketones to form labile Schiff bases that can be reduced to secondary amines under mild conditions for greater stability. Conjugations with this molecule most commonly use the amine-carboxylate reaction with a carbodiimide such as EDC. Alternatively, activation of carboxylate as the NHS or TFP ester followed by reaction under slightly basic conditions also permits conjugation of the carboxylate and amino moieties.

Specifications

Unit Size 100mg, 1000mg
Molecular Weight 1074.29; single compound
Chemical formula C₄₈H₉₉NO₂₄
CAS 933789-97-0
Purity > 97%
Spacers dPEG® Spacer is 71 atoms and 86.0 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride or water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Amino-dPEG®₂₄-OH appeared first on VectorLabs.

]]>

Description

Amino-dPEG®24-OH, product number QBD-10868, also known as Amino-dPEG®24-alcohol, is a long (71 atoms, 86.0 Å), monodispersed PEGylation reagent designed to modify surfaces and biomolecules. One end of the molecule terminates with a primary amine, while the other end terminates with a primary alcohol group. This extremely hydrophilic PEGylation reagent reacts with carboxylate groups via the primary amine, leaving the hydroxy terminus free for functionalization and further reactions or as a hydrophilicity or charge modifier for the conjugate molecule.

The most common uses for Amino-dPEG®24-OH include modifying biomolecules and passivating surfaces with a highly hydrophilic coating. The primary amine on one end of the dPEG® linker reacts with carboxylates to form stable amide bonds and with aldehydes and ketones to form labile Schiff bases that can be reduced to secondary amines under mild conditions for greater stability. Conjugations with this molecule most commonly use the amine-carboxylate reaction with a carbodiimide such as EDC. Alternatively, activation of carboxylate as the NHS or TFP ester followed by reaction under slightly basic conditions also permits conjugation of the carboxylate and amino moieties.

Specifications

Unit Size100mg, 1000mg
Molecular Weight1074.29; single compound
Chemical formulaC₄₈H₉₉NO₂₄
CAS933789-97-0
Purity> 97%
SpacersdPEG® Spacer is 71 atoms and 86.0 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Real-Time Video Imaging of Protease Expression In Vivo. Lei Zhu, Jin Xie, Magdalena Swierczewska, Fan Zhang, Qimeng Quan, Ying Ma, Xuexun Fang, Kwangmeyung Kim, Seulki Lee, Xiaoyuan Chen.Theranostics. 2011, (1) pp. 18-27. January 12, 2011. http://www.thno.org/v01p0018.htm.

The post Amino-dPEG®₂₄-OH appeared first on VectorLabs.

]]> Amino-dPEG®₄-OH https://staging.vectorlabs.com/products/amino-dpeg4-oh/ Sat, 24 Feb 2024 02:07:38 +0000 https://staging.vectorlabs.com/?post_type=product&p=35589 Amino-dPEG®4-OH, product number QBD-10249, is a monodisperse PEGylation reagent designed for chemical modification of biomolecules and surfaces. The primary amine on one end of the molecule reacts with carboxylates to form amide bonds and with aldehydes and ketones to form labile Schiff bases. The hydrophilic, non-immunogenic, discrete polyethylene glycol (dPEG®) spacer improves water solubility and increases the hydrodynamic volume of conjugates. The terminal hydroxy group can be modified to add different functional groups.

When used to modify biomolecules or passivate surfaces, amino-dPEG®4-OH creates an extremely hydrophilic coating on the modified surface or molecule. The primary amine on one end of the dPEG® linker reacts with carboxylates, aldehydes, and ketones. Conjugations with this molecule most commonly use the amine-carboxylate reaction because it forms stable amide bonds. A carbodiimide such as EDC directly connects the amino group to a carboxylate. Alternatively, activation of carboxylate as the NHS or TFP ester followed by reaction under slightly basic conditions also permits conjugation of the carboxylate and amino moieties.

The amino group also reacts with aldehydes and ketones to form Schiff bases. Schiff bases are reducible to secondary amines for improved stability.

The published uses of Amino-dPEG®4-OH include the following:
Surface coating of iron oxide nanoparticles;
Surface coating of quantum dots;
Development of a confocal imaging system to measure passive transport across membranes; and,
Development of a label-free detector of pyrophosphate.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 193.24; single compound
Chemical formula C₈H₁₉NO₄
CAS 86770-74-3
Purity > 98%
Spacers dPEG® Spacer is 13 atoms and 14.3 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, DMAC, DMSO or water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Amino-dPEG®₄-OH appeared first on VectorLabs.

]]>

Description

Amino-dPEG®4-OH, product number QBD-10249, is a monodisperse PEGylation reagent designed for chemical modification of biomolecules and surfaces. The primary amine on one end of the molecule reacts with carboxylates to form amide bonds and with aldehydes and ketones to form labile Schiff bases. The hydrophilic, non-immunogenic, discrete polyethylene glycol (dPEG®) spacer improves water solubility and increases the hydrodynamic volume of conjugates. The terminal hydroxy group can be modified to add different functional groups.

When used to modify biomolecules or passivate surfaces, amino-dPEG®4-OH creates an extremely hydrophilic coating on the modified surface or molecule. The primary amine on one end of the dPEG® linker reacts with carboxylates, aldehydes, and ketones. Conjugations with this molecule most commonly use the amine-carboxylate reaction because it forms stable amide bonds. A carbodiimide such as EDC directly connects the amino group to a carboxylate. Alternatively, activation of carboxylate as the NHS or TFP ester followed by reaction under slightly basic conditions also permits conjugation of the carboxylate and amino moieties.

The amino group also reacts with aldehydes and ketones to form Schiff bases. Schiff bases are reducible to secondary amines for improved stability.

The published uses of Amino-dPEG®4-OH include the following:
Surface coating of iron oxide nanoparticles;
Surface coating of quantum dots;
Development of a confocal imaging system to measure passive transport across membranes; and,
Development of a label-free detector of pyrophosphate.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight193.24; single compound
Chemical formulaC₈H₁₉NO₄
CAS86770-74-3
Purity> 98%
SpacersdPEG® Spacer is 13 atoms and 14.3 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, DMAC, DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Label-Free Detection of Proteins in Crude Cell Lysate with Antibody Arrays by a Surface Plasmon Resonance Imaging Technique. Motoki Kyo, Kazue Usui-Aoki, and Hisashi Koga. Analytical Chemistry. 2005, 77 (22), pp 7115–7121. October 18, 2005. DOI: 10.1021/ac050884a.

Development of an oligo (ethylene glycol)-based SPR immunosensor for TNT detection. Yutaka Mizuta, Takeshi Onodera, Praveen Singh, Kiyoshi Matsumoto, Norio Miura, Kiyoshi Toko. Biosensors and Bioelectronics. 2008, 24 (2), pp 191-197. October 15, 2008. DOI:10.1016/j.bios.2008.03.042.

Real-Time Video Imaging of Protease Expression In Vivo. Lei Zhu, Jin Xie, Magdalena Swierczewska, Fan Zhang, Qimeng Quan, Ying Ma, Xuexun Fang, Kwangmeyung Kim, Seulki Lee, Xiaoyuan Chen. Theranostics. 2011, (1) pp 18-27. January 12, 2011. http://www.thno.org/v01p0018.htm.

Confocal imaging to quantify passive transport across biomimetic lipid membranes. Su Li, Peichi Hu, and Noah Malmstadt. Analytical Chemistry. 2010, 82 (18) pp 7766-7771 September 15, 2010. DOI: 10.1021/ac1016826.

Label-free electrical detection of pyrophosphate generated from DNA polymerase reactions on field-effect devices. Grace M. Credo, Xing Su, Kai Wu, Oguz H. Elibol, David J. Liua, Bobby Reddy Jr., Ta-Wei Tsai, Brian R. Dorvel, Jonathan S. Daniels, Rashid Bashir, and Madoo Varma. Analyst. 2012, 137 (6) pp 1351-1362. March 21, 2012. DOI:10.1039/c2an15930a.

Synthesis of Biotinylated r-D-Mannoside or N-Acetyl _-D-Glucosaminoside Decorated Gold Nanoparticles: Study of Their Biomolecular Recognition with Con A and WGA Lectins. Xiaoze Jiang, Abdelghani Housni, Guillaume Gody, Paul Boullanger, Marie-The´re`se Charreyre, Thierry Delair, and Ravin Narain. Bioconjugate Chem. 2010, 21 pp 521–530. February 3, 2010. DOI: 10.1021/bc900431p.

Surface Chemical Functionalization of Cylindrical Nanopores Derived from a Polystyrene−Poly(methylmethacrylate) Diblock Copolymer via Amidation. Yongxin Li and Takashi Ito. Langmuir. 2008, 24 (16) pp 8959–8963. July 1, 2008. DOI: 10.1021/la800992f.

Permeation Studies across Symmetric and Asymmetric Membranes in Microdroplet Arrays. Simon Bachler, Marion Ort, Stefanie D. Krämer, and Petra S. Dittrich. Analytical Chemistry. 2021. Volume 93, 12, 5137-5144. 03/31/2021. https://doi.org/10.1021/acs.analchem.0c04939

The post Amino-dPEG®₄-OH appeared first on VectorLabs.

]]> Amino-dPEG®₈-OH https://staging.vectorlabs.com/products/amino-dpeg8-oh/ Sat, 24 Feb 2024 02:07:31 +0000 https://staging.vectorlabs.com/?post_type=product&p=35551 Amino-dPEG®8-OH, product number QBD-10249, is a monodisperse PEGylation reagent designed for chemical modification of biomolecules and surfaces. The primary amine on one end of the molecule reacts with carboxylates to form amide bonds and with aldehydes and ketones to form labile Schiff bases. The hydrophilic, non-immunogenic, discrete polyethylene glycol (dPEG®) spacer improves water solubility and increases the hydrodynamic volume of conjugates. The terminal hydroxy group can be modified to add different functional groups.

Description

Amino-dPEG®8-OH is a monodisperse PEGylation reagent designed for chemical modification of biomolecules and surfaces. The primary amine on one end of the molecule reacts with carboxylates to form amide bonds and with aldehydes and ketones to form labile Schiff bases. The hydrophilic, non-immunogenic, discrete polyethylene glycol (dPEG®) spacer improves water solubility and increases the hydrodynamic volume of conjugates. The terminal hydroxy group can be modified to add different functional groups.

Amino-dPEG®8-OH has many possible uses. The most common uses are modifying biomolecules and passivating surfaces with an extremely hydrophilic coating. The primary amine on one end of the dPEG® linker reacts with carboxylates, aldehydes, and ketones. Conjugations with this molecule most commonly use the amine-carboxylate reaction because it forms stable amide bonds. A carbodiimide such as EDC directly connects the amino group to a carboxylate. Alternatively, activation of carboxylate as the NHS or TFP ester followed by reaction under slightly basic conditions also permits conjugation of the carboxylate and amino moieties.

The amino group also reacts with aldehydes and ketones to form Schiff bases. Schiff bases are reducible to secondary amines for improved stability.

The published uses of Amino-dPEG®8-OH include the following:
Surface coating of iron oxide nanoparticles;
Surface coating of quantum dots;
Development of a confocal imaging system to measure passive transport across membranes; and,
Development of a label-free detector of pyrophosphate.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 369.45; single compound
Chemical formula C₁₆H₃₅NO₈
CAS 352439-37-3
Purity > 98%
Spacers dPEG® Spacer is 28 atoms and 32.1 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, DMAC, DMSO or water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Amino-dPEG®₈-OH appeared first on VectorLabs.

]]>

Amino-dPEG®8-OH, product number QBD-10249, is a monodisperse PEGylation reagent designed for chemical modification of biomolecules and surfaces. The primary amine on one end of the molecule reacts with carboxylates to form amide bonds and with aldehydes and ketones to form labile Schiff bases. The hydrophilic, non-immunogenic, discrete polyethylene glycol (dPEG®) spacer improves water solubility and increases the hydrodynamic volume of conjugates. The terminal hydroxy group can be modified to add different functional groups.

Description

Amino-dPEG®8-OH is a monodisperse PEGylation reagent designed for chemical modification of biomolecules and surfaces. The primary amine on one end of the molecule reacts with carboxylates to form amide bonds and with aldehydes and ketones to form labile Schiff bases. The hydrophilic, non-immunogenic, discrete polyethylene glycol (dPEG®) spacer improves water solubility and increases the hydrodynamic volume of conjugates. The terminal hydroxy group can be modified to add different functional groups.

Amino-dPEG®8-OH has many possible uses. The most common uses are modifying biomolecules and passivating surfaces with an extremely hydrophilic coating. The primary amine on one end of the dPEG® linker reacts with carboxylates, aldehydes, and ketones. Conjugations with this molecule most commonly use the amine-carboxylate reaction because it forms stable amide bonds. A carbodiimide such as EDC directly connects the amino group to a carboxylate. Alternatively, activation of carboxylate as the NHS or TFP ester followed by reaction under slightly basic conditions also permits conjugation of the carboxylate and amino moieties.

The amino group also reacts with aldehydes and ketones to form Schiff bases. Schiff bases are reducible to secondary amines for improved stability.

The published uses of Amino-dPEG®8-OH include the following:
Surface coating of iron oxide nanoparticles;
Surface coating of quantum dots;
Development of a confocal imaging system to measure passive transport across membranes; and,
Development of a label-free detector of pyrophosphate.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight369.45; single compound
Chemical formulaC₁₆H₃₅NO₈
CAS352439-37-3
Purity> 98%
SpacersdPEG® Spacer is 28 atoms and 32.1 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, DMAC, DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

  1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.
  2. How a grafting anchor tailors cellular uptake and in vivo fate of dendronized iron oxide nanoparticles. C. Bordeianu, A. Parat, C. Affolter-Zbaraszczuk, R. N. Muller, S. Boutry, S. Begin-Colin, F. Meyer, S. Laurent, and D. Felder-Flesch. Journal of Materials Chemistry B. 2017, 2013 (00) pp 1-3. May 26, 2017. DOI: 10.1039/C7TB00781G.
  3. Confocal imaging to quantify passive transport across biomimetic lipid membranes. Su Li, Peichi Hu, and Noah Malmstadt. Analytical Chemistry. 2010, 82 (18) pp 7766-7771. September 15, 2010. DOI: 10.1021/ac1016826.
  4. Label-free electrical detection of pyrophosphate generated from DNA polymerase reactions on field-effect devices. Grace M. Credo, Xing Su, Kai Wu, Oguz H. Elibol, David J. Liua, Bobby Reddy Jr., Ta-Wei Tsai, Brian R. Dorvel, Jonathan S. Daniels, Rashid Bashir, and Madoo Varma. Analyst. 2012 137 (6) pp 1351-1362. March 21, 2012. DOI:10.1039/c2an15930a.
  5. Quantum Dots with Multivalent and Compact Polymer Coatings for Efficient Fluorescence Resonance Energy Transfer and Self-Assembled Biotagging. Hongwei Duan , Min Kuang and Y. Andrew Wang. Chemistry of Materials. 2010, 22 (15) pp 4372–4378. July 13, 2010. DOI: 10.1021/cm100442x.

The post Amino-dPEG®₈-OH appeared first on VectorLabs.

]]> Amino-dPEG®₁₂-OH https://staging.vectorlabs.com/products/amino-dpeg12-oh/ Sat, 24 Feb 2024 02:05:05 +0000 https://staging.vectorlabs.com/?post_type=product&p=35168 Amino-dPEG®12-OH, product number QBD-10170, is a medium-length, discrete PEG (dPEG®) compound that is useful for modifying and passivating surfaces with a highly hydrophilic coating. The primary amine reacts with carboxylates and their active esters, aldehydes, and ketones. The terminal OH group can be further transformed to introduce other moieties onto the modified molecule or surface.

Description

"Amino-dPEG®12-OH, product number QBD-10170, also known as Amino-dPEG®12-alcohol, is a medium-length, monodispersed PEGylation reagent designed to modify surfaces and biomolecules. One end of the molecule terminates with a primary amine, while the other end terminates with a primary alcohol group. This extremely hydrophilic PEGylation reagent modifies biomolecules and surfaces that possess carboxylate groups. If desired, the terminal alcohol moiety can be transformed with appropriate functional groups to further modify the biomolecule or surface.

Amino-dPEG®12-OH has many possible uses. The most common uses are modifying biomolecules and passivating surfaces with a highly hydrophilic coating. The primary amine on one end of the dPEG® linker reacts with carboxylates, aldehydes, and ketones. Conjugations with this molecule most commonly use the amine-carboxylate reaction because it forms stable amide bonds. A carbodiimide such as EDC directly connects the amino group to a carboxylate. Alternatively, activation of carboxylate as the NHS or TFP ester followed by reaction under slightly basic conditions also permits conjugation of the carboxylate and amino moieties.

The amino group also reacts with aldehydes and ketones to form Schiff bases. Schiff bases are reducible to secondary amines for improved stability.

The published uses of Amino-dPEG®12-OH include the following:
Stabilizing artificial membranes;
Real-time imaging of in vivo protease expression;
Developing a confocal imaging system to monitor passive membrane transport; and,
Development of a label-free pyrophosphate detector."

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 545.66; single compound
Chemical formula C₂₄H₅₁NO₁₂
CAS 933789-97-0
Purity > 98%
Spacers dPEG® Spacer is 38 atoms and 42.7 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, DMAC or DMSO or water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post Amino-dPEG®₁₂-OH appeared first on VectorLabs.

]]>

Amino-dPEG®12-OH, product number QBD-10170, is a medium-length, discrete PEG (dPEG®) compound that is useful for modifying and passivating surfaces with a highly hydrophilic coating. The primary amine reacts with carboxylates and their active esters, aldehydes, and ketones. The terminal OH group can be further transformed to introduce other moieties onto the modified molecule or surface.

Description

Amino-dPEG®12-OH, product number QBD-10170, also known as Amino-dPEG®12-alcohol, is a medium-length, monodispersed PEGylation reagent designed to modify surfaces and biomolecules. One end of the molecule terminates with a primary amine, while the other end terminates with a primary alcohol group. This extremely hydrophilic PEGylation reagent modifies biomolecules and surfaces that possess carboxylate groups. If desired, the terminal alcohol moiety can be transformed with appropriate functional groups to further modify the biomolecule or surface.

Amino-dPEG®12-OH has many possible uses. The most common uses are modifying biomolecules and passivating surfaces with a highly hydrophilic coating. The primary amine on one end of the dPEG® linker reacts with carboxylates, aldehydes, and ketones. Conjugations with this molecule most commonly use the amine-carboxylate reaction because it forms stable amide bonds. A carbodiimide such as EDC directly connects the amino group to a carboxylate. Alternatively, activation of carboxylate as the NHS or TFP ester followed by reaction under slightly basic conditions also permits conjugation of the carboxylate and amino moieties.

The amino group also reacts with aldehydes and ketones to form Schiff bases. Schiff bases are reducible to secondary amines for improved stability.

The published uses of Amino-dPEG®12-OH include the following:
Stabilizing artificial membranes;
Real-time imaging of in vivo protease expression;
Developing a confocal imaging system to monitor passive membrane transport; and,
Development of a label-free pyrophosphate detector.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight545.66; single compound
Chemical formulaC₂₄H₅₁NO₁₂
CAS933789-97-0
Purity> 98%
SpacersdPEG® Spacer is 38 atoms and 42.7 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, DMAC or DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

  1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

  2. Addition of Cleaved Tail Fragments during Lipid Oxidation Stabilizes Membrane Permeability Behavior. Kristina A. Runas, Shiv J. Acharya, Jacob J. Schmidt, and Noah Malmstadt. Langmuir. 2015, December 24, 2015. DOI: 10.1021/acs.langmuir.5b02980.

  3. Real-Time Video Imaging of Protease Expression In Vivo. Lei Zhu, Jin Xie, Magdalena Swierczewska, Fan Zhang, Qimeng Quan, Ying Ma, Xuexun Fang, Kwangmeyung Kim, Seulki Lee, Xiaoyuan Chen. Theranostics. 2011, (1) 2011. 1:18-27 c. http://www.thno.org/v01p0018.htm.

  4. Confocal imaging to quantify passive transport across biomimetic lipid membranes. Su Li, Peichi Hu, and Noah Malmstadt. Analytical Chemistry. 2010, 82 (18) pp 7766-7771. September 15, 2010. DOI: 10.1021/ac1016826

  5. Confocal imaging to quantify passive transport across biomimetic lipid membranes. Su Li, Peichi Hu, and Noah Malmstadt. Analytical Chemistry. 2010, 82 (18) pp 7766-7771. September 15, 2010. DOI: 10.1021/ac1016826.

  6. Label-free electrical detection of pyrophosphate generated from DNA polymerase reactions on field-effect devices. Grace M. Credo, Xing Su, Kai Wu, Oguz H. Elibol, David J. Liua, Bobby Reddy Jr., Ta-Wei Tsai, Brian R. Dorvel, Jonathan S. Daniels, Rashid Bashir, and Madoo Varma. Analyst. 2012 137 (6) p 1351-1362. March 21, 2012. DOI:10.1039/c2an15930a.

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