Functional Linkers – VectorLabs https://staging.vectorlabs.com From linker design and synthesis, bioconjugated design and manufacturing, biomolecule labeling and functionalization, and detection system and solutions, our team is here to help you move forward, with impact. Wed, 22 Oct 2025 17:17:53 +0000 en-US hourly 1 https://wordpress.org/?v=6.8.3 https://staging.vectorlabs.com/wp-content/uploads/2024/11/V-favicon-02-100x100.png Functional Linkers – VectorLabs https://staging.vectorlabs.com 32 32 DNP-dPEG®₁₂-NHS ester https://staging.vectorlabs.com/products/dnp-dpeg12-nhs-ester/ Sat, 24 Feb 2024 02:10:22 +0000 https://staging.vectorlabs.com/?post_type=product&p=36147 DNP-dPEG®12-NHS ester, product number QBD-10399, is a medium-length (40 atoms), single molecular weight, discrete polyethylene glycol (dPEG®) linker functionalized on one end with the fluorescent hapten 2,4-dinitrophenol and the N-hydroxysuccinimidyl (NHS) ester of propionic acid on the other end. The NHS ester reacts with free amines to form stable amide bonds. The DNP end of the molecule may be used as a hapten in the development of vaccines or immunotherapeutic applications.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 880.89; single compound
Chemical formula C₃₇H₆₀N₄O₂₀
CAS 1334178-01-6
Purity > 98%
Spacers dPEG® Spacer is 40 atoms and 46.4 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetontrile, DMAC, DMSO or water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

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Description

DNP-dPEG®12-NHS ester, product number QBD-10399, is a medium-length (40 atoms), single molecular weight, discrete polyethylene glycol (dPEG®) linker functionalized on one end with the fluorescent hapten 2,4-dinitrophenol and the N-hydroxysuccinimidyl (NHS) ester of propionic acid on the other end. The NHS ester reacts with free amines to form stable amide bonds. The DNP end of the molecule may be used as a hapten in the development of vaccines or immunotherapeutic applications.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight880.89; single compound
Chemical formulaC₃₇H₆₀N₄O₂₀
CAS1334178-01-6
Purity> 98%
SpacersdPEG® Spacer is 40 atoms and 46.4 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetontrile, DMAC, DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

The post DNP-dPEG®₁₂-NHS ester appeared first on VectorLabs.

]]> DNP-dPEG®₁₂-acid https://staging.vectorlabs.com/products/dnp-dpeg12-acid/ Sat, 24 Feb 2024 02:10:21 +0000 https://staging.vectorlabs.com/?post_type=product&p=36139 DNP-dPEG®12-acid, product number QBD-10398, is a medium-length (40 atoms), single molecular weight, discrete polyethylene glycol (dPEG®) linker functionalized on one end with the fluorescent hapten 2,4-dinitrophenol and propionic acid on the other end. The propionic acid reacts with free amines after activation with a carbodiimide to form stable amide bonds. The DNP end of the molecule functions as a hapten for use in development for vaccines or immunotherapeutic applications.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 783.82; single compound
Chemical formula C₃₃H₅₇N₃O₁₈
CAS 1334178-00-5
Purity > 98%
Spacers dPEG® Spacer is 40 atoms and 50 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetontrile, DMAC, DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post DNP-dPEG®₁₂-acid appeared first on VectorLabs.

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Description

DNP-dPEG®12-acid, product number QBD-10398, is a medium-length (40 atoms), single molecular weight, discrete polyethylene glycol (dPEG®) linker functionalized on one end with the fluorescent hapten 2,4-dinitrophenol and propionic acid on the other end. The propionic acid reacts with free amines after activation with a carbodiimide to form stable amide bonds. The DNP end of the molecule functions as a hapten for use in development for vaccines or immunotherapeutic applications.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight783.82; single compound
Chemical formulaC₃₃H₅₇N₃O₁₈
CAS1334178-00-5
Purity> 98%
SpacersdPEG® Spacer is 40 atoms and 50 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetontrile, DMAC, DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

The post DNP-dPEG®₁₂-acid appeared first on VectorLabs.

]]> DNP-dPEG®₄-NHS ester https://staging.vectorlabs.com/products/dnp-dpeg4-nhs-ester/ Sat, 24 Feb 2024 02:10:14 +0000 https://staging.vectorlabs.com/?post_type=product&p=36069 DNP-dPEG®4-NHS ester, product number QBD-10347, consists of a short (16 atoms) single molecular weight, discrete-chain-length (dPEG®) linker functionalized with a 2,4-dinitrophenyl group on one end and a N-hydroxysuccinimidyl (NHS) ester on the other. The NHS ester reacts optimally with free amines in the pH 7.0 - 7.5 range. The fluorescent label 2,4-dinitrophenol, also known as nitrophen, when attached to a non-immunogenic PEG spacer, functions as a hapten. Due to its strong immune response, it may be useful in designing vaccines or in other immunotherapeutic applications.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 528.47; single compound
Chemical formula C₂₁H₂₈N₄O₁₂
CAS 858126-78-0
Purity > 98%
Spacers dPEG® Spacer is 16 atoms and 18.0 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetontrile, DMAC, DMSO or water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post DNP-dPEG®₄-NHS ester appeared first on VectorLabs.

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Description

DNP-dPEG®4-NHS ester, product number QBD-10347, consists of a short (16 atoms) single molecular weight, discrete-chain-length (dPEG®) linker functionalized with a 2,4-dinitrophenyl group on one end and a N-hydroxysuccinimidyl (NHS) ester on the other. The NHS ester reacts optimally with free amines in the pH 7.0 – 7.5 range. The fluorescent label 2,4-dinitrophenol, also known as nitrophen, when attached to a non-immunogenic PEG spacer, functions as a hapten. Due to its strong immune response, it may be useful in designing vaccines or in other immunotherapeutic applications.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight528.47; single compound
Chemical formulaC₂₁H₂₈N₄O₁₂
CAS858126-78-0
Purity> 98%
SpacersdPEG® Spacer is 16 atoms and 18.0 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetontrile, DMAC, DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). See his chapter 19 especially in hapten-carrier chemistry and applications, as well as Chapter 18 on Discrete PEG pegylation reagents, with much of the chapter featuring our reagents.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

The post DNP-dPEG®₄-NHS ester appeared first on VectorLabs.

]]> DNP-dPEG®₄-acid https://staging.vectorlabs.com/products/dnp-dpeg4-acid/ Sat, 24 Feb 2024 02:10:13 +0000 https://staging.vectorlabs.com/?post_type=product&p=36058 Amino-dPEG®12-ODMT, product number QBD-10342, is designed for nucleic acid modification in applications where PEGylation improves the therapeutic or diagnostic profile. It contains a medium-length (38 atoms), single molecular weight, discrete PEG (dPEG®) linker with a free primary amine on one end and dimethoxytrityl-protected oxygen on the other. Following oligonucleotide synthesis, amino-dPEG®12-ODMT can be conjugated to phosphate groups on either end of the chain using water-soluble 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) chemistry. The 4,4′-dimethoxytrityl group can then be removed using a weak acid, such as dilute dichloroacetic acid, leaving the dPEG® linker terminated with a hydroxy group. Studies have shown that 3′ end capping (including PEGylation) helps the oligonucleotide chain resist nuclease degradation, while 5′ end PEGylation reduces renal clearance of the aptamer.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 848.03; single compound
Chemical formula C₁₇H₂₅N₃O₁₀
CAS 879571-23-0
Purity > 97%
Spacers dPEG® Spacer is 38 atoms and 43.9 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, Acetontrile, DMAC, DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post DNP-dPEG®₄-acid appeared first on VectorLabs.

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Description

DNP-dPEG®₄-acid – This product consists of the 2,4-dinitrophenyl hapten group on a short, discrete PEG spacer that terminates in a carboxylic acid for conjugation to amines and other appropriate reactive groups after activation with a carbodiimide.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight848.03; single compound
Chemical formulaC₁₇H₂₅N₃O₁₀
CAS879571-23-0
Purity> 97%
SpacersdPEG® Spacer is 38 atoms and 43.9 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetontrile, DMAC, DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). See his chapter 19 especially in hapten-carrier chemistry and applications, as well as Chapter 18 on Discrete PEG pegylation reagents, with much of the chapter featuring our reagents.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

The post DNP-dPEG®₄-acid appeared first on VectorLabs.

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