Methoxy-terminated Linkers – VectorLabs https://staging.vectorlabs.com From linker design and synthesis, bioconjugated design and manufacturing, biomolecule labeling and functionalization, and detection system and solutions, our team is here to help you move forward, with impact. Wed, 22 Oct 2025 17:21:20 +0000 en-US hourly 1 https://wordpress.org/?v=6.8.3 https://staging.vectorlabs.com/wp-content/uploads/2024/11/V-favicon-02-100x100.png Methoxy-terminated Linkers – VectorLabs https://staging.vectorlabs.com 32 32 m-dPEG®₂₅-DSPE https://staging.vectorlabs.com/products/m-dpeg25-dspe/ Sat, 24 Feb 2024 02:16:48 +0000 https://staging.vectorlabs.com/?post_type=product&p=39490 m-dPEG®25-DSPE, product number QBD-11373, modifies the lipid 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) with a long (77 atoms, 90.0 Å), methoxy-terminated, single molecular weight, discrete polyethylene glycol (dPEG®) spacer. This product is designed to protect liposomes and micelles from opsonization and elimination by the reticuloendothelial system (RES). The m-dPEG®25 spacer offers protection from opsonization comparable to the traditional polymer mPEG2000, while the smaller spacer size compared to mPEG2000 allows for more efficient uptake into cells. The methyl-capped dPEG® spacer has a neutral charge.

Vector Laboratories' dPEG® products are highly pure single molecular weight compounds with a discrete chain length. Traditional PEG compounds used to coat liposomes and micelles consist of an intractable mixture of different chain lengths and molecular weights. The non-uniform polymeric mixture leads to irreproducible purity profiles, unlike dPEG® compounds.

Specifications

Unit Size 25 mg, 100 mg
Molecular Weight 1891.416; single compound
Chemical formula C₉₃H₁₈₄NO₃₄P
CAS N/A
Purity > 98%
Spacers dPEG® Spacer is 77 atoms and 90.0 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene Chloride, Chloroform, or Acetonitrile.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post m-dPEG®₂₅-DSPE appeared first on VectorLabs.

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Description

m-dPEG®25-DSPE, product number QBD-11373, modifies the lipid 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) with a long (77 atoms, 90.0 Å), methoxy-terminated, single molecular weight, discrete polyethylene glycol (dPEG®) spacer. This product is designed to protect liposomes and micelles from opsonization and elimination by the reticuloendothelial system (RES). The m-dPEG®25 spacer offers protection from opsonization comparable to the traditional polymer mPEG2000, while the smaller spacer size compared to mPEG2000 allows for more efficient uptake into cells. The methyl-capped dPEG® spacer has a neutral charge.

Vector Laboratories’ dPEG® products are highly pure single molecular weight compounds with a discrete chain length. Traditional PEG compounds used to coat liposomes and micelles consist of an intractable mixture of different chain lengths and molecular weights. The non-uniform polymeric mixture leads to irreproducible purity profiles, unlike dPEG® compounds.

Specifications

Unit Size25 mg, 100 mg
Molecular Weight1891.416; single compound
Chemical formulaC₉₃H₁₈₄NO₃₄P
CASN/A
Purity> 98%
SpacersdPEG® Spacer is 77 atoms and 90.0 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene Chloride, Chloroform, or Acetonitrile.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

The post m-dPEG®₂₅-DSPE appeared first on VectorLabs.

]]> m-dPEG®₂₅-amido-dPEG®₂₄-DSPE https://staging.vectorlabs.com/products/m-dpeg25-amido-dpeg25-dspe/ Sat, 24 Feb 2024 02:14:54 +0000 https://staging.vectorlabs.com/?post_type=product&p=37443 m-dPEG®25-amido-dPEG®24-DSPE, product number QBD-11095, modifies the lipid 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) with a long (153 atoms, 179.8 Å), methoxy-terminated, single molecular weight, discrete polyethylene glycol (dPEG®) spacer. The spacer length is equivalent to a monodispersed mPEG49. This product is designed to protect liposomes and micelles from opsonization and elimination by the reticuloendothelial system (RES). The m-dPEG® spacer offers protection from opsonization comparable to the traditional polymer mPEG2000, but the monodispersed m-dPEG® product is a single compound, not a non-uniform (dispersed) polymer. The methyl-capped dPEG® spacer has a neutral charge.

Vector Laboratories' dPEG® products are highly pure single molecular weight compounds with a discrete chain length. Traditional PEG compounds used to coat liposomes and micelles consist of an intractable mixture of different chain lengths and molecular weights. The non-uniform polymeric mixture leads to irreproducible purity profiles, unlike dPEG® compounds.

Specifications

Unit Size 25 mg, 100mg
Molecular Weight 3019.76; single compound
Chemical formula C₁₄₄H₂₈₅N₂O₅₉P
CAS N/A
Purity > 98%
Spacers dPEG® Spacer is 153 atoms and 179.8 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene Chloride, Methanol, Acetonitrile, or DMF.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post m-dPEG®₂₅-amido-dPEG®₂₄-DSPE appeared first on VectorLabs.

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Description

m-dPEG®25-amido-dPEG®24-DSPE, product number QBD-11095, modifies the lipid 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) with a long (153 atoms, 179.8 Å), methoxy-terminated, single molecular weight, discrete polyethylene glycol (dPEG®) spacer. The spacer length is equivalent to a monodispersed mPEG49. This product is designed to protect liposomes and micelles from opsonization and elimination by the reticuloendothelial system (RES). The m-dPEG® spacer offers protection from opsonization comparable to the traditional polymer mPEG2000, but the monodispersed m-dPEG® product is a single compound, not a non-uniform (dispersed) polymer. The methyl-capped dPEG® spacer has a neutral charge.

Vector Laboratories’ dPEG® products are highly pure single molecular weight compounds with a discrete chain length. Traditional PEG compounds used to coat liposomes and micelles consist of an intractable mixture of different chain lengths and molecular weights. The non-uniform polymeric mixture leads to irreproducible purity profiles, unlike dPEG® compounds.

Specifications

Unit Size25 mg, 100mg
Molecular Weight3019.76; single compound
Chemical formulaC₁₄₄H₂₈₅N₂O₅₉P
CASN/A
Purity> 98%
SpacersdPEG® Spacer is 153 atoms and 179.8 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene Chloride, Methanol, Acetonitrile, or DMF.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

The post m-dPEG®₂₅-amido-dPEG®₂₄-DSPE appeared first on VectorLabs.

]]> m-dPEG®₁₂-amido-dPEG®₂₄-DSPE https://staging.vectorlabs.com/products/m-dpeg12-amido-dpeg24-dspe/ Sat, 24 Feb 2024 02:14:53 +0000 https://staging.vectorlabs.com/?post_type=product&p=37435 m-dPEG®12-amido-dPEG®24-DSPE, product number QBD-11094, modifies the lipid 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) with a long (114 atoms, 132.3 Å), methoxy-terminated, single molecular weight, discrete polyethylene glycol (dPEG®) spacer. The spacer length is equivalent to a monodispersed mPEG36. This product is designed to protect liposomes and micelles from opsonization and elimination by the reticuloendothelial system (RES). The m-dPEG® spacer offers protection from opsonization comparable to the traditional polymer mPEG2000, while the slightly smaller spacer size compared to mPEG2000 allows for more efficient uptake into cells. The methyl-capped dPEG® spacer has a neutral charge.

Vector Laboratories' dPEG® products are highly pure single molecular weight compounds with a discrete chain length. Traditional PEG compounds used to coat liposomes and micelles consist of an intractable mixture of different chain lengths and molecular weights. The non-uniform polymeric mixture leads to irreproducible purity profiles, unlike dPEG® compounds.

Specifications

Unit Size 25 mg, 100mg
Molecular Weight 2447.07; single compound
Chemical formula C₁₁₈H₂₃₃N₂O₄₆P
CAS N/A
Purity > 98%
Spacers dPEG® Spacer is 114 atoms and 132.3 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene Chloride, Methanol, Acetonitrile, or DMF.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post m-dPEG®₁₂-amido-dPEG®₂₄-DSPE appeared first on VectorLabs.

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Description

m-dPEG®12-amido-dPEG®24-DSPE, product number QBD-11094, modifies the lipid 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) with a long (114 atoms, 132.3 Å), methoxy-terminated, single molecular weight, discrete polyethylene glycol (dPEG®) spacer. The spacer length is equivalent to a monodispersed mPEG36. This product is designed to protect liposomes and micelles from opsonization and elimination by the reticuloendothelial system (RES). The m-dPEG® spacer offers protection from opsonization comparable to the traditional polymer mPEG2000, while the slightly smaller spacer size compared to mPEG2000 allows for more efficient uptake into cells. The methyl-capped dPEG® spacer has a neutral charge.

Vector Laboratories’ dPEG® products are highly pure single molecular weight compounds with a discrete chain length. Traditional PEG compounds used to coat liposomes and micelles consist of an intractable mixture of different chain lengths and molecular weights. The non-uniform polymeric mixture leads to irreproducible purity profiles, unlike dPEG® compounds.

Specifications

Unit Size25 mg, 100mg
Molecular Weight2447.07; single compound
Chemical formulaC₁₁₈H₂₃₃N₂O₄₆P
CASN/A
Purity> 98%
SpacersdPEG® Spacer is 114 atoms and 132.3 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene Chloride, Methanol, Acetonitrile, or DMF.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

The post m-dPEG®₁₂-amido-dPEG®₂₄-DSPE appeared first on VectorLabs.

]]> m-dPEG®₈-DSPE https://staging.vectorlabs.com/products/m-dpeg8-dspe/ Sat, 24 Feb 2024 02:14:45 +0000 https://staging.vectorlabs.com/?post_type=product&p=37366 m-dPEG®8-DSPE, product number QBD-11024, modifies the lipid 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) with a short (26 atoms, 29.8 Å), methoxy-terminated, single molecular weight, discrete polyethylene glycol (dPEG®) spacer. This product is designed to protect liposomes and micelles from opsonization and elimination by the reticuloendothelial system (RES). The m-dPEG®8 spacer offers protection from opsonization comparable to the traditional polymer mPEG2000, while the smaller spacer size compared to mPEG2000 allows for more efficient uptake into cells. The methyl-capped dPEG® spacer has a neutral charge.

Vector Laboratories' dPEG® products are highly pure single molecular weight compounds with a discrete chain length. Traditional PEG compounds used to coat liposomes and micelles consist of an intractable mixture of different chain lengths and molecular weights. The non-uniform polymeric mixture leads to irreproducible purity profiles, unlike dPEG® compounds.

Specifications

Unit Size 25 mg, 100mg
Molecular Weight 1142.52; single compound
Chemical formula C₅₉H₁₁₆NO₁₇P
CAS N/A
Purity > 96%
Spacers dPEG® Spacer is 26 atoms and 29.8 Å, avg.
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene Chloride.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post m-dPEG®₈-DSPE appeared first on VectorLabs.

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Description

m-dPEG®8-DSPE, product number QBD-11024, modifies the lipid 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) with a short (26 atoms, 29.8 Å), methoxy-terminated, single molecular weight, discrete polyethylene glycol (dPEG®) spacer. This product is designed to protect liposomes and micelles from opsonization and elimination by the reticuloendothelial system (RES). The m-dPEG®8 spacer offers protection from opsonization comparable to the traditional polymer mPEG2000, while the smaller spacer size compared to mPEG2000 allows for more efficient uptake into cells. The methyl-capped dPEG® spacer has a neutral charge.

Vector Laboratories’ dPEG® products are highly pure single molecular weight compounds with a discrete chain length. Traditional PEG compounds used to coat liposomes and micelles consist of an intractable mixture of different chain lengths and molecular weights. The non-uniform polymeric mixture leads to irreproducible purity profiles, unlike dPEG® compounds.

Specifications

Unit Size25 mg, 100mg
Molecular Weight1142.52; single compound
Chemical formulaC₅₉H₁₁₆NO₁₇P
CASN/A
Purity> 96%
SpacersdPEG® Spacer is 26 atoms and 29.8 Å, avg.
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene Chloride.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Ligand-targeted liposome design: challenges and fundamental considerations. Gavin T. Noble, Jared F. Stefanick, Jonathan D. Ashley, Tanyel Kiziltepe, Basar Bilgicer. Trends in Biotechnology. 2014, 32 (1) pp 32-45. January 2014. DOI: 10.1016/j.tibtech.2013.09.007.

The post m-dPEG®₈-DSPE appeared first on VectorLabs.

]]> m-dPEG®₁₃-DSPE https://staging.vectorlabs.com/products/m-dpeg13-dspe/ Sat, 24 Feb 2024 02:04:36 +0000 https://staging.vectorlabs.com/?post_type=product&p=34864 m-dPEG®13-DSPE, product number QBD-10052, is composed of the lipid 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine (DSPE), modified with a methoxy-terminated, single molecular weight, discrete polyethylene glycol (dPEG®). The medium-length (41 atoms, 47.1 Å) dPEG® spacer protects liposomes and micelles from opsonization and elimination by the reticuloendothelial system (RES).

Specifications

Unit Size 25 mg, 100 mg
Molecular Weight 1362.79; single compound
Chemical formula C₆₉H₁₃₆NO₂₂P
CAS
N/A
Purity > 98%
Spacers
dPEG® spacer is 41 atoms and 47.1 Å.
Shipping
Ambient
Typical solubility properties (for additional information contact Customer Support) DCM, Ethyl acetate, Acetonitrile, Methanol, or MTBE
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post m-dPEG®₁₃-DSPE appeared first on VectorLabs.

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Description

m-dPEG®13-DSPE, product number QBD-10052, is composed of the lipid 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine (DSPE), modified with a methoxy-terminated, single molecular weight, discrete polyethylene glycol (dPEG®). The medium-length (41 atoms, 47.1 Å) dPEG® spacer protects liposomes and micelles from opsonization and elimination by the reticuloendothelial system (RES).

Specifications

Unit Size 25 mg, 100 mg
Molecular Weight 1362.79; single compound
Chemical formula C₆₉H₁₃₆NO₂₂P
CAS
N/A
Purity > 98%
Spacers
dPEG® spacer is 41 atoms and 47.1 Å.
Shipping
Ambient
Typical solubility properties (for additional information contact Customer Support) DCM, Ethyl acetate, Acetonitrile, Methanol, or MTBE
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

  1. Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

  2. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

The post m-dPEG®₁₃-DSPE appeared first on VectorLabs.

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