Accelerating Ligands – VectorLabs https://staging.vectorlabs.com From linker design and synthesis, bioconjugated design and manufacturing, biomolecule labeling and functionalization, and detection system and solutions, our team is here to help you move forward, with impact. Wed, 22 Oct 2025 17:08:06 +0000 en-US hourly 1 https://wordpress.org/?v=6.8.3 https://staging.vectorlabs.com/wp-content/uploads/2024/11/V-favicon-02-100x100.png Accelerating Ligands – VectorLabs https://staging.vectorlabs.com 32 32 BTTP https://staging.vectorlabs.com/products/bttp/ Tue, 19 Sep 2023 19:32:16 +0000 https://staging.vectorlabs.com/?post_type=product&p=22052 Description

BTTP is a newest generation, accelerating ligand for CuAAC that provides much greater rate enhancement compared to previous generation ligands (e.g. THPTA or TBTA). More importantly, it minimizes perturbations to the physiological state of the cells or organisms probed and allows for effective bioconjugation with suppressed cell cytotoxicity by further lowering copper loading in the catalyst formulation.

Specifications

Unit Size 100 mg, 500 mg, 1000 mg
Molecular weight 430.56
Chemical composition C20H34N10O
CAS 1334179-85-9
Solubility DMSO, DMF, MeOH
Purity >95% (HPLC)
Appearance Off-white to grey solid
Storage Conditions 4°C.
Shipping Conditions Ambient temperature

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Description

BTTP is a newest generation, accelerating ligand for CuAAC that provides much greater rate enhancement compared to previous generation ligands (e.g. THPTA or TBTA). More importantly, it minimizes perturbations to the physiological state of the cells or organisms probed and allows for effective bioconjugation with suppressed cell cytotoxicity by further lowering copper loading in the catalyst formulation.

Specifications

Unit Size100 mg, 500 mg, 1000 mg
Molecular weight430.56
Chemical compositionC20H34N10O
CAS1334179-85-9
SolubilityDMSO, DMF, MeOH
Purity>95% (HPLC)
AppearanceOff-white to grey solid
Storage Conditions4°C.
Shipping ConditionsAmbient temperature

Documents

Selected References

  1. Maiyun, Y., et al. (2014). Biocompatible click chemistry enabled compartment-specific pH measurement inside E. coli. Nature Communications. 5: 4981. [PubMed]
  2. Wang, W., et al. (2011). Sulfated ligands for the copper(I)-catalyzed azide-alkyne cycloaddition. Chem Asian J., 6(10), 2796-802. [PubMed]

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]]> TBTA https://staging.vectorlabs.com/products/tbta/ Tue, 19 Sep 2023 19:20:44 +0000 https://staging.vectorlabs.com/?post_type=product&p=21843 Description

TBTA was introduced shortly after the copper-catalyzed azide-alkyne cycloaddition reaction was discovered to mitigate thermodynamic instability of Cu(I) in aerobic media. TBTA is a water-insoluble ligand and must be first dissolved in DMSO or DMF.

Specifications

Unit Size 100 mg, 500 mg, 1 g
Molecular weight 530.62
Chemical composition C30H30N10
CAS 510758-28-8
Solubility DMSO, DMF, DCM, THF, Chloroform
Purity >95% (HPLC)
Appearance Off-white to grey solid
Storage Conditions 4°C.
Shipping Conditions Ambient temperature

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Description

TBTA was introduced shortly after the copper-catalyzed azide-alkyne cycloaddition reaction was discovered to mitigate thermodynamic instability of Cu(I) in aerobic media. TBTA is a water-insoluble ligand and must be first dissolved in DMSO or DMF.

Specifications

Unit Size100 mg, 500 mg, 1 g
Molecular weight530.62
Chemical compositionC30H30N10
CAS510758-28-8
SolubilityDMSO, DMF, DCM, THF, Chloroform
Purity>95% (HPLC)
AppearanceOff-white to grey solid
Storage Conditions4°C.
Shipping ConditionsAmbient temperature

Documents

Selected References

  1. David, L. L., et al. (2021). Chemical Proteomics Approach for Profiling the NAD Interactome. J Am Chem Soc., 143 (18), 6787-6791. [PubMed]
  2. Gray, R. A. V., et al. (2021). Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry. JoVE Journal, 10 (3791), 62107. [JoVE Journal]
  3. Pratt Matthew R., et al. (2020). Acetylated Chemical Reporters of Glycosylation Can Display Metabolism-Dependent Background Labeling of Proteins but Are Generally Reliable Tools for the Identification of Glycoproteins. Frontiers in Chemistry, 8, 318. [Frontiers in Chemistry]
  4. White, F. K. H., et al. (2019). S-Palmitoylation of junctophilin-2 is critical for its role in tethering the sarcoplasmic reticulum to the plasma membrane. J Biol Chem., 294 (36), 13487-13501. [PubMed]

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]]> BTTES https://staging.vectorlabs.com/products/bttes/ Tue, 19 Sep 2023 19:20:15 +0000 https://staging.vectorlabs.com/?post_type=product&p=21837 Description

BTTES is a newest generation, water-soluble accelerating ligand for CuAAC that provides much greater rate enhancement compared to previous generation ligands (e.g. THPTA or TBTA). More importantly, it minimizes perturbations to the physiological state of the cells or organisms probed and allows for effective bioconjugation with suppressed cell cytotoxicity by further lowering Cu loading in the catalyst formulation.

Specifications

Unit Size 100 mg, 500 mg, 1000 mg
Molecular weight 494.62
Chemical composition C20H34N10O3
CAS N/A
Solubility Water, DMSO, DMF, MeOH
Purity >95% (HPLC)
Appearance Off-white to grey solid
Storage Conditions 4°C.
Shipping Conditions Ambient temperature

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Description

BTTES is a newest generation, water-soluble accelerating ligand for CuAAC that provides much greater rate enhancement compared to previous generation ligands (e.g. THPTA or TBTA). More importantly, it minimizes perturbations to the physiological state of the cells or organisms probed and allows for effective bioconjugation with suppressed cell cytotoxicity by further lowering Cu loading in the catalyst formulation.

Specifications

Unit Size100 mg, 500 mg, 1000 mg
Molecular weight494.62
Chemical compositionC20H34N10O3
CASN/A
SolubilityWater, DMSO, DMF, MeOH
Purity>95% (HPLC)
AppearanceOff-white to grey solid
Storage Conditions4°C.
Shipping ConditionsAmbient temperature

Documents

Selected References

  1. Banerjee, C., et al. (2022). Visualizing the Conformational Dynamics of Membrane Receptors Using Single-Molecule FRET. J Vis Exp., 186. [PubMed]
  2. Schamber, M. R., et al. (2022). Conformational fingerprinting of allosteric modulators in metabotropic glutamate receptor 2. Elife, 11:e78982. [PubMed]
  3. Schamber, M. R., et al. (2022). Mechanism of sensitivity modulation in the calcium-sensing receptor via electrostatic tuning. Nat Commun., 13 (1), 2194. [PubMed]
  4. BSoriano del Amo, D., et al. (2010). Biocompatible copper(I) catalysts for in vivo imaging of glycans J. Am. Chem. Soc.,. 132(47): 16893–9. [PubMed]

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]]> BTTAA https://staging.vectorlabs.com/products/bttaa/ Tue, 19 Sep 2023 19:19:48 +0000 https://staging.vectorlabs.com/?post_type=product&p=21832 Description

BTTAA is a newest generation, water-soluble accelerating ligand for CuAAC that provides much greater rate enhancement compared to previous generation ligands (e.g. THPTA or TBTA). More importantly, it minimizes perturbations to the physiological state of the cells or organisms probed and allows for effective bioconjugation with suppressed cell cytotoxicity by further lowering copper loading in the catalyst formulation.

Specifications

Unit Size 100 mg, 500 mg, 1000 mg
Molecular weight 430.52
Chemical composition C19H30N10O2
CAS 1334179-85-9
Solubility Water, DMSO, DMF, MeOH
Purity >95% (HPLC)
Appearance Off-white to grey solid
Storage Conditions 4°C.
Shipping Conditions Ambient temperature

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Description

BTTAA is a newest generation, water-soluble accelerating ligand for CuAAC that provides much greater rate enhancement compared to previous generation ligands (e.g. THPTA or TBTA). More importantly, it minimizes perturbations to the physiological state of the cells or organisms probed and allows for effective bioconjugation with suppressed cell cytotoxicity by further lowering copper loading in the catalyst formulation.

Specifications

Unit Size100 mg, 500 mg, 1000 mg
Molecular weight430.52
Chemical compositionC19H30N10O2
CAS1334179-85-9
SolubilityWater, DMSO, DMF, MeOH
Purity>95% (HPLC)
AppearanceOff-white to grey solid
Storage Conditions4°C.
Shipping ConditionsAmbient temperature

Documents

Selected References

  1. Graham, A. J., et al. (2022). Extracellular Electron Transfer Enables Cellular Control of Cu(I)-Catalyzed Alkyne-Azide Cycloaddition. ACS Cent Sci., 8 (2), 246-257. [PubMed]
  2. Tharp, J. M., et al. (2021). Genetic Encoding of Three Distinct Noncanonical Amino Acids Using Reprogrammed Initiator and Nonsense Codons. ACS Chem Biol., 16 (4), 766-774. [PubMed]
  3. Wood, T. M., et al. (2021). Optimization of Metabolic Oligosaccharide Engineering with Ac4GalNAlk and Ac4GlcNAlk by an Engineered Pyrophosphorylase. ACS Chem. Biol., [PubMed]
  4. Li, B., et al. (2020). TMEM132A, a Novel Wnt Signaling Pathway Regulator Through Wntless (WLS) Interaction. Front Cell Dev Biol., 8, 599890. [PubMed]
  5. Simon P. Wisnovsky, et al. (2020). Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation. PNAS, 117 (41), 25293-25301. [PNAS]
  6. Jun Kit Ow, M., et al. (2020). Super-Resolution Fluorescence Microscopy Reveals Nanoscale Catalytic Heterogeneity on Single Copper Nanowires. ACS Appl. Nano Mater.,, 3, 4, 3163–7. [ACSPublications]
  7. Jiang, H., et al. (2014). Monitoring Dynamic Glycosylation in Vivo Using Supersensitive Click Chemistry. Bioconjugate Chem.,, 25, 698-706. [PubMed]
  8. Uttamapinant, C., et al. (2012). Fast, Cell-Compatible Click Chemistry with Copper-Chelating Azides for Biomolecular Labeling. Angew. Chem. Int. Ed,., 51, 5852-56. [PubMed]
  9. Besanceney-Webler, C., et al. (2011). Increasing the efficacy of bioorthogonal click reactions for bioconjugation: a comparative study. Angew. Chem. Int. Ed,. 50 (35): 8051–6. [PubMed]

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]]> THPTA https://staging.vectorlabs.com/products/thpta/ Tue, 19 Sep 2023 19:19:46 +0000 https://staging.vectorlabs.com/?post_type=product&p=21827 Description

THPTA (tris-hydroxypropyltriazolylmethylamine) is a water-soluble, very effective accelerating ligand for copper-catalyzed Alkyne-Azide click chemistry reactions (CuAAC). In addition to greatly enhancing the rate of CuAAC, THPTA minimizes perturbations to the physiological state of the cells or organisms probed and allows for the effective bioconjugation with suppressed cell cytotoxicity by further lowering Cu loading in the catalyst formulation. The water-soluble THPTA ligand further simplifies click chemistry by allowing the entire reaction to be run in water.

Specifications

Unit Size 100 mg, 500 mg, 1000 mg, 5 g
Chemical composition C18H30N10O3
Molecular weight 434.50
CAS 760952-88-3
Solubility Water, DMSO, DMF, MeOH
Purity >95% (HPLC)
Appearance Off-white to grey solid
Storage Conditions 4°C.
Shipping Conditions Ambient temperature

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Description

THPTA (tris-hydroxypropyltriazolylmethylamine) is a water-soluble, very effective accelerating ligand for copper-catalyzed Alkyne-Azide click chemistry reactions (CuAAC). In addition to greatly enhancing the rate of CuAAC, THPTA minimizes perturbations to the physiological state of the cells or organisms probed and allows for the effective bioconjugation with suppressed cell cytotoxicity by further lowering Cu loading in the catalyst formulation. The water-soluble THPTA ligand further simplifies click chemistry by allowing the entire reaction to be run in water.

Specifications

Unit Size100 mg, 500 mg, 1000 mg, 5 g  
Chemical compositionC18H30N10O3
Molecular weight434.50
CAS760952-88-3
SolubilityWater, DMSO, DMF, MeOH
Purity>95% (HPLC)
AppearanceOff-white to grey solid
Storage Conditions4°C.
Shipping ConditionsAmbient temperature

Documents

Selected References

  1. Graham, A. J., et al. (2022). Extracellular Electron Transfer Enables Cellular Control of Cu(I)-Catalyzed Alkyne-Azide Cycloaddition. ACS Cent Sci., 8 (2), 246-257. [PubMed]
  2. Loebel , C., et al. (2022). Metabolic labeling of secreted matrix to investigate cell-material interactions in tissue engineering and mechanobiology. Nat Protoc., 10.1038, Online ahead of print. [PubMed]
  3. Leach, R. W., et al. (2021). Activity-based RNA-modifying enzyme probing reveals DUS3L-mediated dihydrouridylation. Nat Chem Biol., 17 (11), 1178-1187. [PubMed]
  4. Buch-Larsen, S. C., et al. (2021). Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets. Elife, 10, e60480. [PubMed]
  5. Kang, D., et al. (2021). Bioorthogonal Retro-Cope Elimination Reaction of N, N-Dialkylhydroxylamines and Strained Alkynes. J Am Chem Soc., 143 (15), 5616-5621. [PubMed]
  6. Bazrafshan, A. et al. (2021). DNA Gold Nanoparticle Motors Demonstrate Processive Motion with Bursts of Speed Up to 50 nm Per Second. ACS Publications, Online ahead of print. [PubMed]
  7. Baskin, J. A., et al. (2021). A chemoproteomics approach to profile phospholipase D-derived phosphatidyl alcohol interactions. Cambridge: Cambridge Open Engage, This content is a preprint and has not been peer-reviewed. [ChemRxiv.]
  8. Batrouni, A. G., et al. (2021). A palmitoylation code controls PI4KIIIα complex formation and PI(4,5)P2 homeostasis at the plasma membrane bioRxiv, This content is a preprint and has not been peer-reviewed. [bioRxiv]
  9. Feng, S., et al. (2021). Combining Metabolic Alkyne Labeling and Click Chemistry for Secretome Analysis of Serum-Containing Conditioned Medium†. Chin. J. Chem., 39, 1843-1848. [Wiley Online Library]
  10. Willems, L. I., et al. (2020). Tandem Bioorthogonal Labeling Uncovers Endogenous Cotranslationally O-GlcNAc Modified Nascent Proteins. J Am Chem Soc., 142 (37), 15729-15739. [PubMed]
  11. Daughtry, J. L., et al. (2020). Clickable Galactose Analogues for Imaging Glycans in Developing Zebrafish. ACS Chem Biol., 15 (2), 318-324. [PubMed]
  12. Tong, M., et al. (2020). Effective Method for Accurate and Sensitive Quantitation of Rapid Changes of Newly Synthesized Proteins. Anal. Chem., 92(14), 10048-57. [PubMed]

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