Homobifunctional Carboxyl Reactive Monoprotected – VectorLabs https://staging.vectorlabs.com From linker design and synthesis, bioconjugated design and manufacturing, biomolecule labeling and functionalization, and detection system and solutions, our team is here to help you move forward, with impact. Wed, 22 Oct 2025 17:16:47 +0000 en-US hourly 1 https://wordpress.org/?v=6.8.3 https://staging.vectorlabs.com/wp-content/uploads/2024/11/V-favicon-02-100x100.png Homobifunctional Carboxyl Reactive Monoprotected – VectorLabs https://staging.vectorlabs.com 32 32 t-boc-N-EDA https://staging.vectorlabs.com/products/t-boc-n-eda/ Sat, 24 Feb 2024 02:07:24 +0000 https://staging.vectorlabs.com/?post_type=product&p=35509 t-boc-N-EDA, product number QBD-10226, CAS number 57260-73-8, is the boc-protected form of ethylenediamine. It is not a dPEG® product. However, it can be useful in bioconjugation reactions where an exceptionally short, monoprotected, homobifunctional crosslinker is needed. The free primary amine reacts with activated esters of carboxylic acids (for example, the N-hydroxysuccinimidyl ester, also known as NHS) to form amide bonds. Treatment of the resulting conjugate with acid (for example, TFA) removes the boc protecting group from the protected amine, leaving a primary amine that is free to react.

Specifications

Unit Size 1000 mg
Molecular Weight 160.21; single compound
Chemical formula C₁₅H₃₂N₂O₅
CAS 57260-73-8
Purity > 98%
Spacers dPEG® Spacer is 4 atoms and 3.8 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, DMAC or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

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Description

t-boc-N-EDA, product number QBD-10226, CAS number 57260-73-8, is the boc-protected form of ethylenediamine. It is not a dPEG® product. However, it can be useful in bioconjugation reactions where an exceptionally short, monoprotected, homobifunctional crosslinker is needed. The free primary amine reacts with activated esters of carboxylic acids (for example, the N-hydroxysuccinimidyl ester, also known as NHS) to form amide bonds. Treatment of the resulting conjugate with acid (for example, TFA) removes the boc protecting group from the protected amine, leaving a primary amine that is free to react.

Specifications

Unit Size1000 mg
Molecular Weight160.21; single compound
Chemical formulaC₁₅H₃₂N₂O₅
CAS57260-73-8
Purity> 98%
SpacersdPEG® Spacer is 4 atoms and 3.8 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, DMAC or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

  1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.
  2. DEVD-NucView 488: a novel class of enzyme substrates for real-time detection of caspase-3 activity in live cells. Hui Cen, Fei Mao, Ida Aronchik, Rholinelle Joy Fuentes, and Gary L. Firestone. The FASEB Journal. 2008, (22), pp 2243-2252. July 2010. DOI: 10.1096/fj.07-099234.

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