Heterobifunctional Thiol & Carboxyl Reactive – VectorLabs https://staging.vectorlabs.com From linker design and synthesis, bioconjugated design and manufacturing, biomolecule labeling and functionalization, and detection system and solutions, our team is here to help you move forward, with impact. Wed, 22 Oct 2025 17:16:47 +0000 en-US hourly 1 https://wordpress.org/?v=6.8.3 https://staging.vectorlabs.com/wp-content/uploads/2024/11/V-favicon-02-100x100.png Heterobifunctional Thiol & Carboxyl Reactive – VectorLabs https://staging.vectorlabs.com 32 32 Bis-Maleimide amine,TFA salt https://staging.vectorlabs.com/products/bis-maleimide-aminetfa-salt/ Sat, 24 Feb 2024 02:07:27 +0000 https://staging.vectorlabs.com/?post_type=product&p=35523 Bis-Maleimide amine, TFA salt, product number QBD-10232, is a crosslinking product designed to bridge disulfide bonds. Built around a lysine core, maleimido-propanoate modifies both the α and ε amino groups of lysine. Diaminohexane converts the carboxylic acid of lysine to an amine (as a TFA salt). This is not a dPEG® product; however, it can react with the carboxylic acid termini of dPEG® products to form new products.

Description

Bis-Maleimide amine, TFA salt, product number QBD-10232, is a crosslinking product designed to bridge disulfide bonds. Built around a lysine core, maleimido-propanoate groups modify the α and ε amine of lysine. Diaminohexane converts the carboxylic acid of lysine to an amine (as a TFA salt). This is not a dPEG® product; however, it can react with the carboxylic acid termini of dPEG® products to form new products.

Bis-Maleimide amine, TFA salt, is designed to bridge disulfide bonds. The spacer length from maleimide reactive site through the α-amino group to the terminal amine-TFA salt is 17 atoms and 19.1 Å. The spacer length from the maleimide double bond through the ε-amino group to the terminal amine-TFA salt is 21 atoms and 19.6 Å.
Bis-Maleimide amine, TFA salt, is designed to bridge disulfide bonds. The spacer length from maleimide reactive site through the α-amino group to the terminal amine-TFA salt is 17 atoms and 19.1 Å. The spacer length from the maleimide double bond through the ε-amino group to the terminal amine-TFA salt is 21 atoms and 19.6 Å.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 660.64; single compound
Chemical formula C₂₈H₃₉F₃N₆O₉
CAS 1301738-40-8
Purity > 95%
Spacers Spacer is 17 and 21 atoms and 19.1 and 19.6 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) DMAC, DMSO or water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

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Bis-Maleimide amine, TFA salt, product number QBD-10232, is a crosslinking product designed to bridge disulfide bonds. Built around a lysine core, maleimido-propanoate modifies both the α and ε amino groups of lysine. Diaminohexane converts the carboxylic acid of lysine to an amine (as a TFA salt). This is not a dPEG® product; however, it can react with the carboxylic acid termini of dPEG® products to form new products.

Description

Bis-Maleimide amine, TFA salt, product number QBD-10232, is a crosslinking product designed to bridge disulfide bonds. Built around a lysine core, maleimido-propanoate groups modify the α and ε amine of lysine. Diaminohexane converts the carboxylic acid of lysine to an amine (as a TFA salt). This is not a dPEG® product; however, it can react with the carboxylic acid termini of dPEG® products to form new products.

Bis-Maleimide amine, TFA salt, is designed to bridge disulfide bonds. The spacer length from maleimide reactive site through the α-amino group to the terminal amine-TFA salt is 17 atoms and 19.1 Å. The spacer length from the maleimide double bond through the ε-amino group to the terminal amine-TFA salt is 21 atoms and 19.6 Å.
Bis-Maleimide amine, TFA salt, is designed to bridge disulfide bonds. The spacer length from maleimide reactive site through the α-amino group to the terminal amine-TFA salt is 17 atoms and 19.1 Å. The spacer length from the maleimide double bond through the ε-amino group to the terminal amine-TFA salt is 21 atoms and 19.6 Å.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight660.64; single compound
Chemical formulaC₂₈H₃₉F₃N₆O₉
CAS1301738-40-8
Purity> 95%
SpacersSpacer is 17 and 21 atoms and 19.1 and 19.6 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)DMAC, DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

  1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.
  2. Mono-PEGylated Dimeric Exendin-4 as High Receptor Binding and Long-Acting Conjugates for Type 2 Anti-Diabetes Therapeutics.Tae Hyung Kim, Hai Hua Jiang, Seulki Lee, Yu Seok Youn, Chan Woong Park,Youngro Byun, Xiaoyuan Chen, and Kang Choon Lee. Bioconjugate Chem. 2011, 22 (4), pp 625–632. March 14, 2011. DOI: 10.1021/bc100404x.
  3. Reorienting the Fab Domains of Trastuzumab Results in Potent HER2 Activators. Justin M. Scheer, Wendy Sandoval, J. Michael Elliott, Lily Shao, Elizabeth Luis, Sock-Cheng Lewin-Koh, Gabriele Schaefer, Richard Vandlen. PLOS ONE. 2012, 7 (12) e51817. December 20, 2012. DOI: 10.1371/journal.pone.0051817.

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]]> MPS-EDA.TFA https://staging.vectorlabs.com/products/mps-eda-tfa/ Sat, 24 Feb 2024 02:05:10 +0000 https://staging.vectorlabs.com/?post_type=product&p=35201 MPS-EDA•TFA, product number QBD-10177, is the trifluoroacetic acid salt of N-(2-aminoethyl)-3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamide. This product crosslinks a sulfhydryl group and a carboxylic acid. The spacer length from the maleimide reactive site to the terminal nitrogen is ten (10) atoms long (10.7 Å). The product is a highly water-soluble white solid. It is extremely stable under recommended storage conditions. Although this product does not contain a dPEG® linker or spacer, it can be conjugated to the carboxylic acid termini of various dPEG® products to form maleimide-functionalized constructs.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 325.24; single compound
Chemical formula C₁₁H₁₄F₃N₃O₅
CAS 11550-02-00
Purity > 98%
Spacers Spacer is 10 atoms and 10.7 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) DMAC, DMSO or water.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

The post MPS-EDA.TFA appeared first on VectorLabs.

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Description

MPS-EDA•TFA, product number QBD-10177, is the trifluoroacetic acid salt of N-(2-aminoethyl)-3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamide. This product crosslinks a sulfhydryl group and a carboxylic acid. The spacer length from the maleimide reactive site to the terminal nitrogen is ten (10) atoms long (10.7 Å). The product is a highly water-soluble white solid. It is extremely stable under recommended storage conditions. Although this product does not contain a dPEG® linker or spacer, it can be conjugated to the carboxylic acid termini of various dPEG® products to form maleimide-functionalized constructs.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight325.24; single compound
Chemical formulaC₁₁H₁₄F₃N₃O₅
CAS11550-02-00
Purity> 98%
SpacersSpacer is 10 atoms and 10.7 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)DMAC, DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

Documents

References

  1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

The post MPS-EDA.TFA appeared first on VectorLabs.

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