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BioChronicles Blog

Engineered Antibodies for Neurodegenerative Disease Research

Neurodegenerative diseases like Alzheimer’s disease (AD) and Parkinson’s disease (PD) are complex and prescient subjects of research, characterized by the accumulation of misfolded proteins in the nervous system that exhibit pathogen behavior (Armstrong, 2020). With as many as 6.2 million Americans with AD and nearly a million with PD in the United States alone, and those numbers expected to rise, the need for comprehensive understanding of the pathways that contribute to neurodegenerative pathogenesis is only growing

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Chimeric vs. Humanized Antibodies

Antibody engineering and recombinant production have greatly impacted the research, biotechnology, and therapeutics fields. Recombinant DNA technology allows scientists to reformat antibodies into different isotypes, subtypes, species, formats, etc.

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